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Inactive tuberculosis

MedGen UID:
294255
•Concept ID:
C1609538
•
Disease or Syndrome
Synonyms: Latent Tuberculosis; Latent tuberculosis infection
SNOMED CT: Inactive tuberculosis (11999007); Tuberculosis infection latent (11999007); LTBI - Latent tuberculosis infection (11999007)
 
Monarch Initiative: MONDO:0040753

Definition

The asymptomatic presence of Mycobacterium tuberculosis in the body, which is determined by a positive result to a tuberculin skin test or interferon-gamma release assay. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInactive tuberculosis

Professional guidelines

PubMed

The value of serum interferon-gamma level in the differential diagnosis of active and inactive pulmonary tuberculosis.
Köksal D, Unsal E, Poyraz B, Kaya A, Savaş H, Sipit T, Gönüllü U
Tuberk Toraks 2006;54(1):17-21. PMID: 16615013
Clinical utility of a commercial ligase chain reaction kit for the diagnosis of smear-negative pulmonary tuberculosis.
Kwiatkowska S, Marczak J, Zieba M, Nowak D
Int J Tuberc Lung Dis 1999 May;3(5):421-5. PMID: 10331732
Presumptive diagnosis and treatment of pulmonary tuberculosis based on radiographic findings.
Gordin FM, Slutkin G, Schecter G, Goodman PC, Hopewell PC
Am Rev Respir Dis 1989 May;139(5):1090-3. doi: 10.1164/ajrccm/139.5.1090. PMID: 2496633

Recent clinical studies

Etiology

Nomogram to determine predictive risk for active tuberculosis based on the QuantiFERON-TB Gold In-Tube test.
Wang Q, Zhu F, Cai Y, Zhu T, Lu X
Sci Rep 2023 Jul 24;13(1):11963. doi: 10.1038/s41598-023-38900-5. PMID: 37488139Free PMC Article
The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis.
Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, Oradini-Alacreu A, Odone A, Rogozinska E, Häcker B, Cobelens F, Kranzer K, Houben RMGJ, Esmail H
Lancet Respir Med 2023 Apr;11(4):367-379. Epub 2023 Mar 23 doi: 10.1016/S2213-2600(23)00097-8. PMID: 36966795
Tuberculosis preventive treatment among individuals with inactive tuberculosis suggested by untreated radiographic abnormalities: a community-based randomized controlled trial.
Zhang H, Xin H, Du Y, Cao X, Pan S, Liu J, Guan L, Shen F, Liu Z, Zhang B, Wang D, Feng B, Du J, Guan X, He Y, He Y, Zhang Z, Yan J, Jin Q, Gao L; LATENTTB TRIAL2-NSTM study team
Emerg Microbes Infect 2023 Dec;12(1):e2169195. doi: 10.1080/22221751.2023.2169195. PMID: 36637403Free PMC Article
Reflections on the immunology of tuberculosis: will we ever unravel the skein?
de Martino M, Galli L, Chiappini E
BMC Infect Dis 2014;14 Suppl 1(Suppl 1):S1. Epub 2014 Jan 8 doi: 10.1186/1471-2334-14-S1-S1. PMID: 24564297Free PMC Article
Invasive pulmonary aspergillosis.
Kristan SS, Kern I, Music E
Respiration 2002;69(6):521-5. doi: 10.1159/000066470. PMID: 12457005

Diagnosis

Nomogram to determine predictive risk for active tuberculosis based on the QuantiFERON-TB Gold In-Tube test.
Wang Q, Zhu F, Cai Y, Zhu T, Lu X
Sci Rep 2023 Jul 24;13(1):11963. doi: 10.1038/s41598-023-38900-5. PMID: 37488139Free PMC Article
Anti-Tubercular Activity of Pyrazinamide Conjugates: Synthesis and Structure-Activity Relationship Studies.
Wahan SK, Sharma S, Chawla PA
Mini Rev Med Chem 2023;23(6):700-718. doi: 10.2174/1389557522666220819092431. PMID: 35986542
Clinico-radiological and bronchoscopic predictors of microbiological yield in sputum negative tuberculosis in Pakistan.
Ejaz T, Malik MI, Ahmed J, Azam R, Jamal Y, Saadia S
Monaldi Arch Chest Dis 2021 Dec 6;92(3) doi: 10.4081/monaldi.2021.1976. PMID: 34873901
Reflections on the immunology of tuberculosis: will we ever unravel the skein?
de Martino M, Galli L, Chiappini E
BMC Infect Dis 2014;14 Suppl 1(Suppl 1):S1. Epub 2014 Jan 8 doi: 10.1186/1471-2334-14-S1-S1. PMID: 24564297Free PMC Article
Invasive pulmonary aspergillosis.
Kristan SS, Kern I, Music E
Respiration 2002;69(6):521-5. doi: 10.1159/000066470. PMID: 12457005

Therapy

Tuberculosis preventive treatment among individuals with inactive tuberculosis suggested by untreated radiographic abnormalities: a community-based randomized controlled trial.
Zhang H, Xin H, Du Y, Cao X, Pan S, Liu J, Guan L, Shen F, Liu Z, Zhang B, Wang D, Feng B, Du J, Guan X, He Y, He Y, Zhang Z, Yan J, Jin Q, Gao L; LATENTTB TRIAL2-NSTM study team
Emerg Microbes Infect 2023 Dec;12(1):e2169195. doi: 10.1080/22221751.2023.2169195. PMID: 36637403Free PMC Article
Anti-Tubercular Activity of Pyrazinamide Conjugates: Synthesis and Structure-Activity Relationship Studies.
Wahan SK, Sharma S, Chawla PA
Mini Rev Med Chem 2023;23(6):700-718. doi: 10.2174/1389557522666220819092431. PMID: 35986542
The impact of smoking on airflow limitation in subjects with history of asthma and inactive tuberculosis.
Kim HJ, Baek S, Kim HJ, Lee JS, Oh YM, Lee SD, Lee SW
PLoS One 2015;10(4):e0125020. Epub 2015 Apr 27 doi: 10.1371/journal.pone.0125020. PMID: 25915938Free PMC Article
Preventive therapy with isoniazid for "inactive" tuberculosis.
Snider DE Jr, Farer LS
Chest 1978 Jan;73(1):4-6. doi: 10.1378/chest.73.1.4. PMID: 340154
Lifelong follow-up of inactive tuberculosis: its value and limitations.
Nakielna EM, Cragg R, Grzybowski S
Am Rev Respir Dis 1975 Dec;112(6):765-72. doi: 10.1164/arrd.1975.112.6.765. PMID: 812398

Prognosis

Nomogram to determine predictive risk for active tuberculosis based on the QuantiFERON-TB Gold In-Tube test.
Wang Q, Zhu F, Cai Y, Zhu T, Lu X
Sci Rep 2023 Jul 24;13(1):11963. doi: 10.1038/s41598-023-38900-5. PMID: 37488139Free PMC Article
Clinico-radiological and bronchoscopic predictors of microbiological yield in sputum negative tuberculosis in Pakistan.
Ejaz T, Malik MI, Ahmed J, Azam R, Jamal Y, Saadia S
Monaldi Arch Chest Dis 2021 Dec 6;92(3) doi: 10.4081/monaldi.2021.1976. PMID: 34873901
Anthracofibrosis involving lung parenchyma: CT findings and long-term follow-up.
Yoon RG, Kim MY, Shim TS, Jang SJ
J Comput Assist Tomogr 2012 Nov-Dec;36(6):636-40. doi: 10.1097/RCT.0b013e318268eba9. PMID: 23192198
Overseas screening for tuberculosis in U.S.-bound immigrants and refugees.
Liu Y, Weinberg MS, Ortega LS, Painter JA, Maloney SA
N Engl J Med 2009 Jun 4;360(23):2406-15. doi: 10.1056/NEJMoa0809497. PMID: 19494216
Lifelong follow-up of inactive tuberculosis: its value and limitations.
Nakielna EM, Cragg R, Grzybowski S
Am Rev Respir Dis 1975 Dec;112(6):765-72. doi: 10.1164/arrd.1975.112.6.765. PMID: 812398

Clinical prediction guides

Nomogram to determine predictive risk for active tuberculosis based on the QuantiFERON-TB Gold In-Tube test.
Wang Q, Zhu F, Cai Y, Zhu T, Lu X
Sci Rep 2023 Jul 24;13(1):11963. doi: 10.1038/s41598-023-38900-5. PMID: 37488139Free PMC Article
Tuberculosis preventive treatment among individuals with inactive tuberculosis suggested by untreated radiographic abnormalities: a community-based randomized controlled trial.
Zhang H, Xin H, Du Y, Cao X, Pan S, Liu J, Guan L, Shen F, Liu Z, Zhang B, Wang D, Feng B, Du J, Guan X, He Y, He Y, Zhang Z, Yan J, Jin Q, Gao L; LATENTTB TRIAL2-NSTM study team
Emerg Microbes Infect 2023 Dec;12(1):e2169195. doi: 10.1080/22221751.2023.2169195. PMID: 36637403Free PMC Article
Clinico-radiological and bronchoscopic predictors of microbiological yield in sputum negative tuberculosis in Pakistan.
Ejaz T, Malik MI, Ahmed J, Azam R, Jamal Y, Saadia S
Monaldi Arch Chest Dis 2021 Dec 6;92(3) doi: 10.4081/monaldi.2021.1976. PMID: 34873901
Is the quality of life different in patients with active and inactive tuberculosis?
Unalan D, Soyuer F, Ceyhan O, Basturk M, Ozturk A
Indian J Tuberc 2008 Jul;55(3):127-37. PMID: 18807744
Patterns of coal workers' pneumoconiosis in Appalachian former coal miners.
Young RC Jr, Rachal RE, Carr PG, Press HC
J Natl Med Assoc 1992 Jan;84(1):41-8. PMID: 1602501Free PMC Article

Recent systematic reviews

The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis.
Sossen B, Richards AS, Heinsohn T, Frascella B, Balzarini F, Oradini-Alacreu A, Odone A, Rogozinska E, Häcker B, Cobelens F, Kranzer K, Houben RMGJ, Esmail H
Lancet Respir Med 2023 Apr;11(4):367-379. Epub 2023 Mar 23 doi: 10.1016/S2213-2600(23)00097-8. PMID: 36966795

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