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Cleft lip and alveolus

MedGen UID:
720590
•Concept ID:
C1298692
•
Congenital Abnormality
Synonyms: cleft lip and alveolus; Cleft lip and cleft of alveolar process of maxilla
SNOMED CT: Cleft lip and cleft of alveolar process of maxilla (373643003)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0015420
Orphanet: ORPHA141291

Definition

Cleft lip and alveolus is a fissure type embryopathy that involves the upper lip, nasal base and alveolar ridge in variable degrees. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCleft lip and alveolus

Professional guidelines

PubMed

Pain management at iliac donor sites after grafting of alveolar clefts.
Tache A, Mommaerts MY
Int J Oral Maxillofac Surg 2022 Jan;51(1):62-69. Epub 2021 Jun 3 doi: 10.1016/j.ijom.2021.05.004. PMID: 34090758
The prenatal diagnosis and classification of cleft palate: the role and value of magnetic resonance imaging.
Zheng W, Li B, Zou Y, Lou F
Eur Radiol 2019 Oct;29(10):5600-5606. Epub 2019 Mar 18 doi: 10.1007/s00330-019-06089-9. PMID: 30887208
Dental caries in the primary dentition of german children with cleft lip, alveolus, and palate.
Kirchberg A, Makuch A, Hemprich A, Hirsch C
Cleft Palate Craniofac J 2014 May;51(3):308-13. Epub 2012 Dec 13 doi: 10.1597/12-106. PMID: 23237430

Recent clinical studies

Etiology

Three-Dimensional Analysis of Vomer Volume and Deviation in Patients With Unilateral Cleft Lip and Alveolus.
Li SL, Wu D, Yin NB, Song T, Wang YQ
J Craniofac Surg 2022 Nov-Dec 01;33(8):2411-2416. Epub 2022 Nov 4 doi: 10.1097/SCS.0000000000008802. PMID: 36409866
Prevalence of Dental Anomalies in Patients With Unilateral Cleft Lip and Alveolus Treated With Gingivoperiosteoplasty.
Gibson TL, Grayson BH, Cutting CB, Shetye PR
Cleft Palate Craniofac J 2022 Aug;59(8):1017-1023. Epub 2021 Jul 14 doi: 10.1177/10556656211031124. PMID: 34259074
Pain management at iliac donor sites after grafting of alveolar clefts.
Tache A, Mommaerts MY
Int J Oral Maxillofac Surg 2022 Jan;51(1):62-69. Epub 2021 Jun 3 doi: 10.1016/j.ijom.2021.05.004. PMID: 34090758
Variations in Orofacial Clefts.
Jahanbin A, Jamalinasab A, Niazi AE
J Craniofac Surg 2021 Mar-Apr 01;32(2):e179-e182. doi: 10.1097/SCS.0000000000007027. PMID: 33705067
The Skoog Lip Repair for Unilateral Cleft Lip Deformity: The Uppsala Experience.
Falk-Delgado A, Lång A, Hakelius M, Skoog V, Nowinski D
Plast Reconstr Surg 2018 May;141(5):1226-1233. doi: 10.1097/PRS.0000000000004321. PMID: 29697619

Diagnosis

Clinical Applications of Artificial Intelligence and Machine Learning in Children with Cleft Lip and Palate-A Systematic Review.
Huqh MZU, Abdullah JY, Wong LS, Jamayet NB, Alam MK, Rashid QF, Husein A, Ahmad WMAW, Eusufzai SZ, Prasadh S, Subramaniyan V, Fuloria NK, Fuloria S, Sekar M, Selvaraj S
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710860. PMID: 36078576Free PMC Article
Examining Risk of Speech-Language Disorders in Children With Cleft Lip.
Deatherage J, Bourgeois T, O'Brien M, Baylis AL
J Craniofac Surg 2022 Mar-Apr 01;33(2):395-399. doi: 10.1097/SCS.0000000000008000. PMID: 35385904
The application of three-dimensional ultrasound with reformatting technique in the diagnosis of fetal cleft lip/palate.
Ji C, Yang Z, Yin L, Deng X, Pan Q, Lu B, Zhang J, Jiang W, Jiang X
J Clin Ultrasound 2021 May;49(4):307-314. Epub 2021 Mar 4 doi: 10.1002/jcu.22994. PMID: 33665816
Accurate diagnosis of fetal cleft lip/palate by typical signs of magnetic resonance imaging.
Tian M, Xiao L, Jian N, Wei X, Liu S, Zhao H, Li G, Zhang S, Liang W, Lin N, Lin X
Prenat Diagn 2019 Sep;39(10):883-889. Epub 2019 Jul 23 doi: 10.1002/pd.5499. PMID: 31169321
Orthodontic burden of care for patients with a cleft lip and/or palate.
Hameed O, Amin N, Haria P, Patel B, Hay N
J Orthod 2019 Mar;46(1):63-67. Epub 2019 Jan 23 doi: 10.1177/1465312518823010. PMID: 31056071

Therapy

Correlation between alveolar cleft morphology and the outcome of secondary alveolar bone grafting for unilateral cleft lip and palate.
Yu X, Huang Y, Li W
BMC Oral Health 2022 Jun 22;22(1):251. doi: 10.1186/s12903-022-02265-4. PMID: 35733126Free PMC Article
Pain management at iliac donor sites after grafting of alveolar clefts.
Tache A, Mommaerts MY
Int J Oral Maxillofac Surg 2022 Jan;51(1):62-69. Epub 2021 Jun 3 doi: 10.1016/j.ijom.2021.05.004. PMID: 34090758
Comparison of 2- and 3-dimensional radiologic evaluation of secondary alveolar bone grafting of clefts: a systematic review.
Yu X, Guo R, Li W
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct;130(4):455-463. Epub 2020 Jun 15 doi: 10.1016/j.oooo.2020.04.815. PMID: 32553577
The Skoog Lip Repair for Unilateral Cleft Lip Deformity: The Uppsala Experience.
Falk-Delgado A, Lång A, Hakelius M, Skoog V, Nowinski D
Plast Reconstr Surg 2018 May;141(5):1226-1233. doi: 10.1097/PRS.0000000000004321. PMID: 29697619
Change in grafted secondary alveolar bone in patients with UCLP and UCLA. A three-dimensional computed tomography study.
Kim KR, Kim S, Baek SH
Angle Orthod 2008 Jul;78(4):631-40. doi: 10.2319/0003-3219(2008)078[0631:CIGSAB]2.0.CO;2. PMID: 18302461

Prognosis

Relevance of Fetal Brain Magnetic Resonance Imaging Compared to Ultrasound for Detecting Cerebral Anomalies in Fetuses with Cleft Lip and/or Palate: A Cohort Study.
Eydoux R, Lesieur E, Blanc J, Girard N, D'ercole C, Sigaudy S, Chaumoitre K, Bretelle F
Fetal Diagn Ther 2023;50(1):37-46. Epub 2023 Jan 9 doi: 10.1159/000528906. PMID: 36623502
Clinical Applications of Artificial Intelligence and Machine Learning in Children with Cleft Lip and Palate-A Systematic Review.
Huqh MZU, Abdullah JY, Wong LS, Jamayet NB, Alam MK, Rashid QF, Husein A, Ahmad WMAW, Eusufzai SZ, Prasadh S, Subramaniyan V, Fuloria NK, Fuloria S, Sekar M, Selvaraj S
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710860. PMID: 36078576Free PMC Article
Correlation between alveolar cleft morphology and the outcome of secondary alveolar bone grafting for unilateral cleft lip and palate.
Yu X, Huang Y, Li W
BMC Oral Health 2022 Jun 22;22(1):251. doi: 10.1186/s12903-022-02265-4. PMID: 35733126Free PMC Article
Prevalence of Tympanostomy Tube Placement in Relation to Cleft Width and Type.
Schwarz SJ, Brandenburg LS, Weingart JV, Schupp W, Füssinger MA, Pantke CF, Beck RL, Metzger MC
Laryngoscope 2021 Nov;131(11):E2764-E2769. Epub 2021 Jun 18 doi: 10.1002/lary.29602. PMID: 34142721
The Skoog Lip Repair for Unilateral Cleft Lip Deformity: The Uppsala Experience.
Falk-Delgado A, Lång A, Hakelius M, Skoog V, Nowinski D
Plast Reconstr Surg 2018 May;141(5):1226-1233. doi: 10.1097/PRS.0000000000004321. PMID: 29697619

Clinical prediction guides

Clinical Applications of Artificial Intelligence and Machine Learning in Children with Cleft Lip and Palate-A Systematic Review.
Huqh MZU, Abdullah JY, Wong LS, Jamayet NB, Alam MK, Rashid QF, Husein A, Ahmad WMAW, Eusufzai SZ, Prasadh S, Subramaniyan V, Fuloria NK, Fuloria S, Sekar M, Selvaraj S
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710860. PMID: 36078576Free PMC Article
Correlation between alveolar cleft morphology and the outcome of secondary alveolar bone grafting for unilateral cleft lip and palate.
Yu X, Huang Y, Li W
BMC Oral Health 2022 Jun 22;22(1):251. doi: 10.1186/s12903-022-02265-4. PMID: 35733126Free PMC Article
Comparison of 2- and 3-dimensional radiologic evaluation of secondary alveolar bone grafting of clefts: a systematic review.
Yu X, Guo R, Li W
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct;130(4):455-463. Epub 2020 Jun 15 doi: 10.1016/j.oooo.2020.04.815. PMID: 32553577
Subphenotyping and Classification of Cleft Lip and Alveolus in Adult Unoperated Patients: A New Embryological Approach.
Vermeij-Keers C, Rozendaal AM, Luijsterburg AJM, Latief BS, Lekkas C, Kragt L, Ongkosuwito EM
Cleft Palate Craniofac J 2018 Oct;55(9):1267-1276. Epub 2018 Apr 13 doi: 10.1177/1055665618767106. PMID: 29652537
Prediction of the Need for Orthognathic Surgery in Patients With Cleft Lip and/or Palate.
Park HM, Kim PJ, Kim HG, Kim S, Baek SH
J Craniofac Surg 2015 Jun;26(4):1159-62. doi: 10.1097/SCS.0000000000001605. PMID: 26080148

Recent systematic reviews

Clinical Applications of Artificial Intelligence and Machine Learning in Children with Cleft Lip and Palate-A Systematic Review.
Huqh MZU, Abdullah JY, Wong LS, Jamayet NB, Alam MK, Rashid QF, Husein A, Ahmad WMAW, Eusufzai SZ, Prasadh S, Subramaniyan V, Fuloria NK, Fuloria S, Sekar M, Selvaraj S
Int J Environ Res Public Health 2022 Aug 31;19(17) doi: 10.3390/ijerph191710860. PMID: 36078576Free PMC Article
Pain management at iliac donor sites after grafting of alveolar clefts.
Tache A, Mommaerts MY
Int J Oral Maxillofac Surg 2022 Jan;51(1):62-69. Epub 2021 Jun 3 doi: 10.1016/j.ijom.2021.05.004. PMID: 34090758
Comparison of 2- and 3-dimensional radiologic evaluation of secondary alveolar bone grafting of clefts: a systematic review.
Yu X, Guo R, Li W
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct;130(4):455-463. Epub 2020 Jun 15 doi: 10.1016/j.oooo.2020.04.815. PMID: 32553577

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