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Aspirin-induced asthma

MedGen UID:
230819
•Concept ID:
C1319853
•
Disease or Syndrome; Finding
Synonyms: Aspirin Induced Asthma; Aspirin Induced Asthma Syndrome; Aspirin Induced Asthmas; Aspirin-Induced Asthma; Aspirin-Induced Asthma Syndrome; Aspirin-Induced Asthma Syndromes; Aspirin-Induced Asthmas; Asthma Syndrome, Aspirin-Induced; Asthma Syndromes, Aspirin-Induced; Asthma, Aspirin Induced; Asthma, Aspirin-Induced; Asthma, NSAID induced; Asthma, NSAID-induced; Asthmas, Aspirin Induced; Asthmas, Aspirin-Induced; Asthmas, NSAID-induced; Induced Asthma, Aspirin; Induced Asthmas, Aspirin; NSAID-induced Asthma; NSAID-induced Asthmas; Syndrome, Aspirin-Induced Asthma; Syndromes, Aspirin-Induced Asthma
SNOMED CT: Aspirin-induced asthma (407674008)
 
HPO: HP:0012042

Definition

A type of asthma in which aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) that inhibit cyclooxygen-ase 1 (COX-1) exacerbate bronchoconstriction. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAspirin-induced asthma

Conditions with this feature

Asthma, nasal polyps, and aspirin intolerance
MedGen UID:
347198
•Concept ID:
C1859648
•
Disease or Syndrome
See: Condition Record
Asthma, nasal polyps, and aspirin intolerance

Professional guidelines

PubMed

Current complications and treatment of aspirin-exacerbated respiratory disease.
Cook KA, Stevenson DD
Expert Rev Respir Med 2016 Dec;10(12):1305-1316. Epub 2016 Nov 17 doi: 10.1080/17476348.2016.1258306. PMID: 27817219
Management options for patients with aspirin and nonsteroidal antiinflammatory drug sensitivity.
Knowles SR, Drucker AM, Weber EA, Shear NH
Ann Pharmacother 2007 Jul;41(7):1191-200. Epub 2007 Jul 3 doi: 10.1345/aph.1K023. PMID: 17609236
Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management.
Szczeklik A, Stevenson DD
J Allergy Clin Immunol 2003 May;111(5):913-21; quiz 922. doi: 10.1067/mai.2003.1487. PMID: 12743549

Recent clinical studies

Etiology

The chronic rhinosinusitis practice parameter.
Kim SL, Rank MA, Peters AT
Ann Allergy Asthma Immunol 2023 Sep;131(3):307-310. Epub 2022 Dec 17 doi: 10.1016/j.anai.2022.12.022. PMID: 37667905
Recent Updates in Understanding NSAID Hypersensitivity.
Minaldi E, Cahill K
Curr Allergy Asthma Rep 2023 Mar;23(3):181-188. Epub 2023 Feb 9 doi: 10.1007/s11882-023-01064-3. PMID: 36757490
Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA
J Allergy Clin Immunol 2021 Mar;147(3):827-844. Epub 2020 Dec 9 doi: 10.1016/j.jaci.2020.10.043. PMID: 33307116Free PMC Article

Diagnosis

Recent Updates in Understanding NSAID Hypersensitivity.
Minaldi E, Cahill K
Curr Allergy Asthma Rep 2023 Mar;23(3):181-188. Epub 2023 Feb 9 doi: 10.1007/s11882-023-01064-3. PMID: 36757490
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA
J Allergy Clin Immunol 2021 Mar;147(3):827-844. Epub 2020 Dec 9 doi: 10.1016/j.jaci.2020.10.043. PMID: 33307116Free PMC Article
Understanding the immunology of asthma: Pathophysiology, biomarkers, and treatments for asthma endotypes.
Gans MD, Gavrilova T
Paediatr Respir Rev 2020 Nov;36:118-127. Epub 2019 Oct 9 doi: 10.1016/j.prrv.2019.08.002. PMID: 31678040
Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Niżankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzyńska A
Allergy 2019 Jan;74(1):28-39. Epub 2018 Oct 2 doi: 10.1111/all.13599. PMID: 30216468
Aspirin-Exacerbated Respiratory Disease.
Walgama ES, Hwang PH
Otolaryngol Clin North Am 2017 Feb;50(1):83-94. doi: 10.1016/j.otc.2016.08.007. PMID: 27888917

Therapy

Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM
J Allergy Clin Immunol 2021 Aug;148(2):574-584. Epub 2021 Jun 16 doi: 10.1016/j.jaci.2021.05.043. PMID: 34144111Free PMC Article
The role of aspirin desensitization followed by oral aspirin therapy in managing patients with aspirin-exacerbated respiratory disease: A Work Group Report from the Rhinitis, Rhinosinusitis and Ocular Allergy Committee of the American Academy of Allergy, Asthma & Immunology.
Stevens WW, Jerschow E, Baptist AP, Borish L, Bosso JV, Buchheit KM, Cahill KN, Campo P, Cho SH, Keswani A, Levy JM, Nanda A, Laidlaw TM, White AA
J Allergy Clin Immunol 2021 Mar;147(3):827-844. Epub 2020 Dec 9 doi: 10.1016/j.jaci.2020.10.043. PMID: 33307116Free PMC Article
Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper.
Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, Bonini M, Heffler E, Klimek L, Laidlaw TM, Mullol J, Niżankowska-Mogilnicka E, Park HS, Sanak M, Sanchez-Borges M, Sanchez-Garcia S, Scadding G, Taniguchi M, Torres MJ, White AA, Wardzyńska A
Allergy 2019 Jan;74(1):28-39. Epub 2018 Oct 2 doi: 10.1111/all.13599. PMID: 30216468
Aspirin-Exacerbated Respiratory Disease.
Walgama ES, Hwang PH
Otolaryngol Clin North Am 2017 Feb;50(1):83-94. doi: 10.1016/j.otc.2016.08.007. PMID: 27888917

Prognosis

Lower serum 15-HETE level predicts nasal ILC2 accumulation during COX-1 inhibition in AERD.
Badrani JH, Cavagnero K, Eastman JJ, Kim AS, Strohm A, Yan C, Deconde A, Zuraw BL, White AA, Christiansen SC, Doherty TA
J Allergy Clin Immunol 2023 Nov;152(5):1330-1335.e1. Epub 2023 Aug 3 doi: 10.1016/j.jaci.2023.06.028. PMID: 37543185Free PMC Article
Inflammatory heterogeneity in aspirin-exacerbated respiratory disease.
Scott WC, Cahill KN, Milne GL, Li P, Sheng Q, Huang LC, Dennis S, Snyder J, Bauer AM, Chandra RK, Chowdhury NI, Turner JH
J Allergy Clin Immunol 2021 Apr;147(4):1318-1328.e5. Epub 2020 Nov 12 doi: 10.1016/j.jaci.2020.11.001. PMID: 33189729Free PMC Article
Asthma pharmacotherapy: an update on leukotriene treatments.
Trinh HKT, Lee SH, Cao TBT, Park HS
Expert Rev Respir Med 2019 Dec;13(12):1169-1178. Epub 2019 Sep 26 doi: 10.1080/17476348.2019.1670640. PMID: 31544544
Potential Biomarkers for NSAID-Exacerbated Respiratory Disease.
Park H, Choi Y, Jung CG, Park HS
Mediators Inflamm 2017;2017:8160148. Epub 2017 Aug 9 doi: 10.1155/2017/8160148. PMID: 28852271Free PMC Article
Upper airways in aspirin-exacerbated respiratory disease.
Choi JH, Kim JH, Park HS
Curr Opin Allergy Clin Immunol 2015 Feb;15(1):21-6. doi: 10.1097/ACI.0000000000000122. PMID: 25546326

Clinical prediction guides

Lower serum 15-HETE level predicts nasal ILC2 accumulation during COX-1 inhibition in AERD.
Badrani JH, Cavagnero K, Eastman JJ, Kim AS, Strohm A, Yan C, Deconde A, Zuraw BL, White AA, Christiansen SC, Doherty TA
J Allergy Clin Immunol 2023 Nov;152(5):1330-1335.e1. Epub 2023 Aug 3 doi: 10.1016/j.jaci.2023.06.028. PMID: 37543185Free PMC Article
Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count.
Bachert C, Sousa AR, Han JK, Schlosser RJ, Sowerby LJ, Hopkins C, Maspero JF, Smith SG, Kante O, Karidi-Andrioti DE, Mayer B, Chan RH, Yancey SW, Chaker AM
J Allergy Clin Immunol 2022 May;149(5):1711-1721.e6. Epub 2022 Jan 7 doi: 10.1016/j.jaci.2021.10.040. PMID: 35007624
Asthma pharmacotherapy: an update on leukotriene treatments.
Trinh HKT, Lee SH, Cao TBT, Park HS
Expert Rev Respir Med 2019 Dec;13(12):1169-1178. Epub 2019 Sep 26 doi: 10.1080/17476348.2019.1670640. PMID: 31544544
Woakes' syndrome.
El Fakiri MM, Lakhdar Y, Raji A
BMJ Case Rep 2019 Mar 31;12(3) doi: 10.1136/bcr-2018-229021. PMID: 30936362Free PMC Article
Aspirin-sensitive asthma and upper airway diseases.
Chang JE, Chin W, Simon R
Am J Rhinol Allergy 2012 Jan-Feb;26(1):27-30. doi: 10.2500/ajra.2012.26.3721. PMID: 22391075Free PMC Article

Recent systematic reviews

Relationship Between Alcohol Intolerance and Aspirin-Exacerbated Respiratory Disease (AERD): Systematic Review.
Candelo E, McCalla M, Valderrama OA, Avila-Castano K, Chelf C, Olomu O, Donaldson AM
Otolaryngol Head Neck Surg 2023 Jul;169(1):12-20. Epub 2023 Jan 29 doi: 10.1002/ohn.248. PMID: 36939486
Management of United Airway Disease Focused on Patients With Asthma and Chronic Rhinosinusitis With Nasal Polyps: A Systematic Review.
Mullol J, Maldonado M, Castillo JA, Miguel-Blanco C, Dávila I, Domínguez-Ortega J, Blanco-Aparicio M
J Allergy Clin Immunol Pract 2022 Sep;10(9):2438-2447.e9. Epub 2022 May 12 doi: 10.1016/j.jaip.2022.04.039. PMID: 35568331
Meta-analysis Exploring Sinopulmonary Outcomes of Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease.
Chaaban MR, Moffatt D, Wright AE, Cowthran JA, Hsu ES, Kuo YF
Otolaryngol Head Neck Surg 2021 Jan;164(1):11-18. Epub 2020 Jun 23 doi: 10.1177/0194599820932137. PMID: 32571140
Aspirin desensitization therapy in aspirin-exacerbated respiratory disease: a systematic review.
Larivée N, Chin CJ
Int Forum Allergy Rhinol 2020 Apr;10(4):450-464. Epub 2020 Jan 16 doi: 10.1002/alr.22520. PMID: 31951112
Benefits and harms of aspirin desensitization for aspirin-exacerbated respiratory disease: a systematic review and meta-analysis.
Chu DK, Lee DJ, Lee KM, Schünemann HJ, Szczeklik W, Lee JM
Int Forum Allergy Rhinol 2019 Dec;9(12):1409-1419. Epub 2019 Sep 13 doi: 10.1002/alr.22428. PMID: 31518069

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