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Actinic porokeratosis

MedGen UID:
730668
•Concept ID:
C1442958
•
Disease or Syndrome
SNOMED CT: Actinic porokeratosis (856006); Actinic porokeratosis (41495000)

Professional guidelines

PubMed

Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy.
Atzmony L, Lim YH, Hamilton C, Leventhal JS, Wagner A, Paller AS, Choate KA
J Am Acad Dermatol 2020 Jan;82(1):123-131. Epub 2019 Aug 23 doi: 10.1016/j.jaad.2019.08.043. PMID: 31449901Free PMC Article
Light and laser treatment modalities for disseminated superficial actinic porokeratosis: a systematic review.
Aird GA, Sitenga JL, Nguyen AH, Vaudreuil A, Huerter CJ
Lasers Med Sci 2017 May;32(4):945-952. Epub 2017 Feb 27 doi: 10.1007/s10103-017-2179-9. PMID: 28239750
Disseminated superficial actinic porokeratosis: a treatment review.
Skupsky H, Skupsky J, Goldenberg G
J Dermatolog Treat 2012 Feb;23(1):52-6. Epub 2010 Oct 22 doi: 10.3109/09546634.2010.495381. PMID: 20964569

Recent clinical studies

Therapy

A Review of the Efficacy of Topical Statins for Treating Disseminated Superficial Actinic Porokeratosis.
Ghani H, Richards E, Truong TM, Rao BK, Zhang A
J Drugs Dermatol 2023 Oct 1;22(10):1053-1057. doi: 10.36849/JDD.7540. PMID: 37801522
Safety and Efficacy of Topical Lovastatin Plus Cholesterol Cream vs Topical Lovastatin Cream Alone for the Treatment of Disseminated Superficial Actinic Porokeratosis: A Randomized Clinical Trial.
Santa Lucia G, Snyder A, Lateef A, Drohan A, Gregoski MJ, Barton V, Elston DM
JAMA Dermatol 2023 May 1;159(5):488-495. doi: 10.1001/jamadermatol.2023.0205. PMID: 36947042Free PMC Article
Topical cholesterol/lovastatin for the treatment of porokeratosis: A pathogenesis-directed therapy.
Atzmony L, Lim YH, Hamilton C, Leventhal JS, Wagner A, Paller AS, Choate KA
J Am Acad Dermatol 2020 Jan;82(1):123-131. Epub 2019 Aug 23 doi: 10.1016/j.jaad.2019.08.043. PMID: 31449901Free PMC Article
Light and laser treatment modalities for disseminated superficial actinic porokeratosis: a systematic review.
Aird GA, Sitenga JL, Nguyen AH, Vaudreuil A, Huerter CJ
Lasers Med Sci 2017 May;32(4):945-952. Epub 2017 Feb 27 doi: 10.1007/s10103-017-2179-9. PMID: 28239750
Pustular porokeratosis.
Miller DD, Ruben BS
J Cutan Pathol 2009 Nov;36(11):1191-3. Epub 2009 Jun 4 doi: 10.1111/j.1600-0560.2009.01251.x. PMID: 19508498

Prognosis

Eruptive disseminated porokeratosis associated with corticosteroid-induced immunosuppression.
Bednarek R, Ezra N, Toubin Y, Linos K, Mousdicas N
Clin Exp Dermatol 2015 Oct;40(7):753-6. Epub 2015 Mar 18 doi: 10.1111/ced.12636. PMID: 25800103
Porokeratoses: an update of clinical, aetiopathogenic and therapeutic features.
Kanitakis J
Eur J Dermatol 2014 Sep-Oct;24(5):533-44. doi: 10.1684/ejd.2014.2402. PMID: 25115203
Detection of a novel missense mutation in the mevalonate kinase gene in one Chinese family with DSAP.
Lu WS, Zheng XD, Yao XH, Zhang LF, Hu B, Lu YJ
Int J Clin Exp Pathol 2014;7(2):728-32. Epub 2014 Jan 15 PMID: 24551296Free PMC Article
Dohi Memorial Lecture. New aspects of cutaneous mosaicism.
Happle R
J Dermatol 2002 Nov;29(11):681-92. doi: 10.1111/j.1346-8138.2002.tb00204.x. PMID: 12484429
Rapid development of disseminated superficial porokeratosis after transplant induction therapy.
Fields LL, White CR Jr, Maziarz RT
Bone Marrow Transplant 1995 Jun;15(6):993-5. PMID: 7581104

Clinical prediction guides

Dermoscopy of porokeratosis: results from a multicentre study of the International Dermoscopy Society.
Zaar O, Polesie S, Navarrete-Dechent C, Errichetti E, Akay BN, Jaimes J, Cabo H, Cohen Sabban E, Paoli J
J Eur Acad Dermatol Venereol 2021 Oct;35(10):2091-2096. Epub 2021 Jun 25 doi: 10.1111/jdv.17439. PMID: 34077570
Topical simvastatin-cholesterol for disseminated superficial actinic porokeratosis: An open-label, split-body clinical trial.
Byth LA, Byth J
Australas J Dermatol 2021 Aug;62(3):310-313. Epub 2021 May 24 doi: 10.1111/ajd.13601. PMID: 34028808
Drugs associated with development of porokeratosis: A systematic review.
Lu JD, Mufti A, Sachdeva M, Rahat S, Lansang RP, Yeung J
Dermatol Ther 2021 Jan;34(1):e14560. Epub 2020 Dec 1 doi: 10.1111/dth.14560. PMID: 33210788
Dermoscopy of Disseminated Superficial Actinic Porokeratosis.
Nicola A, Magliano J
Actas Dermosifiliogr 2017 Jun;108(5):e33-e37. Epub 2016 Mar 23 doi: 10.1016/j.ad.2015.09.025. PMID: 27015657
Porokeratosis in Singapore: an Asian perspective.
Tan LS, Chong WS
Australas J Dermatol 2012 May;53(2):e40-4. Epub 2012 Jan 19 doi: 10.1111/j.1440-0960.2011.00856.x. PMID: 22571584

Recent systematic reviews

Effects of Blue Light on the Skin and Its Therapeutic Uses: Photodynamic Therapy and Beyond.
Pieper C, Lee EB, Swali R, Harp K, Wysong A
Dermatol Surg 2022 Aug 1;48(8):802-808. Epub 2022 Jun 24 doi: 10.1097/DSS.0000000000003500. PMID: 35917260
Drugs associated with development of porokeratosis: A systematic review.
Lu JD, Mufti A, Sachdeva M, Rahat S, Lansang RP, Yeung J
Dermatol Ther 2021 Jan;34(1):e14560. Epub 2020 Dec 1 doi: 10.1111/dth.14560. PMID: 33210788
Light and laser treatment modalities for disseminated superficial actinic porokeratosis: a systematic review.
Aird GA, Sitenga JL, Nguyen AH, Vaudreuil A, Huerter CJ
Lasers Med Sci 2017 May;32(4):945-952. Epub 2017 Feb 27 doi: 10.1007/s10103-017-2179-9. PMID: 28239750

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