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Chronic venous insufficiency

MedGen UID:
727071
•Concept ID:
C1306557
•
Disease or Syndrome
Synonyms: chronic venous insufficiency; chronic venous insufficiency (disease); venous insufficiency (disease), chronic
SNOMED CT: Chronic venous insufficiency (20696009)
 
Monarch Initiative: MONDO:0000492

Definition

Chronic form of venous insufficiency (disease). [from MONDO]

Professional guidelines

PubMed

Chronic venous insufficiency: a comprehensive review of management.
Azar J, Rao A, Oropallo A
J Wound Care 2022 Jun 2;31(6):510-519. doi: 10.12968/jowc.2022.31.6.510. PMID: 35678787
Venous Ulcers: Diagnosis and Treatment.
Bonkemeyer Millan S, Gan R, Townsend PE
Am Fam Physician 2019 Sep 1;100(5):298-305. PMID: 31478635
Stasis Dermatitis: Pathophysiology, Evaluation, and Management.
Sundaresan S, Migden MR, Silapunt S
Am J Clin Dermatol 2017 Jun;18(3):383-390. doi: 10.1007/s40257-016-0250-0. PMID: 28063094

Recent clinical studies

Etiology

Chronic venous insufficiency: a comprehensive review of management.
Azar J, Rao A, Oropallo A
J Wound Care 2022 Jun 2;31(6):510-519. doi: 10.12968/jowc.2022.31.6.510. PMID: 35678787
Chronic venous insufficiency, cardiovascular disease, and mortality: a population study.
Prochaska JH, Arnold N, Falcke A, Kopp S, Schulz A, Buch G, Moll S, Panova-Noeva M, Jünger C, Eggebrecht L, Pfeiffer N, Beutel M, Binder H, Grabbe S, Lackner KJ, Ten Cate-Hoek A, Espinola-Klein C, Münzel T, Wild PS
Eur Heart J 2021 Oct 21;42(40):4157-4165. doi: 10.1093/eurheartj/ehab495. PMID: 34387673
Effects of preventive use of compression stockings for elderly with chronic venous insufficiency and swollen legs: a systematic review and meta-analysis.
Dahm KT, Myrhaug HT, Strømme H, Fure B, Brurberg KG
BMC Geriatr 2019 Mar 7;19(1):76. doi: 10.1186/s12877-019-1087-1. PMID: 30845919Free PMC Article
A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency.
Orr L, Klement KA, McCrossin L, O'Sullivan Drombolis D, Houghton PE, Spaulding S, Burke S
Ostomy Wound Manage 2017 Aug;63(8):30-43. doi: 10.25270/owm.2017.08.3043. PMID: 28873064
Management of lymphoedema.
Yüksel A, Gürbüz O, Velioğlu Y, Kumtepe G, Şenol S
Vasa 2016;45(4):283-91. doi: 10.1024/0301-1526/a000539. PMID: 27428496

Diagnosis

Peripheral Edema: Evaluation and Management in Primary Care.
Patel H, Skok C, DeMarco A
Am Fam Physician 2022 Nov;106(5):557-564. PMID: 36379502
Post-thrombotic syndrome.
Visonà A, Quere I, Mazzolai L, Amitrano M, Lugli M, Madaric J, Prandoni P; European Society of Vascular Medicine (ESVM)
Vasa 2021 Sep;50(5):331-340. Epub 2021 Mar 15 doi: 10.1024/0301-1526/a000946. PMID: 33720757
Chronic venous insufficiency and varicose veins of the lower extremities.
Youn YJ, Lee J
Korean J Intern Med 2019 Mar;34(2):269-283. Epub 2018 Oct 26 doi: 10.3904/kjim.2018.230. PMID: 30360023Free PMC Article
Chronic venous insufficiency - a review of pathophysiology, diagnosis, and treatment.
Santler B, Goerge T
J Dtsch Dermatol Ges 2017 May;15(5):538-556. doi: 10.1111/ddg.13242. PMID: 28485865
Chronic venous insufficiency.
Eberhardt RT, Raffetto JD
Circulation 2014 Jul 22;130(4):333-46. doi: 10.1161/CIRCULATIONAHA.113.006898. PMID: 25047584

Therapy

Balneotherapy for chronic venous insufficiency.
de Moraes Silva MA, Nakano LC, Cisneros LL, Miranda F Jr
Cochrane Database Syst Rev 2023 Jan 9;1(1):CD013085. doi: 10.1002/14651858.CD013085.pub3. PMID: 36622745Free PMC Article
Compression bandages or stockings versus no compression for treating venous leg ulcers.
Shi C, Dumville JC, Cullum N, Connaughton E, Norman G
Cochrane Database Syst Rev 2021 Jul 26;7(7):CD013397. doi: 10.1002/14651858.CD013397.pub2. PMID: 34308565Free PMC Article
Phlebotonics for venous insufficiency.
Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D, Uriona Tuma SM, Stein AT, Moreno Carriles RMM, Vargas E, Bonfill Cosp X
Cochrane Database Syst Rev 2020 Nov 3;11(11):CD003229. doi: 10.1002/14651858.CD003229.pub4. PMID: 33141449Free PMC Article
Effects of preventive use of compression stockings for elderly with chronic venous insufficiency and swollen legs: a systematic review and meta-analysis.
Dahm KT, Myrhaug HT, Strømme H, Fure B, Brurberg KG
BMC Geriatr 2019 Mar 7;19(1):76. doi: 10.1186/s12877-019-1087-1. PMID: 30845919Free PMC Article
Horse chestnut seed extract for chronic venous insufficiency.
Pittler MH, Ernst E
Cochrane Database Syst Rev 2012 Nov 14;11(11):CD003230. doi: 10.1002/14651858.CD003230.pub4. PMID: 23152216Free PMC Article

Prognosis

The TOPOS study.
Sebastian T, Barco S, Voci D, Lichtenberg M, Schlager O, Jalaie H, de Graaf R, Erbel C, Massmann A, Schindewolf M, Spirk D
Vasa 2024 May;53(3):217-224. Epub 2024 Mar 25 doi: 10.1024/0301-1526/a001118. PMID: 38525891
Chronic venous insufficiency, cardiovascular disease, and mortality: a population study.
Prochaska JH, Arnold N, Falcke A, Kopp S, Schulz A, Buch G, Moll S, Panova-Noeva M, Jünger C, Eggebrecht L, Pfeiffer N, Beutel M, Binder H, Grabbe S, Lackner KJ, Ten Cate-Hoek A, Espinola-Klein C, Münzel T, Wild PS
Eur Heart J 2021 Oct 21;42(40):4157-4165. doi: 10.1093/eurheartj/ehab495. PMID: 34387673
Diagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review.
Chopard R, Albertsen IE, Piazza G
JAMA 2020 Nov 3;324(17):1765-1776. doi: 10.1001/jama.2020.17272. PMID: 33141212
Venous Ulcers: Diagnosis and Treatment.
Bonkemeyer Millan S, Gan R, Townsend PE
Am Fam Physician 2019 Sep 1;100(5):298-305. PMID: 31478635
Varicose veins of lower extremities, hemodynamics and treatment methods.
Chwała M, Szczeklik W, Szczeklik M, Aleksiejew-Kleszczyński T, Jagielska-Chwała M
Adv Clin Exp Med 2015 Jan-Feb;24(1):5-14. doi: 10.17219/acem/31880. PMID: 25923081

Clinical prediction guides

Peripheral Edema: Evaluation and Management in Primary Care.
Patel H, Skok C, DeMarco A
Am Fam Physician 2022 Nov;106(5):557-564. PMID: 36379502
Chronic venous insufficiency, cardiovascular disease, and mortality: a population study.
Prochaska JH, Arnold N, Falcke A, Kopp S, Schulz A, Buch G, Moll S, Panova-Noeva M, Jünger C, Eggebrecht L, Pfeiffer N, Beutel M, Binder H, Grabbe S, Lackner KJ, Ten Cate-Hoek A, Espinola-Klein C, Münzel T, Wild PS
Eur Heart J 2021 Oct 21;42(40):4157-4165. doi: 10.1093/eurheartj/ehab495. PMID: 34387673
Post-thrombotic syndrome.
Visonà A, Quere I, Mazzolai L, Amitrano M, Lugli M, Madaric J, Prandoni P; European Society of Vascular Medicine (ESVM)
Vasa 2021 Sep;50(5):331-340. Epub 2021 Mar 15 doi: 10.1024/0301-1526/a000946. PMID: 33720757
Diagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review.
Chopard R, Albertsen IE, Piazza G
JAMA 2020 Nov 3;324(17):1765-1776. doi: 10.1001/jama.2020.17272. PMID: 33141212
Horse chestnut seed extract for chronic venous insufficiency.
Pittler MH, Ernst E
Cochrane Database Syst Rev 2012 Nov 14;11(11):CD003230. doi: 10.1002/14651858.CD003230.pub4. PMID: 23152216Free PMC Article

Recent systematic reviews

Injection sclerotherapy for varicose veins.
de Ávila Oliveira R, Riera R, Vasconcelos V, Baptista-Silva JC
Cochrane Database Syst Rev 2021 Dec 10;12(12):CD001732. doi: 10.1002/14651858.CD001732.pub3. PMID: 34883526Free PMC Article
Phlebotonics for venous insufficiency.
Martinez-Zapata MJ, Vernooij RW, Simancas-Racines D, Uriona Tuma SM, Stein AT, Moreno Carriles RMM, Vargas E, Bonfill Cosp X
Cochrane Database Syst Rev 2020 Nov 3;11(11):CD003229. doi: 10.1002/14651858.CD003229.pub4. PMID: 33141449Free PMC Article
Diagnosis and Treatment of Lower Extremity Venous Thromboembolism: A Review.
Chopard R, Albertsen IE, Piazza G
JAMA 2020 Nov 3;324(17):1765-1776. doi: 10.1001/jama.2020.17272. PMID: 33141212
A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency.
Orr L, Klement KA, McCrossin L, O'Sullivan Drombolis D, Houghton PE, Spaulding S, Burke S
Ostomy Wound Manage 2017 Aug;63(8):30-43. doi: 10.25270/owm.2017.08.3043. PMID: 28873064
Horse chestnut seed extract for chronic venous insufficiency.
Pittler MH, Ernst E
Cochrane Database Syst Rev 2012 Nov 14;11(11):CD003230. doi: 10.1002/14651858.CD003230.pub4. PMID: 23152216Free PMC Article

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