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Malignant Thymoma

MedGen UID:
231175
Concept ID:
C1322286
Neoplastic Process
Synonyms: Malignant thymoma; Thymoma, malignant
SNOMED CT: Malignant thymoma (15949004); Thymoma, malignant (15949004); Malignant thymoma (444596001)

Definition

A thymoma that has an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize. Although any morphologic subtype of thymoma may eventually have a malignant clinical course, this term is most often associated with thymoma types B3 and C. [from NCI]

Professional guidelines

PubMed

Spaggiari L, Casiraghi M, Guarize J
Curr Opin Oncol 2012 Mar;24(2):117-22. doi: 10.1097/CCO.0b013e32834ea6bb. PMID: 22143371
Giaccone G
Curr Opin Oncol 2005 Mar;17(2):140-6. doi: 10.1097/01.cco.0000152628.43867.8e. PMID: 15725919
Cowen D, Hannoun-Levi JM, Resbeut M, Alzieu C
Oncology (Williston Park) 1998 Jul;12(7):1001-5; discussion 1006. PMID: 9684271

Recent clinical studies

Etiology

Nagano T, Kotani Y, Kobayashi K, Tomita N, Nakata K, Sakashita A, Funada Y, Nagai H, Itoh T, Nishimura Y
BMJ Case Rep 2011 May 10;2011 doi: 10.1136/bcr.03.2011.3936. PMID: 22696713Free PMC Article
Harris K, Elsayegh D, Azab B, Alkaied H, Chalhoub M
World J Surg Oncol 2011 Aug 23;9:95. doi: 10.1186/1477-7819-9-95. PMID: 21861913Free PMC Article
Karras A, de Montpreville V, Fakhouri F, Grünfeld JP, Lesavre P; Groupe d'Etudes des Néphropathies Associées aux Thymomes
Nephrol Dial Transplant 2005 Jun;20(6):1075-82. Epub 2005 Mar 23 doi: 10.1093/ndt/gfh615. PMID: 15788438
Cowen D, Hannoun-Levi JM, Resbeut M, Alzieu C
Oncology (Williston Park) 1998 Jul;12(7):1001-5; discussion 1006. PMID: 9684271
Gibson TC
Am Heart J 1975 Sep;90(3):389-96. doi: 10.1016/0002-8703(75)90330-0. PMID: 1099888

Diagnosis

Alexakou Z, Liatsos G, Vasileiou N, Vamvakaris I, Mani I, Alexopoulou A
Am J Med Sci 2021 Sep;362(3):324-330. Epub 2021 May 4 doi: 10.1016/j.amjms.2021.04.012. PMID: 33961845
Alothaimeen HS, Memon MA
Asian Pac J Cancer Prev 2020 Mar 1;21(3):653-661. doi: 10.31557/APJCP.2020.21.3.653. PMID: 32212790Free PMC Article
Harris K, Elsayegh D, Azab B, Alkaied H, Chalhoub M
World J Surg Oncol 2011 Aug 23;9:95. doi: 10.1186/1477-7819-9-95. PMID: 21861913Free PMC Article
McHayleh W, Kressel B, Nylen ES
South Med J 2005 Aug;98(8):836-8. doi: 10.1097/01.SMJ.0000163313.35350.79. PMID: 16144186
Warren WH
Semin Thorac Cardiovasc Surg 2000 Apr;12(2):119-29. doi: 10.1053/ct.2000.5078. PMID: 10807434

Therapy

Alexakou Z, Liatsos G, Vasileiou N, Vamvakaris I, Mani I, Alexopoulou A
Am J Med Sci 2021 Sep;362(3):324-330. Epub 2021 May 4 doi: 10.1016/j.amjms.2021.04.012. PMID: 33961845
Spaggiari L, Casiraghi M, Guarize J
Curr Opin Oncol 2012 Mar;24(2):117-22. doi: 10.1097/CCO.0b013e32834ea6bb. PMID: 22143371
Warren WH
Semin Thorac Cardiovasc Surg 2000 Apr;12(2):119-29. doi: 10.1053/ct.2000.5078. PMID: 10807434
Cowen D, Hannoun-Levi JM, Resbeut M, Alzieu C
Oncology (Williston Park) 1998 Jul;12(7):1001-5; discussion 1006. PMID: 9684271
Gibson TC
Am Heart J 1975 Sep;90(3):389-96. doi: 10.1016/0002-8703(75)90330-0. PMID: 1099888

Prognosis

Alexakou Z, Liatsos G, Vasileiou N, Vamvakaris I, Mani I, Alexopoulou A
Am J Med Sci 2021 Sep;362(3):324-330. Epub 2021 May 4 doi: 10.1016/j.amjms.2021.04.012. PMID: 33961845
Spaggiari L, Casiraghi M, Guarize J
Curr Opin Oncol 2012 Mar;24(2):117-22. doi: 10.1097/CCO.0b013e32834ea6bb. PMID: 22143371
Harris K, Elsayegh D, Azab B, Alkaied H, Chalhoub M
World J Surg Oncol 2011 Aug 23;9:95. doi: 10.1186/1477-7819-9-95. PMID: 21861913Free PMC Article
Giaccone G
Curr Opin Oncol 2005 Mar;17(2):140-6. doi: 10.1097/01.cco.0000152628.43867.8e. PMID: 15725919
Walker AN, Mills SE, Fechner RE
Semin Diagn Pathol 1990 Nov;7(4):250-65. PMID: 2284513

Clinical prediction guides

Alothaimeen HS, Memon MA
Asian Pac J Cancer Prev 2020 Mar 1;21(3):653-661. doi: 10.31557/APJCP.2020.21.3.653. PMID: 32212790Free PMC Article
Zhang Z, Wu B, Niu L, Mu F, Chen J, Li J, Zuo J, Xu K
Cryobiology 2013 Oct;67(2):170-4. Epub 2013 Jul 9 doi: 10.1016/j.cryobiol.2013.06.008. PMID: 23846104
Harris K, Elsayegh D, Azab B, Alkaied H, Chalhoub M
World J Surg Oncol 2011 Aug 23;9:95. doi: 10.1186/1477-7819-9-95. PMID: 21861913Free PMC Article
Lee BW, Ihm SH, Shin HS, Yoo HJ
Intern Med 2008;47(11):1009-12. Epub 2008 Jun 2 doi: 10.2169/internalmedicine.47.0838. PMID: 18520111
Karras A, de Montpreville V, Fakhouri F, Grünfeld JP, Lesavre P; Groupe d'Etudes des Néphropathies Associées aux Thymomes
Nephrol Dial Transplant 2005 Jun;20(6):1075-82. Epub 2005 Mar 23 doi: 10.1093/ndt/gfh615. PMID: 15788438

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