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Generalized vitiligo

MedGen UID:
725821
•Concept ID:
C1304470
•
Disease or Syndrome
Synonym: Vitiligo, generalized
SNOMED CT: Generalized vitiligo (403269008)

Professional guidelines

PubMed

Harmine and Kaempferol treatment enhances NFATC1 and FOXP3 mediated regulatory T-cells' suppressive capacity in generalized vitiligo.
Giri PS, Bharti AH, Kode J, Begum R, Dwivedi M
Int Immunopharmacol 2023 Dec;125(Pt B):111174. Epub 2023 Nov 9 doi: 10.1016/j.intimp.2023.111174. PMID: 37951194
Consensus on the treatment of vitiligo - Brazilian Society of Dermatology.
Dellatorre G, Antelo DAP, Bedrikow RB, Cestari TF, Follador I, Ramos DG, Silva de Castro CC
An Bras Dermatol 2020 Nov-Dec;95 Suppl 1(Suppl 1):70-82. Epub 2020 Oct 10 doi: 10.1016/j.abd.2020.05.007. PMID: 33153826Free PMC Article
Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.
Alikhan A, Felsten LM, Daly M, Petronic-Rosic V
J Am Acad Dermatol 2011 Sep;65(3):473-491. doi: 10.1016/j.jaad.2010.11.061. PMID: 21839315

Recent clinical studies

Etiology

Characteristics of Vitiligo in Children and Adolescents.
Chauhan PS, Sharma H, Dhattarwal N, Mahajan VK, Mehta KS, Sharma A, Sharma R, Verma YR, Chandel M
Skinmed 2020;18(5):278-285. Epub 2020 Oct 1 PMID: 33160437
Phototherapy for Vitiligo: A Systematic Review and Meta-analysis.
Bae JM, Jung HM, Hong BY, Lee JH, Choi WJ, Lee JH, Kim GM
JAMA Dermatol 2017 Jul 1;153(7):666-674. doi: 10.1001/jamadermatol.2017.0002. PMID: 28355423Free PMC Article
Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.
Alikhan A, Felsten LM, Daly M, Petronic-Rosic V
J Am Acad Dermatol 2011 Sep;65(3):473-491. doi: 10.1016/j.jaad.2010.11.061. PMID: 21839315
Shared genetic relationships underlying generalized vitiligo and autoimmune thyroid disease.
Spritz RA
Thyroid 2010 Jul;20(7):745-54. doi: 10.1089/thy.2010.1643. PMID: 20578892Free PMC Article
Common pigmentation disorders.
Plensdorf S, Martinez J
Am Fam Physician 2009 Jan 15;79(2):109-16. PMID: 19178061

Diagnosis

Exploring genetic associations between vitiligo and mental disorders using Mendelian randomization.
Wang Y, Yao T, Lin Y, Ye L, Li S, Gao Y, Wu J
Exp Dermatol 2024 Jan;33(1):e14979. Epub 2023 Nov 17 doi: 10.1111/exd.14979. PMID: 37975615
Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.
Alikhan A, Felsten LM, Daly M, Petronic-Rosic V
J Am Acad Dermatol 2011 Sep;65(3):473-491. doi: 10.1016/j.jaad.2010.11.061. PMID: 21839315
Update on childhood vitiligo.
Silverberg NB
Curr Opin Pediatr 2010 Aug;22(4):445-52. doi: 10.1097/MOP.0b013e32833b6ac3. PMID: 20616733
Common pigmentation disorders.
Plensdorf S, Martinez J
Am Fam Physician 2009 Jan 15;79(2):109-16. PMID: 19178061
Vitiligo. Therapeutic advances.
Jimbow K
Dermatol Clin 1998 Apr;16(2):399-407. doi: 10.1016/s0733-8635(05)70021-8. PMID: 9589212

Therapy

Exploring genetic associations between vitiligo and mental disorders using Mendelian randomization.
Wang Y, Yao T, Lin Y, Ye L, Li S, Gao Y, Wu J
Exp Dermatol 2024 Jan;33(1):e14979. Epub 2023 Nov 17 doi: 10.1111/exd.14979. PMID: 37975615
Imatinib-induced generalized vitiligo.
Jain A
Br J Haematol 2022 Jun;197(5):511. Epub 2022 Mar 14 doi: 10.1111/bjh.18096. PMID: 35285938
Phototherapy for Vitiligo: A Systematic Review and Meta-analysis.
Bae JM, Jung HM, Hong BY, Lee JH, Choi WJ, Lee JH, Kim GM
JAMA Dermatol 2017 Jul 1;153(7):666-674. doi: 10.1001/jamadermatol.2017.0002. PMID: 28355423Free PMC Article
Vitiligo therapy.
Lotti T, Berti S, Moretti S
Expert Opin Pharmacother 2009 Dec;10(17):2779-85. doi: 10.1517/14656560903357509. PMID: 19929701
Vitiligo. Therapeutic advances.
Jimbow K
Dermatol Clin 1998 Apr;16(2):399-407. doi: 10.1016/s0733-8635(05)70021-8. PMID: 9589212

Prognosis

Characteristics of Vitiligo in Children and Adolescents.
Chauhan PS, Sharma H, Dhattarwal N, Mahajan VK, Mehta KS, Sharma A, Sharma R, Verma YR, Chandel M
Skinmed 2020;18(5):278-285. Epub 2020 Oct 1 PMID: 33160437
Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up.
Alikhan A, Felsten LM, Daly M, Petronic-Rosic V
J Am Acad Dermatol 2011 Sep;65(3):473-491. doi: 10.1016/j.jaad.2010.11.061. PMID: 21839315
Vitiligo: a review of the published work.
Yaghoobi R, Omidian M, Bagherani N
J Dermatol 2011 May;38(5):419-31. doi: 10.1111/j.1346-8138.2010.01139.x. PMID: 21667529
Update on childhood vitiligo.
Silverberg NB
Curr Opin Pediatr 2010 Aug;22(4):445-52. doi: 10.1097/MOP.0b013e32833b6ac3. PMID: 20616733
Mixed vitiligo.
Mulekar SV, Al Issa A, Asaad M, Ghwish B, Al Eisa A
J Cutan Med Surg 2006 Mar-Apr;10(2):104-7. doi: 10.2310/7750.2006.00018. PMID: 17241584

Clinical prediction guides

Exploring genetic associations between vitiligo and mental disorders using Mendelian randomization.
Wang Y, Yao T, Lin Y, Ye L, Li S, Gao Y, Wu J
Exp Dermatol 2024 Jan;33(1):e14979. Epub 2023 Nov 17 doi: 10.1111/exd.14979. PMID: 37975615
Clinical profile of generalized vitiligo patients with associated autoimmune/autoinflammatory diseases.
van Geel N, Speeckaert M, Brochez L, Lambert J, Speeckaert R
J Eur Acad Dermatol Venereol 2014 Jun;28(6):741-6. Epub 2013 Apr 17 doi: 10.1111/jdv.12169. PMID: 23590677
Clinical pattern of vitiligo.
Habib A, Raza N
J Coll Physicians Surg Pak 2012 Jan;22(1):61-2. PMID: 22237197
Autoimmune etiology of generalized vitiligo.
Le Poole IC, Luiten RM
Curr Dir Autoimmun 2008;10:227-43. doi: 10.1159/000131485. PMID: 18460889
Mixed vitiligo.
Mulekar SV, Al Issa A, Asaad M, Ghwish B, Al Eisa A
J Cutan Med Surg 2006 Mar-Apr;10(2):104-7. doi: 10.2310/7750.2006.00018. PMID: 17241584

Recent systematic reviews

Phototherapy for Vitiligo: A Systematic Review and Meta-analysis.
Bae JM, Jung HM, Hong BY, Lee JH, Choi WJ, Lee JH, Kim GM
JAMA Dermatol 2017 Jul 1;153(7):666-674. doi: 10.1001/jamadermatol.2017.0002. PMID: 28355423Free PMC Article

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