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Benign prostatic hyperplasia(BPH)

MedGen UID:
312369
•Concept ID:
C1704272
•
Pathologic Function
Synonym: BPH
SNOMED CT: Nodular hyperplasia of prostate gland (266569009); BPH - benign prostatic hyperplasia (266569009); Benign prostatic hyperplasia (266569009); Benign enlargement of prostate (266569009); Benign prostatic hypertrophy (266569009); BEP - Benign enlargement of prostate (266569009)
 
HPO: HP:0008711
Monarch Initiative: MONDO:0010811
OMIM®: 600082

Definition

Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth of the prostate gland, and is histologically defined as hyperplasia of the prostate gland. BPH is an age-related phenomenon in men beginning at about age 40 years. BPH may result in prostatic enlargement and clinical symptoms most commonly affecting the lower urinary tract. These symptoms may be obstructive, including hesitancy, weak flow, and urinary retention, or irritative, including increased frequency and urgency. However, not all men with histologic BPH will develop prostatic enlargement or urinary symptoms (review by Roehrborn, 2005). [from OMIM]

Clinical features

From HPO
Benign prostatic hyperplasia
MedGen UID:
312369
•Concept ID:
C1704272
•
Pathologic Function
Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth of the prostate gland, and is histologically defined as hyperplasia of the prostate gland. BPH is an age-related phenomenon in men beginning at about age 40 years. BPH may result in prostatic enlargement and clinical symptoms most commonly affecting the lower urinary tract. These symptoms may be obstructive, including hesitancy, weak flow, and urinary retention, or irritative, including increased frequency and urgency. However, not all men with histologic BPH will develop prostatic enlargement or urinary symptoms (review by Roehrborn, 2005).
See: Feature record | Search on this feature

Conditions with this feature

Benign prostatic hyperplasia
MedGen UID:
312369
•Concept ID:
C1704272
•
Pathologic Function
Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth of the prostate gland, and is histologically defined as hyperplasia of the prostate gland. BPH is an age-related phenomenon in men beginning at about age 40 years. BPH may result in prostatic enlargement and clinical symptoms most commonly affecting the lower urinary tract. These symptoms may be obstructive, including hesitancy, weak flow, and urinary retention, or irritative, including increased frequency and urgency. However, not all men with histologic BPH will develop prostatic enlargement or urinary symptoms (review by Roehrborn, 2005).
See: Condition Record
Benign prostatic hyperplasia

Professional guidelines

PubMed

Treatment of Benign Prostatic Hyperplasia by Natural Drugs.
Csikós E, Horváth A, Ács K, Papp N, Balázs VL, Dolenc MS, Kenda M, Kočevar Glavač N, Nagy M, Protti M, Mercolini L, Horváth G, Farkas Á, On Behalf Of The Oemonom
Molecules 2021 Nov 25;26(23) doi: 10.3390/molecules26237141. PMID: 34885733Free PMC Article
Current Treatment for Benign Prostatic Hyperplasia.
Miernik A, Gratzke C
Dtsch Arztebl Int 2020 Dec 4;117(49):843-854. doi: 10.3238/arztebl.2020.0843. PMID: 33593479Free PMC Article
Drug-induced urinary retention: incidence, management and prevention.
Verhamme KM, Sturkenboom MC, Stricker BH, Bosch R
Drug Saf 2008;31(5):373-88. doi: 10.2165/00002018-200831050-00002. PMID: 18422378

Recent clinical studies

Etiology

Benign prostatic hyperplasia.
Infante Hernández S, Gómez Rivas J, Moreno Sierra J
Med Clin (Barc) 2024 Oct 25;163(8):407-414. Epub 2024 Jul 15 doi: 10.1016/j.medcli.2024.04.014. PMID: 39013719
Surgical Complications in the Management of Benign Prostatic Hyperplasia Treatment.
Ottaiano N, Shelton T, Sanekommu G, Benson CR
Curr Urol Rep 2022 May;23(5):83-92. Epub 2022 Mar 9 doi: 10.1007/s11934-022-01091-z. PMID: 35262855
Quality of life and erectile dysfunction in patients with benign prostatic hyperplasia.
Montiel-Jarquín ÁJ, Gutiérrez-Quiroz CT, Pérez-Vázquez AL, Ortiz-Agustín JJ, García-Galicia A, Loría-Castellanos J
Cir Cir 2021;89(2):218-222. doi: 10.24875/CIRU.20000071. PMID: 33784271
Current Treatment for Benign Prostatic Hyperplasia.
Miernik A, Gratzke C
Dtsch Arztebl Int 2020 Dec 4;117(49):843-854. doi: 10.3238/arztebl.2020.0843. PMID: 33593479Free PMC Article
Rezūm Water Vapor Thermal Therapy for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: 4-Year Results From Randomized Controlled Study.
McVary KT, Rogers T, Roehrborn CG
Urology 2019 Apr;126:171-179. Epub 2019 Jan 21 doi: 10.1016/j.urology.2018.12.041. PMID: 30677455

Diagnosis

Benign prostatic hyperplasia.
Infante Hernández S, Gómez Rivas J, Moreno Sierra J
Med Clin (Barc) 2024 Oct 25;163(8):407-414. Epub 2024 Jul 15 doi: 10.1016/j.medcli.2024.04.014. PMID: 39013719
Current Treatment for Benign Prostatic Hyperplasia.
Miernik A, Gratzke C
Dtsch Arztebl Int 2020 Dec 4;117(49):843-854. doi: 10.3238/arztebl.2020.0843. PMID: 33593479Free PMC Article
Urinary Retention.
Billet M, Windsor TA
Emerg Med Clin North Am 2019 Nov;37(4):649-660. Epub 2019 Aug 16 doi: 10.1016/j.emc.2019.07.005. PMID: 31563200
Benign Prostatic Hyperplasia.
Langan RC
Prim Care 2019 Jun;46(2):223-232. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.003. PMID: 31030823
What is a disease? What is the disease clinical benign prostatic hyperplasia (BPH)?
Foo KT
World J Urol 2019 Jul;37(7):1293-1296. Epub 2019 Feb 25 doi: 10.1007/s00345-019-02691-0. PMID: 30805683Free PMC Article

Therapy

Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED.
Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT, Kaplan S, Gravas S, Chapple C, Gacci M
Curr Urol Rep 2020 Oct 27;21(12):56. doi: 10.1007/s11934-020-01009-7. PMID: 33108544Free PMC Article
Post-finasteride syndrome: a surmountable challenge for clinicians.
Traish AM
Fertil Steril 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. PMID: 32033719
Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications.
Solomon ZJ, Mirabal JR, Mazur DJ, Kohn TP, Lipshultz LI, Pastuszak AW
Sex Med Rev 2019 Jan;7(1):84-94. Epub 2018 Nov 30 doi: 10.1016/j.sxmr.2018.09.006. PMID: 30503797Free PMC Article
What's New in Rezūm?
Pathak P, Helo S, McVary KT
Eur Urol Focus 2018 Jan;4(1):32-35. Epub 2018 Mar 9 doi: 10.1016/j.euf.2018.02.011. PMID: 29530631
Dutasteride.
Evans HC, Goa KL
Drugs Aging 2003;20(12):905-16; discussion 917-8. doi: 10.2165/00002512-200320120-00005. PMID: 14565784

Prognosis

Benign prostatic hyperplasia burden comparison between China and United States based on the Global Burden of Disease Study 2019.
Liu D, Li C, Li Y, Zhou L, Li J, Wang Y, Wan X, Zhou L, Wang L
World J Urol 2023 Dec;41(12):3629-3634. Epub 2023 Oct 13 doi: 10.1007/s00345-023-04658-8. PMID: 37831157
Frailty and Lower Urinary Tract Symptoms.
Suskind AM
Curr Urol Rep 2017 Sep;18(9):67. doi: 10.1007/s11934-017-0720-9. PMID: 28718161Free PMC Article
The Epidemiology of Benign Prostatic Hyperplasia Associated with Lower Urinary Tract Symptoms: Prevalence and Incident Rates.
Egan KB
Urol Clin North Am 2016 Aug;43(3):289-97. doi: 10.1016/j.ucl.2016.04.001. PMID: 27476122
Obstructive uropathy.
Tseng TY, Stoller ML
Clin Geriatr Med 2009 Aug;25(3):437-43. doi: 10.1016/j.cger.2009.06.003. PMID: 19765491
Complications of transurethral resection of the prostate (TURP)--incidence, management, and prevention.
Rassweiler J, Teber D, Kuntz R, Hofmann R
Eur Urol 2006 Nov;50(5):969-79; discussion 980. Epub 2006 Jan 30 doi: 10.1016/j.eururo.2005.12.042. PMID: 16469429

Clinical prediction guides

Outcome Measures and Inclusion/Exclusion Criteria in Benign Prostatic Hyperplasia Trials on ClinicalTrials.gov.
Tram M, Zipkin J, Srivastava S, Welliver C
Urol Pract 2023 May;10(3):254-260. Epub 2023 Mar 16 doi: 10.1097/UPJ.0000000000000397. PMID: 37103503
Benign Prostatic Hyperplasia: Clinical Manifestations, Imaging, and Patient Selection for Prostate Artery Embolization.
Powell T, Kellner D, Ayyagari R
Tech Vasc Interv Radiol 2020 Sep;23(3):100688. Epub 2020 Oct 6 doi: 10.1016/j.tvir.2020.100688. PMID: 33308530
Benign prostatic hyperplasia: clinical manifestations and evaluation.
Santos Dias J
Tech Vasc Interv Radiol 2012 Dec;15(4):265-9. doi: 10.1053/j.tvir.2012.09.007. PMID: 23244722
Benign prostatic hyperplasia and lower urinary tract symptoms: research priorities.
De Nunzio C, Ahyai S, Autorino R, Bachmann A, Bialek W, Briganti A, Reich O, Sosnowski R, Thiruchelvam N, Novara G; European Association of Urology Young Academic Urologists BPH Group
Eur Urol 2011 Dec;60(6):1205-6. Epub 2011 Sep 7 doi: 10.1016/j.eururo.2011.08.055. PMID: 21930341
The Abrams-Griffiths nomogram.
Lim CS, Abrams P
World J Urol 1995;13(1):34-9. doi: 10.1007/BF00182664. PMID: 7539679

Recent systematic reviews

Minimally Invasive Treatments for Benign Prostatic Obstruction: A Systematic Review and Network Meta-analysis.
Cornu JN, Zantek P, Burtt G, Martin C, Martin A, Springate C, Chughtai B
Eur Urol 2023 Jun;83(6):534-547. Epub 2023 Mar 22 doi: 10.1016/j.eururo.2023.02.028. PMID: 36964042
Minimally Invasive Treatment in Benign Prostatic Hyperplasia (BPH).
Sciacqua LV, Vanzulli A, Di Meo R, Pellegrino G, Lavorato R, Vitale G, Carrafiello G
Technol Cancer Res Treat 2023 Jan-Dec;22:15330338231155000. doi: 10.1177/15330338231155000. PMID: 36794408Free PMC Article
Histotripsy: the first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound.
Xu Z, Hall TL, Vlaisavljevich E, Lee FT Jr
Int J Hyperthermia 2021;38(1):561-575. doi: 10.1080/02656736.2021.1905189. PMID: 33827375Free PMC Article
Benign prostate hyperplasia and nutrition.
Das K, Buchholz N
Clin Nutr ESPEN 2019 Oct;33:5-11. Epub 2019 Aug 12 doi: 10.1016/j.clnesp.2019.07.015. PMID: 31451276
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338

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