U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eosinophilic pneumonia

MedGen UID:
282904
•Concept ID:
C1527407
•
Disease or Syndrome
Synonym: Loeffler syndrome
SNOMED CT: EP - Eosinophilic pneumonia (367542003); Eosinophilic pneumonia (367542003)
 
HPO: HP:0032071
Monarch Initiative: MONDO:0005749

Definition

The presence of eosinophils in lung tissue, generally as detected by tissue biopsy, with or without blood eosinophilia. [from HPO]

Professional guidelines

PubMed

Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Recent clinical studies

Etiology

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Smoking-related interstitial lung disease.
Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Smoking-associated interstitial lung disease: update and review.
Dawod YT, Cook NE, Graham WB, Madhani-Lovely F, Thao C
Expert Rev Respir Med 2020 Aug;14(8):825-834. Epub 2020 May 22 doi: 10.1080/17476348.2020.1766971. PMID: 32379511
Amiodarone: review of pulmonary effects and toxicity.
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Diagnosis

Eosinophilic Lung Diseases.
Cottin V
Immunol Allergy Clin North Am 2023 May;43(2):289-322. doi: 10.1016/j.iac.2023.01.002. PMID: 37055090
Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Eosinophilic Lung Diseases.
Cottin V
Clin Chest Med 2016 Sep;37(3):535-56. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.015. PMID: 27514599

Therapy

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Smoking-related interstitial lung disease.
Serrano Gotarredona MP, Navarro Herrero S, Gómez Izquierdo L, Rodríguez Portal JA
Radiologia (Engl Ed) 2022 Dec;64 Suppl 3:277-289. doi: 10.1016/j.rxeng.2022.10.008. PMID: 36737166
Immunomodulatory treatment of interstitial lung disease.
van den Bosch L, Luppi F, Ferrara G, Mura M
Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117002. doi: 10.1177/17534666221117002. PMID: 35938712Free PMC Article
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Smoking-associated interstitial lung disease: update and review.
Dawod YT, Cook NE, Graham WB, Madhani-Lovely F, Thao C
Expert Rev Respir Med 2020 Aug;14(8):825-834. Epub 2020 May 22 doi: 10.1080/17476348.2020.1766971. PMID: 32379511

Prognosis

Smoking-Related Interstitial Lung Diseases.
Alarcon-Calderon A, Vassallo R, Yi ES, Ryu JH
Immunol Allergy Clin North Am 2023 May;43(2):273-287. Epub 2023 Mar 1 doi: 10.1016/j.iac.2023.01.007. PMID: 37055089
Allergic bronchopulmonary aspergillosis.
Patel G, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):421-424. doi: 10.2500/aap.2019.40.4262. PMID: 31690385
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Eosinophilic Pneumonias.
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Clinical prediction guides

Acute eosinophilic pneumonia in twins.
Ichihara S, Komiya K, Yamatani I, Omori S, Umeki K, Hiramatsu K, Kadota JI
Respir Investig 2023 Jan;61(1):1-4. Epub 2022 Nov 16 doi: 10.1016/j.resinv.2022.10.004. PMID: 36400689
Eosinophilia Induced by Blocking the IL-4/IL-13 Pathway: Potential Mechanisms and Clinical Outcomes.
Olaguibel JM, Sastre J, Rodríguez JM, Del Pozo V
J Investig Allergol Clin Immunol 2022 Jun 20;32(3):165-180. Epub 2022 May 6 doi: 10.18176/jiaci.0823. PMID: 35522053
Drug-induced eosinophilic pneumonia: A review of 196 case reports.
Bartal C, Sagy I, Barski L
Medicine (Baltimore) 2018 Jan;97(4):e9688. doi: 10.1097/MD.0000000000009688. PMID: 29369189Free PMC Article
Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials.
Hanania NA, Korenblat P, Chapman KR, Bateman ED, Kopecky P, Paggiaro P, Yokoyama A, Olsson J, Gray S, Holweg CT, Eisner M, Asare C, Fischer SK, Peng K, Putnam WS, Matthews JG
Lancet Respir Med 2016 Oct;4(10):781-796. Epub 2016 Sep 5 doi: 10.1016/S2213-2600(16)30265-X. PMID: 27616196
Amiodarone: review of pulmonary effects and toxicity.
Papiris SA, Triantafillidou C, Kolilekas L, Markoulaki D, Manali ED
Drug Saf 2010 Jul 1;33(7):539-58. doi: 10.2165/11532320-000000000-00000. PMID: 20553056

Recent systematic reviews

Daptomycin-Induced Eosinophilic Pneumonia: A Case Report and Systematic Review.
Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L
Chemotherapy 2024;69(2):85-99. Epub 2023 Nov 14 doi: 10.1159/000535190. PMID: 37963447
COVID-19 mimics on chest CT: a pictorial review and radiologic guide.
Hochhegger B, Zanon M, Altmayer S, Mandelli NS, Stüker G, Mohammed TL, Verma N, Meirelles GSP, Marchiori E
Br J Radiol 2021 Feb 1;94(1118):20200703. Epub 2020 Dec 9 doi: 10.1259/bjr.20200703. PMID: 33296607Free PMC Article
The risk of respiratory tract infections and interstitial lung disease with interleukin 12/23 and interleukin 23 antagonists in patients with autoimmune diseases: A systematic review and meta-analysis.
Akiyama S, Yamada A, Micic D, Sakuraba A
J Am Acad Dermatol 2021 Mar;84(3):676-690. Epub 2020 Aug 11 doi: 10.1016/j.jaad.2020.08.026. PMID: 32791083Free PMC Article
Acute eosinophilic pneumonia associated with non-cigarette smoking products: a systematic review.
Chaaban T
Adv Respir Med 2020;88(2):142-146. doi: 10.5603/ARM.2020.0088. PMID: 32383466

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...