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Lung Mucosa-Associated Lymphoid Tissue Lymphoma

MedGen UID:
237139
Concept ID:
C1367652
Neoplastic Process
Synonyms: BALT lymphoma; BALT Lymphoma; BALToma; Bronchial MALT Lymphoma; Bronchial Mucosa-Associated Lymphoid Tissue Lymphoma; Bronchial-associated lymphoid tissue lymphoma; Bronchus-Associated Lymphoid Tissue Lymphoma; Lung Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Lung MALT Lymphoma; Pulmonary Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Pulmonary MALT Lymphoma; Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma
SNOMED CT: Bronchial-associated lymphoid tissue lymphoma (128803008); BALT lymphoma (128803008)

Definition

An extranodal marginal zone lymphoma that arises from the lung. It is characterized by the neoplastic proliferation of small B-lymphocytes, monocytoid cells and cells with plasma cell differentiation in the marginal zones of reactive lymphoid follicles. The neoplastic cells infiltrate the interfollicular areas and the bronchial epithelium forming lymphoepithelial lesions. The neoplasm is usually discovered as a mass in a chest x-ray in asymptomatic patients. When symptoms occur, they include cough, dyspnea, hemoptysis, and chest pain. If the lung lesions are resectable, surgery can result in prolonged remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Mucosa-Associated Lymphoid Tissue Lymphoma

Professional guidelines

PubMed

Sirajuddin A, Raparia K, Lewis VA, Franks TJ, Dhand S, Galvin JR, White CS
Radiographics 2016 Jan-Feb;36(1):53-70. doi: 10.1148/rg.2016140339. PMID: 26761531
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Recent clinical studies

Etiology

Liu C, Zhu J, Zhao L, Li G, Sun J, Zhang S, Liang X
Biomark Med 2024;18(10-12):513-521. Epub 2024 Aug 13 doi: 10.1080/17520363.2024.2347199. PMID: 39136445Free PMC Article
Roy AM, Venkata AN, Yadala S
Chest 2021 Apr;159(4):e247-e250. Epub 2021 Apr 6 doi: 10.1016/j.chest.2020.10.051. PMID: 34022027
da Silva SP, Resnick E, Lucas M, Lortan J, Patel S, Cunningham-Rundles C, Gatter K, Liu Q, Jaffe ES, Chapel H
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Diagnosis

Wang Y, Deng X, Xie J, Lu T, Qian R, Guo Z, Zeng X, Liao J, Ding Z, Zhou M, Niu X
Cell Biol Toxicol 2024 Jun 12;40(1):45. doi: 10.1007/s10565-024-09888-z. PMID: 38864940Free PMC Article
Perlepe G, Kotsiou OS, Karetsi E, Papadopoulos D, Ioannou M, Gourgoulianis KI
Thorax 2021 Oct;76(10):1057-1059. Epub 2021 Jul 16 doi: 10.1136/thoraxjnl-2020-215374. PMID: 34272334
Zeppa P, Cozzolino I
Monogr Clin Cytol 2018;23:81-92. Epub 2017 Nov 13 doi: 10.1159/000478884. PMID: 29130993
Borie R, Wislez M, Antoine M, Cadranel J
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Travis WD, Galvin JR
Thorax 2001 Dec;56(12):964-71. doi: 10.1136/thorax.56.12.964. PMID: 11713361Free PMC Article

Therapy

Wen YC, Huang TC, Tsai WC, Lai SW
Medicina (Kaunas) 2024 Apr 25;60(5) doi: 10.3390/medicina60050706. PMID: 38792889Free PMC Article
Catteeuw J, Koegelenberg CFN, Bruwer JW, Sissolak G, Schroeter L, Mohamed N, Irusen EM
Chest 2014 Sep;146(3):e92-e96. doi: 10.1378/chest.13-2790. PMID: 25180750
Wu YF, Huang TW, Kao CC, Lee SC
Interact Cardiovasc Thorac Surg 2012 Jun;14(6):771-2. Epub 2012 Feb 26 doi: 10.1093/icvts/ivr116. PMID: 22371385Free PMC Article
Chong EA, Svoboda J, Cherian S, Andreadis C, Downs LH, Zhuang H, Alavi A, Tsai DE, Schuster SJ
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Travis WD, Galvin JR
Thorax 2001 Dec;56(12):964-71. doi: 10.1136/thorax.56.12.964. PMID: 11713361Free PMC Article

Prognosis

Roy AM, Venkata AN, Yadala S
Chest 2021 Apr;159(4):e247-e250. Epub 2021 Apr 6 doi: 10.1016/j.chest.2020.10.051. PMID: 34022027
Borie R, Wislez M, Antoine M, Cadranel J
Respiration 2017;94(2):157-175. Epub 2017 Jun 14 doi: 10.1159/000477740. PMID: 28609772
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Yahalom J
Ann Hematol 2001;80 Suppl 3:B100-5. doi: 10.1007/pl00022769. PMID: 11757688

Clinical prediction guides

Liu C, Zhu J, Zhao L, Li G, Sun J, Zhang S, Liang X
Biomark Med 2024;18(10-12):513-521. Epub 2024 Aug 13 doi: 10.1080/17520363.2024.2347199. PMID: 39136445Free PMC Article
Wang Y, Deng X, Xie J, Lu T, Qian R, Guo Z, Zeng X, Liao J, Ding Z, Zhou M, Niu X
Cell Biol Toxicol 2024 Jun 12;40(1):45. doi: 10.1007/s10565-024-09888-z. PMID: 38864940Free PMC Article
van Ginkel MS, Arends S, van der Vegt B, Nijland M, Spijkervet FKL, Vissink A, Kroese FGM, Glaudemans AWJM, Bootsma H
Rheumatology (Oxford) 2023 Oct 3;62(10):3323-3331. doi: 10.1093/rheumatology/kead071. PMID: 36759907Free PMC Article
Bi W, Zhao S, Wu C, Gao J, Zhao S, Yang S, Deng Y, Nie P, Yu X, Deng H, Zang X, Ma X, Han J, Asuquo I, Wang X, Xue X
J Surg Oncol 2021 Apr;123(5):1336-1344. Epub 2021 Feb 1 doi: 10.1002/jso.26403. PMID: 33523526
Kim KM, Kim HC, Jeon KN, Kim HG, Kang JH, Hahm JR, Lee GW
Yonsei Med J 2008 Feb 29;49(1):155-8. doi: 10.3349/ymj.2008.49.1.155. PMID: 18306483Free PMC Article

Recent systematic reviews

Xiao J, He B, Zou Y, Chen X, Lu X, Xie M, Li W, He S, You S, Chen Q
Sci Rep 2016 Jul 26;6:30437. doi: 10.1038/srep30437. PMID: 27457567Free PMC Article

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