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Short palate

MedGen UID:: 237241
•Concept ID:: C1398301
•: Congenital Abnormality

Professional guidelines

PubMed

Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.

Terryah ST, Fellner RC, Ahmad S, Moore PJ, Reidel B, Sesma JI, Kim CS, Garland AL, Scott DW, Sabater JR, Carpenter J, Randell SH, Kesimer M, Abraham WM, Arendshorst WJ, Tarran R
Am J Physiol Lung Cell Mol Physiol 2018 Jan 1;314(1):L192-L205. Epub 2017 Oct 5 doi: 10.1152/ajplung.00546.2016. PMID: 28982737 Free PMC Article

Differential short palate, lung, and nasal epithelial clone 1 suppression in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps: implications for pathogenesis and treatment.

Wei Y, Han M, Wen W, Li H
Curr Opin Allergy Clin Immunol 2016 Feb;16(1):31-8. doi: 10.1097/ACI.0000000000000228. PMID: 26658012

Treatment of persistent post-adenoidectomy velopharyngeal insufficiency by sphincter pharyngoplasty.

Abdel-Aziz M, Dewidar H, El-Hoshy H, Aziz AA
Int J Pediatr Otorhinolaryngol 2009 Oct;73(10):1329-33. Epub 2009 Jul 14 doi: 10.1016/j.ijporl.2009.05.026. PMID: 19604585

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Recent clinical studies

Etiology

SPLUNC1 as a biomarker of pulmonary exacerbations in children with cystic fibrosis.

Ben-Meir E, Perrem L, Shaw M, Ratjen F, Grasemann H
J Cyst Fibros 2024 Mar;23(2):288-292. Epub 2024 Feb 27 doi: 10.1016/j.jcf.2024.02.009. PMID: 38413298

IS SURGICAL TREATMENT OF VELOPHARYNGEAL INSUFFICIENCY BY MYOMUCOSAL POSTERIOR PHARYNGEAL FLAP A CONTRAINDICATION FOR NASAL INTUBATION? A NARRATIVE REVIEW.

Smiljanić I, Knežević P, Milić M, Tarle M, Lauš P, Jurišić I
Acta Clin Croat 2023 Apr;62(Suppl1):91-98. doi: 10.20471/acc.2023.62.s1.11. PMID: 38746620 Free PMC Article

SPLUNC1: a novel marker of cystic fibrosis exacerbations.

Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ
Eur Respir J 2021 Nov;58(5) Epub 2021 Nov 11 doi: 10.1183/13993003.00507-2020. PMID: 33958427 Free PMC Article

Diverse phenotypes and endotypes of fungus balls caused by mixed bacterial colonization in chronic rhinosinusitis.

Kim DK, Wi YC, Shin SJ, Kim KR, Kim DW, Cho SH
Int Forum Allergy Rhinol 2019 Nov;9(11):1360-1366. Epub 2019 Aug 12 doi: 10.1002/alr.22410. PMID: 31403760

Partial Adenoidectomy in Patients With Palatal Abnormalities.

Salna I, Jervis-Bardy J, Wabnitz D, Rees G, Psaltis A, Johnson A
J Craniofac Surg 2019 Jul;30(5):e454-e460. doi: 10.1097/SCS.0000000000005533. PMID: 31299813

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Diagnosis

SPLUNC1: a novel marker of cystic fibrosis exacerbations.

SPX-101 Is a Novel Epithelial Sodium Channel-targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport.

Scott DW, Walker MP, Sesma J, Wu B, Stuhlmiller TJ, Sabater JR, Abraham WM, Crowder TM, Christensen DJ, Tarran R
Am J Respir Crit Care Med 2017 Sep 15;196(6):734-744. doi: 10.1164/rccm.201612-2445OC. PMID: 28481660

SPLUNC1 Is a Significant Marker in Pleural Effusion from Lung Cancer Compared to Tuberculosis.

Xue JL, Yi L, Yan ZH, Li X, Wang XJ, Wei PJ, Zeng JE, Zhao YL, Zhang HT
Monoclon Antib Immunodiagn Immunother 2015 Jun;34(3):206-12. doi: 10.1089/mab.2014.0073. PMID: 26090599 Free PMC Article

Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.

Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R
Proc Natl Acad Sci U S A 2013 Oct 1;110(40):15973-8. Epub 2013 Sep 16 doi: 10.1073/pnas.1311999110. PMID: 24043776 Free PMC Article

Submucous cleft palate: an often-missed diagnosis.

Ha KM, Cleland H, Greensmith A, Chong D, Macgill K, Verhoeven A, Hutson JM
J Craniofac Surg 2013 May;24(3):878-85. doi: 10.1097/SCS.0b013e31827fef4b. PMID: 23714901

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Therapy

SPLUNC1 as a biomarker of pulmonary exacerbations in children with cystic fibrosis.

Ben-Meir E, Perrem L, Shaw M, Ratjen F, Grasemann H
J Cyst Fibros 2024 Mar;23(2):288-292. Epub 2024 Feb 27 doi: 10.1016/j.jcf.2024.02.009. PMID: 38413298

The effect of BPIFA1/SPLUNC1 genetic variation on its expression and function in asthmatic airway epithelium.

Schaefer N, Li X, Seibold MA, Jarjour NN, Denlinger LC, Castro M, Coverstone AM, Teague WG, Boomer J, Bleecker ER, Meyers DA, Moore WC, Hawkins GA, Fahy J, Phillips BR, Mauger DT, Dakhama A, Gellatly S, Pavelka N, Berman R, Di YP, Wenzel SE, Chu HW
JCI Insight 2019 Apr 18;4(8) doi: 10.1172/jci.insight.127237. PMID: 30996135 Free PMC Article

SPX-101 Is a Novel Epithelial Sodium Channel-targeted Therapeutic for Cystic Fibrosis That Restores Mucus Transport.

beta2-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells.

Gross CA, Bowler RP, Green RM, Weinberger AR, Schnell C, Chu HW
BMC Pulm Med 2010 May 14;10:30. doi: 10.1186/1471-2466-10-30. PMID: 20470412 Free PMC Article

Treatment of persistent post-adenoidectomy velopharyngeal insufficiency by sphincter pharyngoplasty.

Abdel-Aziz M, Dewidar H, El-Hoshy H, Aziz AA
Int J Pediatr Otorhinolaryngol 2009 Oct;73(10):1329-33. Epub 2009 Jul 14 doi: 10.1016/j.ijporl.2009.05.026. PMID: 19604585

See all (9)

Prognosis

SPLUNC1: a novel marker of cystic fibrosis exacerbations.

SPLUNC1 Is a Significant Marker in Pleural Effusion from Lung Cancer Compared to Tuberculosis.

Xue JL, Yi L, Yan ZH, Li X, Wang XJ, Wei PJ, Zeng JE, Zhao YL, Zhang HT
Monoclon Antib Immunodiagn Immunother 2015 Jun;34(3):206-12. doi: 10.1089/mab.2014.0073. PMID: 26090599 Free PMC Article

Submucous cleft palate: an often-missed diagnosis.

Ha KM, Cleland H, Greensmith A, Chong D, Macgill K, Verhoeven A, Hutson JM
J Craniofac Surg 2013 May;24(3):878-85. doi: 10.1097/SCS.0b013e31827fef4b. PMID: 23714901

Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein.

Gorr SU, Abdolhosseini M, Shelar A, Sotsky J
Biochem Soc Trans 2011 Aug;39(4):1028-32. doi: 10.1042/BST0391028. PMID: 21787342 Free PMC Article

Function and regulation of SPLUNC1 protein in Mycoplasma infection and allergic inflammation.

Chu HW, Thaikoottathil J, Rino JG, Zhang G, Wu Q, Moss T, Refaeli Y, Bowler R, Wenzel SE, Chen Z, Zdunek J, Breed R, Young R, Allaire E, Martin RJ
J Immunol 2007 Sep 15;179(6):3995-4002. doi: 10.4049/jimmunol.179.6.3995. PMID: 17785838

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Clinical prediction guides

SPLUNC1 is a negative regulator of the Orai1 Ca(2+) channel.

Wu T, Goriounova AS, Worthington EN, Wrennall JA, Ghosh A, Ahmad S, Flori Sassano M, Tarran R
Physiol Rep 2022 May;10(10):e15306. doi: 10.14814/phy2.15306. PMID: 35581745 Free PMC Article

SPLUNC1: a novel marker of cystic fibrosis exacerbations.

The Multifunctional Roles of Short Palate, Lung, and Nasal Epithelium Clone 1 in Regulating Airway Surface Liquid and Participating in Airway Host Defense.

Liu Q, Wang Z, Zhang W
J Interferon Cytokine Res 2021 Apr;41(4):139-148. doi: 10.1089/jir.2020.0141. PMID: 33885339

Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein.

Gorr SU, Abdolhosseini M, Shelar A, Sotsky J
Biochem Soc Trans 2011 Aug;39(4):1028-32. doi: 10.1042/BST0391028. PMID: 21787342 Free PMC Article

Cerebro-costo-mandibular syndrome.

Plötz FB, van Essen AJ, Bosschaart AN, Bos AP
Am J Med Genet 1996 Mar 29;62(3):286-92. doi: 10.1002/(SICI)1096-8628(19960329)62:3<286::AID-AJMG16>3.0.CO;2-G. PMID: 8882789

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Short palate

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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