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Telomere length, mean leukocyte(LTL)

MedGen UID:
322996
•Concept ID:
C1836777
•
Disease or Syndrome
Synonym: LTL
 
OMIM®: 609113

Professional guidelines

PubMed

Metformin and insulin treatment prevent placental telomere attrition in boys exposed to maternal diabetes.
Garcia-Martin I, Penketh RJA, Janssen AB, Jones RE, Grimstead J, Baird DM, John RM
PLoS One 2018;13(12):e0208533. Epub 2018 Dec 11 doi: 10.1371/journal.pone.0208533. PMID: 30533028Free PMC Article
Early and recent psychosocial stress and telomere length in older adults.
Schaakxs R, Wielaard I, Verhoeven JE, Beekman AT, Penninx BW, Comijs HC
Int Psychogeriatr 2016 Mar;28(3):405-13. Epub 2015 Aug 12 doi: 10.1017/S1041610215001155. PMID: 26265356
The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length.
Verhoeven JE, van Oppen P, Puterman E, Elzinga B, Penninx BW
Psychosom Med 2015 Oct;77(8):882-91. doi: 10.1097/PSY.0000000000000226. PMID: 26374947

Recent clinical studies

Etiology

Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure.
Aung N, Wang Q, van Duijvenboden S, Burns R, Stoma S, Raisi-Estabragh Z, Ahmet S, Allara E, Wood A, Di Angelantonio E, Danesh J, Munroe PB, Young A, Harvey NC, Codd V, Nelson CP, Petersen SE, Samani NJ
JAMA Cardiol 2023 Sep 1;8(9):808-815. doi: 10.1001/jamacardio.2023.2167. PMID: 37494011Free PMC Article
Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants.
Liu R, Xiang M, Pilling LC, Melzer D, Wang L, Manning KJ, Steffens DC, Bowden J, Fortinsky RH, Kuchel GA, Rhee TG, Diniz BS, Kuo CL
Aging Cell 2023 Jul;22(7):e13808. Epub 2023 May 30 doi: 10.1111/acel.13808. PMID: 37254630Free PMC Article
Association of Telomere Length With Risk of Disease and Mortality.
Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
JAMA Intern Med 2022 Mar 1;182(3):291-300. doi: 10.1001/jamainternmed.2021.7804. PMID: 35040871Free PMC Article
Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population.
Rattan P, Penrice DD, Ahn JC, Ferrer A, Patnaik M, Shah VH, Kamath PS, Mangaonkar AA, Simonetto DA
Hepatol Commun 2022 Feb;6(2):399-410. Epub 2021 Aug 28 doi: 10.1002/hep4.1803. PMID: 34558851Free PMC Article
Polygenic basis and biomedical consequences of telomere length variation.
Codd V, Wang Q, Allara E, Musicha C, Kaptoge S, Stoma S, Jiang T, Hamby SE, Braund PS, Bountziouka V, Budgeon CA, Denniff M, Swinfield C, Papakonstantinou M, Sheth S, Nanus DE, Warner SC, Wang M, Khera AV, Eales J, Ouwehand WH, Thompson JR, Di Angelantonio E, Wood AM, Butterworth AS, Danesh JN, Nelson CP, Samani NJ
Nat Genet 2021 Oct;53(10):1425-1433. Epub 2021 Oct 5 doi: 10.1038/s41588-021-00944-6. PMID: 34611362Free PMC Article

Diagnosis

Deficit Accumulation Index and Biological Markers of Aging in Survivors of Childhood Cancer.
Williams AM, Mandelblatt JS, Wang M, Dong Q, Armstrong GT, Bhakta N, Brinkman TM, Ehrhardt MJ, Mulrooney DA, Gilmore N, Robison LL, Yasui Y, Small BJ, Srivastava D, Hudson MM, Ness KK, Krull KR, Wang Z
JAMA Netw Open 2023 Nov 1;6(11):e2344015. doi: 10.1001/jamanetworkopen.2023.44015. PMID: 37983031Free PMC Article
Telomere length and verbal learning in bipolar disorders.
Mlakar V, Birkenæs V, Elvsaashagen T, Ormerod MBEG, Quintana DS, Ueland T, Melle I, Lagerberg TV, Djurovic S, Martin-Ruiz C, Steen NE, Andreassen OA, Aas M
J Affect Disord 2023 Oct 15;339:555-560. Epub 2023 Jul 17 doi: 10.1016/j.jad.2023.07.087. PMID: 37459977
Shorter leukocyte telomere length protects against NAFLD progression in children.
Wojcicki JM, Gill RM, Wilson L, Lin J, Rosenthal P
Sci Rep 2023 Apr 3;13(1):5446. doi: 10.1038/s41598-023-31149-y. PMID: 37012261Free PMC Article
Common electrocardiogram measures are not associated with telomere length.
von Falkenhausen AS, Freudling R, Waldenberger M, Gieger C, Peters A, Müller-Nurasyid M, Kääb S, Sinner MF
Aging (Albany NY) 2022 Jul 5;14(14):5620-5627. doi: 10.18632/aging.204149. PMID: 35787517Free PMC Article
Leukocyte telomere length and late-life depression.
Schaakxs R, Verhoeven JE, Oude Voshaar RC, Comijs HC, Penninx BWJH
Am J Geriatr Psychiatry 2015 Apr;23(4):423-432. Epub 2014 Jun 19 doi: 10.1016/j.jagp.2014.06.003. PMID: 25028345

Therapy

Predicted leukocyte telomere length and risk of myeloid neoplasms.
Sullivan SM, Cole B, Lane J, Meredith JJ, Langer E, Hooten AJ, Roesler M, McGraw KL, Pankratz N, Poynter JN
Hum Mol Genet 2023 Oct 4;32(20):2996-3005. doi: 10.1093/hmg/ddad126. PMID: 37531260Free PMC Article
Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure.
Aung N, Wang Q, van Duijvenboden S, Burns R, Stoma S, Raisi-Estabragh Z, Ahmet S, Allara E, Wood A, Di Angelantonio E, Danesh J, Munroe PB, Young A, Harvey NC, Codd V, Nelson CP, Petersen SE, Samani NJ
JAMA Cardiol 2023 Sep 1;8(9):808-815. doi: 10.1001/jamacardio.2023.2167. PMID: 37494011Free PMC Article
Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants.
Liu R, Xiang M, Pilling LC, Melzer D, Wang L, Manning KJ, Steffens DC, Bowden J, Fortinsky RH, Kuchel GA, Rhee TG, Diniz BS, Kuo CL
Aging Cell 2023 Jul;22(7):e13808. Epub 2023 May 30 doi: 10.1111/acel.13808. PMID: 37254630Free PMC Article
Telomere length in patients with osteoarthritis: a systematic review and meta-analysis.
Xie H, Ma Y, Shao M, Kong J, Zhou T, Wang F, Cai G, Xu S, Pan F
Aging Clin Exp Res 2022 Mar;34(3):495-503. Epub 2021 Jul 27 doi: 10.1007/s40520-021-01944-6. PMID: 34313963
Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D
Aging Cell 2019 Dec;18(6):e13017. Epub 2019 Aug 24 doi: 10.1111/acel.13017. PMID: 31444995Free PMC Article

Prognosis

Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults.
Kuo CL, Chen Z, Liu P, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Diniz BS
Aging Cell 2024 Aug;23(8):e14195. Epub 2024 May 15 doi: 10.1111/acel.14195. PMID: 38747160Free PMC Article
Predicted leukocyte telomere length and risk of myeloid neoplasms.
Sullivan SM, Cole B, Lane J, Meredith JJ, Langer E, Hooten AJ, Roesler M, McGraw KL, Pankratz N, Poynter JN
Hum Mol Genet 2023 Oct 4;32(20):2996-3005. doi: 10.1093/hmg/ddad126. PMID: 37531260Free PMC Article
Shorter leukocyte telomere length protects against NAFLD progression in children.
Wojcicki JM, Gill RM, Wilson L, Lin J, Rosenthal P
Sci Rep 2023 Apr 3;13(1):5446. doi: 10.1038/s41598-023-31149-y. PMID: 37012261Free PMC Article
Association of Telomere Length With Risk of Disease and Mortality.
Schneider CV, Schneider KM, Teumer A, Rudolph KL, Hartmann D, Rader DJ, Strnad P
JAMA Intern Med 2022 Mar 1;182(3):291-300. doi: 10.1001/jamainternmed.2021.7804. PMID: 35040871Free PMC Article
Inverse Association of Telomere Length With Liver Disease and Mortality in the US Population.
Rattan P, Penrice DD, Ahn JC, Ferrer A, Patnaik M, Shah VH, Kamath PS, Mangaonkar AA, Simonetto DA
Hepatol Commun 2022 Feb;6(2):399-410. Epub 2021 Aug 28 doi: 10.1002/hep4.1803. PMID: 34558851Free PMC Article

Clinical prediction guides

Predicted leukocyte telomere length and risk of myeloid neoplasms.
Sullivan SM, Cole B, Lane J, Meredith JJ, Langer E, Hooten AJ, Roesler M, McGraw KL, Pankratz N, Poynter JN
Hum Mol Genet 2023 Oct 4;32(20):2996-3005. doi: 10.1093/hmg/ddad126. PMID: 37531260Free PMC Article
Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure.
Aung N, Wang Q, van Duijvenboden S, Burns R, Stoma S, Raisi-Estabragh Z, Ahmet S, Allara E, Wood A, Di Angelantonio E, Danesh J, Munroe PB, Young A, Harvey NC, Codd V, Nelson CP, Petersen SE, Samani NJ
JAMA Cardiol 2023 Sep 1;8(9):808-815. doi: 10.1001/jamacardio.2023.2167. PMID: 37494011Free PMC Article
Telomere length and verbal learning in bipolar disorders.
Mlakar V, Birkenæs V, Elvsaashagen T, Ormerod MBEG, Quintana DS, Ueland T, Melle I, Lagerberg TV, Djurovic S, Martin-Ruiz C, Steen NE, Andreassen OA, Aas M
J Affect Disord 2023 Oct 15;339:555-560. Epub 2023 Jul 17 doi: 10.1016/j.jad.2023.07.087. PMID: 37459977
Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants.
Liu R, Xiang M, Pilling LC, Melzer D, Wang L, Manning KJ, Steffens DC, Bowden J, Fortinsky RH, Kuchel GA, Rhee TG, Diniz BS, Kuo CL
Aging Cell 2023 Jul;22(7):e13808. Epub 2023 May 30 doi: 10.1111/acel.13808. PMID: 37254630Free PMC Article
Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants.
Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D
Aging Cell 2019 Dec;18(6):e13017. Epub 2019 Aug 24 doi: 10.1111/acel.13017. PMID: 31444995Free PMC Article

Recent systematic reviews

Is COVID-19 severity associated with telomere length? A systematic review and meta-analysis.
Haridoss M, Ayyasamy L, Bagepally BS
Virus Genes 2023 Aug;59(4):489-498. Epub 2023 Jun 1 doi: 10.1007/s11262-023-02010-1. PMID: 37261700Free PMC Article
Telomere length in patients with osteoarthritis: a systematic review and meta-analysis.
Xie H, Ma Y, Shao M, Kong J, Zhou T, Wang F, Cai G, Xu S, Pan F
Aging Clin Exp Res 2022 Mar;34(3):495-503. Epub 2021 Jul 27 doi: 10.1007/s40520-021-01944-6. PMID: 34313963
The impact of hypertension on leukocyte telomere length: a systematic review and meta-analysis of human studies.
Tellechea ML, Pirola CJ
J Hum Hypertens 2017 Feb;31(2):99-105. Epub 2016 Jun 30 doi: 10.1038/jhh.2016.45. PMID: 27357526
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis.
Haycock PC, Heydon EE, Kaptoge S, Butterworth AS, Thompson A, Willeit P
BMJ 2014 Jul 8;349:g4227. doi: 10.1136/bmj.g4227. PMID: 25006006Free PMC Article
A systematic review of leukocyte telomere length and age in adults.
Müezzinler A, Zaineddin AK, Brenner H
Ageing Res Rev 2013 Mar;12(2):509-19. Epub 2013 Jan 16 doi: 10.1016/j.arr.2013.01.003. PMID: 23333817

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