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Mal de Debarquement

MedGen UID:
345629
Concept ID:
C1608983
Disease or Syndrome
Synonyms: Disembarkment syndrome; Mal de debarquement syndrome; MdDS; Sickness of disembarkment
SNOMED CT: Mal de debarquement syndrome (446079007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0016217
Orphanet: ORPHA210272

Definition

Mal de débarquement (MdD) is a rare otorhinolaryngological disease characterized by a persistent sensation of motion such as rocking, swaying, tumbling and/or bobbing following a period of exposure to passive movement, usually an ocean cruise or other types of water, train, automobile or air travel and less commonly other movements (like sleeping on a waterbed). Onset may be spontaneous in some patients. Manifestations begin shortly after the stimulus, persist for 6 months to years and may be associated with anxiety, fatigue and impaired cognition. Symptoms are often accentuated when in an enclosed space or when attempting to be motionless (sitting, lying down or standing in a stationary position) and are relieved when in passive motion such as in a moving car, airplane or train. [from ORDO]

Professional guidelines

PubMed

Kinkhabwala CM, Yuen E, Brennan E, Cadena A, Rizk HG
Otol Neurotol 2023 Apr 1;44(4):e197-e203. Epub 2023 Feb 15 doi: 10.1097/MAO.0000000000003832. PMID: 36791362
Schenk SM, Wagner JM, Miller JA, Lyons-White TM, Venn EC, April MD, Long B, Schauer SG, Oliver JJ
Mil Med 2018 Nov 1;183(11-12):e775-e778. doi: 10.1093/milmed/usy108. PMID: 29788412
Ghavami Y, Haidar YM, Ziai KN, Moshtaghi O, Bhatt J, Lin HW, Djalilian HR
Laryngoscope 2017 Jul;127(7):1670-1675. Epub 2016 Oct 12 doi: 10.1002/lary.26299. PMID: 27730651Free PMC Article

Recent clinical studies

Etiology

Riley J, Gleghorn D, Doudican BC, Cha YH
J Neurol 2022 Apr;269(4):2149-2161. Epub 2021 Sep 19 doi: 10.1007/s00415-021-10767-4. PMID: 34541614
Cha YH
Continuum (Minneap Minn) 2021 Apr 1;27(2):420-446. doi: 10.1212/CON.0000000000000932. PMID: 34351113
Beh SC, Chiang HS, Sanderson C
Laryngoscope 2021 May;131(5):E1653-E1661. Epub 2020 Nov 2 doi: 10.1002/lary.29214. PMID: 33135784
Saha K, Cha YH
Semin Neurol 2020 Feb;40(1):160-164. Epub 2020 Jan 27 doi: 10.1055/s-0039-3402740. PMID: 31986543
Hain TC, Hanna PA, Rheinberger MA
Arch Otolaryngol Head Neck Surg 1999 Jun;125(6):615-20. doi: 10.1001/archotol.125.6.615. PMID: 10367916

Diagnosis

Cha YH
Continuum (Minneap Minn) 2021 Apr 1;27(2):420-446. doi: 10.1212/CON.0000000000000932. PMID: 34351113
Beh SC, Chiang HS, Sanderson C
Laryngoscope 2021 May;131(5):E1653-E1661. Epub 2020 Nov 2 doi: 10.1002/lary.29214. PMID: 33135784
Saha K, Cha YH
Semin Neurol 2020 Feb;40(1):160-164. Epub 2020 Jan 27 doi: 10.1055/s-0039-3402740. PMID: 31986543
Van Ombergen A, Van Rompaey V, Maes LK, Van de Heyning PH, Wuyts FL
J Neurol 2016 May;263(5):843-854. Epub 2015 Nov 11 doi: 10.1007/s00415-015-7962-6. PMID: 26559820Free PMC Article
Hain TC, Hanna PA, Rheinberger MA
Arch Otolaryngol Head Neck Surg 1999 Jun;125(6):615-20. doi: 10.1001/archotol.125.6.615. PMID: 10367916

Therapy

Ceriani CEJ
Curr Pain Headache Rep 2024 Jul;28(7):633-639. Epub 2024 May 23 doi: 10.1007/s11916-024-01245-3. PMID: 38780828Free PMC Article
Kinkhabwala CM, Yuen E, Brennan E, Cadena A, Rizk HG
Otol Neurotol 2023 Apr 1;44(4):e197-e203. Epub 2023 Feb 15 doi: 10.1097/MAO.0000000000003832. PMID: 36791362
Beh SC, Chiang HS, Sanderson C
Laryngoscope 2021 May;131(5):E1653-E1661. Epub 2020 Nov 2 doi: 10.1002/lary.29214. PMID: 33135784
Ghavami Y, Haidar YM, Ziai KN, Moshtaghi O, Bhatt J, Lin HW, Djalilian HR
Laryngoscope 2017 Jul;127(7):1670-1675. Epub 2016 Oct 12 doi: 10.1002/lary.26299. PMID: 27730651Free PMC Article
Van Ombergen A, Van Rompaey V, Maes LK, Van de Heyning PH, Wuyts FL
J Neurol 2016 May;263(5):843-854. Epub 2015 Nov 11 doi: 10.1007/s00415-015-7962-6. PMID: 26559820Free PMC Article

Prognosis

Tommas NM, Ferguson M
Mil Med 2024 Aug 30;189(9-10):e2280-e2283. doi: 10.1093/milmed/usae014. PMID: 38330077
Arnardottir NY, Jonsdottir SS, Petersen H
PLoS One 2022;17(8):e0273477. Epub 2022 Aug 26 doi: 10.1371/journal.pone.0273477. PMID: 36018861Free PMC Article
Chen Y, Cha YH, Gleghorn D, Doudican BC, Shou G, Ding L, Yuan H
J Neural Eng 2021 Nov 30;18(6) doi: 10.1088/1741-2552/ac314b. PMID: 34670201Free PMC Article
Cha YH, Shou G, Gleghorn D, Doudican BC, Yuan H, Ding L
Brain Topogr 2018 Nov;31(6):1047-1058. Epub 2018 Aug 11 doi: 10.1007/s10548-018-0671-6. PMID: 30099627Free PMC Article
Cha YH, Brodsky J, Ishiyama G, Sabatti C, Baloh RW
J Neurol 2008 Jul;255(7):1038-44. Epub 2008 May 30 doi: 10.1007/s00415-008-0837-3. PMID: 18500497Free PMC Article

Clinical prediction guides

Reuten AJC, Smeets JBJ, Martens MH, Bos JE
Exp Brain Res 2022 Oct;240(10):2677-2685. Epub 2022 Aug 20 doi: 10.1007/s00221-022-06442-3. PMID: 35986767Free PMC Article
Mucci V, Hamid M, Jacquemyn Y, Browne CJ
Curr Opin Neurol 2022 Feb 1;35(1):135-141. doi: 10.1097/WCO.0000000000001019. PMID: 34864753
Riley J, Gleghorn D, Doudican BC, Cha YH
J Neurol 2022 Apr;269(4):2149-2161. Epub 2021 Sep 19 doi: 10.1007/s00415-021-10767-4. PMID: 34541614
Beh SC, Chiang HS, Sanderson C
Laryngoscope 2021 May;131(5):E1653-E1661. Epub 2020 Nov 2 doi: 10.1002/lary.29214. PMID: 33135784
Cha YH, Gleghorn D, Doudican B
Otol Neurotol 2019 Oct;40(9):e928-e937. doi: 10.1097/MAO.0000000000002341. PMID: 31436631Free PMC Article

Recent systematic reviews

Kinkhabwala CM, Yuen E, Brennan E, Cadena A, Rizk HG
Otol Neurotol 2023 Apr 1;44(4):e197-e203. Epub 2023 Feb 15 doi: 10.1097/MAO.0000000000003832. PMID: 36791362
Livingstone DM, Smith KA, Lange B
Diving Hyperb Med 2017 Jun;47(2):97-109. doi: 10.28920/dhm47.2.97-109. PMID: 28641322Free PMC Article
Van Ombergen A, Van Rompaey V, Maes LK, Van de Heyning PH, Wuyts FL
J Neurol 2016 May;263(5):843-854. Epub 2015 Nov 11 doi: 10.1007/s00415-015-7962-6. PMID: 26559820Free PMC Article

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