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Papulopustular Rosacea

MedGen UID:
304290
•Concept ID:
C1449853
•
Disease or Syndrome
Synonym: Rosacea, Papulopustular

Professional guidelines

PubMed

A Review of the Current Modalities for the Treatment of Papulopustular Rosacea.
McGregor SP, Alinia H, Snyder A, Tuchayi SM, Fleischer A Jr, Feldman SR
Dermatol Clin 2018 Apr;36(2):135-150. Epub 2017 Dec 21 doi: 10.1016/j.det.2017.11.009. PMID: 29499797
Swiss S1 guideline for the treatment of rosacea.
Anzengruber F, Czernielewski J, Conrad C, Feldmeyer L, Yawalkar N, Häusermann P, Cozzio A, Mainetti C, Goldblum D, Läuchli S, Imhof L, Brand C, Laffitte E, Navarini AA
J Eur Acad Dermatol Venereol 2017 Nov;31(11):1775-1791. Epub 2017 Aug 21 doi: 10.1111/jdv.14349. PMID: 28833645
Rosacea: Diagnosis and Treatment.
Oge' LK, Muncie HL, Phillips-Savoy AR
Am Fam Physician 2015 Aug 1;92(3):187-96. PMID: 26280139

Recent clinical studies

Etiology

Rosacea Epidemiological Investigation and Etiology Exploration in the Plateau Area.
Wen W, Dahl C, Zhang Y
Ann Plast Surg 2024 Aug 1;93(2S Suppl 1):S55-S58. doi: 10.1097/SAP.0000000000003999. PMID: 39101850
Tofacitinib for the treatment of erythematotelangiectatic and papulopustular rosacea: A retrospective case series.
Sun YH, Man XY, Xuan XY, Huang CZ, Shen Y, Lao LM
Dermatol Ther 2022 Nov;35(11):e15848. Epub 2022 Oct 10 doi: 10.1111/dth.15848. PMID: 36175135
Association between rosacea and smoking: A systematic review and meta-analysis.
Yuan X, Yin D
Dermatol Ther 2021 Mar;34(2):e14747. Epub 2021 Jan 13 doi: 10.1111/dth.14747. PMID: 33406295
Demodex and rosacea: Is there a relationship?
Gonzalez-Hinojosa D, Jaime-Villalonga A, Aguilar-Montes G, Lammoglia-Ordiales L
Indian J Ophthalmol 2018 Jan;66(1):36-38. doi: 10.4103/ijo.IJO_514_17. PMID: 29283119Free PMC Article
Interventions for rosacea.
van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD003262. doi: 10.1002/14651858.CD003262.pub5. PMID: 25919144Free PMC Article

Diagnosis

Tofacitinib for the treatment of erythematotelangiectatic and papulopustular rosacea: A retrospective case series.
Sun YH, Man XY, Xuan XY, Huang CZ, Shen Y, Lao LM
Dermatol Ther 2022 Nov;35(11):e15848. Epub 2022 Oct 10 doi: 10.1111/dth.15848. PMID: 36175135
Childhood rosacea and related disorders.
Noguera-Morel L, Hernández-Martín A, Torrelo A
Clin Exp Dermatol 2021 Apr;46(3):430-437. Epub 2020 Nov 20 doi: 10.1111/ced.14419. PMID: 33217048
The Role of IL-17 in Papulopustular Rosacea and Future Directions.
Amir Ali A, Vender R, Vender R
J Cutan Med Surg 2019 Nov/Dec;23(6):635-641. Epub 2019 Aug 12 doi: 10.1177/1203475419867611. PMID: 31402691
Pharmacologic treatments for rosacea.
Layton AM
Clin Dermatol 2017 Mar-Apr;35(2):207-212. Epub 2016 Oct 27 doi: 10.1016/j.clindermatol.2016.10.016. PMID: 28274361
Rosacea: Diagnosis and Treatment.
Oge' LK, Muncie HL, Phillips-Savoy AR
Am Fam Physician 2015 Aug 1;92(3):187-96. PMID: 26280139

Therapy

The versatility of azelaic acid in dermatology.
Searle T, Ali FR, Al-Niaimi F
J Dermatolog Treat 2022 Mar;33(2):722-732. Epub 2020 Aug 4 doi: 10.1080/09546634.2020.1800579. PMID: 32730109
Childhood rosacea and related disorders.
Noguera-Morel L, Hernández-Martín A, Torrelo A
Clin Exp Dermatol 2021 Apr;46(3):430-437. Epub 2020 Nov 20 doi: 10.1111/ced.14419. PMID: 33217048
The Role of IL-17 in Papulopustular Rosacea and Future Directions.
Amir Ali A, Vender R, Vender R
J Cutan Med Surg 2019 Nov/Dec;23(6):635-641. Epub 2019 Aug 12 doi: 10.1177/1203475419867611. PMID: 31402691
Rosacea: Diagnosis and Treatment.
Oge' LK, Muncie HL, Phillips-Savoy AR
Am Fam Physician 2015 Aug 1;92(3):187-96. PMID: 26280139
Interventions for rosacea.
van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD003262. doi: 10.1002/14651858.CD003262.pub5. PMID: 25919144Free PMC Article

Prognosis

Low-dose isotretinoin versus minocycline in the treatment of rosacea.
Shemer A, Gupta AK, Kassem R, Sharon N, Quinlan EM, Galili E
Dermatol Ther 2021 Jul;34(4):e14986. Epub 2021 May 24 doi: 10.1111/dth.14986. PMID: 33993601
Combined treatment of recalcitrant papulopustular rosacea involving pulsed dye laser and fractional microneedling radiofrequency with low-dose isotretinoin.
Kwon HH, Jung JY, Lee WY, Bae Y, Park GH
J Cosmet Dermatol 2020 Jan;19(1):105-111. Epub 2019 May 18 doi: 10.1111/jocd.12982. PMID: 31102325
Rosacea and Demodicosis: Little-known Diagnostic Signs and Symptoms.
Forton FMN, De Maertelaer V
Acta Derm Venereol 2019 Jan 1;99(1):47-52. doi: 10.2340/00015555-3041. PMID: 30226528
Demodex and rosacea: Is there a relationship?
Gonzalez-Hinojosa D, Jaime-Villalonga A, Aguilar-Montes G, Lammoglia-Ordiales L
Indian J Ophthalmol 2018 Jan;66(1):36-38. doi: 10.4103/ijo.IJO_514_17. PMID: 29283119Free PMC Article
Rosacea and its management: an overview.
Gupta AK, Chaudhry MM
J Eur Acad Dermatol Venereol 2005 May;19(3):273-85. doi: 10.1111/j.1468-3083.2005.01216.x. PMID: 15857452

Clinical prediction guides

Oral tranexamic acid treats papulopustular rosacea by improving the skin barrier.
Xu Z, Yu B, Xu B, Ye S, Qing Y, Zhao B, Hong S, Wu N, Wu J
J Cosmet Dermatol 2024 Sep;23(9):2918-2926. Epub 2024 May 7 doi: 10.1111/jocd.16339. PMID: 38712728
Barrier function-related genes and proteins have an altered expression in acne-involved skin.
Dull K, Lénárt K, Dajnoki Z, Póliska S, Uchiyama E, Hendrik Z, Szegedi A, Törőcsik D
J Eur Acad Dermatol Venereol 2023 Jul;37(7):1415-1425. Epub 2023 Apr 12 doi: 10.1111/jdv.19062. PMID: 36971768
Tofacitinib for the treatment of erythematotelangiectatic and papulopustular rosacea: A retrospective case series.
Sun YH, Man XY, Xuan XY, Huang CZ, Shen Y, Lao LM
Dermatol Ther 2022 Nov;35(11):e15848. Epub 2022 Oct 10 doi: 10.1111/dth.15848. PMID: 36175135
Demodex and rosacea: Is there a relationship?
Gonzalez-Hinojosa D, Jaime-Villalonga A, Aguilar-Montes G, Lammoglia-Ordiales L
Indian J Ophthalmol 2018 Jan;66(1):36-38. doi: 10.4103/ijo.IJO_514_17. PMID: 29283119Free PMC Article
The management of rosacea.
Rebora A
Am J Clin Dermatol 2002;3(7):489-96. doi: 10.2165/00128071-200203070-00005. PMID: 12180896

Recent systematic reviews

Assessment of Frequency of Rosacea Subtypes in Patients With Rosacea: A Systematic Review and Meta-analysis.
Barakji YA, Rønnstad ATM, Christensen MO, Zachariae C, Wienholtz NKF, Halling AS, Maul JT, Thomsen SF, Egeberg A, Thyssen JP
JAMA Dermatol 2022 Jun 1;158(6):617-625. doi: 10.1001/jamadermatol.2022.0526. PMID: 35385049Free PMC Article
Association between rosacea and smoking: A systematic review and meta-analysis.
Yuan X, Yin D
Dermatol Ther 2021 Mar;34(2):e14747. Epub 2021 Jan 13 doi: 10.1111/dth.14747. PMID: 33406295
Role of Demodex mite infestation in rosacea: A systematic review and meta-analysis.
Chang YS, Huang YC
J Am Acad Dermatol 2017 Sep;77(3):441-447.e6. Epub 2017 Jul 12 doi: 10.1016/j.jaad.2017.03.040. PMID: 28711190
Interventions for rosacea.
van Zuuren EJ, Fedorowicz Z, Carter B, van der Linden MM, Charland L
Cochrane Database Syst Rev 2015 Apr 28;2015(4):CD003262. doi: 10.1002/14651858.CD003262.pub5. PMID: 25919144Free PMC Article
Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials.
Liu RH, Smith MK, Basta SA, Farmer ER
Arch Dermatol 2006 Aug;142(8):1047-52. doi: 10.1001/archderm.142.8.1047. PMID: 16924055

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