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Sclerotic fibroma

MedGen UID:
698520
•Concept ID:
C1275237
•
Neoplastic Process
Synonym: Storiform collagenoma
SNOMED CT: Storiform collagenoma (403993007); Sclerotic fibroma (709002005); Storiform collagenoma (709002005)

Definition

Small white or flesh-colored waxy papules ranging in size from 0.5 to 1.2 cm. [from SNOMEDCT_US]

Professional guidelines

PubMed

The differential diagnosis between sclerotic fibroma and sclerosing perineurioma: An unresolved challenge.
Saggini A, Baciorri F
J Cutan Pathol 2020 Feb;47(2):195-196. Epub 2019 Dec 9 doi: 10.1111/cup.13620. PMID: 31782178

Recent clinical studies

Etiology

Superficial fibromas with CTNNB1 mutation.
Kuntze A, Meliß RR, Ermert L, Falkenberg KD, Puller AC, Trautmann M, Hartmann W, Wardelmann E
Genes Chromosomes Cancer 2024 May;63(5):e23247. doi: 10.1002/gcc.23247. PMID: 38757718
Utilizing PTEN immunohistochemistry as a screening test for Cowden syndrome.
Hartsough E, DeSimone MS, Lorenzo ME, Dias-Santagata D, Nose V, Hoang MP
Am J Clin Pathol 2024 May 2;161(5):490-500. doi: 10.1093/ajcp/aqad177. PMID: 38206110
Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Benign mesenchymal tumors of the external ear: A series of 14 cases.
AbdullGaffar B, Manzlgi M, Saleem N
Ann Diagn Pathol 2019 Aug;41:62-68. Epub 2019 May 20 doi: 10.1016/j.anndiagpath.2019.05.011. PMID: 31132654
Sclerotic fibroma-like change in various neoplastic and inflammatory skin lesions: is sclerotic fibroma a distinct entity?
High WA, Stewart D, Essary LR, Kageyama NP, Hoang MP, Cockerell CJ
J Cutan Pathol 2004 May;31(5):373-8. doi: 10.1111/j.0303-6987.2004.00199.x. PMID: 15059222

Diagnosis

Utilizing PTEN immunohistochemistry as a screening test for Cowden syndrome.
Hartsough E, DeSimone MS, Lorenzo ME, Dias-Santagata D, Nose V, Hoang MP
Am J Clin Pathol 2024 May 2;161(5):490-500. doi: 10.1093/ajcp/aqad177. PMID: 38206110
Storiform collagenoma (sclerotic fibroma) of the oral mucosa.
Elledge R, Nandra B, Bates T, Zardo D, Parmar S
Br J Oral Maxillofac Surg 2020 Feb;58(2):231-233. Epub 2019 Nov 21 doi: 10.1016/j.bjoms.2019.11.005. PMID: 31761569
Benign mesenchymal tumors of the external ear: A series of 14 cases.
AbdullGaffar B, Manzlgi M, Saleem N
Ann Diagn Pathol 2019 Aug;41:62-68. Epub 2019 May 20 doi: 10.1016/j.anndiagpath.2019.05.011. PMID: 31132654
Sclerosing Dermatofibrosarcoma Protuberans Shows Significant Overlap With Sclerotic Fibroma in Both Routine and Immunohistochemical Analysis: A Potential Diagnostic Pitfall.
Abdaljaleel MY, North JP
Am J Dermatopathol 2017 Feb;39(2):83-88. doi: 10.1097/DAD.0000000000000584. PMID: 28134725
Sclerotic lipoma: lipomas simulating sclerotic fibroma.
Zelger BG, Zelger B, Steiner H, Rütten A
Histopathology 1997 Aug;31(2):174-81. doi: 10.1046/j.1365-2559.1997.2310836.x. PMID: 9279570

Therapy

Selected case from the Arkadi M. Rywlin International Pathology Slide Seminar: sclerotic (fibroma-like) lipoma, dorsum of right hand.
Allen PW
Adv Anat Pathol 2013 Jan;20(1):68-72. doi: 10.1097/PAP.0b013e31827b65e3. PMID: 23232574
Sclerotic (fibroma-like) lipoma: a distinctive lipoma variant with a predilection for the distal extremities.
Laskin WB, Fetsch JF, Michal M, Miettinen M
Am J Dermatopathol 2006 Aug;28(4):308-16. doi: 10.1097/00000372-200608000-00003. PMID: 16871033

Prognosis

Superficial fibromas with CTNNB1 mutation.
Kuntze A, Meliß RR, Ermert L, Falkenberg KD, Puller AC, Trautmann M, Hartmann W, Wardelmann E
Genes Chromosomes Cancer 2024 May;63(5):e23247. doi: 10.1002/gcc.23247. PMID: 38757718
Germline mutation of the PTEN gene in a Japanese patient with Cowden's disease.
Kato N, Kimura K, Sugawara H, Aoyagi S, Ikeda T, Horii A
Int J Oncol 2001 May;18(5):1017-22. doi: 10.3892/ijo.18.5.1017. PMID: 11295050
Sclerosing perineurioma: a clinicopathologic study of 19 cases of a distinctive soft tissue lesion with a predilection for the fingers and palms of young adults.
Fetsch JF, Miettinen M
Am J Surg Pathol 1997 Dec;21(12):1433-42. doi: 10.1097/00000478-199712000-00005. PMID: 9414186

Clinical prediction guides

Giant cell collagenomas associated with Cowden syndrome: A case report.
Salusti-Simpson M, Madrid M, Cook D
J Cutan Pathol 2024 May;51(5):345-347. Epub 2024 Feb 9 doi: 10.1111/cup.14595. PMID: 38337148
Sclerosing Dermatofibrosarcoma Protuberans Shows Significant Overlap With Sclerotic Fibroma in Both Routine and Immunohistochemical Analysis: A Potential Diagnostic Pitfall.
Abdaljaleel MY, North JP
Am J Dermatopathol 2017 Feb;39(2):83-88. doi: 10.1097/DAD.0000000000000584. PMID: 28134725
Sclerotic fibroma-like change in various neoplastic and inflammatory skin lesions: is sclerotic fibroma a distinct entity?
High WA, Stewart D, Essary LR, Kageyama NP, Hoang MP, Cockerell CJ
J Cutan Pathol 2004 May;31(5):373-8. doi: 10.1111/j.0303-6987.2004.00199.x. PMID: 15059222
Solitary sclerotic fibroma of the skin: degenerated sclerotic change of inflammatory conditions, especially folliculitis.
Chang SN, Chun SI, Moon TK, Park WH
Am J Dermatopathol 2000 Feb;22(1):22-5. doi: 10.1097/00000372-200002000-00004. PMID: 10698211
Solitary sclerotic fibroma of the skin: a sclerotic dermatofibroma?
Pujol RM, de Castro F, Schroeter AL, Su WP
Am J Dermatopathol 1996 Dec;18(6):620-4. doi: 10.1097/00000372-199612000-00013. PMID: 8989937

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