U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vein of Galen malformation

MedGen UID:
287069
•Concept ID:
C1562503
•
Congenital Abnormality
Synonyms: Galen Malformations Veins; Malformations Vein, Galen; Malformations Veins, Galen; Vein Of Galen Malformation; Vein of Galen Malformations
SNOMED CT: Vein of Galen malformation (416792008)

Definition

An arteriovenous malformation in the vein of Galen that is located at the base of the brain. The malformation may result in developmental delays, hydrocephalus, seizures, and congestive heart failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVein of Galen malformation

Professional guidelines

PubMed

Prenatal treatment of a vein of Galen malformation by embolization and 1-year follow-up.
Naggara O, Stirnemann J, Boulouis G, Orbach DB, Grévent D, James S, Boddaert N, Kossorotoff M, Blauwblomme T, Ville Y
Am J Obstet Gynecol 2024 Mar;230(3):372-374. Epub 2023 Dec 1 doi: 10.1016/j.ajog.2023.11.1248. PMID: 38043773
Epidemiology, Diagnostics, and Management of Vein of Galen Malformation.
Brevis Nuñez F, Dohna-Schwake C
Pediatr Neurol 2021 Jun;119:50-55. Epub 2021 Mar 3 doi: 10.1016/j.pediatrneurol.2021.02.007. PMID: 33895584
Multimodality Management of Vein of Galen Malformations-An Institutional Experience.
Hosmann A, El-Garci A, Gatterbauer B, Bavinzski G, Knosp E, Gruber A
World Neurosurg 2018 Apr;112:e837-e847. Epub 2018 Feb 3 doi: 10.1016/j.wneu.2018.01.172. PMID: 29408495

Recent clinical studies

Etiology

Prenatal treatment of a vein of Galen malformation by embolization and 1-year follow-up.
Naggara O, Stirnemann J, Boulouis G, Orbach DB, Grévent D, James S, Boddaert N, Kossorotoff M, Blauwblomme T, Ville Y
Am J Obstet Gynecol 2024 Mar;230(3):372-374. Epub 2023 Dec 1 doi: 10.1016/j.ajog.2023.11.1248. PMID: 38043773
Epidemiology, Diagnostics, and Management of Vein of Galen Malformation.
Brevis Nuñez F, Dohna-Schwake C
Pediatr Neurol 2021 Jun;119:50-55. Epub 2021 Mar 3 doi: 10.1016/j.pediatrneurol.2021.02.007. PMID: 33895584
Cerebral vascular malformations and their imaging modalities.
Zafar A, Fiani B, Hadi H, Arshad M, Cathel A, Naeem M, Parsons MS, Farooqui M, Bucklin AA, Leone MJ, Baig A, Quadri SA
Neurol Sci 2020 Sep;41(9):2407-2421. Epub 2020 Apr 25 doi: 10.1007/s10072-020-04415-4. PMID: 32335778
Long-term outcome of vein of Galen malformation.
Taffin H, Maurey H, Ozanne A, Durand P, Husson B, Knebel JF, Adamsbaum C, Deiva K, Saliou G
Dev Med Child Neurol 2020 Jun;62(6):729-734. Epub 2019 Nov 12 doi: 10.1111/dmcn.14392. PMID: 31713850
Pediatric Congenital Cerebrovascular Anomalies.
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722

Diagnosis

Vein of Galen Malformations.
Devarajan A, Goldman D, Shigematsu T, Berenstein A, Fifi JT
Neurosurg Clin N Am 2024 Jul;35(3):363-374. Epub 2024 Apr 9 doi: 10.1016/j.nec.2024.02.008. PMID: 38782529
Cerebral arteriovenous fistulae.
Alexander MD, Darflinger R, Cooke DL, Halbach VV
Handb Clin Neurol 2021;176:179-198. doi: 10.1016/B978-0-444-64034-5.00004-3. PMID: 33272395
Vein of Galen Malformation.
Cordova EG, Levy P, Kheir JN, Orbach DB, Barnewolt C, Estroff JA
Neoreviews 2020 Oct;21(10):e678-e686. Epub 2020 Oct 1 doi: 10.1542/neo.21-10-e678. PMID: 33004561
Human genetics and molecular mechanisms of vein of Galen malformation.
Duran D, Karschnia P, Gaillard JR, Karimy JK, Youngblood MW, DiLuna ML, Matouk CC, Aagaard-Kienitz B, Smith ER, Orbach DB, Rodesch G, Berenstein A, Gunel M, Kahle KT
J Neurosurg Pediatr 2018 Apr;21(4):367-374. Epub 2018 Jan 19 doi: 10.3171/2017.9.PEDS17365. PMID: 29350590
Vein of Galen malformation.
Hoang S, Choudhri O, Edwards M, Guzman R
Neurosurg Focus 2009 Nov;27(5):E8. doi: 10.3171/2009.8.FOCUS09168. PMID: 19877798

Therapy

Factors Contributing to Major Neurological Complications From Vein of Galen Malformation Embolization.
Bhatia K, Mendes Pereira V, Krings T, Ter Brugge K, Kortman H, Dirks P, Armstrong D, Shroff M, Muthusami P
JAMA Neurol 2020 Aug 1;77(8):992-999. doi: 10.1001/jamaneurol.2020.0825. PMID: 32338714Free PMC Article
Hydrocephalus in vein of Galen malformation: etiologies and therapeutic management implications.
Meila D, Grieb D, Melber K, Jacobs C, Maslehaty H, Petridis A, El Habony R, Lanfermann H, Scholz M, Brassel F
Acta Neurochir (Wien) 2016 Jul;158(7):1279-84. Epub 2016 May 13 doi: 10.1007/s00701-016-2836-y. PMID: 27173099
Outcome and complications of endovascular embolization for vein of Galen malformations: a systematic review and meta-analysis.
Yan J, Wen J, Gopaul R, Zhang CY, Xiao SW
J Neurosurg 2015 Oct;123(4):872-90. Epub 2015 Jul 31 doi: 10.3171/2014.12.JNS141249. PMID: 26230476
Management and outcome of vein of Galen malformation.
McSweeney N, Brew S, Bhate S, Cox T, Roebuck DJ, Ganesan V
Arch Dis Child 2010 Nov;95(11):903-9. Epub 2010 Jul 6 doi: 10.1136/adc.2009.177584. PMID: 20605862
Anesthesia and intracranial arteriovenous malformation.
Sinha PK, Neema PK, Rathod RC
Neurol India 2004 Jun;52(2):163-70. PMID: 15269462

Prognosis

Prenatal treatment of a vein of Galen malformation by embolization and 1-year follow-up.
Naggara O, Stirnemann J, Boulouis G, Orbach DB, Grévent D, James S, Boddaert N, Kossorotoff M, Blauwblomme T, Ville Y
Am J Obstet Gynecol 2024 Mar;230(3):372-374. Epub 2023 Dec 1 doi: 10.1016/j.ajog.2023.11.1248. PMID: 38043773
Hydrocephalus in Vein of Galen Malformations.
Paramasivam S
Neurol India 2021 Nov-Dec;69(Supplement):S376-S379. doi: 10.4103/0028-3886.332279. PMID: 35102992
Vein of Galen Malformation.
Stone McGuire L, Nikas D
N Engl J Med 2020 Oct 8;383(15):e90. doi: 10.1056/NEJMicm1913659. PMID: 33027572
Pediatric Congenital Cerebrovascular Anomalies.
Goyal P, Mangla R, Gupta S, Malhotra A, Almast J, Sapire J, Kolar B
J Neuroimaging 2019 Mar;29(2):165-181. Epub 2018 Oct 31 doi: 10.1111/jon.12575. PMID: 30378722
Vein of Galen malformation.
Hoang S, Choudhri O, Edwards M, Guzman R
Neurosurg Focus 2009 Nov;27(5):E8. doi: 10.3171/2009.8.FOCUS09168. PMID: 19877798

Clinical prediction guides

High Output Cardiovascular Physiology and Outcomes in Fetal Diagnosis of Vein of Galen Malformation.
Jhaveri S, Berenstein A, Srivastava S, Shigematsu T, Geiger MK
Pediatr Cardiol 2021 Aug;42(6):1416-1424. Epub 2021 May 8 doi: 10.1007/s00246-021-02627-9. PMID: 33963894
Epidemiology, Diagnostics, and Management of Vein of Galen Malformation.
Brevis Nuñez F, Dohna-Schwake C
Pediatr Neurol 2021 Jun;119:50-55. Epub 2021 Mar 3 doi: 10.1016/j.pediatrneurol.2021.02.007. PMID: 33895584
Long-term outcome of vein of Galen malformation.
Taffin H, Maurey H, Ozanne A, Durand P, Husson B, Knebel JF, Adamsbaum C, Deiva K, Saliou G
Dev Med Child Neurol 2020 Jun;62(6):729-734. Epub 2019 Nov 12 doi: 10.1111/dmcn.14392. PMID: 31713850
EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease.
Zeng X, Hunt A, Jin SC, Duran D, Gaillard J, Kahle KT
Trends Mol Med 2019 Apr;25(4):265-286. Epub 2019 Feb 25 doi: 10.1016/j.molmed.2019.01.009. PMID: 30819650Free PMC Article
Presentation, course, and outcome of postneonatal presentations of vein of Galen malformation: a large, single-institution case series.
Gopalan V, Rennie A, Robertson F, Kanagarajah L, Toolis C, Bhate S, Ganesan V
Dev Med Child Neurol 2018 Apr;60(4):424-429. Epub 2018 Jan 23 doi: 10.1111/dmcn.13676. PMID: 29359331

Recent systematic reviews

Outcome and complications of endovascular embolization for vein of Galen malformations: a systematic review and meta-analysis.
Yan J, Wen J, Gopaul R, Zhang CY, Xiao SW
J Neurosurg 2015 Oct;123(4):872-90. Epub 2015 Jul 31 doi: 10.3171/2014.12.JNS141249. PMID: 26230476

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...