U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Follicular Lymphoma with Predominantly Diffuse Growth Pattern

MedGen UID:
234201
•Concept ID:
C1333290
•
Neoplastic Process
Synonyms: Diffuse follicle center lymphoma; Diffuse Follicle Centre Lymphoma; Diffuse Follicular Lymphoma; Follicle Centre Lymphoma Diffuse
SNOMED CT: Diffuse follicle center lymphoma (449220000)

Definition

A lymphoma with the morphologic and immunophenotypic features of a follicular lymphoma characterized by the presence of a diffuse growth pattern with only focal and usually small micronodular foci. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFollicular Lymphoma with Predominantly Diffuse Growth Pattern

Recent clinical studies

Etiology

Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene.
Schmidt J, Gong S, Marafioti T, Mankel B, Gonzalez-Farre B, Balagué O, Mozos A, Cabeçadas J, van der Walt J, Hoehn D, Rosenwald A, Ott G, Dojcinov S, Egan C, Nadeu F, Ramis-Zaldívar JE, Clot G, Bárcena C, Pérez-Alonso V, Endris V, Penzel R, Lome-Maldonado C, Bonzheim I, Fend F, Campo E, Jaffe ES, Salaverria I, Quintanilla-Martinez L
Blood 2016 Aug 25;128(8):1101-11. Epub 2016 Jun 2 doi: 10.1182/blood-2016-03-703819. PMID: 27257180Free PMC Article

Diagnosis

Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations.
Siddiqi IN, Friedman J, Barry-Holson KQ, Ma C, Thodima V, Kang I, Padmanabhan R, Dias LM, Kelly KR, Brynes RK, Kamalakaran S, Houldsworth J
Mod Pathol 2016 Jun;29(6):570-81. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.51. PMID: 26965583
Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma.
Chiu A, Frizzera G, Mathew S, Hyjek EM, Chadburn A, Tam W, Knowles DM, Orazi A
Mod Pathol 2009 Nov;22(11):1507-17. Epub 2009 Jul 24 doi: 10.1038/modpathol.2009.106. PMID: 19633642
Focal follicular features in tonsillar diffuse large B-cell lymphomas: follicular lymphoma with diffuse areas or follicular colonization.
Ree HJ, Kikuchi M, Lee SS, Ohshima K, Yang WI, Ko YH, Cho EY, Rhee JC
Hum Pathol 2002 Jul;33(7):732-40. doi: 10.1053/hupa.2002.125371. PMID: 12196925
Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathologic study of 26 cases.
Shia J, Teruya-Feldstein J, Pan D, Hegde A, Klimstra DS, Chaganti RS, Qin J, Portlock CS, Filippa DA
Am J Surg Pathol 2002 Feb;26(2):216-24. doi: 10.1097/00000478-200202000-00008. PMID: 11812943
Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse.
Swerdlow SH, Habeshaw JA, Murray LJ, Dhaliwal HS, Lister TA, Stansfeld AG
Am J Pathol 1983 Nov;113(2):181-97. PMID: 6416075Free PMC Article

Therapy

Does a diffuse growth pattern predict for survival in patients with low-grade follicular lymphoma?
Bhagavathi S, Gu K, Loberiza FR, Bast M, Vose JM, Weisenburger DD
Leuk Lymphoma 2009 Jun;50(6):900-3. doi: 10.1080/10428190902919192. PMID: 19504394
Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathologic study of 26 cases.
Shia J, Teruya-Feldstein J, Pan D, Hegde A, Klimstra DS, Chaganti RS, Qin J, Portlock CS, Filippa DA
Am J Surg Pathol 2002 Feb;26(2):216-24. doi: 10.1097/00000478-200202000-00008. PMID: 11812943

Prognosis

Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease.
Nann D, Ramis-Zaldivar JE, Müller I, Gonzalez-Farre B, Schmidt J, Egan C, Salmeron-Villalobos J, Clot G, Mattern S, Otto F, Mankel B, Colomer D, Balagué O, Szablewski V, Lome-Maldonado C, Leoncini L, Dojcinov S, Chott A, Copie-Bergman C, Bonzheim I, Fend F, Jaffe ES, Campo E, Salaverria I, Quintanilla-Martinez L
Blood Adv 2020 Nov 24;4(22):5652-5665. doi: 10.1182/bloodadvances.2020002944. PMID: 33211828Free PMC Article
Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma.
Chiu A, Frizzera G, Mathew S, Hyjek EM, Chadburn A, Tam W, Knowles DM, Orazi A
Mod Pathol 2009 Nov;22(11):1507-17. Epub 2009 Jul 24 doi: 10.1038/modpathol.2009.106. PMID: 19633642
Does a diffuse growth pattern predict for survival in patients with low-grade follicular lymphoma?
Bhagavathi S, Gu K, Loberiza FR, Bast M, Vose JM, Weisenburger DD
Leuk Lymphoma 2009 Jun;50(6):900-3. doi: 10.1080/10428190902919192. PMID: 19504394
Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. A multiparameter study of 18 cases at diagnosis and relapse.
Swerdlow SH, Habeshaw JA, Murray LJ, Dhaliwal HS, Lister TA, Stansfeld AG
Am J Pathol 1983 Nov;113(2):181-97. PMID: 6416075Free PMC Article

Clinical prediction guides

Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene.
Schmidt J, Gong S, Marafioti T, Mankel B, Gonzalez-Farre B, Balagué O, Mozos A, Cabeçadas J, van der Walt J, Hoehn D, Rosenwald A, Ott G, Dojcinov S, Egan C, Nadeu F, Ramis-Zaldívar JE, Clot G, Bárcena C, Pérez-Alonso V, Endris V, Penzel R, Lome-Maldonado C, Bonzheim I, Fend F, Campo E, Jaffe ES, Salaverria I, Quintanilla-Martinez L
Blood 2016 Aug 25;128(8):1101-11. Epub 2016 Jun 2 doi: 10.1182/blood-2016-03-703819. PMID: 27257180Free PMC Article
Characterization of a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations.
Siddiqi IN, Friedman J, Barry-Holson KQ, Ma C, Thodima V, Kang I, Padmanabhan R, Dias LM, Kelly KR, Brynes RK, Kamalakaran S, Houldsworth J
Mod Pathol 2016 Jun;29(6):570-81. Epub 2016 Mar 11 doi: 10.1038/modpathol.2016.51. PMID: 26965583
Does a diffuse growth pattern predict for survival in patients with low-grade follicular lymphoma?
Bhagavathi S, Gu K, Loberiza FR, Bast M, Vose JM, Weisenburger DD
Leuk Lymphoma 2009 Jun;50(6):900-3. doi: 10.1080/10428190902919192. PMID: 19504394
Primary follicular lymphoma of the gastrointestinal tract: a clinical and pathologic study of 26 cases.
Shia J, Teruya-Feldstein J, Pan D, Hegde A, Klimstra DS, Chaganti RS, Qin J, Portlock CS, Filippa DA
Am J Surg Pathol 2002 Feb;26(2):216-24. doi: 10.1097/00000478-200202000-00008. PMID: 11812943
Ileal lymphoma in swine.
Tanimoto T, Minami A, Yano S, Ohtsuki Y
Vet Pathol 1994 Nov;31(6):629-36. doi: 10.1177/030098589403100601. PMID: 7863577

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...