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Helicobacter pylori infection, susceptibility to

MedGen UID:
325004
Concept ID:
C1838332
Disease or Syndrome
Synonym: HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO
 
Gene (location): IFNGR1 (6q23.3)
 
Monarch Initiative: MONDO:0010853
OMIM®: 600263

Definition

Helicobacter pylori is a microaerophilic, gram-negative bacterium that colonizes the gastric mucosa of approximately 50% of the world's population, and is a primary pathogenic factor in benign and malignant gastroduodenal disease (Warren and Marshall, 1983; Blaser and Parsonnet, 1994). Tomb et al. (1997) reported the complete sequence of the circular genome of H. pylori. The 1,667,867-bp genome contains 1,590 predicted coding sequences (genes). Sequence analysis of these genes indicated that the organism has systems for motility, for scavenging iron, and for DNA restriction and modification. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH. [from OMIM]

Clinical features

From HPO
Helicobacter pylori infection
MedGen UID:
208857
Concept ID:
C0850666
Disease or Syndrome
A recurrent infection of the GI tract with helicobacter pylori, a gram-negative, microaerophilic bacterium usually found in the stomach.

Professional guidelines

PubMed

Homan M, Jones NL, Bontems P, Carroll MW, Czinn SJ, Gold BD, Goodman K, Harris PR, Jerris R, Kalach N, Kori M, Megraud F, Rowland M, Tavares M; on behalf of ESPGHAN/NASPGHAN
J Pediatr Gastroenterol Nutr 2024 Sep;79(3):758-785. Epub 2024 Aug 15 doi: 10.1002/jpn3.12314. PMID: 39148213
Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262

Curated

UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019

Recent clinical studies

Etiology

Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Usui Y, Taniyama Y, Endo M, Koyanagi YN, Kasugai Y, Oze I, Ito H, Imoto I, Tanaka T, Tajika M, Niwa Y, Iwasaki Y, Aoi T, Hakozaki N, Takata S, Suzuki K, Terao C, Hatakeyama M, Hirata M, Sugano K, Yoshida T, Kamatani Y, Nakagawa H, Matsuda K, Murakami Y, Spurdle AB, Matsuo K, Momozawa Y
N Engl J Med 2023 Mar 30;388(13):1181-1190. doi: 10.1056/NEJMoa2211807. PMID: 36988593
Wu Y, Murray GK, Byrne EM, Sidorenko J, Visscher PM, Wray NR
Nat Commun 2021 Feb 19;12(1):1146. doi: 10.1038/s41467-021-21280-7. PMID: 33608531Free PMC Article
Burucoa C, Axon A
Helicobacter 2017 Sep;22 Suppl 1 doi: 10.1111/hel.12403. PMID: 28891138
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262

Diagnosis

Homan M, Jones NL, Bontems P, Carroll MW, Czinn SJ, Gold BD, Goodman K, Harris PR, Jerris R, Kalach N, Kori M, Megraud F, Rowland M, Tavares M; on behalf of ESPGHAN/NASPGHAN
J Pediatr Gastroenterol Nutr 2024 Sep;79(3):758-785. Epub 2024 Aug 15 doi: 10.1002/jpn3.12314. PMID: 39148213
Schuetz AN, Theel ES, Cole NC, Rothstein TE, Gordy GG, Patel R
J Clin Microbiol 2024 Feb 14;62(2):e0073223. Epub 2024 Jan 9 doi: 10.1128/jcm.00732-23. PMID: 38193664Free PMC Article
Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G
World J Gastroenterol 2014 Sep 28;20(36):12847-59. doi: 10.3748/wjg.v20.i36.12847. PMID: 25278682Free PMC Article

Therapy

Schuetz AN, Theel ES, Cole NC, Rothstein TE, Gordy GG, Patel R
J Clin Microbiol 2024 Feb 14;62(2):e0073223. Epub 2024 Jan 9 doi: 10.1128/jcm.00732-23. PMID: 38193664Free PMC Article
Moss SF, Shah SC, Tan MC, El-Serag HB
Gastroenterology 2024 Feb;166(2):267-283. Epub 2023 Oct 6 doi: 10.1053/j.gastro.2023.09.047. PMID: 37806461Free PMC Article
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262
Hu Y, Zhu Y, Lu NH
Front Cell Infect Microbiol 2017;7:168. Epub 2017 May 5 doi: 10.3389/fcimb.2017.00168. PMID: 28529929Free PMC Article
Yonezawa H, Osaki T, Kamiya S
Biomed Res Int 2015;2015:914791. Epub 2015 May 19 doi: 10.1155/2015/914791. PMID: 26078970Free PMC Article

Prognosis

Guo X, Zhao X, Lu X, Zhao L, Zeng Q, Chen F, Zhang Z, Xu M, Feng S, Fan T, Wei W, Zhang X, Pang J, You X, Song D, Wang Y, Jiang J
Signal Transduct Target Ther 2024 Jul 8;9(1):183. doi: 10.1038/s41392-024-01895-0. PMID: 38972904Free PMC Article
Zu M, Hao X, Ning J, Zhou X, Gong Y, Lang Y, Xu W, Zhang J, Ding S
Biomed Pharmacother 2023 Jul;163:114751. Epub 2023 Apr 26 doi: 10.1016/j.biopha.2023.114751. PMID: 37105073
Dutta U, Bush N, Kalsi D, Popli P, Kapoor VK
Chin Clin Oncol 2019 Aug;8(4):33. doi: 10.21037/cco.2019.08.03. PMID: 31484488
Argueta EA, Moss SF
Curr Opin Gastroenterol 2019 Nov;35(6):544-550. doi: 10.1097/MOG.0000000000000578. PMID: 31433314
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G
World J Gastroenterol 2014 Sep 28;20(36):12847-59. doi: 10.3748/wjg.v20.i36.12847. PMID: 25278682Free PMC Article

Clinical prediction guides

Mannion A, Dzink-Fox J, Shen Z, Piazuelo MB, Wilson KT, Correa P, Peek RM Jr, Camargo MC, Fox JG
J Clin Microbiol 2021 Apr 20;59(5) doi: 10.1128/JCM.03203-20. PMID: 33692136Free PMC Article
Savoldi A, Carrara E, Graham DY, Conti M, Tacconelli E
Gastroenterology 2018 Nov;155(5):1372-1382.e17. Epub 2018 Jul 7 doi: 10.1053/j.gastro.2018.07.007. PMID: 29990487Free PMC Article
Hu Y, Zhu Y, Lu NH
Front Cell Infect Microbiol 2017;7:168. Epub 2017 May 5 doi: 10.3389/fcimb.2017.00168. PMID: 28529929Free PMC Article
Yonezawa H, Osaki T, Kamiya S
Biomed Res Int 2015;2015:914791. Epub 2015 May 19 doi: 10.1155/2015/914791. PMID: 26078970Free PMC Article
Patel SK, Pratap CB, Jain AK, Gulati AK, Nath G
World J Gastroenterol 2014 Sep 28;20(36):12847-59. doi: 10.3748/wjg.v20.i36.12847. PMID: 25278682Free PMC Article

Recent systematic reviews

Savoldi A, Carrara E, Graham DY, Conti M, Tacconelli E
Gastroenterology 2018 Nov;155(5):1372-1382.e17. Epub 2018 Jul 7 doi: 10.1053/j.gastro.2018.07.007. PMID: 29990487Free PMC Article
Jones NL, Koletzko S, Goodman K, Bontems P, Cadranel S, Casswall T, Czinn S, Gold BD, Guarner J, Elitsur Y, Homan M, Kalach N, Kori M, Madrazo A, Megraud F, Papadopoulou A, Rowland M; ESPGHAN, NASPGHAN
J Pediatr Gastroenterol Nutr 2017 Jun;64(6):991-1003. doi: 10.1097/MPG.0000000000001594. PMID: 28541262
Jaruvongvanich V, Sanguankeo A, Jaruvongvanich S, Upala S
Mult Scler Relat Disord 2016 May;7:92-7. Epub 2016 Mar 30 doi: 10.1016/j.msard.2016.03.013. PMID: 27237767
Dhurandhar NV, Bailey D, Thomas D
Obes Rev 2015 Dec;16(12):1017-29. Epub 2015 Sep 10 doi: 10.1111/obr.12320. PMID: 26354800
O'Connor A, Vaira D, Gisbert JP, O'Morain C
Helicobacter 2014 Sep;19 Suppl 1:38-45. doi: 10.1111/hel.12163. PMID: 25167944

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2019
      UK NICE Clinical Guideline CG184, Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management, 2019

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