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Complex atypical endometrial hyperplasia

MedGen UID:
724029
•Concept ID:
C1302454
•
Disease or Syndrome
SNOMED CT: Complex atypical endometrial hyperplasia (399497006)

Professional guidelines

PubMed

Fertility-Sparing Management Using Progestin for Young Women with Endometrial Cancer From a Population-Based Study.
Kim SR, van der Zanden C, Ikiz H, Kuzelijevic B, Havelock J, Kwon JS
J Obstet Gynaecol Can 2018 Mar;40(3):328-333. Epub 2017 Oct 3 doi: 10.1016/j.jogc.2017.06.037. PMID: 28986185
Updates on Conservative Management of Endometrial Cancer.
Corzo C, Barrientos Santillan N, Westin SN, Ramirez PT
J Minim Invasive Gynecol 2018 Feb;25(2):308-313. Epub 2017 Aug 3 doi: 10.1016/j.jmig.2017.07.022. PMID: 28782618
Management options and fertility-preserving therapy for premenopausal endometrial hyperplasia and early-stage endometrial cancer.
Gressel GM, Parkash V, Pal L
Int J Gynaecol Obstet 2015 Dec;131(3):234-9. Epub 2015 Sep 8 doi: 10.1016/j.ijgo.2015.06.031. PMID: 26384790

Recent clinical studies

Etiology

Uptake and Outcomes of Sentinel Lymph Node Mapping in Women With Atypical Endometrial Hyperplasia.
Dioun S, Chen L, Melamed A, Gockley A, St Clair CM, Hou JY, Tergas AI, Khoury-Collado F, Hur C, Hershman DL, Wright JD
Obstet Gynecol 2021 May 1;137(5):924-934. doi: 10.1097/AOG.0000000000004352. PMID: 33831939
Proteomic analysis in endometrial cancer and endometrial hyperplasia tissues by 2D-DIGE technique.
Ceylan Y, Akpınar G, Doger E, Kasap M, Guzel N, Karaosmanoglu K, Kopuk SY, Yucesoy I
J Gynecol Obstet Hum Reprod 2020 Feb;49(2):101652. Epub 2019 Nov 26 doi: 10.1016/j.jogoh.2019.101652. PMID: 31783195
Updates on Conservative Management of Endometrial Cancer.
Corzo C, Barrientos Santillan N, Westin SN, Ramirez PT
J Minim Invasive Gynecol 2018 Feb;25(2):308-313. Epub 2017 Aug 3 doi: 10.1016/j.jmig.2017.07.022. PMID: 28782618
Management options and fertility-preserving therapy for premenopausal endometrial hyperplasia and early-stage endometrial cancer.
Gressel GM, Parkash V, Pal L
Int J Gynaecol Obstet 2015 Dec;131(3):234-9. Epub 2015 Sep 8 doi: 10.1016/j.ijgo.2015.06.031. PMID: 26384790
Complex atypical endometrial hyperplasia: the risk of unrecognized adenocarcinoma and value of preoperative dilation and curettage.
Suh-Burgmann E, Hung YY, Armstrong MA
Obstet Gynecol 2009 Sep;114(3):523-529. doi: 10.1097/AOG.0b013e3181b190d5. PMID: 19701030

Diagnosis

Proteomic analysis in endometrial cancer and endometrial hyperplasia tissues by 2D-DIGE technique.
Ceylan Y, Akpınar G, Doger E, Kasap M, Guzel N, Karaosmanoglu K, Kopuk SY, Yucesoy I
J Gynecol Obstet Hum Reprod 2020 Feb;49(2):101652. Epub 2019 Nov 26 doi: 10.1016/j.jogoh.2019.101652. PMID: 31783195
Updates on Conservative Management of Endometrial Cancer.
Corzo C, Barrientos Santillan N, Westin SN, Ramirez PT
J Minim Invasive Gynecol 2018 Feb;25(2):308-313. Epub 2017 Aug 3 doi: 10.1016/j.jmig.2017.07.022. PMID: 28782618
Fertility-Sparing Treatment of Early Endometrial Cancer and Complex Atypical Hyperplasia in Young Women of Childbearing Potential.
Pronin SM, Novikova OV, Andreeva JY, Novikova EG
Int J Gynecol Cancer 2015 Jul;25(6):1010-4. doi: 10.1097/IGC.0000000000000467. PMID: 25950126
Complex atypical endometrial hyperplasia: the risk of unrecognized adenocarcinoma and value of preoperative dilation and curettage.
Suh-Burgmann E, Hung YY, Armstrong MA
Obstet Gynecol 2009 Sep;114(3):523-529. doi: 10.1097/AOG.0b013e3181b190d5. PMID: 19701030
The endometrial hyperplasias revisited.
Sivridis E, Giatromanolaki A
Virchows Arch 2008 Sep;453(3):223-31. Epub 2008 Aug 23 doi: 10.1007/s00428-008-0650-5. PMID: 18726114

Therapy

Fertility-Sparing Treatment in Young Women with Atypical Endometrial Hyperplasia and Low-Grade Endometrial Cancer: A Tertiary Center Experience.
Shikeli S, Gowri V, Rawahi TA
JBRA Assist Reprod 2020 Oct 6;24(4):466-469. doi: 10.5935/1518-0557.20200037. PMID: 32569453Free PMC Article
Updates on Conservative Management of Endometrial Cancer.
Corzo C, Barrientos Santillan N, Westin SN, Ramirez PT
J Minim Invasive Gynecol 2018 Feb;25(2):308-313. Epub 2017 Aug 3 doi: 10.1016/j.jmig.2017.07.022. PMID: 28782618
Fertility-Sparing Treatment of Early Endometrial Cancer and Complex Atypical Hyperplasia in Young Women of Childbearing Potential.
Pronin SM, Novikova OV, Andreeva JY, Novikova EG
Int J Gynecol Cancer 2015 Jul;25(6):1010-4. doi: 10.1097/IGC.0000000000000467. PMID: 25950126
Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: a meta-analysis and systematic review of the literature.
Baker J, Obermair A, Gebski V, Janda M
Gynecol Oncol 2012 Apr;125(1):263-70. Epub 2011 Dec 3 doi: 10.1016/j.ygyno.2011.11.043. PMID: 22196499
The endometrial hyperplasias revisited.
Sivridis E, Giatromanolaki A
Virchows Arch 2008 Sep;453(3):223-31. Epub 2008 Aug 23 doi: 10.1007/s00428-008-0650-5. PMID: 18726114

Prognosis

Proteomic analysis in endometrial cancer and endometrial hyperplasia tissues by 2D-DIGE technique.
Ceylan Y, Akpınar G, Doger E, Kasap M, Guzel N, Karaosmanoglu K, Kopuk SY, Yucesoy I
J Gynecol Obstet Hum Reprod 2020 Feb;49(2):101652. Epub 2019 Nov 26 doi: 10.1016/j.jogoh.2019.101652. PMID: 31783195
Fertility-Sparing Treatment of Early Endometrial Cancer and Complex Atypical Hyperplasia in Young Women of Childbearing Potential.
Pronin SM, Novikova OV, Andreeva JY, Novikova EG
Int J Gynecol Cancer 2015 Jul;25(6):1010-4. doi: 10.1097/IGC.0000000000000467. PMID: 25950126
Diagnostic criteria for distinguishing endometrial adenocarcinoma from complex atypical endometrial hyperplasia.
Mittal K, Salem A, Lo A
Hum Pathol 2014 Jan;45(1):98-103. Epub 2013 Oct 31 doi: 10.1016/j.humpath.2013.08.009. PMID: 24182562
Accuracy of frozen sections for intraoperative diagnosis of complex atypical endometrial hyperplasia.
Turan T, Karadag B, Karabuk E, Tulunay G, Ozgul N, Gultekin M, Boran N, Isikdogan Z, Kose MF
Asian Pac J Cancer Prev 2012;13(5):1953-6. doi: 10.7314/apjcp.2012.13.5.1953. PMID: 22901153
Complex atypical endometrial hyperplasia: the risk of unrecognized adenocarcinoma and value of preoperative dilation and curettage.
Suh-Burgmann E, Hung YY, Armstrong MA
Obstet Gynecol 2009 Sep;114(3):523-529. doi: 10.1097/AOG.0b013e3181b190d5. PMID: 19701030

Clinical prediction guides

Proteomic analysis in endometrial cancer and endometrial hyperplasia tissues by 2D-DIGE technique.
Ceylan Y, Akpınar G, Doger E, Kasap M, Guzel N, Karaosmanoglu K, Kopuk SY, Yucesoy I
J Gynecol Obstet Hum Reprod 2020 Feb;49(2):101652. Epub 2019 Nov 26 doi: 10.1016/j.jogoh.2019.101652. PMID: 31783195
Irisin immunostaining characteristics of breast and ovarian cancer cells.
Kuloglu T, Celik O, Aydin S, Hanifi Ozercan I, Acet M, Aydin Y, Artas G, Turk A, Yardim M, Ozan G, Hanifi Yalcin M, Kocaman N
Cell Mol Biol (Noisy-le-grand) 2016 Jul 31;62(8):40-4. PMID: 27545213
Diagnostic criteria for distinguishing endometrial adenocarcinoma from complex atypical endometrial hyperplasia.
Mittal K, Salem A, Lo A
Hum Pathol 2014 Jan;45(1):98-103. Epub 2013 Oct 31 doi: 10.1016/j.humpath.2013.08.009. PMID: 24182562
Coexistent atypical polypoid adenomyoma and complex atypical endometrial hyperplasia in the uterus.
Horita A, Kurata A, Komatsu K, Yajima M, Sakamoto A
Diagn Cytopathol 2010 Jul;38(7):527-32. doi: 10.1002/dc.21263. PMID: 19950396
Complex atypical endometrial hyperplasia: the risk of unrecognized adenocarcinoma and value of preoperative dilation and curettage.
Suh-Burgmann E, Hung YY, Armstrong MA
Obstet Gynecol 2009 Sep;114(3):523-529. doi: 10.1097/AOG.0b013e3181b190d5. PMID: 19701030

Recent systematic reviews

Efficacy of oral or intrauterine device-delivered progestin in patients with complex endometrial hyperplasia with atypia or early endometrial adenocarcinoma: a meta-analysis and systematic review of the literature.
Baker J, Obermair A, Gebski V, Janda M
Gynecol Oncol 2012 Apr;125(1):263-70. Epub 2011 Dec 3 doi: 10.1016/j.ygyno.2011.11.043. PMID: 22196499

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