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Mucocutaneous leishmaniasis

MedGen UID:
233065
•Concept ID:
C1328252
•
Disease or Syndrome
Synonyms: Leishmaniases, Mucocutaneous; Leishmaniasis, Mucocutaneous; Mucocutaneous Leishmaniases; Mucocutaneous Leishmaniasis
SNOMED CT: Mucocutaneous infection caused by Leishmania (721813000); Mucocutaneous leishmaniasis (721813000)
 
Monarch Initiative: MONDO:0005859

Definition

The most common form of leishmaniasis that is transmitted through the bite of female phlebotomine sand flies or after exposure to leishmania parasites. It is characterized by skin lesions at the site of insect bite which typically develop within weeks or months after exposure. The lesions typically progress from small papules to open sores with raised borders and central ulcers which can be covered with scales or crust. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucocutaneous leishmaniasis

Professional guidelines

PubMed

Treatment of mucocutaneous leishmaniasis - A systematic review.
Fischer T, Fischer M, Schliemann S, Elsner P
J Dtsch Dermatol Ges 2024 Jun;22(6):763-773. Epub 2024 May 20 doi: 10.1111/ddg.15424. PMID: 38769082
Exploring Innovative Leishmaniasis Treatment: Drug Targets from Pre-Clinical to Clinical Findings.
Santana W, de Oliveira SSC, Ramos MH, Santos ALS, Dolabella SS, Souto EB, Severino P, Jain S
Chem Biodivers 2021 Sep;18(9):e2100336. Epub 2021 Aug 9 doi: 10.1002/cbdv.202100336. PMID: 34369662
Current and emerging medications for the treatment of leishmaniasis.
Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412

Recent clinical studies

Etiology

Human genetic polymorphism and Leishmaniasis.
Bharati K
Infect Genet Evol 2022 Mar;98:105203. Epub 2022 Jan 4 doi: 10.1016/j.meegid.2021.105203. PMID: 34990851
Some Scaffolds as Anti-leishmanial Agents: A Review.
Mahender T, Pankaj W, Kumar SP, Ankur V, Kumar SS
Mini Rev Med Chem 2022;22(5):743-757. doi: 10.2174/1389557521666210913115116. PMID: 34517799
Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives.
Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA
J Am Acad Dermatol 2015 Dec;73(6):897-908; quiz 909-10. doi: 10.1016/j.jaad.2014.08.051. PMID: 26568335
An update on pharmacotherapy for leishmaniasis.
Sundar S, Chakravarty J
Expert Opin Pharmacother 2015 Feb;16(2):237-52. Epub 2014 Oct 25 doi: 10.1517/14656566.2015.973850. PMID: 25346016Free PMC Article
Cutaneous and mucocutaneous leishmaniasis.
David CV, Craft N
Dermatol Ther 2009 Nov-Dec;22(6):491-502. doi: 10.1111/j.1529-8019.2009.01272.x. PMID: 19889134

Diagnosis

Lingual Mucocutaneous Leishmaniasis.
Sanz Sánchez CI, Rodríguez Pastor E, Cabanás Vega R
Acta Otorrinolaringol Esp (Engl Ed) 2021 Nov-Dec;72(6):403-404. doi: 10.1016/j.otoeng.2021.02.001. PMID: 34844681
Mucocutaneous leishmaniasis (espundia).
Roca B, Roca M
Postgrad Med J 2020 Dec;96(1142):789. Epub 2020 Feb 29 doi: 10.1136/postgradmedj-2019-137465. PMID: 32114490
Real-time PCR applications for diagnosis of leishmaniasis.
Galluzzi L, Ceccarelli M, Diotallevi A, Menotta M, Magnani M
Parasit Vectors 2018 May 2;11(1):273. doi: 10.1186/s13071-018-2859-8. PMID: 29716641Free PMC Article
Leishmaniasis.
Herwaldt BL
Lancet 1999 Oct 2;354(9185):1191-9. doi: 10.1016/S0140-6736(98)10178-2. PMID: 10513726
Leishmaniasis.
Grevelink SA, Lerner EA
J Am Acad Dermatol 1996 Feb;34(2 Pt 1):257-72. doi: 10.1016/s0190-9622(96)80121-6. PMID: 8642091

Therapy

Some Scaffolds as Anti-leishmanial Agents: A Review.
Mahender T, Pankaj W, Kumar SP, Ankur V, Kumar SS
Mini Rev Med Chem 2022;22(5):743-757. doi: 10.2174/1389557521666210913115116. PMID: 34517799
Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives.
Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA
J Am Acad Dermatol 2015 Dec;73(6):897-908; quiz 909-10. doi: 10.1016/j.jaad.2014.08.051. PMID: 26568335
An update on pharmacotherapy for leishmaniasis.
Sundar S, Chakravarty J
Expert Opin Pharmacother 2015 Feb;16(2):237-52. Epub 2014 Oct 25 doi: 10.1517/14656566.2015.973850. PMID: 25346016Free PMC Article
Cutaneous and mucocutaneous leishmaniasis.
David CV, Craft N
Dermatol Ther 2009 Nov-Dec;22(6):491-502. doi: 10.1111/j.1529-8019.2009.01272.x. PMID: 19889134
Leishmaniasis.
Herwaldt BL
Lancet 1999 Oct 2;354(9185):1191-9. doi: 10.1016/S0140-6736(98)10178-2. PMID: 10513726

Prognosis

Leishmaniasis and Trace Element Alterations: a Systematic Review.
Taghipour A, Abdoli A, Ramezani A, Abolghazi A, Mofazzal Jahromi MA, Maani S, Heidar Nejadi SM, Rasti S, Shams M, Ghasemi E
Biol Trace Elem Res 2021 Oct;199(10):3918-3938. Epub 2021 Jan 6 doi: 10.1007/s12011-020-02505-0. PMID: 33405078
Mucocutaneous leishmaniasis (espundia).
Roca B, Roca M
Postgrad Med J 2020 Dec;96(1142):789. Epub 2020 Feb 29 doi: 10.1136/postgradmedj-2019-137465. PMID: 32114490
Current and emerging medications for the treatment of leishmaniasis.
Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412
Cutaneous and mucocutaneous leishmaniasis: Differential diagnosis, diagnosis, histopathology, and management.
Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA
J Am Acad Dermatol 2015 Dec;73(6):911-26; 927-8. doi: 10.1016/j.jaad.2014.09.014. PMID: 26568336
Cutaneous and mucocutaneous leishmaniasis: Clinical perspectives.
Handler MZ, Patel PA, Kapila R, Al-Qubati Y, Schwartz RA
J Am Acad Dermatol 2015 Dec;73(6):897-908; quiz 909-10. doi: 10.1016/j.jaad.2014.08.051. PMID: 26568335

Clinical prediction guides

Some Scaffolds as Anti-leishmanial Agents: A Review.
Mahender T, Pankaj W, Kumar SP, Ankur V, Kumar SS
Mini Rev Med Chem 2022;22(5):743-757. doi: 10.2174/1389557521666210913115116. PMID: 34517799
Mechanisms of Immunopathogenesis in Cutaneous Leishmaniasis And Post Kala-azar Dermal Leishmaniasis (PKDL).
Volpedo G, Pacheco-Fernandez T, Holcomb EA, Cipriano N, Cox B, Satoskar AR
Front Cell Infect Microbiol 2021;11:685296. Epub 2021 Jun 8 doi: 10.3389/fcimb.2021.685296. PMID: 34169006Free PMC Article
Leishmaniasis and Trace Element Alterations: a Systematic Review.
Taghipour A, Abdoli A, Ramezani A, Abolghazi A, Mofazzal Jahromi MA, Maani S, Heidar Nejadi SM, Rasti S, Shams M, Ghasemi E
Biol Trace Elem Res 2021 Oct;199(10):3918-3938. Epub 2021 Jan 6 doi: 10.1007/s12011-020-02505-0. PMID: 33405078
Current and emerging medications for the treatment of leishmaniasis.
Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412
Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendations.
Monge-Maillo B, López-Vélez R
Clin Infect Dis 2015 May 1;60(9):1398-404. Epub 2015 Jan 18 doi: 10.1093/cid/civ004. PMID: 25601455

Recent systematic reviews

Treatment of mucocutaneous leishmaniasis - A systematic review.
Fischer T, Fischer M, Schliemann S, Elsner P
J Dtsch Dermatol Ges 2024 Jun;22(6):763-773. Epub 2024 May 20 doi: 10.1111/ddg.15424. PMID: 38769082
Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review.
Nuwangi H, Agampodi TC, Price HP, Shepherd T, Weerakoon KG, Agampodi SB
PLoS Negl Trop Dis 2023 Dec;17(12):e0011818. Epub 2023 Dec 28 doi: 10.1371/journal.pntd.0011818. PMID: 38153950Free PMC Article
Leishmaniasis and Trace Element Alterations: a Systematic Review.
Taghipour A, Abdoli A, Ramezani A, Abolghazi A, Mofazzal Jahromi MA, Maani S, Heidar Nejadi SM, Rasti S, Shams M, Ghasemi E
Biol Trace Elem Res 2021 Oct;199(10):3918-3938. Epub 2021 Jan 6 doi: 10.1007/s12011-020-02505-0. PMID: 33405078
Interventions for American cutaneous and mucocutaneous leishmaniasis.
Pinart M, Rueda JR, Romero GA, Pinzón-Flórez CE, Osorio-Arango K, Silveira Maia-Elkhoury AN, Reveiz L, Elias VM, Tweed JA
Cochrane Database Syst Rev 2020 Aug 27;8(8):CD004834. doi: 10.1002/14651858.CD004834.pub3. PMID: 32853410Free PMC Article
Interventions for American cutaneous and mucocutaneous leishmaniasis: a systematic review update.
Reveiz L, Maia-Elkhoury AN, Nicholls RS, Romero GA, Yadon ZE
PLoS One 2013;8(4):e61843. Epub 2013 Apr 29 doi: 10.1371/journal.pone.0061843. PMID: 23637917Free PMC Article

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