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Prosthetic Valve Thrombosis

MedGen UID:
311175
•Concept ID:
C1709735
•
Disease or Syndrome

Definition

The formation of a blood clot that is attached to or near an artificial heart valve; this can cause dysfunction of the valve, and possibly lead to an embolic event should the thrombus become dislodged. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProsthetic Valve Thrombosis

Professional guidelines

PubMed

Chronic thrombosis of bioprostheses: Diagnosis and management.
Shahinian JH, Chan V, Pislaru SV
Prog Cardiovasc Dis 2022 May-Jun;72:15-20. Epub 2022 Jun 25 doi: 10.1016/j.pcad.2022.06.008. PMID: 35764124
Progress in Management of Mechanical Valve Thrombosis.
Schaff HV
J Am Coll Cardiol 2022 Mar 15;79(10):990-992. doi: 10.1016/j.jacc.2022.01.008. PMID: 35272804
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article

Recent clinical studies

Etiology

Oral Anticoagulation.
Altiok E, Marx N
Dtsch Arztebl Int 2018 Nov 16;115(46):776-783. doi: 10.3238/arztebl.2018.0776. PMID: 30602410Free PMC Article
Mechanical and surgical bioprosthetic valve thrombosis.
Lim WY, Lloyd G, Bhattacharyya S
Heart 2017 Dec;103(24):1934-1941. Epub 2017 Aug 5 doi: 10.1136/heartjnl-2017-311856. PMID: 28780576
Prosthetic Heart Valve Thrombosis.
Dangas GD, Weitz JI, Giustino G, Makkar R, Mehran R
J Am Coll Cardiol 2016 Dec 20;68(24):2670-2689. doi: 10.1016/j.jacc.2016.09.958. PMID: 27978952
Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial.
Özkan M, Gündüz S, Gürsoy OM, Karakoyun S, Astarcıoğlu MA, Kalçık M, Aykan AÇ, Çakal B, Bayram Z, Oğuz AE, Ertürk E, Yesin M, Gökdeniz T, Duran NE, Yıldız M, Esen AM
Am Heart J 2015 Aug;170(2):409-18. Epub 2015 May 2 doi: 10.1016/j.ahj.2015.04.025. PMID: 26299240
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article

Diagnosis

Prosthetic Aortic Valve Thrombosis: Surgery or Thrombolysis.
Ria FR, Khan KN, Nahar S, Ahmed T
Mymensingh Med J 2022 Jul;31(3):882-886. PMID: 35780379
Chronic thrombosis of bioprostheses: Diagnosis and management.
Shahinian JH, Chan V, Pislaru SV
Prog Cardiovasc Dis 2022 May-Jun;72:15-20. Epub 2022 Jun 25 doi: 10.1016/j.pcad.2022.06.008. PMID: 35764124
Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations.
Gündüz S, Kalçık M, Gürsoy MO, Güner A, Özkan M
Expert Rev Med Devices 2020 Mar;17(3):209-221. Epub 2020 Mar 5 doi: 10.1080/17434440.2020.1733972. PMID: 32085683
Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial.
Özkan M, Gündüz S, Gürsoy OM, Karakoyun S, Astarcıoğlu MA, Kalçık M, Aykan AÇ, Çakal B, Bayram Z, Oğuz AE, Ertürk E, Yesin M, Gökdeniz T, Duran NE, Yıldız M, Esen AM
Am Heart J 2015 Aug;170(2):409-18. Epub 2015 May 2 doi: 10.1016/j.ahj.2015.04.025. PMID: 26299240
Prosthetic valve thrombosis.
Separham A, Ghaffari S, Aslanabadi N, Sohrabi B, Ghojazadeh M, Anamzadeh E, Hajizadeh R, Davarmoin G
J Card Surg 2015 Mar;30(3):246-50. Epub 2015 Jan 12 doi: 10.1111/jocs.12510. PMID: 25581399

Therapy

Oral Anticoagulation.
Altiok E, Marx N
Dtsch Arztebl Int 2018 Nov 16;115(46):776-783. doi: 10.3238/arztebl.2018.0776. PMID: 30602410Free PMC Article
Prosthetic Heart Valve Thrombosis.
Dangas GD, Weitz JI, Giustino G, Makkar R, Mehran R
J Am Coll Cardiol 2016 Dec 20;68(24):2670-2689. doi: 10.1016/j.jacc.2016.09.958. PMID: 27978952
Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial.
Özkan M, Gündüz S, Gürsoy OM, Karakoyun S, Astarcıoğlu MA, Kalçık M, Aykan AÇ, Çakal B, Bayram Z, Oğuz AE, Ertürk E, Yesin M, Gökdeniz T, Duran NE, Yıldız M, Esen AM
Am Heart J 2015 Aug;170(2):409-18. Epub 2015 May 2 doi: 10.1016/j.ahj.2015.04.025. PMID: 26299240
Prosthetic valve thrombosis.
Separham A, Ghaffari S, Aslanabadi N, Sohrabi B, Ghojazadeh M, Anamzadeh E, Hajizadeh R, Davarmoin G
J Card Surg 2015 Mar;30(3):246-50. Epub 2015 Jan 12 doi: 10.1111/jocs.12510. PMID: 25581399
Antithrombotic and thrombolytic therapy for valvular disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Whitlock RP, Sun JC, Fremes SE, Rubens FD, Teoh KH
Chest 2012 Feb;141(2 Suppl):e576S-e600S. doi: 10.1378/chest.11-2305. PMID: 22315272Free PMC Article

Prognosis

Management of prosthetic valve thrombosis with unfractionated heparin.
Kalkan S, Gürsoy MO, Güner A, Kalçık M, Bayam E, Gündüz S, Özkan M
Int J Cardiol 2024 Jun 1;404:131968. Epub 2024 Mar 19 doi: 10.1016/j.ijcard.2024.131968. PMID: 38503347
Mechanical tricuspid valve thrombosis: A midterm follow-up study.
Shojaeifard M, Omidi N, Erami S, Dehghani Mohammad Abadi H, Hekmat H, Ghorashi SM, Sarrafi Rad N
J Card Surg 2022 Apr;37(4):855-864. Epub 2022 Jan 24 doi: 10.1111/jocs.16209. PMID: 35072279
Oral Anticoagulation.
Altiok E, Marx N
Dtsch Arztebl Int 2018 Nov 16;115(46):776-783. doi: 10.3238/arztebl.2018.0776. PMID: 30602410Free PMC Article
Mechanical and surgical bioprosthetic valve thrombosis.
Lim WY, Lloyd G, Bhattacharyya S
Heart 2017 Dec;103(24):1934-1941. Epub 2017 Aug 5 doi: 10.1136/heartjnl-2017-311856. PMID: 28780576
Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial.
Özkan M, Gündüz S, Gürsoy OM, Karakoyun S, Astarcıoğlu MA, Kalçık M, Aykan AÇ, Çakal B, Bayram Z, Oğuz AE, Ertürk E, Yesin M, Gökdeniz T, Duran NE, Yıldız M, Esen AM
Am Heart J 2015 Aug;170(2):409-18. Epub 2015 May 2 doi: 10.1016/j.ahj.2015.04.025. PMID: 26299240

Clinical prediction guides

Management of prosthetic valve thrombosis with unfractionated heparin.
Kalkan S, Gürsoy MO, Güner A, Kalçık M, Bayam E, Gündüz S, Özkan M
Int J Cardiol 2024 Jun 1;404:131968. Epub 2024 Mar 19 doi: 10.1016/j.ijcard.2024.131968. PMID: 38503347
Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations.
Gündüz S, Kalçık M, Gürsoy MO, Güner A, Özkan M
Expert Rev Med Devices 2020 Mar;17(3):209-221. Epub 2020 Mar 5 doi: 10.1080/17434440.2020.1733972. PMID: 32085683
Oral Anticoagulation.
Altiok E, Marx N
Dtsch Arztebl Int 2018 Nov 16;115(46):776-783. doi: 10.3238/arztebl.2018.0776. PMID: 30602410Free PMC Article
Ultraslow thrombolytic therapy: A novel strategy in the management of PROsthetic MEchanical valve Thrombosis and the prEdictors of outcomE: The Ultra-slow PROMETEE trial.
Özkan M, Gündüz S, Gürsoy OM, Karakoyun S, Astarcıoğlu MA, Kalçık M, Aykan AÇ, Çakal B, Bayram Z, Oğuz AE, Ertürk E, Yesin M, Gökdeniz T, Duran NE, Yıldız M, Esen AM
Am Heart J 2015 Aug;170(2):409-18. Epub 2015 May 2 doi: 10.1016/j.ahj.2015.04.025. PMID: 26299240
Prosthetic valve thrombosis.
Separham A, Ghaffari S, Aslanabadi N, Sohrabi B, Ghojazadeh M, Anamzadeh E, Hajizadeh R, Davarmoin G
J Card Surg 2015 Mar;30(3):246-50. Epub 2015 Jan 12 doi: 10.1111/jocs.12510. PMID: 25581399

Recent systematic reviews

Comprehensive collection of COVID-19 related prosthetic valve failure: a systematic review.
Trieu TK, Birkeland K, Kimchi A, Kedan I
J Thromb Thrombolysis 2023 Apr;55(3):474-489. Epub 2022 Dec 17 doi: 10.1007/s11239-022-02746-x. PMID: 36528721Free PMC Article
Comparison between surgery and fibrinolytic therapy in prosthetic valve thrombosis: A systematic review and meta-analysis.
Sadeghi R, Ahmadzadeh K, Sarveazad A, Haji Aghajani M, Forouzannia SA, Yarahmadi P
J Card Surg 2022 Sep;37(9):2776-2785. Epub 2022 Jun 14 doi: 10.1111/jocs.16681. PMID: 35701901
Thrombolysis in pregnancy: a literature review.
Sousa Gomes M, Guimarães M, Montenegro N
J Matern Fetal Neonatal Med 2019 Jul;32(14):2418-2428. Epub 2018 Feb 11 doi: 10.1080/14767058.2018.1434141. PMID: 29378443
Thrombolytic therapy or surgery for valve prosthesis thrombosis: systematic review and meta-analysis.
Castilho FM, De Sousa MR, Mendonça AL, Ribeiro AL, Cáceres-Lóriga FM
J Thromb Haemost 2014 Aug;12(8):1218-28. doi: 10.1111/jth.12577. PMID: 24698327
Urgent surgery compared with fibrinolytic therapy for the treatment of left-sided prosthetic heart valve thrombosis: a systematic review and meta-analysis of observational studies.
Karthikeyan G, Senguttuvan NB, Joseph J, Devasenapathy N, Bahl VK, Airan B
Eur Heart J 2013 Jun;34(21):1557-66. Epub 2013 Jan 17 doi: 10.1093/eurheartj/ehs486. PMID: 23329151

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