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Direct Hyperbilirubinemia, Neonatal

MedGen UID:
290595
•Concept ID:
C1565885
•
Disease or Syndrome
Synonyms: Hyperbilirubinemia, Neonatal Direct; Neonatal Direct Hyperbilirubinemia

Professional guidelines

PubMed

Hepatobiliary scintigraphy and gamma-GT levels in the differential diagnosis of extrahepatic biliary atresia.
Stipsanelli K, Koutsikos J, Papantoniou V, Arka A, Palestidis C, Tsiouris S, Manolaki A, Zerva C
Q J Nucl Med Mol Imaging 2007 Mar;51(1):74-81. PMID: 17220819
Early differential diagnosis between neonatal hepatitis and biliary atresia.
Hirsig J, Rickham PP
J Pediatr Surg 1980 Feb;15(1):13-5. doi: 10.1016/s0022-3468(80)80394-0. PMID: 6445003

Recent clinical studies

Etiology

Neonatal Hyperbilirubinemia: Evaluation and Treatment.
Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Neonatal Hyperbilirubinemia.
Lee B, Piersante T, Calkins KL
Pediatr Ann 2022 Jun;51(6):e219-e227. Epub 2022 Jun 1 doi: 10.3928/19382359-20220407-02. PMID: 35667102
Neonatal hyperbilirubinaemia: a global perspective.
Olusanya BO, Kaplan M, Hansen TWR
Lancet Child Adolesc Health 2018 Aug;2(8):610-620. Epub 2018 Jun 28 doi: 10.1016/S2352-4642(18)30139-1. PMID: 30119720
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393
Hyperbilirubinemia in the newborn.
Lauer BJ, Spector ND
Pediatr Rev 2011 Aug;32(8):341-9. doi: 10.1542/pir.32-8-341. PMID: 21807875

Diagnosis

Neonatal Hyperbilirubinemia: Evaluation and Treatment.
Par EJ, Hughes CA, DeRico P
Am Fam Physician 2023 May;107(5):525-534. PMID: 37192079
Clinical Practice Guideline Revision: Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Kemper AR, Newman TB, Slaughter JL, Maisels MJ, Watchko JF, Downs SM, Grout RW, Bundy DG, Stark AR, Bogen DL, Holmes AV, Feldman-Winter LB, Bhutani VK, Brown SR, Maradiaga Panayotti GM, Okechukwu K, Rappo PD, Russell TL
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058859. PMID: 35927462
Neonatal Hyperbilirubinemia.
Lee B, Piersante T, Calkins KL
Pediatr Ann 2022 Jun;51(6):e219-e227. Epub 2022 Jun 1 doi: 10.3928/19382359-20220407-02. PMID: 35667102
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393
Hyperbilirubinemia in the newborn.
Lauer BJ, Spector ND
Pediatr Rev 2011 Aug;32(8):341-9. doi: 10.1542/pir.32-8-341. PMID: 21807875

Therapy

Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.
van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Slaughter JL, Kemper AR, Newman TB
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058865. PMID: 35927519
Sunlight for the prevention and treatment of hyperbilirubinemia in term and late preterm neonates.
Horn D, Ehret D, Gautham KS, Soll R
Cochrane Database Syst Rev 2021 Jul 6;7(7):CD013277. doi: 10.1002/14651858.CD013277.pub2. PMID: 34228352Free PMC Article
Phototherapy for neonatal hyperbilirubinemia.
Itoh S, Okada H, Kuboi T, Kusaka T
Pediatr Int 2017 Sep;59(9):959-966. Epub 2017 Aug 7 doi: 10.1111/ped.13332. PMID: 28563973
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Prognosis

Bilirubin Measurement and Phototherapy Use After the AAP 2022 Newborn Hyperbilirubinemia Guideline.
Sarathy L, Chou JH, Romano-Clarke G, Darci KA, Lerou PH
Pediatrics 2024 Apr 1;153(4) doi: 10.1542/peds.2023-063323. PMID: 38482582
Assessment, management, and incidence of neonatal jaundice in healthy neonates cared for in primary care: a prospective cohort study.
van der Geest BAM, de Mol MJS, Barendse ISA, de Graaf JP, Bertens LCM, Poley MJ, Ista E, Kornelisse RF, Reiss IKM, Steegers EAP, Been JV; STARSHIP Study Group
Sci Rep 2022 Aug 23;12(1):14385. doi: 10.1038/s41598-022-17933-2. PMID: 35999237Free PMC Article
Neonatal hyperbilirubinemia and the role of unbound bilirubin.
Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Sunlight for the prevention and treatment of hyperbilirubinemia in term and late preterm neonates.
Horn D, Ehret D, Gautham KS, Soll R
Cochrane Database Syst Rev 2021 Jul 6;7(7):CD013277. doi: 10.1002/14651858.CD013277.pub2. PMID: 34228352Free PMC Article
Vigintiphobia revisited.
Watchko JF
Pediatrics 2005 Jun;115(6):1747-53. doi: 10.1542/peds.2004-1748. PMID: 15930239

Clinical prediction guides

Bilirubin Measurement and Phototherapy Use After the AAP 2022 Newborn Hyperbilirubinemia Guideline.
Sarathy L, Chou JH, Romano-Clarke G, Darci KA, Lerou PH
Pediatrics 2024 Apr 1;153(4) doi: 10.1542/peds.2023-063323. PMID: 38482582
Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review.
Gao C, Guo Y, Huang M, He J, Qiu X
Nutrients 2023 May 10;15(10) doi: 10.3390/nu15102261. PMID: 37242142Free PMC Article
Technical Report: Diagnosis and Management of Hyperbilirubinemia in the Newborn Infant 35 or More Weeks of Gestation.
Slaughter JL, Kemper AR, Newman TB
Pediatrics 2022 Sep 1;150(3) doi: 10.1542/peds.2022-058865. PMID: 35927519
Neonatal hyperbilirubinemia and the role of unbound bilirubin.
Hegyi T, Kleinfeld A
J Matern Fetal Neonatal Med 2022 Dec;35(25):9201-9207. Epub 2021 Dec 26 doi: 10.1080/14767058.2021.2021177. PMID: 34957902
Evaluation and treatment of neonatal hyperbilirubinemia.
Muchowski KE
Am Fam Physician 2014 Jun 1;89(11):873-8. PMID: 25077393

Recent systematic reviews

Transcutaneous bilirubinometry versus total serum bilirubin measurement for newborns.
Okwundu CI, Olowoyeye A, Uthman OA, Smith J, Wiysonge CS, Bhutani VK, Fiander M, Gautham KS
Cochrane Database Syst Rev 2023 May 9;5(5):CD012660. doi: 10.1002/14651858.CD012660.pub2. PMID: 37158489Free PMC Article
Intermittent phototherapy versus continuous phototherapy for neonatal jaundice.
Gottimukkala SB, Lobo L, Gautham KS, Bolisetty S, Fiander M, Schindler T
Cochrane Database Syst Rev 2023 Mar 2;3(3):CD008168. doi: 10.1002/14651858.CD008168.pub2. PMID: 36867730Free PMC Article
Sunlight for the prevention and treatment of hyperbilirubinemia in term and late preterm neonates.
Horn D, Ehret D, Gautham KS, Soll R
Cochrane Database Syst Rev 2021 Jul 6;7(7):CD013277. doi: 10.1002/14651858.CD013277.pub2. PMID: 34228352Free PMC Article
Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis.
Fogarty M, Osborn DA, Askie L, Seidler AL, Hunter K, Lui K, Simes J, Tarnow-Mordi W
Am J Obstet Gynecol 2018 Jan;218(1):1-18. Epub 2017 Oct 30 doi: 10.1016/j.ajog.2017.10.231. PMID: 29097178
Neonatal jaundice: phototherapy.
Woodgate P, Jardine LA
BMJ Clin Evid 2015 May 22;2015 PMID: 25998618Free PMC Article

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