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Neoplastic C-Cell Hyperplasia

MedGen UID:
313478
•Concept ID:
C1709166
•
Neoplastic Process

Definition

A neoplastic process arising from the C-cells of the thyroid gland. It is considered a precursor of hereditary medullary thyroid gland carcinoma, and it is associated with mutations of the RET gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplastic C-Cell Hyperplasia

Professional guidelines

PubMed

Timing and extent of thyroid surgery for gene carriers of hereditary C cell disease--a consensus statement of the European Society of Endocrine Surgeons (ESES).
Niederle B, Sebag F, Brauckhoff M
Langenbecks Arch Surg 2014 Feb;399(2):185-97. Epub 2013 Dec 3 doi: 10.1007/s00423-013-1139-5. PMID: 24297502

Recent clinical studies

Etiology

Histopathological and molecular studies in patients with goiter and hypercalcitoninemia: reactive or neoplastic C-cell hyperplasia?
Verga U, Ferrero S, Vicentini L, Brambilla T, Cirello V, Muzza M, Beck-Peccoz P, Fugazzola L
Endocr Relat Cancer 2007 Jun;14(2):393-403. doi: 10.1677/ERC-06-0053. PMID: 17639053
Physiologic versus neoplastic C-cell hyperplasia of the thyroid: separation of distinct histologic and biologic entities.
Perry A, Molberg K, Albores-Saavedra J
Cancer 1996 Feb 15;77(4):750-6. doi: 10.1002/(sici)1097-0142(19960215)77:4<750::aid-cncr22>3.0.co;2-z. PMID: 8616768

Diagnosis

Histopathological and molecular studies in patients with goiter and hypercalcitoninemia: reactive or neoplastic C-cell hyperplasia?
Verga U, Ferrero S, Vicentini L, Brambilla T, Cirello V, Muzza M, Beck-Peccoz P, Fugazzola L
Endocr Relat Cancer 2007 Jun;14(2):393-403. doi: 10.1677/ERC-06-0053. PMID: 17639053
Frequency and relevance of elevated calcitonin levels in patients with neoplastic and nonneoplastic thyroid disease and in healthy subjects.
Karanikas G, Moameni A, Poetzi C, Zettinig G, Kaserer K, Bieglmayer C, Niederle B, Dudczak R, Pirich C
J Clin Endocrinol Metab 2004 Feb;89(2):515-9. doi: 10.1210/jc.2003-030709. PMID: 14764755
C-cell hyperplasia and medullary thyroid microcarcinoma.
Albores-Saavedra JA, Krueger JE
Endocr Pathol 2001 Winter;12(4):365-77. doi: 10.1385/ep:12:4:365. PMID: 11914470
Physiologic versus neoplastic C-cell hyperplasia of the thyroid: separation of distinct histologic and biologic entities.
Perry A, Molberg K, Albores-Saavedra J
Cancer 1996 Feb 15;77(4):750-6. doi: 10.1002/(sici)1097-0142(19960215)77:4<750::aid-cncr22>3.0.co;2-z. PMID: 8616768

Prognosis

Histopathological and molecular studies in patients with goiter and hypercalcitoninemia: reactive or neoplastic C-cell hyperplasia?
Verga U, Ferrero S, Vicentini L, Brambilla T, Cirello V, Muzza M, Beck-Peccoz P, Fugazzola L
Endocr Relat Cancer 2007 Jun;14(2):393-403. doi: 10.1677/ERC-06-0053. PMID: 17639053

Clinical prediction guides

Histopathological and molecular studies in patients with goiter and hypercalcitoninemia: reactive or neoplastic C-cell hyperplasia?
Verga U, Ferrero S, Vicentini L, Brambilla T, Cirello V, Muzza M, Beck-Peccoz P, Fugazzola L
Endocr Relat Cancer 2007 Jun;14(2):393-403. doi: 10.1677/ERC-06-0053. PMID: 17639053

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