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Persecutory delusion

MedGen UID:
739483
Concept ID:
C1704268
Mental or Behavioral Dysfunction
Synonym: Delusion of persecution
SNOMED CT: Delusion of persecution (216004); Persecutory delusion (216004)
 
HPO: HP:5200415

Definition

False beliefs (or judgements) that are held with extraordinary conviction and subjective certainty that are impervious to other experiences or counterarguments and the content is generally considered impossible for the context and circumstance. Delusional beliefs may arise meaningfully from personal or social experiences, yet are impossible, held with conviction, and irrefutable; more commonly they may be psychologically irreducible, appearing with no logical or meaningful connection to the individual experience. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPersecutory delusion

Professional guidelines

PubMed

Zarrabi H, Khalkhali M, Hamidi A, Ahmadi R, Zavarmousavi M
BMC Psychiatry 2016 Feb 25;16:44. doi: 10.1186/s12888-016-0745-5. PMID: 26911516Free PMC Article

Recent clinical studies

Etiology

Barnby JM, Mehta MA, Moutoussis M
PLoS Comput Biol 2022 Jul;18(7):e1010326. Epub 2022 Jul 25 doi: 10.1371/journal.pcbi.1010326. PMID: 35877675Free PMC Article
Müller H, Betz LT, Bechdolf A
Neurosci Biobehav Rev 2021 Jan;120:542-549. Epub 2020 Oct 24 doi: 10.1016/j.neubiorev.2020.09.025. PMID: 33148471
Zarrabi H, Khalkhali M, Hamidi A, Ahmadi R, Zavarmousavi M
BMC Psychiatry 2016 Feb 25;16:44. doi: 10.1186/s12888-016-0745-5. PMID: 26911516Free PMC Article
Berna F, Huron C, Kazès M, Offerlin-Meyer I, Willard D, Verry P, Hedélin G, Krebs MO, Danion JM
Isr J Psychiatry Relat Sci 2014;51(1):25-33. PMID: 24858632
Mackinnon K, Newman-Taylor K, Stopa L
J Behav Ther Exp Psychiatry 2011 Mar;42(1):54-64. Epub 2010 Jun 9 doi: 10.1016/j.jbtep.2010.05.003. PMID: 20663490

Diagnosis

Freeman D, Loe BS, Kingdon D, Startup H, Molodynski A, Rosebrock L, Brown P, Sheaves B, Waite F, Bird JC
Psychol Med 2021 Jan;51(2):244-253. Epub 2019 Nov 20 doi: 10.1017/S0033291719003155. PMID: 31744588Free PMC Article
Masiran R
BMJ Case Rep 2017 Oct 4;2017 doi: 10.1136/bcr-2017-220817. PMID: 28978587Free PMC Article
Jones SR, Fernyhough C
Cogn Neuropsychiatry 2008 Jul;13(4):281-95. doi: 10.1080/13546800802087830. PMID: 18622786
Srisurapanont M, Ali R, Marsden J, Sunga A, Wada K, Monteiro M
Int J Neuropsychopharmacol 2003 Dec;6(4):347-52. doi: 10.1017/S1461145703003675. PMID: 14604449
Blackwood NJ, Howard RJ, Bentall RP, Murray RM
Am J Psychiatry 2001 Apr;158(4):527-39. doi: 10.1176/appi.ajp.158.4.527. PMID: 11282685

Therapy

Tolmeijer E, Waite F, Isham L, Bringmann L, Timmers R, van den Berg A, Schuurmans H, Staring ABP, de Bont P, van Grunsven R, Stulp G, Wijnen B, van der Gaag M, Freeman D, van den Berg D
Trials 2023 Oct 5;24(1):644. doi: 10.1186/s13063-023-07661-x. PMID: 37798792Free PMC Article
Müller H, Betz LT, Bechdolf A
Neurosci Biobehav Rev 2021 Jan;120:542-549. Epub 2020 Oct 24 doi: 10.1016/j.neubiorev.2020.09.025. PMID: 33148471
Masiran R
BMJ Case Rep 2017 Oct 4;2017 doi: 10.1136/bcr-2017-220817. PMID: 28978587Free PMC Article
Zarrabi H, Khalkhali M, Hamidi A, Ahmadi R, Zavarmousavi M
BMC Psychiatry 2016 Feb 25;16:44. doi: 10.1186/s12888-016-0745-5. PMID: 26911516Free PMC Article
Paholpak P, Rangseekajee P, Foocharoen C
J Psychosom Res 2012 Dec;73(6):448-51. Epub 2012 Aug 29 doi: 10.1016/j.jpsychores.2012.08.006. PMID: 23148813

Prognosis

Suthaharan P, Corlett PR
Sci Rep 2023 Apr 13;13(1):6084. doi: 10.1038/s41598-023-33305-w. PMID: 37055504Free PMC Article
Barnby JM, Mehta MA, Moutoussis M
PLoS Comput Biol 2022 Jul;18(7):e1010326. Epub 2022 Jul 25 doi: 10.1371/journal.pcbi.1010326. PMID: 35877675Free PMC Article
Zarrabi H, Khalkhali M, Hamidi A, Ahmadi R, Zavarmousavi M
BMC Psychiatry 2016 Feb 25;16:44. doi: 10.1186/s12888-016-0745-5. PMID: 26911516Free PMC Article
Mackinnon K, Newman-Taylor K, Stopa L
J Behav Ther Exp Psychiatry 2011 Mar;42(1):54-64. Epub 2010 Jun 9 doi: 10.1016/j.jbtep.2010.05.003. PMID: 20663490
Jones SR, Fernyhough C
Cogn Neuropsychiatry 2008 Jul;13(4):281-95. doi: 10.1080/13546800802087830. PMID: 18622786

Clinical prediction guides

Suthaharan P, Corlett PR
Sci Rep 2023 Apr 13;13(1):6084. doi: 10.1038/s41598-023-33305-w. PMID: 37055504Free PMC Article
Barnby JM, Mehta MA, Moutoussis M
PLoS Comput Biol 2022 Jul;18(7):e1010326. Epub 2022 Jul 25 doi: 10.1371/journal.pcbi.1010326. PMID: 35877675Free PMC Article
Berna F, Huron C, Kazès M, Offerlin-Meyer I, Willard D, Verry P, Hedélin G, Krebs MO, Danion JM
Isr J Psychiatry Relat Sci 2014;51(1):25-33. PMID: 24858632
Mackinnon K, Newman-Taylor K, Stopa L
J Behav Ther Exp Psychiatry 2011 Mar;42(1):54-64. Epub 2010 Jun 9 doi: 10.1016/j.jbtep.2010.05.003. PMID: 20663490
Jones SR, Fernyhough C
Cogn Neuropsychiatry 2008 Jul;13(4):281-95. doi: 10.1080/13546800802087830. PMID: 18622786

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