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Confluent drusen

MedGen UID:
740004
Concept ID:
C1720180
Disease or Syndrome
Synonym: Confluent macular drusen
SNOMED CT: Confluent drusen (420779002); Confluent macular drusen (420779002)

Recent clinical studies

Etiology

Hilely A, Au A, Freund KB, Loewenstein A, Souied EH, Zur D, Sacconi R, Borrelli E, Peiretti E, Iovino C, Sugiura Y, Ellabban AA, Monés J, Waheed NK, Ozdek S, Yalinbas D, Thiele S, de Moura Mendonça LS, Lee MY, Lee WK, Turcotte P, Capuano V, Filali Ansary M, Chakravarthy U, Lommatzsch A, Gunnemann F, Pauleikhoff D, Ip MS, Querques G, Holz FG, Spaide RF, Sadda S, Sarraf D
Br J Ophthalmol 2021 Oct;105(10):1415-1420. Epub 2020 Sep 12 doi: 10.1136/bjophthalmol-2020-317326. PMID: 32920528
Johnson PT, Lewis GP, Talaga KC, Brown MN, Kappel PJ, Fisher SK, Anderson DH, Johnson LV
Invest Ophthalmol Vis Sci 2003 Oct;44(10):4481-8. doi: 10.1167/iovs.03-0436. PMID: 14507896
Anderson DH, Mullins RF, Hageman GS, Johnson LV
Am J Ophthalmol 2002 Sep;134(3):411-31. doi: 10.1016/s0002-9394(02)01624-0. PMID: 12208254
Pauleikhoff D, Koch JM
Curr Opin Ophthalmol 1995 Jun;6(3):51-6. doi: 10.1097/00055735-199506000-00009. PMID: 10150870
Bressler NM, Munoz B, Maguire MG, Vitale SE, Schein OD, Taylor HR, West SK
Arch Ophthalmol 1995 Mar;113(3):301-8. doi: 10.1001/archopht.1995.01100030055022. PMID: 7534060

Diagnosis

Green DJ, Lenassi E, Manning CS, McGaughey D, Sharma V, Black GC, Ellingford JM, Sergouniotis PI
Invest Ophthalmol Vis Sci 2021 Jun 1;62(7):16. doi: 10.1167/iovs.62.7.16. PMID: 34125159Free PMC Article
Hilely A, Au A, Freund KB, Loewenstein A, Souied EH, Zur D, Sacconi R, Borrelli E, Peiretti E, Iovino C, Sugiura Y, Ellabban AA, Monés J, Waheed NK, Ozdek S, Yalinbas D, Thiele S, de Moura Mendonça LS, Lee MY, Lee WK, Turcotte P, Capuano V, Filali Ansary M, Chakravarthy U, Lommatzsch A, Gunnemann F, Pauleikhoff D, Ip MS, Querques G, Holz FG, Spaide RF, Sadda S, Sarraf D
Br J Ophthalmol 2021 Oct;105(10):1415-1420. Epub 2020 Sep 12 doi: 10.1136/bjophthalmol-2020-317326. PMID: 32920528
Querques G, Coscas G, Soubrane G, Souied EH
Eur J Ophthalmol 2010 Mar-Apr;20(2):466-8. doi: 10.1177/112067211002000234. PMID: 19967665
Klein ML, Ferris FL 3rd, Armstrong J, Hwang TS, Chew EY, Bressler SB, Chandra SR; AREDS Research Group
Ophthalmology 2008 Jun;115(6):1026-31. Epub 2007 Nov 5 doi: 10.1016/j.ophtha.2007.08.030. PMID: 17981333
Pauleikhoff D, Koch JM
Curr Opin Ophthalmol 1995 Jun;6(3):51-6. doi: 10.1097/00055735-199506000-00009. PMID: 10150870

Therapy

Hilely A, Au A, Freund KB, Loewenstein A, Souied EH, Zur D, Sacconi R, Borrelli E, Peiretti E, Iovino C, Sugiura Y, Ellabban AA, Monés J, Waheed NK, Ozdek S, Yalinbas D, Thiele S, de Moura Mendonça LS, Lee MY, Lee WK, Turcotte P, Capuano V, Filali Ansary M, Chakravarthy U, Lommatzsch A, Gunnemann F, Pauleikhoff D, Ip MS, Querques G, Holz FG, Spaide RF, Sadda S, Sarraf D
Br J Ophthalmol 2021 Oct;105(10):1415-1420. Epub 2020 Sep 12 doi: 10.1136/bjophthalmol-2020-317326. PMID: 32920528
Yu JJ, Agrón E, Clemons TE, Domalpally A, van Asten F, Keenan TD, Cukras C, Chew EY; Age-Related Eye Disease Study 2 Research Group
Ophthalmology 2019 Feb;126(2):261-273. Epub 2018 Aug 22 doi: 10.1016/j.ophtha.2018.08.017. PMID: 30142373Free PMC Article
Sarks SH, Arnold JJ, Sarks JP, Gilles MC, Walter CJ
Aust N Z J Ophthalmol 1996 Feb;24(1):15-26. doi: 10.1111/j.1442-9071.1996.tb01546.x. PMID: 8743000
Bressler NM, Munoz B, Maguire MG, Vitale SE, Schein OD, Taylor HR, West SK
Arch Ophthalmol 1995 Mar;113(3):301-8. doi: 10.1001/archopht.1995.01100030055022. PMID: 7534060
West S, Vitale S, Hallfrisch J, Muñoz B, Muller D, Bressler S, Bressler NM
Arch Ophthalmol 1994 Feb;112(2):222-7. doi: 10.1001/archopht.1994.01090140098031. PMID: 8311777

Prognosis

Green DJ, Lenassi E, Manning CS, McGaughey D, Sharma V, Black GC, Ellingford JM, Sergouniotis PI
Invest Ophthalmol Vis Sci 2021 Jun 1;62(7):16. doi: 10.1167/iovs.62.7.16. PMID: 34125159Free PMC Article
Edwards M, Lutty GA
Adv Exp Med Biol 2021;1256:89-119. doi: 10.1007/978-3-030-66014-7_4. PMID: 33847999
Hilely A, Au A, Freund KB, Loewenstein A, Souied EH, Zur D, Sacconi R, Borrelli E, Peiretti E, Iovino C, Sugiura Y, Ellabban AA, Monés J, Waheed NK, Ozdek S, Yalinbas D, Thiele S, de Moura Mendonça LS, Lee MY, Lee WK, Turcotte P, Capuano V, Filali Ansary M, Chakravarthy U, Lommatzsch A, Gunnemann F, Pauleikhoff D, Ip MS, Querques G, Holz FG, Spaide RF, Sadda S, Sarraf D
Br J Ophthalmol 2021 Oct;105(10):1415-1420. Epub 2020 Sep 12 doi: 10.1136/bjophthalmol-2020-317326. PMID: 32920528
Bhutto I, Lutty G
Mol Aspects Med 2012 Aug;33(4):295-317. Epub 2012 Apr 21 doi: 10.1016/j.mam.2012.04.005. PMID: 22542780Free PMC Article
Bressler NM, Munoz B, Maguire MG, Vitale SE, Schein OD, Taylor HR, West SK
Arch Ophthalmol 1995 Mar;113(3):301-8. doi: 10.1001/archopht.1995.01100030055022. PMID: 7534060

Clinical prediction guides

Green DJ, Lenassi E, Manning CS, McGaughey D, Sharma V, Black GC, Ellingford JM, Sergouniotis PI
Invest Ophthalmol Vis Sci 2021 Jun 1;62(7):16. doi: 10.1167/iovs.62.7.16. PMID: 34125159Free PMC Article
Edwards M, Lutty GA
Adv Exp Med Biol 2021;1256:89-119. doi: 10.1007/978-3-030-66014-7_4. PMID: 33847999
Bhutto I, Lutty G
Mol Aspects Med 2012 Aug;33(4):295-317. Epub 2012 Apr 21 doi: 10.1016/j.mam.2012.04.005. PMID: 22542780Free PMC Article
Sikorski BL, Bukowska D, Kaluzny JJ, Szkulmowski M, Kowalczyk A, Wojtkowski M
Ophthalmology 2011 Jan;118(1):82-92. Epub 2010 Aug 11 doi: 10.1016/j.ophtha.2010.04.017. PMID: 20705340
Johnson PT, Lewis GP, Talaga KC, Brown MN, Kappel PJ, Fisher SK, Anderson DH, Johnson LV
Invest Ophthalmol Vis Sci 2003 Oct;44(10):4481-8. doi: 10.1167/iovs.03-0436. PMID: 14507896

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