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Esophageal High Grade Intraepithelial Neoplasia

MedGen UID:
232161
•Concept ID:
C1333450
•
Neoplastic Process
Synonyms: Esophageal High-Grade Dysplasia; Esophageal High-Grade Intraepithelial Neoplasia

Definition

A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa. It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia). (WHO, 2000) [from NCI]

Professional guidelines

PubMed

Updated German guideline on diagnosis and treatment of squamous cell carcinoma and adenocarcinoma of the esophagus.
Porschen R, Fischbach W, Gockel I, Hollerbach S, Hölscher A, Jansen PL, Miehlke S, Pech O, Stahl M, Vanhoefer U, Ebert MPA
United European Gastroenterol J 2024 Apr;12(3):399-411. Epub 2024 Jan 29 doi: 10.1002/ueg2.12523. PMID: 38284661Free PMC Article
Preventive Treatment with PD-1 Antibody Increases Tissue-resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis.
Xiao Z, Yan R, Liu H, Huang X, Liang Z, An G, Ge Y
Cancer Prev Res (Phila) 2023 Dec 1;16(12):669-679. doi: 10.1158/1940-6207.CAPR-23-0196. PMID: 37857481Free PMC Article
Biological correlates before esophageal cancer screening and after diagnosis.
Zhu J, Ma S, Chen R, Xie S, Liu Z, Li X, Wei W
Sci Rep 2021 Aug 23;11(1):17015. doi: 10.1038/s41598-021-96548-5. PMID: 34426626Free PMC Article

Recent clinical studies

Etiology

Presence of pink-color sign within 1 min after iodine staining has high diagnostic accordance rate for esophageal high-grade intraepithelial neoplasia/invasive cancer.
Zheng JY, Chen YH, Chen YY, Zheng XL, Zhong SS, Deng WY, Zheng JH, Guo XB, Gao LY, Liang W
Saudi J Gastroenterol 2019 Mar-Apr;25(2):113-118. doi: 10.4103/sjg.SJG_274_18. PMID: 30588952Free PMC Article
Endoscopic and Histopathology Characteristics in Patients with Esophageal High-Grade Intraepithelial Neoplasia.
Sang HM, Cao JL, Soyfoo MD, Zhang WM, Jiang JX, Xu SF
Dig Surg 2019;36(5):384-393. Epub 2018 Jun 26 doi: 10.1159/000490112. PMID: 29945127
A randomized trial comparing multiband mucosectomy and cap-assisted endoscopic resection for endoscopic piecemeal resection of early squamous neoplasia of the esophagus.
Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Diagnosis

Presence of pink-color sign within 1 min after iodine staining has high diagnostic accordance rate for esophageal high-grade intraepithelial neoplasia/invasive cancer.
Zheng JY, Chen YH, Chen YY, Zheng XL, Zhong SS, Deng WY, Zheng JH, Guo XB, Gao LY, Liang W
Saudi J Gastroenterol 2019 Mar-Apr;25(2):113-118. doi: 10.4103/sjg.SJG_274_18. PMID: 30588952Free PMC Article
Endoscopic and Histopathology Characteristics in Patients with Esophageal High-Grade Intraepithelial Neoplasia.
Sang HM, Cao JL, Soyfoo MD, Zhang WM, Jiang JX, Xu SF
Dig Surg 2019;36(5):384-393. Epub 2018 Jun 26 doi: 10.1159/000490112. PMID: 29945127
A randomized trial comparing multiband mucosectomy and cap-assisted endoscopic resection for endoscopic piecemeal resection of early squamous neoplasia of the esophagus.
Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article
Quantitative analysis of the color change after iodine staining for diagnosing esophageal high-grade intraepithelial neoplasia and invasive cancer.
Ishihara R, Yamada T, Iishi H, Kato M, Yamamoto S, Yamamoto S, Masuda E, Tatsumi K, Takeuchi Y, Higashino K, Uedo N, Tatsuta M, Ishiguro S
Gastrointest Endosc 2009 Feb;69(2):213-8. Epub 2008 Aug 20 doi: 10.1016/j.gie.2008.04.052. PMID: 18718584
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Therapy

A randomized trial comparing multiband mucosectomy and cap-assisted endoscopic resection for endoscopic piecemeal resection of early squamous neoplasia of the esophagus.
Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article

Prognosis

A randomized trial comparing multiband mucosectomy and cap-assisted endoscopic resection for endoscopic piecemeal resection of early squamous neoplasia of the esophagus.
Zhang YM, Boerwinkel DF, Qin X, He S, Xue L, Weusten BL, Dawsey SM, Fleischer DE, Dou LZ, Liu Y, Lu N, Bergman JJ, Wang GQ
Endoscopy 2016 Apr;48(4):330-8. Epub 2015 Nov 6 doi: 10.1055/s-0034-1393358. PMID: 26545174Free PMC Article
Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

Clinical prediction guides

Detection and endoscopic therapy of early esophageal adenocarcinoma.
Seewald S, Ang TL, Groth S, Zhong Y, Bertschinger P, Altorfer J, Thonke F, Soehendra N
Curr Opin Gastroenterol 2008 Jul;24(4):521-9. doi: 10.1097/MOG.0b013e3282ff8b1f. PMID: 18622170

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