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Congenital lymphatic malformation

MedGen UID:
724327
•Concept ID:
C1302778
•
Congenital Abnormality
SNOMED CT: Congenital lymphatic malformation (400016000)

Professional guidelines

PubMed

Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development.
Mustillo PJ, Sullivan KE, Chinn IK, Notarangelo LD, Haddad E, Davies EG, de la Morena MT, Hartog N, Yu JE, Hernandez-Trujillo VP, Ip W, Franco J, Gambineri E, Hickey SE, Varga E, Markert ML
J Clin Immunol 2023 Feb;43(2):247-270. Epub 2023 Jan 17 doi: 10.1007/s10875-022-01418-y. PMID: 36648576Free PMC Article
Congenital heart defects in Noonan syndrome: Diagnosis, management, and treatment.
Linglart L, Gelb BD
Am J Med Genet C Semin Med Genet 2020 Mar;184(1):73-80. Epub 2020 Feb 5 doi: 10.1002/ajmg.c.31765. PMID: 32022400Free PMC Article
Vascular malformations: classification, diagnosis and treatment.
Carqueja IM, Sousa J, Mansilha A
Int Angiol 2018 Apr;37(2):127-142. Epub 2018 Feb 8 doi: 10.23736/S0392-9590.18.03961-5. PMID: 29424187

Recent clinical studies

Etiology

A multidisciplinary approach to recurrent cervicothoracic cystic hygroma in an adult.
Cheng LH, Wells FC
Br J Oral Maxillofac Surg 2004 Feb;42(1):66-8. doi: 10.1016/s0266-4356(03)00173-6. PMID: 14706307
Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck.
Sung MW, Lee DW, Kim DY, Lee SJ, Hwang CH, Park SW, Kim KH
Laryngoscope 2001 Aug;111(8):1430-3. doi: 10.1097/00005537-200108000-00020. PMID: 11568580
Tongue lesions in the pediatric population.
Horn C, Thaker HM, Tampakopoulou DA, De Serres LM, Keller JL, Haddad J Jr
Otolaryngol Head Neck Surg 2001 Feb;124(2):164-9. doi: 10.1067/mhn.2001.112304. PMID: 11226950
Bleomycin sclerotherapy in patients with congenital lymphatic malformation in the head and neck.
Sung MW, Chang SO, Choi JH, Kim JY
Am J Otolaryngol 1995 Jul-Aug;16(4):236-41. doi: 10.1016/0196-0709(95)90149-3. PMID: 7573743

Diagnosis

Kaposiform lymphangiomatosis treated with multimodal therapy improves coagulopathy and reduces blood angiopoietin-2 levels.
Crane J, Manfredo J, Boscolo E, Coyan M, Takemoto C, Itkin M, Adams DM, Le Cras TD
Pediatr Blood Cancer 2020 Sep;67(9):e28529. Epub 2020 Jul 7 doi: 10.1002/pbc.28529. PMID: 32634277Free PMC Article
The Possible Role of Color Doppler and Pulse Wave Doppler Ultrasound in the Diagnosis of Cutaneous Lymphangioma Circumscriptum.
Sun Y, Su J, Li SS, Cui LG
J Craniofac Surg 2020 Jan/Feb;31(1):e73-e75. doi: 10.1097/SCS.0000000000005926. PMID: 31634308
Recurrent cystic lymphangioma of the breast: case report and literature review.
Sasi W, Schneider C, Shah R, Ruffles T, Bhagwat P, Mokbel K, Sharma AK
Breast Dis 2010;31(1):43-7. doi: 10.3233/BD-2009-0287. PMID: 20519805
Sonographic findings in a case of scrotal lymphangioma in a 68-year-old male.
Lee WC, Park SB, Lee JH, Jang JC, Choi HJ, Park S, Moon KH
J Clin Ultrasound 2009 Sep;37(7):428-30. doi: 10.1002/jcu.20597. PMID: 19455691
Tongue lesions in the pediatric population.
Horn C, Thaker HM, Tampakopoulou DA, De Serres LM, Keller JL, Haddad J Jr
Otolaryngol Head Neck Surg 2001 Feb;124(2):164-9. doi: 10.1067/mhn.2001.112304. PMID: 11226950

Therapy

The successful management of diffuse lymphangiomatosis using sirolimus: a case report.
Reinglas J, Ramphal R, Bromwich M
Laryngoscope 2011 Sep;121(9):1851-4. Epub 2011 Aug 16 doi: 10.1002/lary.21927. PMID: 22024836
Bleomycin sclerotherapy in congenital lymphatic and vascular malformations of head and neck.
Mathur NN, Rana I, Bothra R, Dhawan R, Kathuria G, Pradhan T
Int J Pediatr Otorhinolaryngol 2005 Jan;69(1):75-80. doi: 10.1016/j.ijporl.2004.08.008. PMID: 15627451
Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck.
Sung MW, Lee DW, Kim DY, Lee SJ, Hwang CH, Park SW, Kim KH
Laryngoscope 2001 Aug;111(8):1430-3. doi: 10.1097/00005537-200108000-00020. PMID: 11568580
Bleomycin sclerotherapy in patients with congenital lymphatic malformation in the head and neck.
Sung MW, Chang SO, Choi JH, Kim JY
Am J Otolaryngol 1995 Jul-Aug;16(4):236-41. doi: 10.1016/0196-0709(95)90149-3. PMID: 7573743

Prognosis

Cystic hygroma in adults: a single-centre experience and review of the literature.
McInerney NJ, O'Keeffe N, Nae A, Morariu J, Timon C
Ir J Med Sci 2023 Oct;192(5):2373-2377. Epub 2023 Jan 16 doi: 10.1007/s11845-022-03271-9. PMID: 36642745Free PMC Article
Kaposiform lymphangiomatosis treated with multimodal therapy improves coagulopathy and reduces blood angiopoietin-2 levels.
Crane J, Manfredo J, Boscolo E, Coyan M, Takemoto C, Itkin M, Adams DM, Le Cras TD
Pediatr Blood Cancer 2020 Sep;67(9):e28529. Epub 2020 Jul 7 doi: 10.1002/pbc.28529. PMID: 32634277Free PMC Article
The successful management of diffuse lymphangiomatosis using sirolimus: a case report.
Reinglas J, Ramphal R, Bromwich M
Laryngoscope 2011 Sep;121(9):1851-4. Epub 2011 Aug 16 doi: 10.1002/lary.21927. PMID: 22024836
A multidisciplinary approach to recurrent cervicothoracic cystic hygroma in an adult.
Cheng LH, Wells FC
Br J Oral Maxillofac Surg 2004 Feb;42(1):66-8. doi: 10.1016/s0266-4356(03)00173-6. PMID: 14706307

Clinical prediction guides

Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck.
Sung MW, Lee DW, Kim DY, Lee SJ, Hwang CH, Park SW, Kim KH
Laryngoscope 2001 Aug;111(8):1430-3. doi: 10.1097/00005537-200108000-00020. PMID: 11568580

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