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Primary Lesion

MedGen UID:
235609
•Concept ID:
C1402294
•
Disease or Syndrome

Definition

A term that refers to a pathologic process in its original anatomic site of growth. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrimary Lesion

Professional guidelines

PubMed

Malignant Melanoma: Skin Cancer-Diagnosis, Prevention, and Treatment.
Ahmed B, Qadir MI, Ghafoor S
Crit Rev Eukaryot Gene Expr 2020;30(4):291-297. doi: 10.1615/CritRevEukaryotGeneExpr.2020028454. PMID: 32894659
Japanese guidelines for atopic dermatitis 2020.
Katoh N, Ohya Y, Ikeda M, Ebihara T, Katayama I, Saeki H, Shimojo N, Tanaka A, Nakahara T, Nagao M, Hide M, Fujita Y, Fujisawa T, Futamura M, Masuda K, Murota H, Yamamoto-Hanada K; Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis 2018, The Japanese Society of Allergology, The Japanese Dermatology Association
Allergol Int 2020 Jul;69(3):356-369. Epub 2020 Apr 4 doi: 10.1016/j.alit.2020.02.006. PMID: 32265116
Primary Brain Tumors in Adults: Diagnosis and Treatment.
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614

Recent clinical studies

Etiology

Primary Brain Tumors in Adults: Diagnosis and Treatment.
Perkins A, Liu G
Am Fam Physician 2016 Feb 1;93(3):211-7. PMID: 26926614
Managing malignant melanoma.
Dzwierzynski WW
Plast Reconstr Surg 2013 Sep;132(3):446e-460e. doi: 10.1097/PRS.0b013e31829ad411. PMID: 23985656
Sarcoma.
Ceyssens S, Stroobants S
Methods Mol Biol 2011;727:191-203. doi: 10.1007/978-1-61779-062-1_11. PMID: 21331935
Hereditary spherocytosis.
Perrotta S, Gallagher PG, Mohandas N
Lancet 2008 Oct 18;372(9647):1411-26. doi: 10.1016/S0140-6736(08)61588-3. PMID: 18940465
Hypertension and vascular disease.
Doyle AE
Am J Hypertens 1991 Feb;4(2 Pt 2):103S-106S. doi: 10.1093/ajh/4.2.103s. PMID: 2021454

Diagnosis

SATB1 mediated tumor colonization and β-catenin nuclear localization are associated with colorectal cancer progression.
Sun L, Wang F, Wang X, Zhang F, Ma S, Lv J
Cancer Biol Ther 2024 Dec 31;25(1):2320307. Epub 2024 Feb 22 doi: 10.1080/15384047.2024.2320307. PMID: 38385627Free PMC Article
Clear cell acanthoma.
Wagner G, Back W, Sachse MM
J Dtsch Dermatol Ges 2021 Jan;19(1):31-36. Epub 2020 Sep 28 doi: 10.1111/ddg.14270. PMID: 32989899
Sarcoma.
Ceyssens S, Stroobants S
Methods Mol Biol 2011;727:191-203. doi: 10.1007/978-1-61779-062-1_11. PMID: 21331935
Understanding neuropathic pain.
Zieglgänsberger W, Berthele A, Tölle TR
CNS Spectr 2005 Apr;10(4):298-308. doi: 10.1017/s1092852900022628. PMID: 15788957
Lung cancer.
Rodescu D
Med Clin North Am 1977 Nov;61(6):1205-18. doi: 10.1016/s0025-7125(16)31256-1. PMID: 72894

Therapy

Efficacy and safety of pembrolizumab with preoperative neoadjuvant chemotherapy in patients with resectable locally advanced head and neck squamous cell carcinomas.
Wang K, Gui L, Lu H, He X, Li D, Liu C, Liu S, Wang X
Front Immunol 2023;14:1189752. Epub 2023 Jul 31 doi: 10.3389/fimmu.2023.1189752. PMID: 37583698Free PMC Article
EGFR-TKIs plus stereotactic body radiation therapy (SBRT) for stage IV Non-small cell lung cancer (NSCLC): A prospective, multicenter, randomized, controlled phase II study.
Peng P, Gong J, Zhang Y, Zhou S, Li Y, Han G, Meng R, Chen Y, Yang M, Shen Q, Chu Q, Xia S, Zhang P, Zhang L, Chen Y, Zhang L
Radiother Oncol 2023 Jul;184:109681. Epub 2023 Apr 25 doi: 10.1016/j.radonc.2023.109681. PMID: 37105304
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future.
Stueven AK, Kayser A, Wetz C, Amthauer H, Wree A, Tacke F, Wiedenmann B, Roderburg C, Jann H
Int J Mol Sci 2019 Jun 22;20(12) doi: 10.3390/ijms20123049. PMID: 31234481Free PMC Article
Neuropathic pain after dental treatment.
Tınastepe N, Oral K
Agri 2013;25(1):1-6. doi: 10.5505/agri.2013.55477. PMID: 23588863
Radiotherapy in osteosarcoma.
Suit HD
Clin Orthop Relat Res 1975 Sep;(111):71-5. doi: 10.1097/00003086-197509000-00009. PMID: 1098830

Prognosis

Treatment Modality and Second Primary Tumors of the Head and Neck.
Ben Arie G, Shafat T, Belochitski O, El-Saied S, Joshua BZ
ORL J Otorhinolaryngol Relat Spec 2021;83(6):420-427. Epub 2021 Sep 29 doi: 10.1159/000513617. PMID: 34587611Free PMC Article
Melanoma of unknown primary: New perspectives for an old story.
Boussios S, Rassy E, Samartzis E, Moschetta M, Sheriff M, Pérez-Fidalgo JA, Pavlidis N
Crit Rev Oncol Hematol 2021 Feb;158:103208. Epub 2020 Dec 28 doi: 10.1016/j.critrevonc.2020.103208. PMID: 33383207
Ablative Therapy for Oligometastatic Non-Small Cell Lung Cancer.
Juan O, Popat S
Clin Lung Cancer 2017 Nov;18(6):595-606. Epub 2017 Mar 14 doi: 10.1016/j.cllc.2017.03.002. PMID: 28377206
Renal cell carcinoma.
Jonasch E, Gao J, Rathmell WK
BMJ 2014 Nov 10;349:g4797. doi: 10.1136/bmj.g4797. PMID: 25385470Free PMC Article
Ectopic ACTH syndrome.
Isidori AM, Kaltsas GA, Grossman AB
Front Horm Res 2006;35:143-156. doi: 10.1159/000094323. PMID: 16809930

Clinical prediction guides

ED diagnosis of peritoneal carcinomatosis.
Scheinfeld D, Schwartz C, Fink AZ
Emerg Radiol 2024 Aug;31(4):475-480. Epub 2024 Jun 5 doi: 10.1007/s10140-024-02238-w. PMID: 38836936Free PMC Article
Prognostic Factors of Extramammary Paget's Disease.
Hatta N
Curr Treat Options Oncol 2018 Aug 15;19(10):47. doi: 10.1007/s11864-018-0567-4. PMID: 30112691
Contribution of Neuro-Imaging for Prediction of Functional Recovery after Ischemic Stroke.
Heiss WD
Cerebrovasc Dis 2017;44(5-6):266-276. Epub 2017 Sep 5 doi: 10.1159/000479594. PMID: 28869961
Genetics of isolated auditory neuropathies.
Del Castillo FJ, Del Castillo I
Front Biosci (Landmark Ed) 2012 Jan 1;17(4):1251-65. doi: 10.2741/3984. PMID: 22201801
Enthesitis.
D'Agostino MA, Olivieri I
Best Pract Res Clin Rheumatol 2006 Jun;20(3):473-86. doi: 10.1016/j.berh.2006.03.007. PMID: 16777577

Recent systematic reviews

The prognostic significance of additional localized treatment to primary lesion in patients undergoing hormone therapy for metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis.
Yamada Y, Urabe F, Kimura S, Iwatani K, Kimura N, Miki J, Kimura T, Kume H
PLoS One 2024;19(6):e0304963. Epub 2024 Jun 10 doi: 10.1371/journal.pone.0304963. PMID: 38857208Free PMC Article
Natural history and treatment options of radiation-induced brain cavernomas: a systematic review.
Patet G, Bartoli A, Meling TR
Neurosurg Rev 2022 Feb;45(1):243-251. Epub 2021 Jul 4 doi: 10.1007/s10143-021-01598-y. PMID: 34218360Free PMC Article
Balloon cell melanoma: a systematic review.
Wei G, Hennessy K, Kevin Heard L, Gaudi S, Mhaskar R, Patel RR, Bennett AE
Int J Dermatol 2022 Mar;61(3):266-277. Epub 2021 Mar 1 doi: 10.1111/ijd.15448. PMID: 33645660
A systematic review of 1143 parapharyngeal space tumors reported over 20 years.
Riffat F, Dwivedi RC, Palme C, Fish B, Jani P
Oral Oncol 2014 May;50(5):421-30. Epub 2014 Feb 28 doi: 10.1016/j.oraloncology.2014.02.007. PMID: 24589290
Sympathectomy for neuropathic pain.
Mailis A, Furlan A
Cochrane Database Syst Rev 2003;(2):CD002918. doi: 10.1002/14651858.CD002918. PMID: 12804444

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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