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Sclerosing Pneumocytoma

MedGen UID:
235268
•Concept ID:
C1334455
•
Neoplastic Process
Synonyms: Hemangioma, Sclerosing, Pulmonary; Lung Sclerosing Hemangioma; Lung Sclerosing Hemangiomas; Pulmonary Sclerosing Hemangioma; Pulmonary Sclerosing Hemangiomas; Sclerosing Hemangioma of the Lung; Sclerosing Hemangioma, Lung; Sclerosing Hemangioma, Pulmonary; Sclerosing Hemangiomas, Lung; Sclerosing Hemangiomas, Pulmonary
SNOMED CT: Pulmonary sclerosing hemangioma (707365008); Sclerosing hemangioma of lung (707365008); Sclerosing pneumocytoma (725967000)

Definition

A benign tumor that arises from the lung. It is characterized by the presence of sclerotic, papillary, solid, and hemorrhagic patterns and hyperplastic type II pneumocytes. Cholesterol clefts, hemosiderin deposition, chronic inflammation, and calcifications may be present. In the majority of cases, it is a solitary and peripheral tumor. Patients are usually asymptomatic. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSclerosing Pneumocytoma

Professional guidelines

PubMed

Analysis of the value of enhanced CT combined with texture analysis in the differential diagnosis of pulmonary sclerosing pneumocytoma and atypical peripheral lung cancer: a feasibility study.
Luo C, Song Y, Liu Y, Wang R, Gao J, Yue S, Ding C
BMC Med Imaging 2022 Feb 2;22(1):16. doi: 10.1186/s12880-022-00745-1. PMID: 35105314Free PMC Article

Recent clinical studies

Etiology

Central and peripheral pulmonary sclerosing pneumocytomas: multi-phase CT study and comparison with Ki-67.
Zhang Y, Ran C, Li W
Radiol Oncol 2023 Sep 1;57(3):310-316. Epub 2023 Sep 4 doi: 10.2478/raon-2023-0042. PMID: 37665739Free PMC Article
Pulmonary sclerosing pneumocytoma and mortality risk.
Kim SJ, Kang HR, Lee CG, Choi SH, Kim YW, Lee HW, Lee CH
BMC Pulm Med 2022 Nov 7;22(1):404. doi: 10.1186/s12890-022-02199-1. PMID: 36344955Free PMC Article
Pulmonary sclerosing pneumocytoma: clinical features and prognosis.
Zheng Q, Zhou J, Li G, Man S, Lin Z, Wang T, Chen B, Lin F
World J Surg Oncol 2022 Apr 30;20(1):140. doi: 10.1186/s12957-022-02603-4. PMID: 35490241Free PMC Article
Molecular Genetic Landscape of Sclerosing Pneumocytomas.
Boland JM, Lee HE, Barr Fritcher EG, Voss JS, Jessen E, Davila JI, Kipp BR, Graham RP, Maleszewski JJ, Yi ES
Am J Clin Pathol 2021 Feb 11;155(3):397-404. doi: 10.1093/ajcp/aqaa136. PMID: 33145590
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008

Diagnosis

Pulmonary sclerosing pneumocytoma and mortality risk.
Kim SJ, Kang HR, Lee CG, Choi SH, Kim YW, Lee HW, Lee CH
BMC Pulm Med 2022 Nov 7;22(1):404. doi: 10.1186/s12890-022-02199-1. PMID: 36344955Free PMC Article
Unusual lung tumors-from morphology to genetics.
Boland JM
Mod Pathol 2022 Jan;35(Suppl 1):57-65. Epub 2021 Sep 13 doi: 10.1038/s41379-021-00914-7. PMID: 34518633
Multiple sclerosing pneumocytomas: a review.
Pal P, Chetty R
J Clin Pathol 2020 Sep;73(9):531-534. Epub 2020 Apr 21 doi: 10.1136/jclinpath-2020-206501. PMID: 32317291
Pulmonary sclerosing pneumocytoma: Cytomorphology and immunoprofile.
Maleki Z, Muller S, Layfield L, Siddiqui MT, Rekhtman N, Pantanowitz L
Cancer Cytopathol 2020 Jun;128(6):414-423. Epub 2020 Feb 5 doi: 10.1002/cncy.22251. PMID: 32022435Free PMC Article
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008

Therapy

CT-based radiomics for differentiating peripherally located pulmonary sclerosing pneumocytoma from carcinoid.
Zhang Y, Yang X, Bi F, Wen L, Niu Y, Yang Y, Lin H, Yu X
Med Phys 2024 Jun;51(6):4219-4230. Epub 2024 Mar 20 doi: 10.1002/mp.17037. PMID: 38507783
Pulmonary sclerosing pneumocytoma and mortality risk.
Kim SJ, Kang HR, Lee CG, Choi SH, Kim YW, Lee HW, Lee CH
BMC Pulm Med 2022 Nov 7;22(1):404. doi: 10.1186/s12890-022-02199-1. PMID: 36344955Free PMC Article
Analysis of the value of enhanced CT combined with texture analysis in the differential diagnosis of pulmonary sclerosing pneumocytoma and atypical peripheral lung cancer: a feasibility study.
Luo C, Song Y, Liu Y, Wang R, Gao J, Yue S, Ding C
BMC Med Imaging 2022 Feb 2;22(1):16. doi: 10.1186/s12880-022-00745-1. PMID: 35105314Free PMC Article
Analysis of the F-18 FDG PET/CT features of pulmonary sclerosing pneumocytoma.
Liu H, Dang H, Wang R, Yao S, Wu Y, Xu B
Nucl Med Commun 2021 Jun 1;42(6):665-671. doi: 10.1097/MNM.0000000000001374. PMID: 33660695
(18) F-FDG PET/CT imaging: A supplementary understanding of pulmonary sclerosing pneumocytoma.
Xu J, Dong Y, Yin G, Jiang W, Yang Z, Xu W, Zhu L
Thorac Cancer 2019 Jul;10(7):1552-1560. Epub 2019 May 27 doi: 10.1111/1759-7714.13100. PMID: 31131992Free PMC Article

Prognosis

Pulmonary sclerosing pneumocytoma containing spindle cells with sarcomatoid features: a case report with literature review.
Liang J, Du Q, Ye X, Huang W
Diagn Pathol 2023 Feb 10;18(1):16. doi: 10.1186/s13000-023-01296-x. PMID: 36759857Free PMC Article
Pulmonary sclerosing pneumocytoma: clinical features and prognosis.
Zheng Q, Zhou J, Li G, Man S, Lin Z, Wang T, Chen B, Lin F
World J Surg Oncol 2022 Apr 30;20(1):140. doi: 10.1186/s12957-022-02603-4. PMID: 35490241Free PMC Article
Unusual lung tumors-from morphology to genetics.
Boland JM
Mod Pathol 2022 Jan;35(Suppl 1):57-65. Epub 2021 Sep 13 doi: 10.1038/s41379-021-00914-7. PMID: 34518633
Sclerosing pneumocytoma mixed with a typical carcinoid tumor: A case report and review of literature.
Wang Z, Yang MQ, Huang WJ, Zhang D, Xu HT
Medicine (Baltimore) 2019 Feb;98(5):e14315. doi: 10.1097/MD.0000000000014315. PMID: 30702609Free PMC Article
A Comparative Study of Intraoperative Cytology and Frozen Sections of Sclerosing Pneumocytoma.
Wu CY, Wang J, Chang NY
Int J Surg Pathol 2016 Oct;24(7):600-6. Epub 2016 May 8 doi: 10.1177/1066896916648448. PMID: 27160435

Clinical prediction guides

Comprehensive Genomic and Transcriptomic Analysis of Sclerosing Pneumocytoma.
Yeh YC, Chu PY, Lin SY, Wang SY, Ho HL, Wang YC
Mod Pathol 2024 Jan;37(1):100354. Epub 2023 Oct 14 doi: 10.1016/j.modpat.2023.100354. PMID: 37844870
Pulmonary sclerosing pneumocytoma and mortality risk.
Kim SJ, Kang HR, Lee CG, Choi SH, Kim YW, Lee HW, Lee CH
BMC Pulm Med 2022 Nov 7;22(1):404. doi: 10.1186/s12890-022-02199-1. PMID: 36344955Free PMC Article
Sclerosing pneumocytoma with carcinoid tumorlets and neuroendocrine cell hyperplasia.
Toro Soto PA, Rivero de Jesús É, Arenas Jiménez J, Aranda López FI
Rev Esp Patol 2022 Sep;55 Suppl 1:S44-S48. Epub 2020 May 6 doi: 10.1016/j.patol.2020.02.009. PMID: 36075662
AKT1 internal tandem duplications and point mutations are the genetic hallmarks of sclerosing pneumocytoma.
Yeh YC, Ho HL, Wu YC, Pan CC, Wang YC, Chou TY
Mod Pathol 2020 Mar;33(3):391-403. Epub 2019 Sep 16 doi: 10.1038/s41379-019-0357-y. PMID: 31527710
Concomitance of pulmonary spindle cell carcinoma and sclerosing pneumocytoma in a woman: A case report.
LuLu X, Jian S
Medicine (Baltimore) 2019 Dec;98(51):e18416. doi: 10.1097/MD.0000000000018416. PMID: 31861007Free PMC Article

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