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Hepatic insufficiency

MedGen UID:
227013
•Concept ID:
C1306571
•
Pathologic Function
Synonyms: Hepatic Insufficiency; Insufficiency, Hepatic; Insufficiency, Liver; Liver Insufficiency
SNOMED CT: Hepatic insufficiency (59927004)

Definition

The inability of the liver to perform its normal synthetic and metabolic functions. [from NCI]

Professional guidelines

PubMed

Monitoring Treatment of Childhood Tuberculosis and the Role of Therapeutic Drug Monitoring.
Cruz AT, Starke JR
Indian J Pediatr 2019 Aug;86(8):732-739. Epub 2019 Feb 28 doi: 10.1007/s12098-019-02882-y. PMID: 30815840
Treatment of Coagulopathy Related to Hepatic Insufficiency.
Barton CA
Crit Care Med 2016 Oct;44(10):1927-33. doi: 10.1097/CCM.0000000000001998. PMID: 27635482
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Recent clinical studies

Etiology

Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.
LaPlante KL, Dhand A, Wright K, Lauterio M
Ann Med 2022 Dec;54(1):1686-1700. doi: 10.1080/07853890.2022.2085881. PMID: 35723082Free PMC Article
Clinical Pharmacokinetics of Daptomycin.
Gregoire N, Chauzy A, Buyck J, Rammaert B, Couet W, Marchand S
Clin Pharmacokinet 2021 Mar;60(3):271-281. Epub 2020 Dec 14 doi: 10.1007/s40262-020-00968-x. PMID: 33313994
Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations.
Wanleenuwat P, Suntharampillai N, Iwanowski P
Seizure 2020 Oct;81:167-174. Epub 2020 Aug 14 doi: 10.1016/j.seizure.2020.08.012. PMID: 32827980
Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents.
Garnock-Jones KP, Keating GM
Paediatr Drugs 2009;11(3):203-26. doi: 10.2165/00148581-200911030-00005. PMID: 19445548
Irinotecan toxicity.
Anthony L
Curr Opin Support Palliat Care 2007 Apr;1(1):35-9. doi: 10.1097/SPC.0b013e328133f2ad. PMID: 18660722

Diagnosis

Rapid Fire: Polypharmacy in the Geriatric Patient.
Martinelli AN
Emerg Med Clin North Am 2021 May;39(2):395-404. Epub 2021 Mar 11 doi: 10.1016/j.emc.2021.01.001. PMID: 33863467
Diagnosis of Budd-Chiari syndrome.
Van Wettere M, Bruno O, Rautou PE, Vilgrain V, Ronot M
Abdom Radiol (NY) 2018 Aug;43(8):1896-1907. doi: 10.1007/s00261-017-1447-2. PMID: 29285598
Liver transplantation for Wilson's disease.
Schilsky ML
Ann N Y Acad Sci 2014 May;1315:45-9. doi: 10.1111/nyas.12454. PMID: 24820352
Colorectal liver metastases.
Tzeng CW, Aloia TA
J Gastrointest Surg 2013 Jan;17(1):195-201; quiz p.201-2. Epub 2012 Oct 3 doi: 10.1007/s11605-012-2022-3. PMID: 23054896
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Therapy

Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance.
LaPlante KL, Dhand A, Wright K, Lauterio M
Ann Med 2022 Dec;54(1):1686-1700. doi: 10.1080/07853890.2022.2085881. PMID: 35723082Free PMC Article
Antibiotic-induced epileptic seizures: mechanisms of action and clinical considerations.
Wanleenuwat P, Suntharampillai N, Iwanowski P
Seizure 2020 Oct;81:167-174. Epub 2020 Aug 14 doi: 10.1016/j.seizure.2020.08.012. PMID: 32827980
Dose recommendations for anticancer drugs in patients with renal or hepatic impairment.
Krens SD, Lassche G, Jansman FGA, Desar IME, Lankheet NAG, Burger DM, van Herpen CML, van Erp NP
Lancet Oncol 2019 Apr;20(4):e200-e207. doi: 10.1016/S1470-2045(19)30145-7. PMID: 30942181
Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents.
Garnock-Jones KP, Keating GM
Paediatr Drugs 2009;11(3):203-26. doi: 10.2165/00148581-200911030-00005. PMID: 19445548
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Prognosis

Prophylaxis of hepatic encephalopathy: current and future drug targets.
Maharshi S, Sharma BC
Hepatol Int 2024 Aug;18(4):1096-1109. Epub 2024 Mar 16 doi: 10.1007/s12072-024-10647-9. PMID: 38492132
Glucagon-like peptide-1 and glucagon-like peptide-2 regulation during human liver regeneration.
Ammann M, Santol J, Pereyra D, Kalchbrenner T, Wuerger T, Laengle J, Smoot RL, Hulla W, Laengle F, Starlinger P
Sci Rep 2023 Sep 25;13(1):15980. doi: 10.1038/s41598-023-43283-8. PMID: 37749369Free PMC Article
Shear wave liver elastography.
Barr RG
Abdom Radiol (NY) 2018 Apr;43(4):800-807. doi: 10.1007/s00261-017-1375-1. PMID: 29116341
Irinotecan toxicity.
Anthony L
Curr Opin Support Palliat Care 2007 Apr;1(1):35-9. doi: 10.1097/SPC.0b013e328133f2ad. PMID: 18660722
Pathophysiology, diagnosis and treatment of ascites in cirrhosis.
Arroyo V
Ann Hepatol 2002 Apr-Jun;1(2):72-9. PMID: 15115971

Clinical prediction guides

Clinical Pharmacokinetics of Daptomycin.
Gregoire N, Chauzy A, Buyck J, Rammaert B, Couet W, Marchand S
Clin Pharmacokinet 2021 Mar;60(3):271-281. Epub 2020 Dec 14 doi: 10.1007/s40262-020-00968-x. PMID: 33313994
Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial.
Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, Cohen V, Filk N, Smith A, Huang F, Rockoff B, Homel P, Fromm C
Ann Emerg Med 2017 Aug;70(2):177-184. Epub 2016 Dec 16 doi: 10.1016/j.annemergmed.2016.10.014. PMID: 27993418
Atomoxetine: a review of its use in attention-deficit hyperactivity disorder in children and adolescents.
Garnock-Jones KP, Keating GM
Paediatr Drugs 2009;11(3):203-26. doi: 10.2165/00148581-200911030-00005. PMID: 19445548
Irinotecan toxicity.
Anthony L
Curr Opin Support Palliat Care 2007 Apr;1(1):35-9. doi: 10.1097/SPC.0b013e328133f2ad. PMID: 18660722
Brivaracetam (UCB 34714).
von Rosenstiel P
Neurotherapeutics 2007 Jan;4(1):84-7. doi: 10.1016/j.nurt.2006.11.004. PMID: 17199019Free PMC Article

Recent systematic reviews

Clinical outcomes of patients with hepatic insufficiency undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis.
Jiang W, Cheng Z, Tu S, Wang X, Xiang C, Zhou W, Chen L
BMC Cardiovasc Disord 2022 Feb 23;22(1):67. doi: 10.1186/s12872-022-02510-2. PMID: 35196988Free PMC Article
A systematic review and meta-analysis of the utility of repeated versus single hepatic resection for colorectal cancer liver metastases.
Wurster EF, Tenckhoff S, Probst P, Jensen K, Dölger E, Knebel P, Diener MK, Büchler MW, Ulrich A
HPB (Oxford) 2017 Jun;19(6):491-497. Epub 2017 Mar 25 doi: 10.1016/j.hpb.2017.02.440. PMID: 28347640
The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis.
Li H, Guo Y, Yang Z, Roy M, Guo Q
Burns 2016 Jun;42(4):717-27. Epub 2015 Oct 9 doi: 10.1016/j.burns.2015.08.023. PMID: 26454425
What is the evidence for the use of low-pressure pneumoperitoneum? A systematic review.
Özdemir-van Brunschot DM, van Laarhoven KC, Scheffer GJ, Pouwels S, Wever KE, Warlé MC
Surg Endosc 2016 May;30(5):2049-65. Epub 2015 Aug 15 doi: 10.1007/s00464-015-4454-9. PMID: 26275545Free PMC Article
Morbidity and mortality related to non-hepatic surgery in patients with liver cirrhosis: a systematic review.
de Goede B, Klitsie PJ, Lange JF, Metselaar HJ, Kazemier G
Best Pract Res Clin Gastroenterol 2012 Feb;26(1):47-59. doi: 10.1016/j.bpg.2012.01.010. PMID: 22482525

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