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Salivary Gland Polymorphous Adenocarcinoma

MedGen UID:
233432
Concept ID:
C1335907
Neoplastic Process
Synonyms: Polymorphous low grade adenocarcinoma of salivary gland; Salivary Gland PmA; Salivary Gland Polymorphous Adenocarcinoma, Classical Variant; Salivary Gland Polymorphous Low Grade Adenocarcinoma; Salivary Gland Terminal Duct Adenocarcinoma
SNOMED CT: Polymorphous low grade adenocarcinoma of salivary gland (423038006)

Definition

A low grade malignant epithelial neoplasm arising from the salivary gland. It usually arises from the oral cavity, with approximately 60% of the cases involving the palate. The most common presenting sign is a painless mass in the palate. It is characterized by the presence of uniform, small to medium size malignant epithelial cells and an infiltrating pattern. There is a variety of morphologic patterns which may be present within an individual tumor, including lobular, papillary, papillary-cystic, cribriform, and trabecular pattern. It usually has a favorable clinical outcome and a low metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary Gland Polymorphous Adenocarcinoma

Professional guidelines

PubMed

Rooper LM, Mansour M, Yonescu R, Oliai BR, Bishop JA, Westra WH
Am J Surg Pathol 2021 Jun 1;45(6):753-764. doi: 10.1097/PAS.0000000000001636. PMID: 33284193
Skálová A, Stenman G, Simpson RHW, Hellquist H, Slouka D, Svoboda T, Bishop JA, Hunt JL, Nibu KI, Rinaldo A, Vander Poorten V, Devaney KO, Steiner P, Ferlito A
Am J Surg Pathol 2018 Feb;42(2):e11-e27. doi: 10.1097/PAS.0000000000000980. PMID: 29076877
Sun G, Yang X, Tang E, Wen J, Lu M, Hu Q
Int J Oral Maxillofac Surg 2010 Sep;39(9):863-8. doi: 10.1016/j.ijom.2010.04.051. PMID: 20605409

Recent clinical studies

Etiology

Hahn E, Xu B, Katabi N, Dogan S, Smith SM, Perez-Ordonez B, Patel PB, MacMillan C, Lubin DJ, Gagan J, Weinreb I, Bishop JA
Mod Pathol 2023 Nov;36(11):100305. Epub 2023 Aug 17 doi: 10.1016/j.modpat.2023.100305. PMID: 37595638Free PMC Article
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Fukumura M, Ishibashi K, Nakaguro M, Nagao T, Saida K, Urano M, Tanigawa M, Hirai H, Yagyuu T, Kikuchi K, Yada N, Sugita Y, Miyabe M, Hasegawa S, Goto M, Yamamoto H, Ohuchi T, Kusafuka K, Ogawa I, Suzuki H, Notohara K, Shimoda M, Tada Y, Kirita T, Takata T, Morinaga S, Maeda H, Warnakulasuriya S, Miyabe S, Nagao T
J Oral Pathol Med 2022 Sep;51(8):710-720. Epub 2022 Aug 15 doi: 10.1111/jop.13336. PMID: 35880805
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Mimica X, Katabi N, McGill MR, Hay A, Zanoni DK, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2019 Aug;95:52-58. Epub 2019 Jun 7 doi: 10.1016/j.oraloncology.2019.06.002. PMID: 31345394Free PMC Article

Diagnosis

Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Katabi N, Xu B
Surg Pathol Clin 2021 Mar;14(1):127-136. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.011. PMID: 33526217Free PMC Article
Seethala RR
Mod Pathol 2017 Jan;30(s1):S84-S95. doi: 10.1038/modpathol.2016.190. PMID: 28060371
Skalova A, Michal M, Simpson RH
Mod Pathol 2017 Jan;30(s1):S27-S43. doi: 10.1038/modpathol.2016.167. PMID: 28060365
Kato H, Kanematsu M, Makita H, Kato K, Hatakeyama D, Shibata T, Mizuta K, Aoki M
Eur J Radiol 2014 Mar;83(3):e137-46. Epub 2013 Dec 12 doi: 10.1016/j.ejrad.2013.11.028. PMID: 24377674

Therapy

López-Janeiro Á, Cabañuz C, Blasco-Santana L, Ruiz-Bravo E
Ann Diagn Pathol 2022 Feb;56:151869. Epub 2021 Nov 18 doi: 10.1016/j.anndiagpath.2021.151869. PMID: 34823074
Gottlieb JB, Joachim M, Leiser Y, Abdelraziq M, Abu El-Naaj I
J Craniofac Surg 2019 Jun;30(4):1228-1230. doi: 10.1097/SCS.0000000000005328. PMID: 30817510
Vargas PA, Cheng Y, Barrett AW, Craig GT, Speight PM
J Oral Pathol Med 2008 May;37(5):309-18. Epub 2008 Jan 30 doi: 10.1111/j.1600-0714.2007.00631.x. PMID: 18248354
Kokemueller H, Swennen G, Brueggemann N, Brachvogel P, Eckardt A, Hausamen JE
Int J Oral Maxillofac Surg 2004 Jul;33(5):423-32. doi: 10.1016/j.ijom.2004.02.007. PMID: 15183404
Mark J, Wedell B, Dahlenfors R, Stenman G
Cancer Genet Cytogenet 1991 Aug;55(1):19-29. doi: 10.1016/0165-4608(91)90230-r. PMID: 1913603

Prognosis

Katabi N, Xu B
Surg Pathol Clin 2021 Mar;14(1):127-136. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.011. PMID: 33526217Free PMC Article
Mimica X, Katabi N, McGill MR, Hay A, Zanoni DK, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2019 Aug;95:52-58. Epub 2019 Jun 7 doi: 10.1016/j.oraloncology.2019.06.002. PMID: 31345394Free PMC Article
Vander Poorten V, Triantafyllou A, Skálová A, Stenman G, Bishop JA, Hauben E, Hunt JL, Hellquist H, Feys S, De Bree R, Mäkitie AA, Quer M, Strojan P, Guntinas-Lichius O, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2018 Jul;275(7):1681-1695. Epub 2018 May 14 doi: 10.1007/s00405-018-4985-5. PMID: 29761209
Seethala RR
Surg Pathol Clin 2017 Mar;10(1):155-176. doi: 10.1016/j.path.2016.11.004. PMID: 28153132
Skalova A, Michal M, Simpson RH
Mod Pathol 2017 Jan;30(s1):S27-S43. doi: 10.1038/modpathol.2016.167. PMID: 28060365

Clinical prediction guides

Fatima S, Ahmed A, Suleman S, Din NU
Ann Diagn Pathol 2023 Dec;67:152220. Epub 2023 Oct 28 doi: 10.1016/j.anndiagpath.2023.152220. PMID: 37924657
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Nonaka T, Takei H
Head Neck Pathol 2022 Dec;16(4):980-990. Epub 2022 May 4 doi: 10.1007/s12105-022-01453-6. PMID: 35507302Free PMC Article
Mimica X, Katabi N, McGill MR, Hay A, Zanoni DK, Shah JP, Wong RJ, Cohen MA, Patel SG, Ganly I
Oral Oncol 2019 Aug;95:52-58. Epub 2019 Jun 7 doi: 10.1016/j.oraloncology.2019.06.002. PMID: 31345394Free PMC Article
Michal M, Kacerovska D, Kazakov DV
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S3-11. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0457-9. PMID: 23821209Free PMC Article

Recent systematic reviews

Nonaka T, Takei H
Head Neck Pathol 2022 Dec;16(4):980-990. Epub 2022 May 4 doi: 10.1007/s12105-022-01453-6. PMID: 35507302Free PMC Article
De Luca P, Tassone D, de Campora L, Simone M, Marra P, Colacurcio V, Scarpa A, Costarelli L, Camaioni A
Eur Arch Otorhinolaryngol 2022 Jun;279(6):2719-2725. Epub 2021 Oct 23 doi: 10.1007/s00405-021-07140-6. PMID: 34687340
Sivakumar N, Narwal A, Pandiar D, Devi A, Anand R, Bansal D, Kamboj M
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Feb;133(2):189-198. Epub 2021 Jul 21 doi: 10.1016/j.oooo.2021.07.010. PMID: 34518135
Gates JC, Gargano SM, Cherkas E, Kraus DH, Tuluc M
J Oral Maxillofac Surg 2021 Sep;79(9):1970-1976. Epub 2021 Apr 20 doi: 10.1016/j.joms.2021.03.027. PMID: 34023291

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