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Age at menopause

MedGen UID:
810903
•Concept ID:
C1629609
•
Finding
Synonyms: Age at Menopause; Age at onset of menopause; Age of menopause; Menopause age
SNOMED CT: Menopause age (773251000); Age at onset of menopause (773251000); Age at menopause (773251000); Age of menopause (773251000)

Definition

The age at which permanent cessation of menses occurs. [from NCI]

Professional guidelines

PubMed

Homozygosity for a stop-gain variant in CCDC201 causes primary ovarian insufficiency.
Oddsson A, Steinthorsdottir V, Oskarsson GR, Styrkarsdottir U, Moore KHS, Isberg S, Halldorsson GH, Sveinbjornsson G, Westergaard D, Nielsen HS, Fridriksdottir R, Jensson BO, Arnadottir GA, Jonsson H, Sturluson A, Snaebjarnarson AS, Andreassen OA, Walters GB, Nyegaard M, Erikstrup C, Steingrimsdottir T, Lie RT, Melsted P, Jonsdottir I, Halldorsson BV, Thorleifsson G, Saemundsdottir J, Magnusson OT; DBDS Genomic Consortium, Banasik K, Sorensen E, Masson G, Pedersen OB, Tryggvadottir L, Haavik J, Ostrowski SR, Stefansson H, Holm H, Rafnar T, Gudbjartsson DF, Sulem P, Stefansson K
Nat Genet 2024 Sep;56(9):1804-1810. Epub 2024 Aug 27 doi: 10.1038/s41588-024-01885-6. PMID: 39192094Free PMC Article
EMAS position statement: Predictors of premature and early natural menopause.
Mishra GD, Chung HF, Cano A, Chedraui P, Goulis DG, Lopes P, Mueck A, Rees M, Senturk LM, Simoncini T, Stevenson JC, Stute P, Tuomikoski P, Lambrinoudaki I
Maturitas 2019 May;123:82-88. Epub 2019 Mar 13 doi: 10.1016/j.maturitas.2019.03.008. PMID: 31027683
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

Recent clinical studies

Etiology

Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis.
Long G, Liu C, Liang T, Zhang Z, Qin Z, Zhan X
J Orthop Surg Res 2023 Aug 5;18(1):574. doi: 10.1186/s13018-023-04051-6. PMID: 37543616Free PMC Article
Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.
Schuermans A, Nakao T, Uddin MM, Hornsby W, Ganesh S, Shadyab AH, Liu S, Haring B, Shufelt CL, Taub MA, Mathias RA, Kooperberg C, Reiner AP, Bick AG, Manson JE, Natarajan P, Honigberg MC
Circ Res 2023 Aug 18;133(5):376-386. Epub 2023 Jul 25 doi: 10.1161/CIRCRESAHA.123.322984. PMID: 37489536Free PMC Article
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.
D'Urso S, Arumugam P, Weider T, Hwang LD, Bond TA, Kemp JP, Warrington NM, Evans DM, O'Mara TA, Moen GH
BMC Med 2022 Nov 1;20(1):419. doi: 10.1186/s12916-022-02585-w. PMID: 36320039Free PMC Article
Stroke in Women.
Christensen H, Bushnell C
Continuum (Minneap Minn) 2020 Apr;26(2):363-385. doi: 10.1212/CON.0000000000000836. PMID: 32224757

Diagnosis

Optimising health after early menopause.
Mishra GD, Davies MC, Hillman S, Chung HF, Roy S, Maclaran K, Hickey M
Lancet 2024 Mar 9;403(10430):958-968. Epub 2024 Mar 5 doi: 10.1016/S0140-6736(23)02800-3. PMID: 38458215
Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis.
Long G, Liu C, Liang T, Zhang Z, Qin Z, Zhan X
J Orthop Surg Res 2023 Aug 5;18(1):574. doi: 10.1186/s13018-023-04051-6. PMID: 37543616Free PMC Article
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
DNA methylation GrimAge strongly predicts lifespan and healthspan.
Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S
Aging (Albany NY) 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684. PMID: 30669119Free PMC Article
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

Therapy

Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause.
Yazdanpanah M, Yazdanpanah N, Gamache I, Ong K, Perry JRB, Manousaki D
Genome Med 2024 May 28;16(1):69. doi: 10.1186/s13073-024-01322-7. PMID: 38802955Free PMC Article
Establishing the relationships between adiposity and reproductive factors: a multivariable Mendelian randomization analysis.
Prince C, Howe LD, Sharp GC, Fraser A, Richmond RC
BMC Med 2023 Sep 12;21(1):350. doi: 10.1186/s12916-023-03051-x. PMID: 37697382Free PMC Article
Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.
Schuermans A, Nakao T, Uddin MM, Hornsby W, Ganesh S, Shadyab AH, Liu S, Haring B, Shufelt CL, Taub MA, Mathias RA, Kooperberg C, Reiner AP, Bick AG, Manson JE, Natarajan P, Honigberg MC
Circ Res 2023 Aug 18;133(5):376-386. Epub 2023 Jul 25 doi: 10.1161/CIRCRESAHA.123.322984. PMID: 37489536Free PMC Article
Identifying potential causal effects of age at menopause: a Mendelian randomization phenome-wide association study.
Magnus MC, Borges MC, Fraser A, Lawlor DA
Eur J Epidemiol 2022 Sep;37(9):971-982. Epub 2022 Sep 3 doi: 10.1007/s10654-022-00903-3. PMID: 36057072Free PMC Article
Treating menopause - MHT and beyond.
Davis SR, Baber RJ
Nat Rev Endocrinol 2022 Aug;18(8):490-502. Epub 2022 May 27 doi: 10.1038/s41574-022-00685-4. PMID: 35624141

Prognosis

Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.
Schuermans A, Nakao T, Uddin MM, Hornsby W, Ganesh S, Shadyab AH, Liu S, Haring B, Shufelt CL, Taub MA, Mathias RA, Kooperberg C, Reiner AP, Bick AG, Manson JE, Natarajan P, Honigberg MC
Circ Res 2023 Aug 18;133(5):376-386. Epub 2023 Jul 25 doi: 10.1161/CIRCRESAHA.123.322984. PMID: 37489536Free PMC Article
The interplay between diabetes mellitus and menopause: clinical implications.
Lambrinoudaki I, Paschou SA, Armeni E, Goulis DG
Nat Rev Endocrinol 2022 Oct;18(10):608-622. Epub 2022 Jul 7 doi: 10.1038/s41574-022-00708-0. PMID: 35798847
DNA methylation GrimAge strongly predicts lifespan and healthspan.
Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S
Aging (Albany NY) 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684. PMID: 30669119Free PMC Article
Molecular Genetics of Premature Ovarian Insufficiency.
Jiao X, Ke H, Qin Y, Chen ZJ
Trends Endocrinol Metab 2018 Nov;29(11):795-807. Epub 2018 Aug 2 doi: 10.1016/j.tem.2018.07.002. PMID: 30078697
Ovarian aging: mechanisms and clinical consequences.
Broekmans FJ, Soules MR, Fauser BC
Endocr Rev 2009 Aug;30(5):465-93. Epub 2009 Jul 9 doi: 10.1210/er.2009-0006. PMID: 19589949

Clinical prediction guides

Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women.
Schuermans A, Nakao T, Uddin MM, Hornsby W, Ganesh S, Shadyab AH, Liu S, Haring B, Shufelt CL, Taub MA, Mathias RA, Kooperberg C, Reiner AP, Bick AG, Manson JE, Natarajan P, Honigberg MC
Circ Res 2023 Aug 18;133(5):376-386. Epub 2023 Jul 25 doi: 10.1161/CIRCRESAHA.123.322984. PMID: 37489536Free PMC Article
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
DNA methylation GrimAge strongly predicts lifespan and healthspan.
Lu AT, Quach A, Wilson JG, Reiner AP, Aviv A, Raj K, Hou L, Baccarelli AA, Li Y, Stewart JD, Whitsel EA, Assimes TL, Ferrucci L, Horvath S
Aging (Albany NY) 2019 Jan 21;11(2):303-327. doi: 10.18632/aging.101684. PMID: 30669119Free PMC Article
Molecular Genetics of Premature Ovarian Insufficiency.
Jiao X, Ke H, Qin Y, Chen ZJ
Trends Endocrinol Metab 2018 Nov;29(11):795-807. Epub 2018 Aug 2 doi: 10.1016/j.tem.2018.07.002. PMID: 30078697
Ovarian aging: mechanisms and clinical consequences.
Broekmans FJ, Soules MR, Fauser BC
Endocr Rev 2009 Aug;30(5):465-93. Epub 2009 Jul 9 doi: 10.1210/er.2009-0006. PMID: 19589949

Recent systematic reviews

Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis.
Long G, Liu C, Liang T, Zhang Z, Qin Z, Zhan X
J Orthop Surg Res 2023 Aug 5;18(1):574. doi: 10.1186/s13018-023-04051-6. PMID: 37543616Free PMC Article
PCOS during the menopausal transition and after menopause: a systematic review and meta-analysis.
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Anti-Müllerian hormone for the diagnosis and prediction of menopause: a systematic review.
Nelson SM, Davis SR, Kalantaridou S, Lumsden MA, Panay N, Anderson RA
Hum Reprod Update 2023 May 2;29(3):327-346. doi: 10.1093/humupd/dmac045. PMID: 36651193Free PMC Article
Age at menopause in India: A systematic review.
Prasad JB, Tyagi NK, Verma P
Diabetes Metab Syndr 2021 Jan-Feb;15(1):373-377. Epub 2021 Jan 20 doi: 10.1016/j.dsx.2021.01.013. PMID: 33524647
The physiology and clinical utility of anti-Mullerian hormone in women.
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

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