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Cellular Myxoma

MedGen UID:
317498
•Concept ID:
C1707332
•
Neoplastic Process
Synonym: Cellular myxoma
SNOMED CT: Cellular myxoma (1290614006); Cellular myxoma (1295217007)

Definition

An intramuscular myxoma with increased cellularity and increased numbers of collagen fibers and blood vessels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Myxoma

Professional guidelines

PubMed

Advances in viral oncolytics for treatment of multiple myeloma - a focused review.
Sarwar A, Hashim L, Faisal MS, Haider MZ, Ahmed Z, Ahmed TF, Shahzad M, Ansar I, Ali S, Aslam MM, Anwer F
Expert Rev Hematol 2021 Dec;14(12):1071-1083. Epub 2021 Sep 15 doi: 10.1080/17474086.2021.1972802. PMID: 34428997
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Cellular factors promoting resistance to effective treatment of glioma with oncolytic myxoma virus.
Zemp FJ, McKenzie BA, Lun X, Reilly KM, McFadden G, Yong VW, Forsyth PA
Cancer Res 2014 Dec 15;74(24):7260-73. Epub 2014 Oct 21 doi: 10.1158/0008-5472.CAN-14-0876. PMID: 25336188Free PMC Article

Recent clinical studies

Etiology

Cellular Myxoma of the Vocal Cord: A Case Report and Review of the Literature.
Val-Bernal JF, Martino M, Longarela MY
Turk Patoloji Derg 2020;36(1):77-81. doi: 10.5146/tjpath.2017.01417. PMID: 29235612Free PMC Article
Fine-needle aspiration of soft tissue perineurioma: A comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics.
Yang EJ, Hornick JL, Qian X
Cancer Cytopathol 2016 Sep;124(9):651-8. Epub 2016 May 9 doi: 10.1002/cncy.21725. PMID: 27159449
Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases.
Hollmann TJ, Bovée JV, Fletcher CD
Am J Surg Pathol 2012 Jun;36(6):789-98. doi: 10.1097/PAS.0b013e31824a0b83. PMID: 22367301
Intramuscular myxomas: a clinicopathologic study with emphasis on surgical management.
Charron P, Smith J
Am Surg 2004 Dec;70(12):1073-7. PMID: 15663047
Cellular myxoma of soft tissue: a clinicopathological study of 38 cases confirming indolent clinical behaviour.
van Roggen JF, McMenamin ME, Fletcher CD
Histopathology 2001 Sep;39(3):287-97. doi: 10.1046/j.1365-2559.2001.01209.x. PMID: 11532040

Diagnosis

The Role of Methylation Analysis in Distinguishing Cellular Myxoma from Low-Grade Myxofibrosarcoma.
Henzinger H, Brčić I, Igrec J, Godschachner TM, Scheipl S, Szkandera J, Jurmeister P, Liegl-Atzwanger B
Int J Mol Sci 2024 May 8;25(10) doi: 10.3390/ijms25105105. PMID: 38791144Free PMC Article
CYP1A1 immunohistochemistry is highly specific for angiofibroma of soft tissue among morphological mimics.
Bauer AH, Fletcher CDM, Hornick JL, Papke DJ Jr
Histopathology 2024 Jan;84(2):381-386. Epub 2023 Oct 19 doi: 10.1111/his.15070. PMID: 37855220
Cellular Myxoma of the Vocal Cord: A Case Report and Review of the Literature.
Val-Bernal JF, Martino M, Longarela MY
Turk Patoloji Derg 2020;36(1):77-81. doi: 10.5146/tjpath.2017.01417. PMID: 29235612Free PMC Article
Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases.
Hollmann TJ, Bovée JV, Fletcher CD
Am J Surg Pathol 2012 Jun;36(6):789-98. doi: 10.1097/PAS.0b013e31824a0b83. PMID: 22367301
Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix.
Willems SM, Mohseny AB, Balog C, Sewrajsing R, Briaire-de Bruijn IH, Knijnenburg J, Cleton-Jansen AM, Sciot R, Fletcher CD, Deelder AM, Szuhai K, Hensbergen PJ, Hogendoorn PC
J Cell Mol Med 2009 Jul;13(7):1291-301. Epub 2009 Mar 13 doi: 10.1111/j.1582-4934.2009.00747.x. PMID: 19320777Free PMC Article

Therapy

Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases.
Hollmann TJ, Bovée JV, Fletcher CD
Am J Surg Pathol 2012 Jun;36(6):789-98. doi: 10.1097/PAS.0b013e31824a0b83. PMID: 22367301

Prognosis

The Role of Methylation Analysis in Distinguishing Cellular Myxoma from Low-Grade Myxofibrosarcoma.
Henzinger H, Brčić I, Igrec J, Godschachner TM, Scheipl S, Szkandera J, Jurmeister P, Liegl-Atzwanger B
Int J Mol Sci 2024 May 8;25(10) doi: 10.3390/ijms25105105. PMID: 38791144Free PMC Article
Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors.
Sunitsch S, Gilg MM, Kashofer K, Gollowitsch F, Leithner A, Liegl-Atzwanger B
Diagn Pathol 2018 Aug 15;13(1):52. doi: 10.1186/s13000-018-0734-8. PMID: 30111377Free PMC Article
Fine-needle aspiration of soft tissue perineurioma: A comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics.
Yang EJ, Hornick JL, Qian X
Cancer Cytopathol 2016 Sep;124(9):651-8. Epub 2016 May 9 doi: 10.1002/cncy.21725. PMID: 27159449
Juxta-articular myxoma: an unusual benign mesenchymal lesion, readily mistaken for malignancy.
Beggan C, Davies K, Leader M
Ir Med J 2014 Jul-Aug;107(7):212-3. PMID: 25226717
Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation.
Dawamneh MF, Amra NK, Amr SS
Acta Cytol 2006 Mar-Apr;50(2):208-12. doi: 10.1159/000325934. PMID: 16610692

Clinical prediction guides

The Role of Methylation Analysis in Distinguishing Cellular Myxoma from Low-Grade Myxofibrosarcoma.
Henzinger H, Brčić I, Igrec J, Godschachner TM, Scheipl S, Szkandera J, Jurmeister P, Liegl-Atzwanger B
Int J Mol Sci 2024 May 8;25(10) doi: 10.3390/ijms25105105. PMID: 38791144Free PMC Article
Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors.
Sunitsch S, Gilg MM, Kashofer K, Gollowitsch F, Leithner A, Liegl-Atzwanger B
Diagn Pathol 2018 Aug 15;13(1):52. doi: 10.1186/s13000-018-0734-8. PMID: 30111377Free PMC Article

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