U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Actinic porokeratosis

MedGen UID:
730668
•Concept ID:
C1442958
•
Disease or Syndrome
SNOMED CT: Actinic porokeratosis (856006); Actinic porokeratosis (41495000)

Professional guidelines

PubMed

Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy.
Atzmony L, Lim YH, Hamilton C, Leventhal JS, Wagner A, Paller AS, Choate KA
J Am Acad Dermatol 2020 Jan;82(1):123-131. Epub 2019 Aug 23 doi: 10.1016/j.jaad.2019.08.043. PMID: 31449901Free PMC Article
Light and laser treatment modalities for disseminated superficial actinic porokeratosis: a systematic review.
Aird GA, Sitenga JL, Nguyen AH, Vaudreuil A, Huerter CJ
Lasers Med Sci 2017 May;32(4):945-952. Epub 2017 Feb 27 doi: 10.1007/s10103-017-2179-9. PMID: 28239750
Disseminated superficial actinic porokeratosis: a treatment review.
Skupsky H, Skupsky J, Goldenberg G
J Dermatolog Treat 2012 Feb;23(1):52-6. Epub 2010 Oct 22 doi: 10.3109/09546634.2010.495381. PMID: 20964569

Recent clinical studies

Etiology

A Review of the Efficacy of Topical Statins for Treating Disseminated Superficial Actinic Porokeratosis.
Ghani H, Richards E, Truong TM, Rao BK, Zhang A
J Drugs Dermatol 2023 Oct 1;22(10):1053-1057. doi: 10.36849/JDD.7540. PMID: 37801522
Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report.
Romagnuolo M, Riva D, Alberti Violetti S, Di Benedetto A, Barberi F, Moltrasio C
Australas J Dermatol 2023 Feb;64(1):e72-e75. Epub 2022 Nov 1 doi: 10.1111/ajd.13943. PMID: 36320094
Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy.
Atzmony L, Lim YH, Hamilton C, Leventhal JS, Wagner A, Paller AS, Choate KA
J Am Acad Dermatol 2020 Jan;82(1):123-131. Epub 2019 Aug 23 doi: 10.1016/j.jaad.2019.08.043. PMID: 31449901Free PMC Article
Porokeratoses: an update of clinical, aetiopathogenic and therapeutic features.
Kanitakis J
Eur J Dermatol 2014 Sep-Oct;24(5):533-44. doi: 10.1684/ejd.2014.2402. PMID: 25115203
Exclusive facial porokeratosis: histopathologically showing follicular cornoid lamellae.
Lee Y, Choi EH
J Dermatol 2011 Nov;38(11):1072-1075. Epub 2011 Sep 20 doi: 10.1111/j.1346-8138.2011.01260.x. PMID: 21933257

Diagnosis

A Review of the Efficacy of Topical Statins for Treating Disseminated Superficial Actinic Porokeratosis.
Ghani H, Richards E, Truong TM, Rao BK, Zhang A
J Drugs Dermatol 2023 Oct 1;22(10):1053-1057. doi: 10.36849/JDD.7540. PMID: 37801522
Dermoscopy of Disseminated Superficial Actinic Porokeratosis.
Nicola A, Magliano J
Actas Dermosifiliogr 2017 Jun;108(5):e33-e37. Epub 2016 Mar 23 doi: 10.1016/j.ad.2015.09.025. PMID: 27015657
Disseminated superficial actinic porokeratosis improved with fractional 1927-nm laser treatments.
Ross NA, Rosenbaum LE, Saedi N, Arndt KA, Dover JS
J Cosmet Laser Ther 2016;18(1):53-5. Epub 2016 Jan 28 doi: 10.3109/14764172.2015.1063657. PMID: 26820042
Pustular porokeratosis.
Miller DD, Ruben BS
J Cutan Pathol 2009 Nov;36(11):1191-3. Epub 2009 Jun 4 doi: 10.1111/j.1600-0560.2009.01251.x. PMID: 19508498
The invisible dermatoses.
Brownstein MH, Rabinowitz AD
J Am Acad Dermatol 1983 Apr;8(4):579-88. doi: 10.1016/s0190-9622(83)80078-4. PMID: 6853792

Therapy

Disseminated superficial actinic porokeratosis following hydroxyurea treatment: A case report.
Romagnuolo M, Riva D, Alberti Violetti S, Di Benedetto A, Barberi F, Moltrasio C
Australas J Dermatol 2023 Feb;64(1):e72-e75. Epub 2022 Nov 1 doi: 10.1111/ajd.13943. PMID: 36320094
Topical simvastatin-cholesterol for disseminated superficial actinic porokeratosis: An open-label, split-body clinical trial.
Byth LA, Byth J
Australas J Dermatol 2021 Aug;62(3):310-313. Epub 2021 May 24 doi: 10.1111/ajd.13601. PMID: 34028808
Disseminated superficial actinic porokeratosis: a treatment review.
Skupsky H, Skupsky J, Goldenberg G
J Dermatolog Treat 2012 Feb;23(1):52-6. Epub 2010 Oct 22 doi: 10.3109/09546634.2010.495381. PMID: 20964569
Pustular porokeratosis.
Miller DD, Ruben BS
J Cutan Pathol 2009 Nov;36(11):1191-3. Epub 2009 Jun 4 doi: 10.1111/j.1600-0560.2009.01251.x. PMID: 19508498
Disseminated superficial "actinic" porokeratosis.
Schwarz T, Seiser A, Gschnait F
J Am Acad Dermatol 1984 Oct;11(4 Pt 2):724-30. doi: 10.1016/s0190-9622(84)70229-5. PMID: 6490996

Prognosis

Eruptive disseminated porokeratosis associated with corticosteroid-induced immunosuppression.
Bednarek R, Ezra N, Toubin Y, Linos K, Mousdicas N
Clin Exp Dermatol 2015 Oct;40(7):753-6. Epub 2015 Mar 18 doi: 10.1111/ced.12636. PMID: 25800103
Exome sequencing identifies SLC17A9 pathogenic gene in two Chinese pedigrees with disseminated superficial actinic porokeratosis.
Cui H, Li L, Wang W, Shen J, Yue Z, Zheng X, Zuo X, Liang B, Gao M, Fan X, Yin X, Shen C, Yang C, Zhang C, Zhang X, Sheng Y, Gao J, Zhu Z, Lin D, Zhang A, Wang Z, Liu S, Sun L, Yang S, Cui Y, Zhang X
J Med Genet 2014 Oct;51(10):699-704. Epub 2014 Sep 1 doi: 10.1136/jmedgenet-2014-102486. PMID: 25180256
Porokeratoses: an update of clinical, aetiopathogenic and therapeutic features.
Kanitakis J
Eur J Dermatol 2014 Sep-Oct;24(5):533-44. doi: 10.1684/ejd.2014.2402. PMID: 25115203
Disseminated superficial actinic porokeratosis in a patient with Sjögren syndrome.
Terranova M, Amato L, Massi D, Fabbri P
Skinmed 2003 Nov-Dec;2(6):390-1. doi: 10.1111/j.1540-9740.2003.02261.x. PMID: 14673257
Rapid development of disseminated superficial porokeratosis after transplant induction therapy.
Fields LL, White CR Jr, Maziarz RT
Bone Marrow Transplant 1995 Jun;15(6):993-5. PMID: 7581104

Clinical prediction guides

Drugs associated with development of porokeratosis: A systematic review.
Lu JD, Mufti A, Sachdeva M, Rahat S, Lansang RP, Yeung J
Dermatol Ther 2021 Jan;34(1):e14560. Epub 2020 Dec 1 doi: 10.1111/dth.14560. PMID: 33210788
Dermoscopy of Disseminated Superficial Actinic Porokeratosis.
Nicola A, Magliano J
Actas Dermosifiliogr 2017 Jun;108(5):e33-e37. Epub 2016 Mar 23 doi: 10.1016/j.ad.2015.09.025. PMID: 27015657
A novel locus for disseminated superficial actinic porokeratosis maps to chromosome 16q24.1-24.3.
Luan J, Niu Z, Zhang J, Crosby ME, Zhang Z, Chu X, Wang Z, Huang W, Xiang L, Zheng Z
Hum Genet 2011 Mar;129(3):329-34. Epub 2010 Dec 14 doi: 10.1007/s00439-010-0929-x. PMID: 21161278
Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3-p31.1.
Liu P, Zhang S, Yao Q, Liu X, Wang X, Huang C, Huang X, Wang P, Yuan M, Liu JY, Wang QK, Liu M
Hum Genet 2008 Jun;123(5):507-13. Epub 2008 Apr 29 doi: 10.1007/s00439-008-0504-x. PMID: 18443824
A novel locus for disseminated superficial porokeratosis maps to chromosome 18p11.3.
Wei S, Yang S, Lin D, Li M, Zhang X, Bu L, Zheng G, Hu L, Kong X, Zhang X
J Invest Dermatol 2004 Nov;123(5):872-5. doi: 10.1111/j.0022-202X.2004.23455.x. PMID: 15482473

Recent systematic reviews

Effects of Blue Light on the Skin and Its Therapeutic Uses: Photodynamic Therapy and Beyond.
Pieper C, Lee EB, Swali R, Harp K, Wysong A
Dermatol Surg 2022 Aug 1;48(8):802-808. Epub 2022 Jun 24 doi: 10.1097/DSS.0000000000003500. PMID: 35917260
Drugs associated with development of porokeratosis: A systematic review.
Lu JD, Mufti A, Sachdeva M, Rahat S, Lansang RP, Yeung J
Dermatol Ther 2021 Jan;34(1):e14560. Epub 2020 Dec 1 doi: 10.1111/dth.14560. PMID: 33210788
Light and laser treatment modalities for disseminated superficial actinic porokeratosis: a systematic review.
Aird GA, Sitenga JL, Nguyen AH, Vaudreuil A, Huerter CJ
Lasers Med Sci 2017 May;32(4):945-952. Epub 2017 Feb 27 doi: 10.1007/s10103-017-2179-9. PMID: 28239750

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...