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HIV Lipodystrophy

MedGen UID:
313244
•Concept ID:
C1708272
•
Neoplastic Process
Synonym: HIV-Lipodystrophy

Definition

A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat. It is associated with antiretroviral therapy. Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHIV Lipodystrophy

Professional guidelines

PubMed

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
Metreleptin treatment of non-HIV lipodystrophy syndromes.
Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177
Thiazolidinediones in the treatment of type 2 diabetes.
Pittas AG, Greenberg AS
Expert Opin Pharmacother 2002 May;3(5):529-40. doi: 10.1517/14656566.3.5.529. PMID: 11996632

Recent clinical studies

Etiology

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
Metreleptin treatment of non-HIV lipodystrophy syndromes.
Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177
Pathophysiology of GHRH-growth hormone-IGF1 axis in HIV/AIDS.
Jain S, Desai N, Bhangoo A
Rev Endocr Metab Disord 2013 Jun;14(2):113-8. doi: 10.1007/s11154-013-9245-9. PMID: 23657561
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'.
Balasubramanyam A, Sekhar RV, Jahoor F, Jones PH, Pownall HJ
Curr Opin Lipidol 2004 Feb;15(1):59-67. doi: 10.1097/00041433-200402000-00011. PMID: 15166810

Diagnosis

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'.
Balasubramanyam A, Sekhar RV, Jahoor F, Jones PH, Pownall HJ
Curr Opin Lipidol 2004 Feb;15(1):59-67. doi: 10.1097/00041433-200402000-00011. PMID: 15166810
HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management.
Carr A
AIDS 2003 Apr;17 Suppl 1:S141-8. PMID: 12870540
Complications of HIV: lipodystrophy, anemia, renal, cardiovascular, and bone diseases.
Balt CA, Nixon H
Nurse Pract Forum 2001 Dec;12(4):199-213. PMID: 11889688

Therapy

Metreleptin treatment of non-HIV lipodystrophy syndromes.
Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177
Therapy for HIV: past, present, and future.
Peters BS, Conway K
Adv Dent Res 2011 Apr;23(1):23-7. doi: 10.1177/0022034511399082. PMID: 21441476
Restorative interventions for HIV facial lipoatrophy.
Carey D, Liew S, Emery S
AIDS Rev 2008 Apr-Jun;10(2):116-24. PMID: 18615122
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'.
Balasubramanyam A, Sekhar RV, Jahoor F, Jones PH, Pownall HJ
Curr Opin Lipidol 2004 Feb;15(1):59-67. doi: 10.1097/00041433-200402000-00011. PMID: 15166810

Prognosis

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy.
Lindegaard B, Larsen LF, Hansen AB, Gerstoft J, Pedersen BK, Reue K
Int J Obes (Lond) 2007 Mar;31(3):449-56. Epub 2006 Jul 18 doi: 10.1038/sj.ijo.0803434. PMID: 16847472
Management of dyslipidemia in patients with complicated metabolic syndrome.
Davidson MH
Am J Cardiol 2005 Aug 22;96(4A):22E-25E. doi: 10.1016/j.amjcard.2005.05.011. PMID: 16098839
HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies.
Koutkia P, Grinspoon S
Annu Rev Med 2004;55:303-17. doi: 10.1146/annurev.med.55.091902.104412. PMID: 14746523

Clinical prediction guides

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy.
Domingo P, Giralt M, Gavaldà-Navarro A, Blasco-Roset A, Delgado-Anglés A, Gallego-Escuredo JM, Gutiérrez MDM, Mateo MG, Cereijo R, Domingo JC, Villarroya F, Villarroya J
Adipocyte 2022 Dec;11(1):143-152. doi: 10.1080/21623945.2022.2042962. PMID: 35300561Free PMC Article
Metformin: the hidden chronicles of a magic drug.
Mahmood K, Naeem M, Rahimnajjad NA
Eur J Intern Med 2013 Jan;24(1):20-6. Epub 2012 Nov 21 doi: 10.1016/j.ejim.2012.10.011. PMID: 23177353
The association of lipodystrophy and oxidative stress biomarkers in HIV-infected men.
Vassimon HS, Deminice R, Machado AA, Monteiro JP, Jordao AA
Curr HIV Res 2010 Jul;8(5):364-9. doi: 10.2174/157016210791330347. PMID: 20353389
Cardiovascular complications in the acquired immunodeficiency syndrome.
Barbaro G, Silva EF
Rev Assoc Med Bras (1992) 2009 Sep-Oct;55(5):621-30. doi: 10.1590/s0104-42302009000500031. PMID: 19918668

Recent systematic reviews

A systematic review of filler agents for aesthetic treatment of HIV facial lipoatrophy (FLA).
Jagdeo J, Ho D, Lo A, Carruthers A
J Am Acad Dermatol 2015 Dec;73(6):1040-54.e14. Epub 2015 Oct 23 doi: 10.1016/j.jaad.2015.08.040. PMID: 26481056

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