U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Invasive Bladder Carcinoma

MedGen UID:
741087
•Concept ID:
C1827293
•
Neoplastic Process
Synonyms: Carcinoma of urinary bladder, invasive; Infiltrating Bladder Carcinoma; Invasive bladder cancer
SNOMED CT: Carcinoma of urinary bladder, invasive (425066001); Invasive bladder cancer (425066001)

Definition

A carcinoma that arises from the bladder mucosa and invades the bladder wall. [from NCI]

Professional guidelines

PubMed

The Challenge of Managing Bladder Cancer and Upper Tract Urothelial Carcinoma: A Review with Treatment Recommendations from the Spanish Oncology Genitourinary Group (SOGUG).
Font A, Luque R, Villa JC, Domenech M, Vázquez S, Gallardo E, Virizuela JA, Beato C, Morales-Barrera R, Gelabert A, Maciá S, Puente J, Rubio G, Maldonado X, Perez-Valderrama B, Pinto A, Fernández Calvo O, Grande E, Garde-Noguera J, Fernández-Parra E, Arranz JÁ
Target Oncol 2019 Feb;14(1):15-32. doi: 10.1007/s11523-019-00619-7. PMID: 30694442
Role of imaging techniques in the diagnosis and follow-up of muscle-invasive bladder carcinoma.
Mesa A, Nava E, Fernández Del Valle A, Argüelles B, Menéndez-Del Llano R, Sal de Rellán S
Actas Urol Esp (Engl Ed) 2018 Sep;42(7):425-434. Epub 2017 Oct 11 doi: 10.1016/j.acuro.2017.08.001. PMID: 29029769
Diagnosis, evaluation and treatment of carcinoma in situ of the urinary bladder: the state of the art.
Williamson SR, Montironi R, Lopez-Beltran A, MacLennan GT, Davidson DD, Cheng L
Crit Rev Oncol Hematol 2010 Nov;76(2):112-26. Epub 2010 Jan 25 doi: 10.1016/j.critrevonc.2010.01.005. PMID: 20097572

Recent clinical studies

Etiology

Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples.
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Surgery for Bladder and Upper Tract Urothelial Cancer.
Venkatramani V, Parekh DJ
Hematol Oncol Clin North Am 2021 Jun;35(3):543-566. Epub 2021 Apr 15 doi: 10.1016/j.hoc.2021.02.005. PMID: 33958150
Immune checkpoint inhibition in upper tract urothelial carcinoma.
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.
Jung M, Jang I, Kim K, Moon KC
Int J Mol Sci 2020 Oct 19;21(20) doi: 10.3390/ijms21207726. PMID: 33086575Free PMC Article
Role of imaging techniques in the diagnosis and follow-up of muscle-invasive bladder carcinoma.
Mesa A, Nava E, Fernández Del Valle A, Argüelles B, Menéndez-Del Llano R, Sal de Rellán S
Actas Urol Esp (Engl Ed) 2018 Sep;42(7):425-434. Epub 2017 Oct 11 doi: 10.1016/j.acuro.2017.08.001. PMID: 29029769

Diagnosis

Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples.
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Molecular classification of urothelial bladder carcinoma.
Schwarzova L, Varchulova Novakova Z, Danisovic L, Ziaran S
Mol Biol Rep 2023 Sep;50(9):7867-7877. Epub 2023 Jul 31 doi: 10.1007/s11033-023-08689-7. PMID: 37525073Free PMC Article
CT of the urinary tract revisited.
Tsili AC, Varkarakis I, Pasoglou V, Anagnostou N, Argyropoulou MI
Eur J Radiol 2023 Mar;160:110717. Epub 2023 Jan 30 doi: 10.1016/j.ejrad.2023.110717. PMID: 36773595
Surgery for Bladder and Upper Tract Urothelial Cancer.
Venkatramani V, Parekh DJ
Hematol Oncol Clin North Am 2021 Jun;35(3):543-566. Epub 2021 Apr 15 doi: 10.1016/j.hoc.2021.02.005. PMID: 33958150
Role of imaging techniques in the diagnosis and follow-up of muscle-invasive bladder carcinoma.
Mesa A, Nava E, Fernández Del Valle A, Argüelles B, Menéndez-Del Llano R, Sal de Rellán S
Actas Urol Esp (Engl Ed) 2018 Sep;42(7):425-434. Epub 2017 Oct 11 doi: 10.1016/j.acuro.2017.08.001. PMID: 29029769

Therapy

Sulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro.
Xie H, Rutz J, Maxeiner S, Grein T, Thomas A, Juengel E, Chun FK, Cinatl J, Haferkamp A, Tsaur I, Blaheta RA
Nutrients 2024 Feb 23;16(5) doi: 10.3390/nu16050623. PMID: 38474751Free PMC Article
Immune checkpoint inhibition in upper tract urothelial carcinoma.
Califano G, Ouzaid I, Verze P, Hermieu JF, Mirone V, Xylinas E
World J Urol 2021 May;39(5):1357-1367. Epub 2020 Oct 31 doi: 10.1007/s00345-020-03502-7. PMID: 33128595
Bladder cancer mortality after a diagnosis of nonmuscle-invasive bladder carcinoma.
Abdel-Rahman O
Future Oncol 2019 Jul;15(19):2267-2275. Epub 2019 Jun 25 doi: 10.2217/fon-2018-0861. PMID: 31237444
Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.
Necchi A, Anichini A, Raggi D, Briganti A, Massa S, Lucianò R, Colecchia M, Giannatempo P, Mortarini R, Bianchi M, Farè E, Monopoli F, Colombo R, Gallina A, Salonia A, Messina A, Ali SM, Madison R, Ross JS, Chung JH, Salvioni R, Mariani L, Montorsi F
J Clin Oncol 2018 Dec 1;36(34):3353-3360. Epub 2018 Oct 20 doi: 10.1200/JCO.18.01148. PMID: 30343614
Neoadjuvant chemotherapy for invasive bladder carcinoma.
Fair WR
Mayo Clin Proc 1988 Jan;63(1):86-7. doi: 10.1016/s0025-6196(12)62671-8. PMID: 3275847

Prognosis

The expression of SP263 in muscle invasive bladder carcinoma and its relationship with clinicopathological features.
Bai Y, Wu X, Weng M, Han Q, Xu L, Chang C, Teng X
Indian J Pathol Microbiol 2023 Oct-Dec;66(4):702-707. doi: 10.4103/ijpm.ijpm_142_22. PMID: 38084519
Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples.
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Molecular classification of urothelial bladder carcinoma.
Schwarzova L, Varchulova Novakova Z, Danisovic L, Ziaran S
Mol Biol Rep 2023 Sep;50(9):7867-7877. Epub 2023 Jul 31 doi: 10.1007/s11033-023-08689-7. PMID: 37525073Free PMC Article
Role of imaging techniques in the diagnosis and follow-up of muscle-invasive bladder carcinoma.
Mesa A, Nava E, Fernández Del Valle A, Argüelles B, Menéndez-Del Llano R, Sal de Rellán S
Actas Urol Esp (Engl Ed) 2018 Sep;42(7):425-434. Epub 2017 Oct 11 doi: 10.1016/j.acuro.2017.08.001. PMID: 29029769
Key signaling pathways in the muscle-invasive bladder carcinoma: Clinical markers for disease modeling and optimized treatment.
Kiselyov A, Bunimovich-Mendrazitsky S, Startsev V
Int J Cancer 2016 Jun 1;138(11):2562-9. Epub 2015 Nov 23 doi: 10.1002/ijc.29918. PMID: 26547270

Clinical prediction guides

Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics.
Wang X, Liu J, Azoitei A, Eiseler T, Meessen S, Jiang W, Zheng X, Makori AW, Eckstein M, Hartmann A, Stilgenbauer S, Elati M, Hohwieler M, Kleger A, John A, Zengerling F, Wezel F, Bolenz C, Günes C
Cell Mol Life Sci 2023 Sep 22;80(10):299. doi: 10.1007/s00018-023-04959-6. PMID: 37740130Free PMC Article
Bladder Epicheck Test: A Novel Tool to Support Urothelial Carcinoma Diagnosis in Urine Samples.
Fiorentino V, Pizzimenti C, Franchina M, Rossi ED, Tralongo P, Carlino A, Larocca LM, Martini M, Fadda G, Pierconti F
Int J Mol Sci 2023 Aug 6;24(15) doi: 10.3390/ijms241512489. PMID: 37569864Free PMC Article
Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.
Jung M, Jang I, Kim K, Moon KC
Int J Mol Sci 2020 Oct 19;21(20) doi: 10.3390/ijms21207726. PMID: 33086575Free PMC Article
Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study.
Necchi A, Anichini A, Raggi D, Briganti A, Massa S, Lucianò R, Colecchia M, Giannatempo P, Mortarini R, Bianchi M, Farè E, Monopoli F, Colombo R, Gallina A, Salonia A, Messina A, Ali SM, Madison R, Ross JS, Chung JH, Salvioni R, Mariani L, Montorsi F
J Clin Oncol 2018 Dec 1;36(34):3353-3360. Epub 2018 Oct 20 doi: 10.1200/JCO.18.01148. PMID: 30343614
Key signaling pathways in the muscle-invasive bladder carcinoma: Clinical markers for disease modeling and optimized treatment.
Kiselyov A, Bunimovich-Mendrazitsky S, Startsev V
Int J Cancer 2016 Jun 1;138(11):2562-9. Epub 2015 Nov 23 doi: 10.1002/ijc.29918. PMID: 26547270

Recent systematic reviews

Efficacy and safety of neoadjuvant PD-1 inhibitors or PD-L1 inhibitors for muscle invasive bladder cancer: a systematic review and meta-analysis.
Huang S, Huang Y, Li C, Liang Y, Huang M, Luo R, Liang W
Front Immunol 2023;14:1332213. Epub 2024 Jan 9 doi: 10.3389/fimmu.2023.1332213. PMID: 38264649Free PMC Article
French AFU Cancer Committee Guidelines - Update 2022-2024: Muscle-Invasive Bladder Cancer (MIBC).
Neuzillet Y, Audenet F, Loriot Y, Allory Y, Masson-Lecomte A, Leon P, Pradère B, Seisen T, Traxer O, Xylinas E, Roumiguié M, Roupret M
Prog Urol 2022 Nov;32(15):1141-1163. doi: 10.1016/j.purol.2022.07.145. PMID: 36400480
Low compliance to guidelines in nonmuscle-invasive bladder carcinoma: A systematic review.
Mori K, Miura N, Babjuk M, Karakiewicz PI, Mostafaei H, Laukhtina E, Quhal F, Motlagh RS, Pradere B, Kimura S, Egawa S, Shariat SF
Urol Oncol 2020 Oct;38(10):774-782. Epub 2020 Jul 10 doi: 10.1016/j.urolonc.2020.06.013. PMID: 32654948
A systematic overview of radiation therapy effects in urinary bladder cancer.
Widmark A, Flodgren P, Damber JE, Hellsten S, Cavallin-Ståhl E
Acta Oncol 2003;42(5-6):567-81. doi: 10.1080/02841860310014408. PMID: 14596515

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...