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Glipizide response

MedGen UID:
322023
•Concept ID:
C1832730
•
Finding
Synonym: Glipizide poor metabolizer
Drug:
Glipizide
MedGen UID:
4900
•Concept ID:
C0017642
•
Pharmacologic Substance
A short-acting, second-generation sulfonylurea with hypoglycemic activity. Glipizide is rapidly absorbed, has a very quick onset of action and a short half-life. This agent is extensively metabolized in the liver and the metabolites as well as the unchanged form are excreted in the urine. [from NCI]
Glipizide
 
Gene (location): G6PD (Xq28)
 
OMIM®: 601130

Professional guidelines

PubMed

Evaluating gliclazide for the treatment of type 2 diabetes mellitus.
Tomlinson B, Li YH, Chan P
Expert Opin Pharmacother 2022 Dec;23(17):1869-1877. Epub 2022 Nov 10 doi: 10.1080/14656566.2022.2141108. PMID: 36300277
Oral hypoglycemic agents in the treatment of type II diabetes.
Tal A
Am Fam Physician 1993 Nov 1;48(6):1089-95. PMID: 8237731
Oral sulfonylureas for the treatment of type II diabetes: an update.
Shank WA Jr, Morrison AD
South Med J 1986 Mar;79(3):337-43. doi: 10.1097/00007611-198603000-00019. PMID: 3082015

Curated

Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.

DailyMed Drug Label, glipizide, 2022

DailyMed Drug Label, GLIPIZIDE, 2019

Recent clinical studies

Etiology

Reflections on the sulphonylurea story: A drug class at risk of extinction or a drug class worth reviving?
Cordiner RLM, Pearson ER
Diabetes Obes Metab 2019 Apr;21(4):761-771. Epub 2019 Feb 11 doi: 10.1111/dom.13596. PMID: 30471177
Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study.
Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB
J Pharm Biomed Anal 2018 Mar 20;151:310-316. Epub 2018 Jan 10 doi: 10.1016/j.jpba.2018.01.010. PMID: 29413979
Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634
Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2-receptor antagonists.
Feely J, Collins WC, Cullen M, el Debani AH, MacWalter RS, Peden NR, Stevenson IH
Br J Clin Pharmacol 1993 Mar;35(3):321-3. doi: 10.1111/j.1365-2125.1993.tb05702.x. PMID: 8471413Free PMC Article
Moderate weight loss and sulfonylurea treatment of non-insulin-dependent diabetes mellitus. Combined effects.
Liu GC, Coulston AM, Lardinois CK, Hollenbeck CB, Moore JG, Reaven GM
Arch Intern Med 1985 Apr;145(4):665-9. PMID: 3885889

Diagnosis

A girl with permanent neonatal diabetes due to KCNJ11 mutation presented with Mauriac syndrome after improper adjustment in sulfonylurea dosage over 6 years.
Chai-Udom R, Sahakitrungruang T, Wacharasindhu S, Supornsilchai V
J Pediatr Endocrinol Metab 2016 Sep 1;29(9):1095-101. doi: 10.1515/jpem-2016-0065. PMID: 27428845
The role of sulphonylureas in the management of type 2 diabetes mellitus.
Rendell M
Drugs 2004;64(12):1339-58. doi: 10.2165/00003495-200464120-00006. PMID: 15200348
Prospective multicenter study of sulfonylurea ingestion in children.
Spiller HA, Villalobos D, Krenzelok EP, Anderson BD, Gorman SE, Rose SR, Fenn J, Anderson DL, Muir SJ, Rodgers GC Jr
J Pediatr 1997 Jul;131(1 Pt 1):141-6. doi: 10.1016/s0022-3476(97)70138-0. PMID: 9255206
Effect of sulphonylurea therapy on insulin sensitivity in non insulin dependent diabetics.
Khandekar S, Sethi BK, Dash RJ
J Assoc Physicians India 1990 Jul;38(7):469-71. PMID: 2127273
High-performance liquid chromatographic determination of glipizide in human plasma and urine.
Emilsson H
J Chromatogr 1987 Oct 30;421(2):319-26. doi: 10.1016/0378-4347(87)80411-5. PMID: 3429586

Therapy

Reflections on the sulphonylurea story: A drug class at risk of extinction or a drug class worth reviving?
Cordiner RLM, Pearson ER
Diabetes Obes Metab 2019 Apr;21(4):761-771. Epub 2019 Feb 11 doi: 10.1111/dom.13596. PMID: 30471177
Drug-drug interactions between rosuvastatin and oral antidiabetic drugs occurring at the level of OATP1B1.
van de Steeg E, Greupink R, Schreurs M, Nooijen IH, Verhoeckx KC, Hanemaaijer R, Ripken D, Monshouwer M, Vlaming ML, DeGroot J, Verwei M, Russel FG, Huisman MT, Wortelboer HM
Drug Metab Dispos 2013 Mar;41(3):592-601. Epub 2012 Dec 17 doi: 10.1124/dmd.112.049023. PMID: 23248200
Sitagliptin.
Lyseng-Williamson KA
Drugs 2007;67(4):587-97. doi: 10.2165/00003495-200767040-00007. PMID: 17352516
Potentiation of the hypoglycaemic response to glipizide in diabetic patients by histamine H2-receptor antagonists.
Feely J, Collins WC, Cullen M, el Debani AH, MacWalter RS, Peden NR, Stevenson IH
Br J Clin Pharmacol 1993 Mar;35(3):321-3. doi: 10.1111/j.1365-2125.1993.tb05702.x. PMID: 8471413Free PMC Article
Hyperglycaemia and absorption of sulphonylurea drugs.
Groop LC, Luzi L, DeFronzo RA, Melander A
Lancet 1989 Jul 15;2(8655):129-30. doi: 10.1016/s0140-6736(89)90184-0. PMID: 2567896

Prognosis

Insulin Secretion Predicts the Response to Antidiabetic Therapy in Patients With New-onset Diabetes.
Abdelgani S, Puckett C, Adams J, Triplitt C, DeFronzo RA, Abdul-Ghani M
J Clin Endocrinol Metab 2021 Nov 19;106(12):3497-3504. doi: 10.1210/clinem/dgab403. PMID: 34343296Free PMC Article
A girl with permanent neonatal diabetes due to KCNJ11 mutation presented with Mauriac syndrome after improper adjustment in sulfonylurea dosage over 6 years.
Chai-Udom R, Sahakitrungruang T, Wacharasindhu S, Supornsilchai V
J Pediatr Endocrinol Metab 2016 Sep 1;29(9):1095-101. doi: 10.1515/jpem-2016-0065. PMID: 27428845
Prospective multicenter study of sulfonylurea ingestion in children.
Spiller HA, Villalobos D, Krenzelok EP, Anderson BD, Gorman SE, Rose SR, Fenn J, Anderson DL, Muir SJ, Rodgers GC Jr
J Pediatr 1997 Jul;131(1 Pt 1):141-6. doi: 10.1016/s0022-3476(97)70138-0. PMID: 9255206
Sulfonylurea-induced decrease of muscle capillary basement membrane thickness in diabetes.
Camerini-Davalos RA, Velasco CA, Glasser M, Bloodworth JM Jr
Diabetes Res Clin Pract 1988 Jul 13;5(2):113-23. doi: 10.1016/s0168-8227(88)80050-0. PMID: 3046878
Influence of sulfonylureas on the secretion, disposal and effect of insulin.
Almér LO, Johansson E, Melander A, Wåhlin-Boll E
Eur J Clin Pharmacol 1982;22(1):27-32. doi: 10.1007/BF00606421. PMID: 7047169

Clinical prediction guides

Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study.
Sahu R, Ahmed T, Sangana R, Punde R, Subudhi BB
J Pharm Biomed Anal 2018 Mar 20;151:310-316. Epub 2018 Jan 10 doi: 10.1016/j.jpba.2018.01.010. PMID: 29413979
Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.
Kosoglou T, Statkevich P, Johnson-Levonas AO, Paolini JF, Bergman AJ, Alton KB
Clin Pharmacokinet 2005;44(5):467-94. doi: 10.2165/00003088-200544050-00002. PMID: 15871634
Pharmacological and biochemical evidence for the regulation of osteocalcin secretion by potassium channels in human osteoblast-like MG-63 cells.
Moreau R, Aubin R, Lapointe JY, Lajeunesse D
J Bone Miner Res 1997 Dec;12(12):1984-92. doi: 10.1359/jbmr.1997.12.12.1984. PMID: 9421231
High-performance liquid chromatographic determination of glipizide in human plasma and urine.
Emilsson H
J Chromatogr 1987 Oct 30;421(2):319-26. doi: 10.1016/0378-4347(87)80411-5. PMID: 3429586
Pharmacokinetics of glyburide.
Pearson JG
Am J Med 1985 Sep 20;79(3B):67-71. doi: 10.1016/s0002-9343(85)80010-3. PMID: 3931464

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    Curated

    • CPIC, 2022
      Gammal et al, Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype. 2 Sept 2022. Clin Pharmacol Ther.
    • DailyMed Drug Label, 2022
      DailyMed Drug Label, glipizide, 2022
    • DailyMed Drug Label, 2019
      DailyMed Drug Label, GLIPIZIDE, 2019

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    Reviews

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