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Loss of Chromosome 11

MedGen UID:
273494
•Concept ID:
C1517950
•
Cell or Molecular Dysfunction
Synonyms: -11; del(11)

Definition

A cytogenetic abnormality that refers to loss of all or part of chromosome 11. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLoss of Chromosome 11

Professional guidelines

PubMed

Genome-wide screening for genetic changes in a matched pair of benign and prostate cancer cell lines using array CGH.
Brookman-Amissah N, Duchesnes C, Williamson MP, Wang Q, Ahmed A, Feneley MR, Mackay A, Freeman A, Fenwick K, Iravani M, Weber B, Ashworth A, Masters JR
Prostate Cancer Prostatic Dis 2005;8(4):335-43. doi: 10.1038/sj.pcan.4500826. PMID: 16130014

Recent clinical studies

Etiology

Comparative Clinicopathologic and Genomic Analysis of Hepatocellular Neoplasm, Not Otherwise Specified, and Hepatoblastoma.
Zhou S, Sarabia SF, Estrine D, Ostrow D, Schmidt RJ, Warren M, Raca G, Shillingford N, Wang L, Pawel B, Stein JE, Biegel JA, Lopez-Terrada D, Mascarenhas L, Ji J
Mod Pathol 2024 Feb;37(2):100385. Epub 2023 Nov 20 doi: 10.1016/j.modpat.2023.100385. PMID: 37992967
Recurrent Loss of Heterozygosity in Pancreatic Neuroendocrine Tumors.
Parilla M, Chapel D, Hechtman JF, Wanjari P, El Jabbour T, Sharma A, Ritterhouse L, Segal J, Vanderbilt C, Klimstra DS, Setia N, Tang L
Am J Surg Pathol 2022 Jun 1;46(6):823-831. Epub 2022 Feb 4 doi: 10.1097/PAS.0000000000001860. PMID: 35125451Free PMC Article
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Wilms tumor: an update.
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520

Diagnosis

Comparative Clinicopathologic and Genomic Analysis of Hepatocellular Neoplasm, Not Otherwise Specified, and Hepatoblastoma.
Zhou S, Sarabia SF, Estrine D, Ostrow D, Schmidt RJ, Warren M, Raca G, Shillingford N, Wang L, Pawel B, Stein JE, Biegel JA, Lopez-Terrada D, Mascarenhas L, Ji J
Mod Pathol 2024 Feb;37(2):100385. Epub 2023 Nov 20 doi: 10.1016/j.modpat.2023.100385. PMID: 37992967
The oculocerebrorenal syndrome of Lowe: an update.
Bökenkamp A, Ludwig M
Pediatr Nephrol 2016 Dec;31(12):2201-2212. Epub 2016 Mar 24 doi: 10.1007/s00467-016-3343-3. PMID: 27011217Free PMC Article
Pathogenesis of familial acromegaly.
Gadelha MR, Frohman LA
Front Horm Res 2010;38:121-126. Epub 2010 Jul 5 doi: 10.1159/000318501. PMID: 20616502
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520
Molecular biology of rhabdomyosarcoma.
Gallego Melcón S, Sánchez de Toledo Codina J
Clin Transl Oncol 2007 Jul;9(7):415-9. doi: 10.1007/s12094-007-0079-3. PMID: 17652054

Therapy

Recurrent oligodendroglioma with changed 1p/19q status.
Barresi V, Mafficini A, Calicchia M, Piredda ML, Musumeci A, Ghimenton C, Scarpa A
Neuropathology 2022 Apr;42(2):160-166. Epub 2022 Feb 10 doi: 10.1111/neup.12789. PMID: 35144313Free PMC Article
Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor.
Takagi M, Yoshida M, Nemoto Y, Tamaichi H, Tsuchida R, Seki M, Uryu K, Nishii R, Miyamoto S, Saito M, Hanada R, Kaneko H, Miyano S, Kataoka K, Yoshida K, Ohira M, Hayashi Y, Nakagawara A, Ogawa S, Mizutani S, Takita J
J Natl Cancer Inst 2017 Nov 1;109(11) doi: 10.1093/jnci/djx062. PMID: 29059438
TMEM16A/ANO1 suppression improves response to antibody-mediated targeted therapy of EGFR and HER2/ERBB2.
Kulkarni S, Bill A, Godse NR, Khan NI, Kass JI, Steehler K, Kemp C, Davis K, Bertrand CA, Vyas AR, Holt DE, Grandis JR, Gaither LA, Duvvuri U
Genes Chromosomes Cancer 2017 Jun;56(6):460-471. Epub 2017 Apr 3 doi: 10.1002/gcc.22450. PMID: 28177558Free PMC Article
Late-onset retinal macular degeneration: clinical insights into an inherited retinal degeneration.
Borooah S, Collins C, Wright A, Dhillon B
Br J Ophthalmol 2009 Mar;93(3):284-9. Epub 2008 Dec 19 doi: 10.1136/bjo.2008.150151. PMID: 19098033
Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.
Schroeder WT, Chao LY, Dao DD, Strong LC, Pathak S, Riccardi V, Lewis WH, Saunders GF
Am J Hum Genet 1987 May;40(5):413-20. PMID: 2883892Free PMC Article

Prognosis

Recurrent Loss of Heterozygosity in Pancreatic Neuroendocrine Tumors.
Parilla M, Chapel D, Hechtman JF, Wanjari P, El Jabbour T, Sharma A, Ritterhouse L, Segal J, Vanderbilt C, Klimstra DS, Setia N, Tang L
Am J Surg Pathol 2022 Jun 1;46(6):823-831. Epub 2022 Feb 4 doi: 10.1097/PAS.0000000000001860. PMID: 35125451Free PMC Article
Pediatric acute myeloid leukemia with t(7;21)(p22;q22).
Paulraj P, Diamond S, Razzaqi F, Ozeran JD, Longhurst M, Andersen EF, Toydemir RM, Hong B
Genes Chromosomes Cancer 2019 Aug;58(8):551-557. Epub 2019 Feb 14 doi: 10.1002/gcc.22740. PMID: 30706625
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Wilms tumor: an update.
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Neuroblastoma: biology and staging.
Mueller S, Matthay KK
Curr Oncol Rep 2009 Nov;11(6):431-8. doi: 10.1007/s11912-009-0059-6. PMID: 19840520

Clinical prediction guides

Clinical and molecular characterization of Beckwith-Wiedemann syndrome in a Chinese population.
Luk HM
J Pediatr Endocrinol Metab 2017 Jan 1;30(1):89-95. doi: 10.1515/jpem-2016-0094. PMID: 27977403
Silver-Russell syndrome in Hong Kong.
Luk HM, Yeung KS, Wong WL, Chung BH, Tong TM, Lo IF
Hong Kong Med J 2016 Dec;22(6):526-33. Epub 2016 Jul 29 doi: 10.12809/hkmj154750. PMID: 27468965
(Epi)genotype-phenotype correlations in Beckwith-Wiedemann syndrome.
Mussa A, Russo S, De Crescenzo A, Freschi A, Calzari L, Maitz S, Macchiaiolo M, Molinatto C, Baldassarre G, Mariani M, Tarani L, Bedeschi MF, Milani D, Melis D, Bartuli A, Cubellis MV, Selicorni A, Cirillo Silengo M, Larizza L, Riccio A, Ferrero GB
Eur J Hum Genet 2016 Feb;24(2):183-90. Epub 2015 Apr 22 doi: 10.1038/ejhg.2015.88. PMID: 25898929Free PMC Article
Familial acromegaly.
Frohman LA, Eguchi K
Growth Horm IGF Res 2004 Jun;14 Suppl A:S90-6. doi: 10.1016/j.ghir.2004.03.021. PMID: 15135786
Oncogenes and tumor-suppressor genes.
Lehman TA, Reddel R, Peiifer AM, Spillare E, Kaighn ME, Weston A, Gerwin BI, Harris CC
Environ Health Perspect 1991 Jun;93:133-44. doi: 10.1289/ehp.9193133. PMID: 1685442Free PMC Article

Recent systematic reviews

Late-onset retinal macular degeneration: clinical insights into an inherited retinal degeneration.
Borooah S, Collins C, Wright A, Dhillon B
Br J Ophthalmol 2009 Mar;93(3):284-9. Epub 2008 Dec 19 doi: 10.1136/bjo.2008.150151. PMID: 19098033

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