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T-lymphoblastic leukemia

MedGen UID:
285633
•Concept ID:
C1521897
•
Neoplastic Process
Synonyms: Mature T-ALL; T Acute Lymphoblastic Leukemia, NOS; T Acute Lymphoblastic Leukemia, Not Otherwise Specified; T-cell acute lymphoblastic leukemia; T-Cell Acute Lymphoblastic Leukemia, NOS; T-Cell Acute Lymphoblastic Leukemia, Not Otherwise Specified
SNOMED CT: T-lymphoblastic leukemia (128824003); T-cell acute lymphoblastic leukemia (128824003)

Definition

T acute lymphoblastic leukemia in which further genetic/molecular characterization is not available. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVT-lymphoblastic leukemia

Professional guidelines

PubMed

Valrubicin-loaded immunoliposomes for specific vesicle-mediated cell death in the treatment of hematological cancers.
Georgievski A, Bellaye PS, Tournier B, Choubley H, Pais de Barros JP, Herbst M, Béduneau A, Callier P, Collin B, Végran F, Ballerini P, Garrido C, Quéré R
Cell Death Dis 2024 May 11;15(5):328. doi: 10.1038/s41419-024-06715-5. PMID: 38734740Free PMC Article
DHODH: a promising target in the treatment of T-cell acute lymphoblastic leukemia.
Sexauer AN, Alexe G, Gustafsson K, Zanetakos E, Milosevic J, Ayres M, Gandhi V, Pikman Y, Stegmaier K, Sykes DB
Blood Adv 2023 Nov 14;7(21):6685-6701. doi: 10.1182/bloodadvances.2023010337. PMID: 37648673Free PMC Article
An "off-the-shelf" fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies.
Cooper ML, Choi J, Staser K, Ritchey JK, Devenport JM, Eckardt K, Rettig MP, Wang B, Eissenberg LG, Ghobadi A, Gehrs LN, Prior JL, Achilefu S, Miller CA, Fronick CC, O'Neal J, Gao F, Weinstock DM, Gutierrez A, Fulton RS, DiPersio JF
Leukemia 2018 Sep;32(9):1970-1983. Epub 2018 Feb 20 doi: 10.1038/s41375-018-0065-5. PMID: 29483708Free PMC Article

Recent clinical studies

Etiology

Key candidate genes and pathways in T lymphoblastic leukemia/lymphoma identified by bioinformatics and serological analyses.
Ren Y, Liang H, Huang Y, Miao Y, Li R, Qiang J, Wu L, Qi J, Li Y, Xia Y, Huang L, Wang S, Kong X, Zhou Y, Zhang Q, Zhu G
Front Immunol 2024;15:1341255. Epub 2024 Feb 23 doi: 10.3389/fimmu.2024.1341255. PMID: 38464517Free PMC Article
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype.
Jain N, Lamb AV, O'Brien S, Ravandi F, Konopleva M, Jabbour E, Zuo Z, Jorgensen J, Lin P, Pierce S, Thomas D, Rytting M, Borthakur G, Kadia T, Cortes J, Kantarjian HM, Khoury JD
Blood 2016 Apr 14;127(15):1863-9. Epub 2016 Jan 8 doi: 10.1182/blood-2015-08-661702. PMID: 26747249Free PMC Article
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Diagnosis

Aggressive Mediastinal Lymphomas.
Wang X, Wang W, Vega F, Quesada AE
Semin Diagn Pathol 2024 May;41(3):125-139. Epub 2021 Jun 16 doi: 10.1053/j.semdp.2021.06.010. PMID: 34175178
Emerging molecular subtypes and therapies in acute lymphoblastic leukemia.
Davis K, Sheikh T, Aggarwal N
Semin Diagn Pathol 2023 May;40(3):202-215. Epub 2023 Apr 9 doi: 10.1053/j.semdp.2023.04.003. PMID: 37120350
International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
T-lymphoblastic leukemia/lymphoma.
You MJ, Medeiros LJ, Hsi ED
Am J Clin Pathol 2015 Sep;144(3):411-22. doi: 10.1309/AJCPMF03LVSBLHPJ. PMID: 26276771
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Therapy

Rare case of simultaneous occurrence of chronic neutrophil leukemia and T lymphoblastic lymphoma: case report and literature review.
Wang SX, Wang F, Tu YC, Zhou YL, Tu ST, Wang JY, Lv KB, Li F
Ann Hematol 2024 Oct;103(10):4319-4323. Epub 2024 Aug 6 doi: 10.1007/s00277-024-05759-z. PMID: 39105740Free PMC Article
An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL).
Wang S, Zhang R, Zhong K, Guo W, Tong A
Biomolecules 2024 Jan 15;14(1) doi: 10.3390/biom14010106. PMID: 38254706Free PMC Article
Bortezomib Is Effective in the Treatment of T Lymphoblastic Leukaemia by Inducing DNA Damage, WEE1 Downregulation, and Mitotic Catastrophe.
Din RU, Jiao A, Qiu Y, Mohan AAM, Yuen KC, Wong HT, Wan TM, Wong PO, Sin CF
Int J Mol Sci 2023 Sep 27;24(19) doi: 10.3390/ijms241914646. PMID: 37834095Free PMC Article
Carvedilol exhibits anti-acute T lymphoblastic leukemia effect in vitro and in vivo via inhibiting β-ARs signaling pathway.
Xu Y, Li J, Luo Y, Ma J, Huang P, Chen Y, He Z
Biochem Biophys Res Commun 2023 Jan 8;639:150-160. Epub 2022 Nov 29 doi: 10.1016/j.bbrc.2022.11.093. PMID: 36495764
Autologous Nanobody-Derived Fratricide-Resistant CD7-CAR T-cell Therapy for Patients with Relapsed and Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma.
Zhang M, Chen D, Fu X, Meng H, Nan F, Sun Z, Yu H, Zhang L, Li L, Li X, Wang X, Wang M, You F, Li Z, Chang Y, Zhou Z, Yan J, Li J, Wu X, Wang Y, Wang Y, Xiang S, Chen Y, Pan G, Xu H, Zhang B, Yang L
Clin Cancer Res 2022 Jul 1;28(13):2830-2843. doi: 10.1158/1078-0432.CCR-21-4097. PMID: 35435984

Prognosis

Key candidate genes and pathways in T lymphoblastic leukemia/lymphoma identified by bioinformatics and serological analyses.
Ren Y, Liang H, Huang Y, Miao Y, Li R, Qiang J, Wu L, Qi J, Li Y, Xia Y, Huang L, Wang S, Kong X, Zhou Y, Zhang Q, Zhu G
Front Immunol 2024;15:1341255. Epub 2024 Feb 23 doi: 10.3389/fimmu.2024.1341255. PMID: 38464517Free PMC Article
Genetics and Diagnostic Approach to Lymphoblastic Leukemia/Lymphoma.
Afkhami M, Ally F, Pullarkat V, Pillai RK
Cancer Treat Res 2021;181:17-43. doi: 10.1007/978-3-030-78311-2_2. PMID: 34626353
Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype.
Jain N, Lamb AV, O'Brien S, Ravandi F, Konopleva M, Jabbour E, Zuo Z, Jorgensen J, Lin P, Pierce S, Thomas D, Rytting M, Borthakur G, Kadia T, Cortes J, Kantarjian HM, Khoury JD
Blood 2016 Apr 14;127(15):1863-9. Epub 2016 Jan 8 doi: 10.1182/blood-2015-08-661702. PMID: 26747249Free PMC Article
T-lymphoblastic leukemia/lymphoma.
You MJ, Medeiros LJ, Hsi ED
Am J Clin Pathol 2015 Sep;144(3):411-22. doi: 10.1309/AJCPMF03LVSBLHPJ. PMID: 26276771
Classification of acute leukemias.
Brunning RD
Semin Diagn Pathol 2003 Aug;20(3):142-53. doi: 10.1016/s0740-2570(03)00031-5. PMID: 14552428

Clinical prediction guides

Key candidate genes and pathways in T lymphoblastic leukemia/lymphoma identified by bioinformatics and serological analyses.
Ren Y, Liang H, Huang Y, Miao Y, Li R, Qiang J, Wu L, Qi J, Li Y, Xia Y, Huang L, Wang S, Kong X, Zhou Y, Zhang Q, Zhu G
Front Immunol 2024;15:1341255. Epub 2024 Feb 23 doi: 10.3389/fimmu.2024.1341255. PMID: 38464517Free PMC Article
An Anti-CD7 Antibody-Drug Conjugate Target Showing Potent Antitumor Activity for T-Lymphoblastic Leukemia (T-ALL).
Wang S, Zhang R, Zhong K, Guo W, Tong A
Biomolecules 2024 Jan 15;14(1) doi: 10.3390/biom14010106. PMID: 38254706Free PMC Article
Universal Anti-CD7 CAR-T Cells Targeting T-ALL and Functional Analysis of CD7 Antigen on T/CAR-T Cells.
Xie L, Gu R, Yang X, Qiu S, Xu Y, Mou J, Wang Y, Xing H, Tang K, Tian Z, Rao Q, Wang M, Wang J
Hum Gene Ther 2023 Dec;34(23-24):1257-1272. Epub 2023 Nov 24 doi: 10.1089/hum.2023.029. PMID: 37861302
Autologous Nanobody-Derived Fratricide-Resistant CD7-CAR T-cell Therapy for Patients with Relapsed and Refractory T-cell Acute Lymphoblastic Leukemia/Lymphoma.
Zhang M, Chen D, Fu X, Meng H, Nan F, Sun Z, Yu H, Zhang L, Li L, Li X, Wang X, Wang M, You F, Li Z, Chang Y, Zhou Z, Yan J, Li J, Wu X, Wang Y, Wang Y, Xiang S, Chen Y, Pan G, Xu H, Zhang B, Yang L
Clin Cancer Res 2022 Jul 1;28(13):2830-2843. doi: 10.1158/1078-0432.CCR-21-4097. PMID: 35435984
LMO2 expression is frequent in T-lymphoblastic leukemia and correlates with survival, regardless of T-cell stage.
Latchmansingh KA, Wang X, Verdun RE, Marques-Piubelli ML, Vega F, You MJ, Chapman J, Lossos IS
Mod Pathol 2022 Sep;35(9):1220-1226. Epub 2022 Mar 23 doi: 10.1038/s41379-022-01063-1. PMID: 35322192Free PMC Article

Recent systematic reviews

Thyroid cancer and T lymphoblastic leukemia in Crohn disease: a case report and literature review.
Byun JM, Baek SK, Yoon HJ, Kim SY, Maeng CH, Park TS, Kim HJ, Choi YY, Um YJ
Lab Med 2015 Spring;46(2):140-5. doi: 10.1309/LMU4KMJDRM3AD6FQ. PMID: 25918193

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