U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Presymptomatic Cancer

MedGen UID:
318046
•Concept ID:
C1709650
•
Neoplastic Process

Definition

The state before the onset or development of clinical disease. Persons who have presymptomatic cancer already have developed the disease of cancer, which is in a pre-clinical state. 2005 [from NCI]

Professional guidelines

PubMed

Management of AL amyloidosis in 2020.
Palladini G, Milani P, Merlini G
Blood 2020 Dec 3;136(23):2620-2627. doi: 10.1182/blood.2020006913. PMID: 33270858
Genetic testing and surveillance guidelines in hereditary pheochromocytoma and paraganglioma.
Muth A, Crona J, Gimm O, Elmgren A, Filipsson K, Stenmark Askmalm M, Sandstedt J, Tengvar M, Tham E
J Intern Med 2019 Feb;285(2):187-204. Epub 2019 Jan 15 doi: 10.1111/joim.12869. PMID: 30536464
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).
Thakker RV, Newey PJ, Walls GV, Bilezikian J, Dralle H, Ebeling PR, Melmed S, Sakurai A, Tonelli F, Brandi ML; Endocrine Society
J Clin Endocrinol Metab 2012 Sep;97(9):2990-3011. Epub 2012 Jun 20 doi: 10.1210/jc.2012-1230. PMID: 22723327

Recent clinical studies

Etiology

Clinical Spectrum and Science Behind the Hamartomatous Polyposis Syndromes.
Yehia L, Heald B, Eng C
Gastroenterology 2023 Apr;164(5):800-811. Epub 2023 Jan 28 doi: 10.1053/j.gastro.2023.01.026. PMID: 36717037
Cost-effectiveness of early cancer surveillance for patients with Li-Fraumeni syndrome.
Tak CR, Biltaji E, Kohlmann W, Maese L, Hainaut P, Villani A, Malkin D, Sherwin CMT, Brixner DI, Schiffman JD
Pediatr Blood Cancer 2019 May;66(5):e27629. Epub 2019 Feb 4 doi: 10.1002/pbc.27629. PMID: 30719841Free PMC Article
Real life cancer comorbidity in Greek patients with diabetes mellitus followed up at a single diabetes center: an unappreciated new diabetes complication.
Thanopoulou A, Pectasides D
J Diabetes Res 2014;2014:231425. Epub 2014 Jul 22 doi: 10.1155/2014/231425. PMID: 25136643Free PMC Article
Moving ahead in diabetics' cancer screening; food for thought from the Hellenic experience.
Karathanasi I, Kamposioras K, Cortinovis I, Karampoiki V, Alevizaki P, Dambrosio M, Zorba E, Panou C, Pantazi E, Bristianou M, Kouiroukidou P, Bouiatiotis E, Xilomenos A, Zavou D, Casazza G, Mauri D; PACMeR
Eur J Cancer Care (Engl) 2009 May;18(3):255-63. Epub 2009 Jan 23 doi: 10.1111/j.1365-2354.2007.00858.x. PMID: 19175670
The stilbestrol-adenosis-carcinoma syndrome.
Ulfelder H
Cancer 1976 Jul;38(1 SUPPL):426-31. doi: 10.1002/1097-0142(197607)38:1<426::aid-cncr2820380166>3.0.co;2-i. PMID: 1277101

Diagnosis

Clinical Spectrum and Science Behind the Hamartomatous Polyposis Syndromes.
Yehia L, Heald B, Eng C
Gastroenterology 2023 Apr;164(5):800-811. Epub 2023 Jan 28 doi: 10.1053/j.gastro.2023.01.026. PMID: 36717037
In Vitro CRISPR-Cas12a-Based Detection of Cancer-Associated TP53 Hotspot Mutations Beyond the crRNA Seed Region.
Kohabir KAV, Nooi LO, Brink A, Brakenhoff RH, Sistermans EA, Wolthuis RMF
CRISPR J 2023 Apr;6(2):127-139. Epub 2023 Jan 13 doi: 10.1089/crispr.2022.0077. PMID: 36637878Free PMC Article
Lymphatic function and anatomy in early stages of lipedema.
Rasmussen JC, Aldrich MB, Fife CE, Herbst KL, Sevick-Muraca EM
Obesity (Silver Spring) 2022 Jul;30(7):1391-1400. Epub 2022 Jun 15 doi: 10.1002/oby.23458. PMID: 35707862Free PMC Article
Cost-effectiveness of early cancer surveillance for patients with Li-Fraumeni syndrome.
Tak CR, Biltaji E, Kohlmann W, Maese L, Hainaut P, Villani A, Malkin D, Sherwin CMT, Brixner DI, Schiffman JD
Pediatr Blood Cancer 2019 May;66(5):e27629. Epub 2019 Feb 4 doi: 10.1002/pbc.27629. PMID: 30719841Free PMC Article
Real life cancer comorbidity in Greek patients with diabetes mellitus followed up at a single diabetes center: an unappreciated new diabetes complication.
Thanopoulou A, Pectasides D
J Diabetes Res 2014;2014:231425. Epub 2014 Jul 22 doi: 10.1155/2014/231425. PMID: 25136643Free PMC Article

Therapy

Real life cancer comorbidity in Greek patients with diabetes mellitus followed up at a single diabetes center: an unappreciated new diabetes complication.
Thanopoulou A, Pectasides D
J Diabetes Res 2014;2014:231425. Epub 2014 Jul 22 doi: 10.1155/2014/231425. PMID: 25136643Free PMC Article
The stilbestrol-adenosis-carcinoma syndrome.
Ulfelder H
Cancer 1976 Jul;38(1 SUPPL):426-31. doi: 10.1002/1097-0142(197607)38:1<426::aid-cncr2820380166>3.0.co;2-i. PMID: 1277101

Prognosis

Cost-effectiveness of early cancer surveillance for patients with Li-Fraumeni syndrome.
Tak CR, Biltaji E, Kohlmann W, Maese L, Hainaut P, Villani A, Malkin D, Sherwin CMT, Brixner DI, Schiffman JD
Pediatr Blood Cancer 2019 May;66(5):e27629. Epub 2019 Feb 4 doi: 10.1002/pbc.27629. PMID: 30719841Free PMC Article

Clinical prediction guides

Real life cancer comorbidity in Greek patients with diabetes mellitus followed up at a single diabetes center: an unappreciated new diabetes complication.
Thanopoulou A, Pectasides D
J Diabetes Res 2014;2014:231425. Epub 2014 Jul 22 doi: 10.1155/2014/231425. PMID: 25136643Free PMC Article
The stilbestrol-adenosis-carcinoma syndrome.
Ulfelder H
Cancer 1976 Jul;38(1 SUPPL):426-31. doi: 10.1002/1097-0142(197607)38:1<426::aid-cncr2820380166>3.0.co;2-i. PMID: 1277101

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...