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Allergic fungal sinusitis

MedGen UID:
740987
•Concept ID:
C1827192
•
Disease or Syndrome
Synonyms: Allergic Fungal Sinusitides; Allergic Fungal Sinusitis; Fungal Sinusitis, Allergic; Sinusitides, Allergic Fungal; Sinusitis, Allergic Fungal
SNOMED CT: Allergic fungal sinusitis (425011002)

Definition

Fungal infection in the PARANASAL SINUSES characterized by common allergy respiratory symptoms, recurrent NASAL POLYPS and/or ASTHMA with buildup of allergic MUCIN. [from MeSH]

Professional guidelines

PubMed

Chronic Rhinosinusitis in Children: Pathophysiology, Evaluation, and Medical Management.
Heath J, Hartzell L, Putt C, Kennedy JL
Curr Allergy Asthma Rep 2018 May 29;18(7):37. doi: 10.1007/s11882-018-0792-8. PMID: 29845321
Surgical treatment of pediatric rhinosinusitis.
Isaacson G
Minerva Pediatr 2015 Aug;67(4):357-68. Epub 2014 Nov 4 PMID: 25369207
Allergic fungal rhinosinusitis: surgical management.
Marple BF
Otolaryngol Clin North Am 2000 Apr;33(2):409-19. doi: 10.1016/s0030-6665(00)80015-8. PMID: 10736414

Recent clinical studies

Etiology

Allergic Fungal Rhinosinusitis: The Role and Expectations of Biologics.
Luong AU, Chua A, Alim BM, Olsson P, Javer A
J Allergy Clin Immunol Pract 2022 Dec;10(12):3156-3162. Epub 2022 Aug 24 doi: 10.1016/j.jaip.2022.08.021. PMID: 36028212
Exposure and Health Effects of Fungi on Humans.
Baxi SN, Portnoy JM, Larenas-Linnemann D, Phipatanakul W; Environmental Allergens Workgroup
J Allergy Clin Immunol Pract 2016 May-Jun;4(3):396-404. Epub 2016 Mar 3 doi: 10.1016/j.jaip.2016.01.008. PMID: 26947460Free PMC Article
The spectrum of allergic fungal diseases of the upper and lower airways.
Rodrigues J, Caruthers C, Azmeh R, Dykewicz MS, Slavin RG, Knutsen AP
Expert Rev Clin Immunol 2016;12(5):531-50. Epub 2016 Feb 19 doi: 10.1586/1744666X.2016.1142874. PMID: 26776889
Pediatric rhinosinusitis.
Magit A
Otolaryngol Clin North Am 2014 Oct;47(5):733-46. Epub 2014 Aug 3 doi: 10.1016/j.otc.2014.06.003. PMID: 25213280
Fungal sinusitis.
deShazo RD
Am J Med Sci 1998 Jul;316(1):39-45. doi: 10.1097/00000441-199807000-00006. PMID: 9671042

Diagnosis

The Myth of Mycotoxins and Mold Injury.
Chang C, Gershwin ME
Clin Rev Allergy Immunol 2019 Dec;57(3):449-455. doi: 10.1007/s12016-019-08767-4. PMID: 31608429
Fungal Sinusitis.
Raz E, Win W, Hagiwara M, Lui YW, Cohen B, Fatterpekar GM
Neuroimaging Clin N Am 2015 Nov;25(4):569-76. Epub 2015 Aug 21 doi: 10.1016/j.nic.2015.07.004. PMID: 26476380
Pediatric rhinosinusitis.
Magit A
Otolaryngol Clin North Am 2014 Oct;47(5):733-46. Epub 2014 Aug 3 doi: 10.1016/j.otc.2014.06.003. PMID: 25213280
Allergic fungal sinusitis.
Schubert MS
Clin Allergy Immunol 2007;20:263-71. PMID: 17534057
Allergic fungal sinusitis.
Schubert MS
Clin Rev Allergy Immunol 2006 Jun;30(3):205-16. doi: 10.1385/CRIAI:30:3:205. PMID: 16785591

Therapy

Allergy immunotherapy for allergic fungal respiratory diseases.
Nelson HS
Allergy Asthma Proc 2023 Nov 1;44(6):395-401. doi: 10.2500/aap.2023.44.230058. PMID: 37919848
Update on allergic fungal rhinosinusitis.
Chua AJ, Jafar A, Luong AU
Ann Allergy Asthma Immunol 2023 Sep;131(3):300-306. Epub 2023 Feb 26 doi: 10.1016/j.anai.2023.02.018. PMID: 36854353
Pediatric rhinosinusitis.
Magit A
Otolaryngol Clin North Am 2014 Oct;47(5):733-46. Epub 2014 Aug 3 doi: 10.1016/j.otc.2014.06.003. PMID: 25213280
Approaching chronic sinusitis.
Sarber KM, Dion GR, Weitzel EK, McMains KC
South Med J 2013 Nov;106(11):642-8. doi: 10.1097/SMJ.0000000000000018. PMID: 24192597
Dematiaceous fungi.
Revankar SG
Mycoses 2007 Mar;50(2):91-101. doi: 10.1111/j.1439-0507.2006.01331.x. PMID: 17305771

Prognosis

Update on allergic fungal rhinosinusitis.
Chua AJ, Jafar A, Luong AU
Ann Allergy Asthma Immunol 2023 Sep;131(3):300-306. Epub 2023 Feb 26 doi: 10.1016/j.anai.2023.02.018. PMID: 36854353
New Developments in Allergic Fungal Rhinosinusitis Pathophysiology and Treatment.
Cameron BH, Luong AU
Am J Rhinol Allergy 2023 Mar;37(2):214-220. doi: 10.1177/19458924231152983. PMID: 36848273
Pediatric rhinosinusitis.
Magit A
Otolaryngol Clin North Am 2014 Oct;47(5):733-46. Epub 2014 Aug 3 doi: 10.1016/j.otc.2014.06.003. PMID: 25213280
Allergic fungal sinusitis.
Schubert MS
Clin Rev Allergy Immunol 2006 Jun;30(3):205-16. doi: 10.1385/CRIAI:30:3:205. PMID: 16785591
Allergic fungal sinusitis.
Schubert MS
Otolaryngol Clin North Am 2004 Apr;37(2):301-26. doi: 10.1016/S0030-6665(03)00152-X. PMID: 15064064

Clinical prediction guides

Eosinophilic mucus diseases.
Arima M, Ito K, Abe T, Oguma T, Asano K, Mukherjee M, Ueki S
Allergol Int 2024 Jul;73(3):362-374. Epub 2024 Apr 8 doi: 10.1016/j.alit.2024.03.002. PMID: 38594175
Histopathology of Allergic Fungal Rhinosinusitis Versus Chronic Rhinosinusitis with Nasal Polyps.
Simpson T, Talati V, Baird AM, Gattuso P, Allen-Proctor MK, Papagiannopoulos P, Batra PS, Filip P, Tajudeen BA
Laryngoscope 2024 Jun;134(6):2617-2621. Epub 2023 Dec 10 doi: 10.1002/lary.31225. PMID: 38073117
Prevalence of allergic fungal sinusitis among patients with nasal polyposis.
Dhanani R, Ghaloo SK, Salam B, Pasha HA, Yousuf FH, Ikram M
J Pak Med Assoc 2021 Jun;71(6):1605-1607. doi: 10.47391/JPMA.050. PMID: 34111081
Chronic Rhinosinusitis-Could Phenotyping or Endotyping Aid Therapy?
Bayar Muluk N, Cingi C, Scadding GK, Scadding G
Am J Rhinol Allergy 2019 Jan;33(1):83-93. Epub 2018 Oct 24 doi: 10.1177/1945892418807590. PMID: 30353741
Sublingual Immunotherapy for Allergic Fungal Sinusitis.
Melzer JM, Driskill BR, Clenney TL, Gessler EM
Ann Otol Rhinol Laryngol 2015 Oct;124(10):782-7. Epub 2015 Apr 22 doi: 10.1177/0003489415583686. PMID: 25902841

Recent systematic reviews

Association between Social Determinants of Health and Allergic Fungal Rhinosinusitis: A Systematic Review and Meta-analysis.
Gutierrez JA 3rd, Durrant FG, Nguyen SA, Chapurin N, Schlosser RJ, Soler ZM
Otolaryngol Head Neck Surg 2023 Nov;169(5):1101-1113. Epub 2023 Jun 9 doi: 10.1002/ohn.396. PMID: 37293865
The Impact of Climatic, Socioeconomic, and Geographic Factors on the Prevalence of Allergic Fungal Rhinosinusitis: A Worldwide Ecological Study.
AlQahtani A, Alim B, Almudhaibery F, Mulafikh D, Almutairi S, Almohanna S, Alfawwaz F
Am J Rhinol Allergy 2022 Jul;36(4):423-431. Epub 2022 Feb 21 doi: 10.1177/19458924211069226. PMID: 35187957
WITHDRAWN: Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis.
Sacks PL, Harvey RJ, Rimmer J, Gallagher RM, Sacks R
Cochrane Database Syst Rev 2018 Sep 5;9(9):CD008263. doi: 10.1002/14651858.CD008263.pub3. PMID: 30184244Free PMC Article
Antifungal therapy in the treatment of chronic rhinosinusitis: a meta-analysis.
Sacks PL 4th, Harvey RJ, Rimmer J, Gallagher RM, Sacks R
Am J Rhinol Allergy 2012 Mar-Apr;26(2):141-7. doi: 10.2500/ajra.2012.26.3710. PMID: 22487292Free PMC Article
Topical and systemic antifungal therapy for the symptomatic treatment of chronic rhinosinusitis.
Sacks PL, Harvey RJ, Rimmer J, Gallagher RM, Sacks R
Cochrane Database Syst Rev 2011 Aug 10;(8):CD008263. doi: 10.1002/14651858.CD008263.pub2. PMID: 21833965

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