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Barretts esophagus with low grade dysplasia

MedGen UID:
233618
Concept ID:
C1334414
Disease or Syndrome
Synonyms: Low Grade Dysplasia in Barrett Esophagus; Low Grade Dysplasia in Barrett's Esophagus
SNOMED CT: Barretts esophagus with low grade dysplasia (1082771000119100)

Definition

A finding indicating the presence of Barrett esophagus in which the crypts are preserved or mildly distorted. There is nuclear elongation, mild pleomorphism and loss of polarity, mucin depletion, and increased number of mitotic figures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBarretts esophagus with low grade dysplasia

Professional guidelines

PubMed

Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Shaheen NJ, Falk GW, Iyer PG, Souza RF, Yadlapati RH, Sauer BG, Wani S
Am J Gastroenterol 2022 Apr 1;117(4):559-587. doi: 10.14309/ajg.0000000000001680. PMID: 35354777Free PMC Article

Recent clinical studies

Etiology

Sarem M, Martínez Cerezo FJ, Salvia Favieres ML, Corti R
Gastroenterol Hepatol 2023 Oct;46(8):637-644. Epub 2022 Oct 13 doi: 10.1016/j.gastrohep.2022.10.002. PMID: 36243250
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Krajciova J, Vackova Z, Spicak J, Martinek J
Minerva Chir 2018 Aug;73(4):366-377. Epub 2018 May 25 doi: 10.23736/S0026-4733.18.07783-0. PMID: 29806757
Shaheen NJ, Falk GW, Iyer PG, Gerson LB; American College of Gastroenterology
Am J Gastroenterol 2016 Jan;111(1):30-50; quiz 51. Epub 2015 Nov 3 doi: 10.1038/ajg.2015.322. PMID: 26526079Free PMC Article
Poehlmann A, Kuester D, Malfertheiner P, Guenther T, Roessner A
Pathol Res Pract 2012 May 15;208(5):269-80. Epub 2012 Apr 27 doi: 10.1016/j.prp.2012.03.007. PMID: 22541897

Diagnosis

Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Shaheen NJ, Falk GW, Iyer PG, Souza RF, Yadlapati RH, Sauer BG, Wani S
Am J Gastroenterol 2022 Apr 1;117(4):559-587. doi: 10.14309/ajg.0000000000001680. PMID: 35354777Free PMC Article
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Shaheen NJ, Falk GW, Iyer PG, Gerson LB; American College of Gastroenterology
Am J Gastroenterol 2016 Jan;111(1):30-50; quiz 51. Epub 2015 Nov 3 doi: 10.1038/ajg.2015.322. PMID: 26526079Free PMC Article

Therapy

Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Martínez-Domínguez SJ, Lanas Á, Domper-Arnal MJ
Med Clin (Barc) 2022 Jul 22;159(2):92-100. Epub 2022 May 21 doi: 10.1016/j.medcli.2022.02.012. PMID: 35606193
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Schlottmann F, Patti MG, Shaheen NJ
World J Surg 2017 Jul;41(7):1705-1711. doi: 10.1007/s00268-017-3977-8. PMID: 28275832

Prognosis

Khoshiwal AM, Frei NF, Pouw RE; TissueCypher SURF LGD Study Pathologists Consortium, Smolko C, Arora M, Siegel JJ, Duits LC, Critchley-Thorne RJ, Bergman JJGHM
Gastroenterology 2023 Nov;165(5):1168-1179.e6. Epub 2023 Aug 30 doi: 10.1053/j.gastro.2023.07.029. PMID: 37657759
Inadomi JM, Saxena N
Dig Dis Sci 2018 Aug;63(8):2094-2104. doi: 10.1007/s10620-018-5148-7. PMID: 29948571
Kaz AM, Grady WM, Stachler MD, Bass AJ
Gastroenterol Clin North Am 2015 Jun;44(2):473-89. Epub 2015 Apr 1 doi: 10.1016/j.gtc.2015.02.015. PMID: 26021206Free PMC Article
Poehlmann A, Kuester D, Malfertheiner P, Guenther T, Roessner A
Pathol Res Pract 2012 May 15;208(5):269-80. Epub 2012 Apr 27 doi: 10.1016/j.prp.2012.03.007. PMID: 22541897
Wani S
Curr Opin Gastroenterol 2012 Jul;28(4):370-6. doi: 10.1097/MOG.0b013e328353af02. PMID: 22508323

Clinical prediction guides

Khoshiwal AM, Frei NF, Pouw RE; TissueCypher SURF LGD Study Pathologists Consortium, Smolko C, Arora M, Siegel JJ, Duits LC, Critchley-Thorne RJ, Bergman JJGHM
Gastroenterology 2023 Nov;165(5):1168-1179.e6. Epub 2023 Aug 30 doi: 10.1053/j.gastro.2023.07.029. PMID: 37657759
Tiftikci NTKA, Cicek B
Eur Rev Med Pharmacol Sci 2022 Aug;26(16):5884-5889. doi: 10.26355/eurrev_202208_29527. PMID: 36066163
Harrison M, Allen JE, Gorrepati VS, López-Jamar JME, Sharma P
Dis Esophagus 2018 Apr 1;31(4) doi: 10.1093/dote/doy004. PMID: 29506235
Akın H, Aydın Y
Turk J Gastroenterol 2017 Dec;28(Suppl 1):S26-S30. doi: 10.5152/tjg.2017.08. PMID: 29199163
Sharma P, Montgomery E
Pathology 2013 Apr;45(3):273-85. doi: 10.1097/PAT.0b013e32835f21d7. PMID: 23442738

Recent systematic reviews

Codipilly DC, Krishna Chandar A, Wang KK, Katzka DA, Goldblum JR, Thota PN, Falk GW, Chak A, Iyer PG
Gastrointest Endosc 2022 Jan;95(1):51-59.e7. Epub 2021 Sep 17 doi: 10.1016/j.gie.2021.09.015. PMID: 34543648Free PMC Article
Sawas T, Majzoub AM, Haddad J, Tielleman T, Nayfeh T, Yadlapati R, Singh S, Kolb J, Vajravelu RK, Katzka DA, Wani S; Post-Endoscopy Esophageal Adenocarcinoma Consensus Panel
Clin Gastroenterol Hepatol 2022 Feb;20(2):e31-e50. Epub 2021 Apr 23 doi: 10.1016/j.cgh.2021.04.032. PMID: 33901662Free PMC Article
Visrodia K, Singh S, Krishnamoorthi R, Ahlquist DA, Wang KK, Iyer PG, Katzka DA
Aliment Pharmacol Ther 2016 Oct;44(8):775-84. Epub 2016 Aug 26 doi: 10.1111/apt.13783. PMID: 27562355
Almond LM, Hodson J, Barr H
Br J Surg 2014 Sep;101(10):1187-95. Epub 2014 Jun 25 doi: 10.1002/bjs.9573. PMID: 24965075
Singh S, Manickam P, Amin AV, Samala N, Schouten LJ, Iyer PG, Desai TK
Gastrointest Endosc 2014 Jun;79(6):897-909.e4; quiz 983.e1, 983.e3. Epub 2014 Feb 17 doi: 10.1016/j.gie.2014.01.009. PMID: 24556051

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