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Pagetoid Reticulosis

MedGen UID:
234569
•Concept ID:
C1367970
•
Neoplastic Process
Synonyms: Disease, Woringer Kolopp; Disease, Woringer-Kolopp; Kolopp Disease, Woringer; Pagetoid Reticuloses; Reticuloses, Pagetoid; Reticulosis, Pagetoid; Woringer Kolopp Disease; Woringer-Kolopp Disease
SNOMED CT: Pagetoid reticulosis (404119000); Pagetoid reticulosis (419386004)

Definition

A variant of mycosis fungoides, characterized by an exclusively intraepidermal atypical (cerebriform) lymphocytic infiltrate. Patients present with a localized psoriasiform or hyperkeratotic patch or plaque, usually in the extremities. Extracutaneous dissemination of the disease has never been reported. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPagetoid Reticulosis

Recent clinical studies

Etiology

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.
Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
Pediatric Mycosis Fungoides: Retrospective Analysis of a Series With CD8 + Profile and Female Predominance.
Purnak S, Mark LA
J Pediatr Hematol Oncol 2022 Oct 1;44(7):e994-e998. Epub 2021 Oct 26 doi: 10.1097/MPH.0000000000002354. PMID: 34699461
Characteristics and outcomes of 727 patients with mycosis fungoides and Sézary syndrome from a Brazilian cohort.
Miyashiro D, Sanches JA
Int J Dermatol 2022 Apr;61(4):442-454. Epub 2021 Aug 26 doi: 10.1111/ijd.15865. PMID: 34435672
CK 8∕18: the key to differentiating intracutaneous lesions with pagetoid features.
Tinca AC, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Chiorean DM, Morariu SH, Turdean SG, Cotoi OS
Rom J Morphol Embryol 2021 Jul-Sep;62(3):757-763. doi: 10.47162/RJME.62.3.13. PMID: 35263404Free PMC Article
CD30 expression and proliferative fraction in nontransformed mycosis fungoides.
Edinger JT, Clark BZ, Pucevich BE, Geskin LJ, Swerdlow SH
Am J Surg Pathol 2009 Dec;33(12):1860-8. doi: 10.1097/PAS.0b013e3181bf677d. PMID: 19898220Free PMC Article

Diagnosis

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.
Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
A review of the solitary cutaneous T-cell lymphomas.
Ally MS, Robson A
J Cutan Pathol 2014 Sep;41(9):703-14. Epub 2014 Apr 26 doi: 10.1111/cup.12353. PMID: 24666254
Case for diagnosis.
Pedrosa AF, Ferreira O, Barros AM, Nogueira A, Bettencourt H, Azevedo F
An Bras Dermatol 2013 Sep-Oct;88(5):824-5. doi: 10.1590/abd1806-4841.20132258. PMID: 24173195Free PMC Article
Pagetoid reticulosis (Woringer-Kolopp disease).
Lichte V, Ghoreschi K, Metzler G, Möhrle M, Geyer A, Röcken M, Schaller M
J Dtsch Dermatol Ges 2009 Apr;7(4):353-4. Epub 2008 Nov 27 doi: 10.1111/j.1610-0387.2008.06936.x. PMID: 19054422
Pagetoid reticulosis.
Smith NP
Clin Exp Dermatol 1982 May;7(3):i-iv. doi: 10.1111/j.1365-2230.1982.tb02421.x. PMID: 6286184

Therapy

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.
Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
Pagetoid reticulosis in a 13-year old female. A unique immunohistochemical profile.
Torre-Castro J, Carrasco Santos L, Rodríguez-Pinilla SM, Requena L
J Cutan Pathol 2020 May;47(5):466-469. Epub 2019 Dec 12 doi: 10.1111/cup.13622. PMID: 31785005
Unilesional plantar mycosis fungoides treated with topical photodynamic therapy - case report and review of the literature.
Kaufmann F, Kettelhack N, Hilty N, Kempf W
J Eur Acad Dermatol Venereol 2017 Oct;31(10):1633-1637. Epub 2017 Mar 13 doi: 10.1111/jdv.14160. PMID: 28168737
Woringer-Kolopp disease mimicking foot dermatitis.
Yao Y, Mark LA
Cutis 2012 Dec;90(6):307-9, 316. PMID: 23409481
Canine cutaneous epitheliotropic T-cell lymphoma: a review.
Fontaine J, Bovens C, Bettenay S, Mueller RS
Vet Comp Oncol 2009 Mar;7(1):1-14. doi: 10.1111/j.1476-5829.2008.00176.x. PMID: 19222826

Prognosis

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.
Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962
Characteristics and outcomes of 727 patients with mycosis fungoides and Sézary syndrome from a Brazilian cohort.
Miyashiro D, Sanches JA
Int J Dermatol 2022 Apr;61(4):442-454. Epub 2021 Aug 26 doi: 10.1111/ijd.15865. PMID: 34435672
CK 8∕18: the key to differentiating intracutaneous lesions with pagetoid features.
Tinca AC, Cocuz IG, Şincu MC, Niculescu R, Sabău AH, Chiorean DM, Morariu SH, Turdean SG, Cotoi OS
Rom J Morphol Embryol 2021 Jul-Sep;62(3):757-763. doi: 10.47162/RJME.62.3.13. PMID: 35263404Free PMC Article
A review of the solitary cutaneous T-cell lymphomas.
Ally MS, Robson A
J Cutan Pathol 2014 Sep;41(9):703-14. Epub 2014 Apr 26 doi: 10.1111/cup.12353. PMID: 24666254
Canine cutaneous epitheliotropic T-cell lymphoma: a review.
Fontaine J, Bovens C, Bettenay S, Mueller RS
Vet Comp Oncol 2009 Mar;7(1):1-14. doi: 10.1111/j.1476-5829.2008.00176.x. PMID: 19222826

Clinical prediction guides

Constant small-cell changes and variable LEF1 expression in DUSP22-rearranged primary cutaneous anaplastic large-cell lymphoma: Analysis of the repeated biopsies of three patients.
Osakada A, Fujimoto M, Ueshima C, Kaku Y, Nishikori M, Inoue N, Takeuchi K, Haga H
Pathol Int 2023 Sep;73(9):456-462. Epub 2023 Aug 2 doi: 10.1111/pin.13360. PMID: 37530485
Pediatric Mycosis Fungoides: Retrospective Analysis of a Series With CD8 + Profile and Female Predominance.
Purnak S, Mark LA
J Pediatr Hematol Oncol 2022 Oct 1;44(7):e994-e998. Epub 2021 Oct 26 doi: 10.1097/MPH.0000000000002354. PMID: 34699461
Characteristics and outcomes of 727 patients with mycosis fungoides and Sézary syndrome from a Brazilian cohort.
Miyashiro D, Sanches JA
Int J Dermatol 2022 Apr;61(4):442-454. Epub 2021 Aug 26 doi: 10.1111/ijd.15865. PMID: 34435672
Primary cutaneous anaplastic large-cell lymphoma with 6p25.3 rearrangement exhibits a biphasic histopathologic pattern: Two case reports and literature review.
Xue YN, Wang Z, Sun JF, Chen H
J Cutan Pathol 2021 Dec;48(12):1463-1470. Epub 2021 Jul 21 doi: 10.1111/cup.14089. PMID: 34164830
Pseudocarcinomatous Hyperplasia, Squamous Cell Carcinoma, and Keratoacanthoma Associated to Lymphomas of the Skin and External Mucous Membranes: A Case Report and Literature Review.
Jeunon T, Assoni A, Verdolin A
Am J Dermatopathol 2020 Sep;42(9):662-672. doi: 10.1097/DAD.0000000000001587. PMID: 31833842

Recent systematic reviews

Woringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.
Osto M, Afify O, Musa A, Ahmed U, Rehman R, Mehregan D
Int J Dermatol 2023 Mar;62(3):312-321. Epub 2022 Apr 29 doi: 10.1111/ijd.16224. PMID: 35485962

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