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Gardner Fibroma

MedGen UID:
317718
•Concept ID:
C1708187
•
Neoplastic Process
Synonyms: Gardner fibroma; Gardner's Fibroma; Gardner-Associated Fibroma
SNOMED CT: Gardner fibroma (703607009); Gardner fibroma (1290941003)

Definition

An uncommon, poorly circumscribed, benign neoplasm arising in the soft tissues of infants, children and adolescents. It is characterized by the presence of haphazardly arranged spindle-shaped fibroblasts, collagenous stroma formation, and plaque-like growth pattern. There is a strong genetic component associating the neoplasm with Gardners syndrome and deep fibromatosis/desmoid tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGardner Fibroma

Professional guidelines

PubMed

Differential diagnostic considerations of desmoid-type fibromatosis.
Goldstein JA, Cates JM
Adv Anat Pathol 2015 Jul;22(4):260-6. doi: 10.1097/PAP.0000000000000077. PMID: 26050263

Recent clinical studies

Etiology

Superficial fibromas with CTNNB1 mutation.
Kuntze A, Meliß RR, Ermert L, Falkenberg KD, Puller AC, Trautmann M, Hartmann W, Wardelmann E
Genes Chromosomes Cancer 2024 May;63(5):e23247. doi: 10.1002/gcc.23247. PMID: 38757718
Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review.
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243
Gardner Fibroma: Clinical and Histopathologic Implications of Germline APC Mutation Association.
Dahl NA, Sheil A, Knapke S, Geller JI
J Pediatr Hematol Oncol 2016 Jul;38(5):e154-7. doi: 10.1097/MPH.0000000000000493. PMID: 26840078
Desmoid-type fibromatosis-associated Gardner fibromas: prevalence and impact on local recurrence.
Cates JM, Stricker TP, Sturgeon D, Coffin CM
Cancer Lett 2014 Oct 28;353(2):176-81. Epub 2014 Jul 23 doi: 10.1016/j.canlet.2014.07.020. PMID: 25064609
Neonatal Gardner fibroma: a sentinel presentation of severe familial adenomatous polyposis.
Levesque S, Ahmed N, Nguyen VH, Nahal A, Blumenkrantz M, Puligandla P, Chong G, Foulkes WD
Pediatrics 2010 Dec;126(6):e1599-602. Epub 2010 Nov 8 doi: 10.1542/peds.2010-1045. PMID: 21059714

Diagnosis

Imaging palpable tumors in pediatrics: Part 2.
Llanos D, de la Pedraja I, Campos L, Armijo J, Ávila LF
Radiologia (Engl Ed) 2023 Jan-Feb;65(1):43-54. doi: 10.1016/j.rxeng.2023.01.001. PMID: 36842785
Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review.
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243
Gardner Fibroma: Clinical and Histopathologic Implications of Germline APC Mutation Association.
Dahl NA, Sheil A, Knapke S, Geller JI
J Pediatr Hematol Oncol 2016 Jul;38(5):e154-7. doi: 10.1097/MPH.0000000000000493. PMID: 26840078
Differential diagnostic considerations of desmoid-type fibromatosis.
Goldstein JA, Cates JM
Adv Anat Pathol 2015 Jul;22(4):260-6. doi: 10.1097/PAP.0000000000000077. PMID: 26050263
Syndrome-associated soft tissue tumours.
Coffin CM, Davis JL, Borinstein SC
Histopathology 2014 Jan;64(1):68-87. Epub 2013 Nov 18 doi: 10.1111/his.12280. PMID: 24236688

Prognosis

Superficial fibromas with CTNNB1 mutation.
Kuntze A, Meliß RR, Ermert L, Falkenberg KD, Puller AC, Trautmann M, Hartmann W, Wardelmann E
Genes Chromosomes Cancer 2024 May;63(5):e23247. doi: 10.1002/gcc.23247. PMID: 38757718
Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review.
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243
Desmoid-type fibromatosis-associated Gardner fibromas: prevalence and impact on local recurrence.
Cates JM, Stricker TP, Sturgeon D, Coffin CM
Cancer Lett 2014 Oct 28;353(2):176-81. Epub 2014 Jul 23 doi: 10.1016/j.canlet.2014.07.020. PMID: 25064609
Neonatal Gardner fibroma: a sentinel presentation of severe familial adenomatous polyposis.
Levesque S, Ahmed N, Nguyen VH, Nahal A, Blumenkrantz M, Puligandla P, Chong G, Foulkes WD
Pediatrics 2010 Dec;126(6):e1599-602. Epub 2010 Nov 8 doi: 10.1542/peds.2010-1045. PMID: 21059714

Clinical prediction guides

Neonatal Gardner fibroma: a sentinel presentation of severe familial adenomatous polyposis.
Levesque S, Ahmed N, Nguyen VH, Nahal A, Blumenkrantz M, Puligandla P, Chong G, Foulkes WD
Pediatrics 2010 Dec;126(6):e1599-602. Epub 2010 Nov 8 doi: 10.1542/peds.2010-1045. PMID: 21059714

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