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Cataract 10 multiple types(CCZS; CTRCT10)

MedGen UID:
318817
•Concept ID:
C1833229
•
Disease or Syndrome
Synonyms: CATARACT 10, CONGENITAL ZONULAR, WITH SUTURAL OPACITIES; Cataract, congenital zonular, with sutural opacities
 
Gene (location): CRYBA1 (17q11.2)
 
Monarch Initiative: MONDO:0010948
OMIM®: 600881

Definition

Mutations in the CRYBA1 gene have been found to cause multiple types of cataract, which have been described as congenital zonular with sutural opacities, congenital nuclear progressive, and progressive lamellar. The preferred title/symbol of this entry was formerly 'Cataract, Congenital Zonular, with Sutural Opacities; CCZS.' [from OMIM]

Clinical features

From HPO
Developmental cataract
MedGen UID:
3202
•Concept ID:
C0009691
•
Congenital Abnormality
A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens.
See: Feature record | Search on this feature
Nuclear cataract
MedGen UID:
140274
•Concept ID:
C0392557
•
Finding
A nuclear cataract is an opacity or clouding that develops in the lens nucleus. That is, a nuclear cataract is one that is located in the center of the lens. The nucleus tends to darken changing from clear to yellow and sometimes brown.
See: Feature record | Search on this feature
Zonular cataract
MedGen UID:
350517
•Concept ID:
C1861821
•
Disease or Syndrome
Zonular cataracts are defined to be cataracts that affect specific regions of the lens.
See: Feature record | Search on this feature
Posterior Y-sutural cataract
MedGen UID:
867202
•Concept ID:
C4021560
•
Pathologic Function
A type of sutural cataract in which the opacity follows the posterior Y suture.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Globe conserving treatment of the only eye in bilateral retinoblastoma.
Lee V, Hungerford JL, Bunce C, Ahmed F, Kingston JE, Plowman PN
Br J Ophthalmol 2003 Nov;87(11):1374-80. doi: 10.1136/bjo.87.11.1374. PMID: 14609838Free PMC Article

Recent clinical studies

Etiology

Femtosecond laser-assisted cataract surgery for the white cataract.
Chee SP, Chan NS, Yang Y, Ti SE
Br J Ophthalmol 2019 Apr;103(4):544-550. Epub 2018 Jun 15 doi: 10.1136/bjophthalmol-2018-312289. PMID: 29907631
Antidepressants and risk of cataract development: A population-based, nested case-control study.
Chou PH, Chu CS, Chen YH, Hsu MY, Huang MW, Lan TH, Lin CH
J Affect Disord 2017 Jun;215:237-244. Epub 2017 Mar 18 doi: 10.1016/j.jad.2017.03.044. PMID: 28342338
Intraoperative Complications of Cataract Surgery in Tehran Province, Iran.
Hashemi H, Rezvan F, Etemad K, Gilasi H, Asgari S, Mahdavi A, Mohazab-Torabi S, Yekta A, Khabazkhoob M
Optom Vis Sci 2016 Mar;93(3):266-71. doi: 10.1097/OPX.0000000000000795. PMID: 26760583
The human health effects of ozone depletion and interactions with climate change.
Norval M, Lucas RM, Cullen AP, de Gruijl FR, Longstreth J, Takizawa Y, van der Leun JC
Photochem Photobiol Sci 2011 Feb;10(2):199-225. Epub 2011 Jan 20 doi: 10.1039/c0pp90044c. PMID: 21253670
Factors affecting risks of congenital malformations. I. Analysis of epidemiologic factors in congenital malformations. Report from the Collaborative Perinatal Project.
Chung CS, Myrianthopoulos NC
Birth Defects Orig Artic Ser 1975;11(10):1-22. PMID: 130944

Diagnosis

Astigmatism profile in the elderly population: Tehran Geriatric Eye Study.
Hashemi H, Asharlous A, Yekta A, Aghamirsalim M, Nabovati P, Sadoughi MM, Khabazkhoob M
Jpn J Ophthalmol 2022 Sep;66(5):461-473. Epub 2022 Aug 10 doi: 10.1007/s10384-022-00936-x. PMID: 35947225
Reasons for choice of glaucoma surgery in eyes not treated with anti-glaucoma medications.
Sugihara K, Fukuda H, Omura T, Tanito M
BMC Ophthalmol 2022 Mar 30;22(1):145. doi: 10.1186/s12886-022-02369-z. PMID: 35354394Free PMC Article
Long-term outcomes and risk factors for failure of glaucoma filtering surgery in eyes with vernal keratoconjunctivitis and steroid-induced glaucoma.
Senthil S, Rao HL, Ali MH, Krishnamurthy R, Dikshit S, Choudhari N, Sastry R, Garudadri C
Indian J Ophthalmol 2022 Mar;70(3):820-825. doi: 10.4103/ijo.IJO_1897_21. PMID: 35225522Free PMC Article
Femtosecond laser-assisted cataract surgery for the white cataract.
Chee SP, Chan NS, Yang Y, Ti SE
Br J Ophthalmol 2019 Apr;103(4):544-550. Epub 2018 Jun 15 doi: 10.1136/bjophthalmol-2018-312289. PMID: 29907631
ALG8-CDG: novel patients and review of the literature.
Höck M, Wegleiter K, Ralser E, Kiechl-Kohlendorfer U, Scholl-Bürgi S, Fauth C, Steichen E, Pichler K, Lefeber DJ, Matthjis G, Keldermans L, Maurer K, Zschocke J, Karall D
Orphanet J Rare Dis 2015 Jun 12;10:73. doi: 10.1186/s13023-015-0289-7. PMID: 26066342Free PMC Article

Therapy

Astigmatism profile in the elderly population: Tehran Geriatric Eye Study.
Hashemi H, Asharlous A, Yekta A, Aghamirsalim M, Nabovati P, Sadoughi MM, Khabazkhoob M
Jpn J Ophthalmol 2022 Sep;66(5):461-473. Epub 2022 Aug 10 doi: 10.1007/s10384-022-00936-x. PMID: 35947225
Investigation of the Changes in Refractive Surgery Trends in Korea.
Ahn JH, Kim DH, Shyn KH
Korean J Ophthalmol 2018 Feb;32(1):8-15. Epub 2018 Jan 25 doi: 10.3341/kjo.2017.0010. PMID: 29376229Free PMC Article
Antidepressants and risk of cataract development: A population-based, nested case-control study.
Chou PH, Chu CS, Chen YH, Hsu MY, Huang MW, Lan TH, Lin CH
J Affect Disord 2017 Jun;215:237-244. Epub 2017 Mar 18 doi: 10.1016/j.jad.2017.03.044. PMID: 28342338
Intraoperative Complications of Cataract Surgery in Tehran Province, Iran.
Hashemi H, Rezvan F, Etemad K, Gilasi H, Asgari S, Mahdavi A, Mohazab-Torabi S, Yekta A, Khabazkhoob M
Optom Vis Sci 2016 Mar;93(3):266-71. doi: 10.1097/OPX.0000000000000795. PMID: 26760583
The human health effects of ozone depletion and interactions with climate change.
Norval M, Lucas RM, Cullen AP, de Gruijl FR, Longstreth J, Takizawa Y, van der Leun JC
Photochem Photobiol Sci 2011 Feb;10(2):199-225. Epub 2011 Jan 20 doi: 10.1039/c0pp90044c. PMID: 21253670

Prognosis

Femtosecond laser-assisted cataract surgery for the white cataract.
Chee SP, Chan NS, Yang Y, Ti SE
Br J Ophthalmol 2019 Apr;103(4):544-550. Epub 2018 Jun 15 doi: 10.1136/bjophthalmol-2018-312289. PMID: 29907631
ALG8-CDG: novel patients and review of the literature.
Höck M, Wegleiter K, Ralser E, Kiechl-Kohlendorfer U, Scholl-Bürgi S, Fauth C, Steichen E, Pichler K, Lefeber DJ, Matthjis G, Keldermans L, Maurer K, Zschocke J, Karall D
Orphanet J Rare Dis 2015 Jun 12;10:73. doi: 10.1186/s13023-015-0289-7. PMID: 26066342Free PMC Article
Clinical and pathologic characteristics of biopsy-proven iris melanoma: a multicenter international study.
Khan S, Finger PT, Yu GP, Razzaq L, Jager MJ, de Keizer RJ, Sandkull P, Seregard S, Gologorsky D, Schefler AC, Murray TG, Kivelä T, Giuliari GP, McGowan H, Simpson ER, Corriveau C, Coupland SE, Damato BE
Arch Ophthalmol 2012 Jan;130(1):57-64. Epub 2011 Sep 12 doi: 10.1001/archophthalmol.2011.286. PMID: 21911649
The human health effects of ozone depletion and interactions with climate change.
Norval M, Lucas RM, Cullen AP, de Gruijl FR, Longstreth J, Takizawa Y, van der Leun JC
Photochem Photobiol Sci 2011 Feb;10(2):199-225. Epub 2011 Jan 20 doi: 10.1039/c0pp90044c. PMID: 21253670
Morbidity profiles of centenarians: survivors, delayers, and escapers.
Evert J, Lawler E, Bogan H, Perls T
J Gerontol A Biol Sci Med Sci 2003 Mar;58(3):232-7. doi: 10.1093/gerona/58.3.m232. PMID: 12634289

Clinical prediction guides

Changes in patient subjective happiness and satisfaction with cataract surgery.
Yotsukura E, Ayaki M, Nezu N, Torii H, Arai H, Sakatani K, Tsubota K, Negishi K
Sci Rep 2020 Oct 14;10(1):17273. doi: 10.1038/s41598-020-72846-2. PMID: 33057036Free PMC Article
Femtosecond laser-assisted cataract surgery for the white cataract.
Chee SP, Chan NS, Yang Y, Ti SE
Br J Ophthalmol 2019 Apr;103(4):544-550. Epub 2018 Jun 15 doi: 10.1136/bjophthalmol-2018-312289. PMID: 29907631
Change in refraction after lens-sparing vitrectomy for rhegmatogenous retinal detachment and epiretinal membrane.
Iwase T, Yamamoto K, Yanagida K, Kobayashi M, Ra E, Murotani K, Terasaki H
Medicine (Baltimore) 2016 Aug;95(32):e4317. doi: 10.1097/MD.0000000000004317. PMID: 27512843Free PMC Article
Human and great ape red blood cells differ in plasmalogen levels and composition.
Moser AB, Steinberg SJ, Watkins PA, Moser HW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia JG
Lipids Health Dis 2011 Jun 17;10:101. doi: 10.1186/1476-511X-10-101. PMID: 21679470Free PMC Article
The human health effects of ozone depletion and interactions with climate change.
Norval M, Lucas RM, Cullen AP, de Gruijl FR, Longstreth J, Takizawa Y, van der Leun JC
Photochem Photobiol Sci 2011 Feb;10(2):199-225. Epub 2011 Jan 20 doi: 10.1039/c0pp90044c. PMID: 21253670

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