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Deep Penetrating Nevus

MedGen UID:
234196
•Concept ID:
C1333268
•
Neoplastic Process
Synonym: Deep penetrating nevus
SNOMED CT: Deep penetrating nevus (1295375009)

Definition

A distinctive melanocytic nevus characterized by a sharply demarcated, circumscribed, and usually wedge-shaped configuration, with the base toward the epidermis and the tip toward the reticular dermis and subcutis. It may simulate melanoma both clinically and histologically. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDeep Penetrating Nevus

Professional guidelines

PubMed

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Blue nevus: classical types and new related entities. A differential diagnostic review.
González-Cámpora R, Galera-Davidson H, Vázquez-Ramírez FJ, Díaz-Cano S
Pathol Res Pract 1994 Jun;190(6):627-35. doi: 10.1016/S0344-0338(11)80402-4. PMID: 7984522

Recent clinical studies

Etiology

Clinical, Morphologic, and Molecular Features of Benign and Intermediate-grade Melanocytic Tumors With Activating Mutations in MAP2K1.
Fumero-Velázquez M, Hagstrom M, Dhillon S, Geraminejad T, Olivares S, Donati M, Nosek D, Waldenbäck P, Kazakov D, Sheffield BS, Tron VA, Gerami P
Am J Surg Pathol 2023 Dec 1;47(12):1438-1448. Epub 2023 Sep 29 doi: 10.1097/PAS.0000000000002131. PMID: 37773074
Deep-penetrating-nevus-like melanoma arising in patients with familial adenomatous polyposis syndrome.
Russell-Goldman E, MacConaill L, Laga AC, Hanna J
J Cutan Pathol 2023 Sep;50(9):801-805. Epub 2023 Feb 6 doi: 10.1111/cup.14393. PMID: 36688401
Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK.
Oulès B, Mourah S, Baroudjian B, Jouenne F, Delyon J, Louveau B, Gruber A, Lebbé C, Battistella M
Virchows Arch 2022 Feb;480(2):475-480. Epub 2021 May 20 doi: 10.1007/s00428-021-03119-0. PMID: 34013383
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article

Diagnosis

PRAME and LEF1 in Combined Deep Penetrating Nevus and Combined Blue Nevus: Utility and Pitfalls.
Vanderbeck K, Rothrock AT, Cho WC, Nagarajan P, Aung PP, Hudgens C, Bassett RL, Ivan D, Prieto VG, Curry JL, Torres-Cabala CA
Am J Dermatopathol 2023 Aug 1;45(8):549-556. Epub 2023 Jul 11 doi: 10.1097/DAD.0000000000002488. PMID: 37462205Free PMC Article
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
The deep penetrating nevus.
Strazzula L, Senna MM, Yasuda M, Belazarian L
J Am Acad Dermatol 2014 Dec;71(6):1234-40. Epub 2014 Aug 28 doi: 10.1016/j.jaad.2014.07.026. PMID: 25175710
Deep penetrating nevus.
Mehregan DA, Mehregan AH
Arch Dermatol 1993 Mar;129(3):328-31. PMID: 8447669

Therapy

Molecular analysis of atypical deep penetrating nevus progressing to melanoma.
Isales MC, Khan AU, Zhang B, Compres EV, Kim D, Tan TL, Beaubier N, Gerami P
J Cutan Pathol 2020 Dec;47(12):1150-1154. Epub 2020 Jul 6 doi: 10.1111/cup.13775. PMID: 32526042
Is melanocytic nevus with focal atypical epithelioid components (clonal nevus) a superficial variant of deep penetrating nevus?
High WA, Alanen KW, Golitz LE
J Am Acad Dermatol 2006 Sep;55(3):460-6. doi: 10.1016/j.jaad.2006.04.054. PMID: 16908352

Prognosis

Molecular characterization of biphenotypic epithelioid and plexiform melanoma with deep penetrating nevus-like features.
Giubellino A, Nelson AC, He Y, Munro SA, Song KY, Glitza Oliva IC, Torres-Cabala C
Pigment Cell Melanoma Res 2022 Mar;35(2):229-237. Epub 2021 Oct 27 doi: 10.1111/pcmr.13017. PMID: 34633770
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Morphologic clues and utility of fluorescence in situ hybridization for the diagnosis of nevoid melanoma.
Yélamos O, Busam KJ, Lee C, Meldi Sholl L, Amin SM, Merkel EA, Obregon R, Guitart J, Gerami P
J Cutan Pathol 2015 Nov;42(11):796-806. Epub 2015 Oct 12 doi: 10.1111/cup.12627. PMID: 26356543

Clinical prediction guides

Molecular characterization of biphenotypic epithelioid and plexiform melanoma with deep penetrating nevus-like features.
Giubellino A, Nelson AC, He Y, Munro SA, Song KY, Glitza Oliva IC, Torres-Cabala C
Pigment Cell Melanoma Res 2022 Mar;35(2):229-237. Epub 2021 Oct 27 doi: 10.1111/pcmr.13017. PMID: 34633770
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Loss of dipeptidyl peptidase IV immunostaining discriminates malignant melanomas from deep penetrating nevi.
Roesch A, Wittschier S, Becker B, Landthaler M, Vogt T
Mod Pathol 2006 Oct;19(10):1378-85. Epub 2006 Jul 7 doi: 10.1038/modpathol.3800663. PMID: 16829852
Linear arrangement of multiple deep penetrating nevi: report of first case and review of literature.
Hassan AS, Schulte KW, Ruzicka T, Megahed M
Arch Dermatol 2003 Dec;139(12):1608-10. doi: 10.1001/archderm.139.12.1608. PMID: 14676079
Deep penetrating nevus.
Mehregan DA, Mehregan AH
Arch Dermatol 1993 Mar;129(3):328-31. PMID: 8447669

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