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Radiation-induced xerostomia

MedGen UID:
698356
•Concept ID:
C1275047
•
Disease or Syndrome
Synonyms: Radiation-Induced Xerostomia; Xerostomia caused by ionizing radiation
SNOMED CT: Radiation-induced xerostomia (403730001); Xerostomia caused by ionizing radiation (403730001)

Definition

Dryness of the oral mucosa secondary to radiation therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRadiation-induced xerostomia

Professional guidelines

PubMed

The standardization of acupuncture treatment for radiation-induced xerostomia: A literature review.
Li LX, Tian G, He J
Chin J Integr Med 2016 Jul;22(7):549-54. Epub 2015 Aug 26 doi: 10.1007/s11655-015-2145-y. PMID: 26311288
Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia.
Radvansky LJ, Pace MB, Siddiqui A
Am J Health Syst Pharm 2013 Jun 15;70(12):1025-32. doi: 10.2146/ajhp120467. PMID: 23719879
Radiation-induced xerostomia: pathophysiology, prevention and treatment.
Bhide SA, Miah AB, Harrington KJ, Newbold KL, Nutting CM
Clin Oncol (R Coll Radiol) 2009 Dec;21(10):737-44. Epub 2009 Oct 14 doi: 10.1016/j.clon.2009.09.002. PMID: 19833490

Recent clinical studies

Etiology

Radiation-induced xerostomia and cariogenic dietary habits.
Kawashima M, Kawabata T, Ando C, Sakuma M, Aoyama T, Ogawa H, Yokota T, Onozawa Y, Mukaigawa T, Nishimura T, Mori K, Yurikusa T
Support Care Cancer 2024 Jan 9;32(2):92. doi: 10.1007/s00520-023-08298-x. PMID: 38193941Free PMC Article
Prediction of Radiation-Induced Parotid Gland-Related Xerostomia in Patients With Head and Neck Cancer: Regeneration-Weighted Dose.
van Rijn-Dekker MI, van Luijk P, Schuit E, van der Schaaf A, Langendijk JA, Steenbakkers RJHM
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):750-762. Epub 2023 May 6 doi: 10.1016/j.ijrobp.2023.04.034. PMID: 37150262
Is Pilocarpine Effective in Preventing Radiation-Induced Xerostomia? A Systematic Review and Meta-analysis.
Yang WF, Liao GQ, Hakim SG, Ouyang DQ, Ringash J, Su YX
Int J Radiat Oncol Biol Phys 2016 Mar 1;94(3):503-11. Epub 2015 Nov 10 doi: 10.1016/j.ijrobp.2015.11.012. PMID: 26867879
Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia.
Radvansky LJ, Pace MB, Siddiqui A
Am J Health Syst Pharm 2013 Jun 15;70(12):1025-32. doi: 10.2146/ajhp120467. PMID: 23719879
Radiation-induced xerostomia: pathophysiology, prevention and treatment.
Bhide SA, Miah AB, Harrington KJ, Newbold KL, Nutting CM
Clin Oncol (R Coll Radiol) 2009 Dec;21(10):737-44. Epub 2009 Oct 14 doi: 10.1016/j.clon.2009.09.002. PMID: 19833490

Diagnosis

Acupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck Cancer: A Multicenter Randomized Clinical Trial.
Cohen L, Danhauer SC, Garcia MK, Dressler EV, Rosenthal DI, Chambers MS, Cusimano A, Brown WM, Ochoa JM, Yang P, Chiang JS, Gordon O, Crutcher R, Kim JK, Russin MP, Lukenbill J, Porosnicu M, Yost KJ, Weaver KE, Lesser GJ
JAMA Netw Open 2024 May 1;7(5):e2410421. doi: 10.1001/jamanetworkopen.2024.10421. PMID: 38739392Free PMC Article
Radiation-induced xerostomia and cariogenic dietary habits.
Kawashima M, Kawabata T, Ando C, Sakuma M, Aoyama T, Ogawa H, Yokota T, Onozawa Y, Mukaigawa T, Nishimura T, Mori K, Yurikusa T
Support Care Cancer 2024 Jan 9;32(2):92. doi: 10.1007/s00520-023-08298-x. PMID: 38193941Free PMC Article
Assessment of Radiation-Induced Xerostomia: Validation of the Xerostomia Questionnaire in Chinese Patients With Head and Neck Cancer.
Jiang N, Wei S, Mårtensson J, Zhao Y, Årestedt K
Cancer Nurs 2021 Mar-Apr 01;44(2):E68-E75. doi: 10.1097/NCC.0000000000000751. PMID: 31633565
Assessment of post-radiotherapy salivary glands.
Cheng SC, Wu VW, Kwong DL, Ying MT
Br J Radiol 2011 May;84(1001):393-402. doi: 10.1259/bjr/66754762. PMID: 21511748Free PMC Article
Radiation-induced xerostomia: pathophysiology, prevention and treatment.
Bhide SA, Miah AB, Harrington KJ, Newbold KL, Nutting CM
Clin Oncol (R Coll Radiol) 2009 Dec;21(10):737-44. Epub 2009 Oct 14 doi: 10.1016/j.clon.2009.09.002. PMID: 19833490

Therapy

Prediction of Radiation-Induced Parotid Gland-Related Xerostomia in Patients With Head and Neck Cancer: Regeneration-Weighted Dose.
van Rijn-Dekker MI, van Luijk P, Schuit E, van der Schaaf A, Langendijk JA, Steenbakkers RJHM
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):750-762. Epub 2023 May 6 doi: 10.1016/j.ijrobp.2023.04.034. PMID: 37150262
Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review.
Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jul;120(1):22-8. Epub 2015 Mar 25 doi: 10.1016/j.oooo.2015.03.007. PMID: 26093680
Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia.
Radvansky LJ, Pace MB, Siddiqui A
Am J Health Syst Pharm 2013 Jun 15;70(12):1025-32. doi: 10.2146/ajhp120467. PMID: 23719879
Radiation-induced xerostomia.
Chambers MS, Rosenthal DI, Weber RS
Head Neck 2007 Jan;29(1):58-63. doi: 10.1002/hed.20456. PMID: 16906511
Preventing radiation induced xerostomia.
Koukourakis MI, Danielidis V
Cancer Treat Rev 2005 Nov;31(7):546-54. Epub 2005 Oct 26 doi: 10.1016/j.ctrv.2005.07.006. PMID: 16257125

Prognosis

Prediction of Radiation-Induced Parotid Gland-Related Xerostomia in Patients With Head and Neck Cancer: Regeneration-Weighted Dose.
van Rijn-Dekker MI, van Luijk P, Schuit E, van der Schaaf A, Langendijk JA, Steenbakkers RJHM
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):750-762. Epub 2023 May 6 doi: 10.1016/j.ijrobp.2023.04.034. PMID: 37150262
Predicting late radiation-induced xerostomia with parotid gland PET biomarkers and dose metrics.
Wilkie JR, Mierzwa ML, Casper KA, Mayo CS, Schipper MJ, Eisbruch A, Worden FP, El Naqa I, Viglianti BL, Rosen BS
Radiother Oncol 2020 Jul;148:30-37. Epub 2020 Apr 6 doi: 10.1016/j.radonc.2020.03.037. PMID: 32311598Free PMC Article
Prevention and management of radiation-induced dermatitis, mucositis, and xerostomia.
Radvansky LJ, Pace MB, Siddiqui A
Am J Health Syst Pharm 2013 Jun 15;70(12):1025-32. doi: 10.2146/ajhp120467. PMID: 23719879
Preventing radiation induced xerostomia.
Koukourakis MI, Danielidis V
Cancer Treat Rev 2005 Nov;31(7):546-54. Epub 2005 Oct 26 doi: 10.1016/j.ctrv.2005.07.006. PMID: 16257125
Radiation-induced xerostomia: pathophysiology, clinical course and supportive treatment.
Guchelaar HJ, Vermes A, Meerwaldt JH
Support Care Cancer 1997 Jul;5(4):281-8. doi: 10.1007/s005200050075. PMID: 9257424

Clinical prediction guides

Acupuncture for Chronic Radiation-Induced Xerostomia in Head and Neck Cancer: A Multicenter Randomized Clinical Trial.
Cohen L, Danhauer SC, Garcia MK, Dressler EV, Rosenthal DI, Chambers MS, Cusimano A, Brown WM, Ochoa JM, Yang P, Chiang JS, Gordon O, Crutcher R, Kim JK, Russin MP, Lukenbill J, Porosnicu M, Yost KJ, Weaver KE, Lesser GJ
JAMA Netw Open 2024 May 1;7(5):e2410421. doi: 10.1001/jamanetworkopen.2024.10421. PMID: 38739392Free PMC Article
Radiation-induced xerostomia and cariogenic dietary habits.
Kawashima M, Kawabata T, Ando C, Sakuma M, Aoyama T, Ogawa H, Yokota T, Onozawa Y, Mukaigawa T, Nishimura T, Mori K, Yurikusa T
Support Care Cancer 2024 Jan 9;32(2):92. doi: 10.1007/s00520-023-08298-x. PMID: 38193941Free PMC Article
Safety and efficacy of oral pilocarpine in radiation-induced xerostomia in oropharyngeal carcinoma patients.
Kaur H, Singh Banipal RP, Singh H, Sonik YA, Sandhu SK
J Cancer Res Ther 2023 Apr-Jun;19(3):788-792. doi: 10.4103/jcrt.jcrt_2346_21. PMID: 37470612
Prediction of Radiation-Induced Parotid Gland-Related Xerostomia in Patients With Head and Neck Cancer: Regeneration-Weighted Dose.
van Rijn-Dekker MI, van Luijk P, Schuit E, van der Schaaf A, Langendijk JA, Steenbakkers RJHM
Int J Radiat Oncol Biol Phys 2023 Nov 1;117(3):750-762. Epub 2023 May 6 doi: 10.1016/j.ijrobp.2023.04.034. PMID: 37150262
Radiotherapy-induced xerostomia, pre-clinical promise of LMS-611.
Paterson C, Caldwell B, Porteous S, McLean A, Messow CM, Thomson M
Support Care Cancer 2016 Feb;24(2):629-636. Epub 2015 Jul 5 doi: 10.1007/s00520-015-2823-5. PMID: 26143037

Recent systematic reviews

Efficacy of bethanechol chloride in the treatment of radiation-induced xerostomia in patients with head and neck cancer: A systematic review and meta-analysis.
Moral Nakamura D, da Graça Pinto H, Baena Elchin C, Thomazotti Berard L, Abreu Alves F, Azeredo Alves Antunes L, Pena Coto N
Radiother Oncol 2023 Sep;186:109715. Epub 2023 May 18 doi: 10.1016/j.radonc.2023.109715. PMID: 37207874
Acupuncture for Radiation-Induced Xerostomia in Cancer Patients: A Systematic Review and Meta-Analysis.
Ni X, Tian T, Chen D, Liu L, Li X, Li F, Liang F, Zhao L
Integr Cancer Ther 2020 Jan-Dec;19:1534735420980825. doi: 10.1177/1534735420980825. PMID: 33307864Free PMC Article
Is Pilocarpine Effective in Preventing Radiation-Induced Xerostomia? A Systematic Review and Meta-analysis.
Yang WF, Liao GQ, Hakim SG, Ouyang DQ, Ringash J, Su YX
Int J Radiat Oncol Biol Phys 2016 Mar 1;94(3):503-11. Epub 2015 Nov 10 doi: 10.1016/j.ijrobp.2015.11.012. PMID: 26867879
Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review.
Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jul;120(1):22-8. Epub 2015 Mar 25 doi: 10.1016/j.oooo.2015.03.007. PMID: 26093680
Salivary gland transfer to prevent radiation-induced xerostomia: a systematic review and meta-analysis.
Sood AJ, Fox NF, O'Connell BP, Lovelace TL, Nguyen SA, Sharma AK, Hornig JD, Day TA
Oral Oncol 2014 Feb;50(2):77-83. Epub 2013 Nov 1 doi: 10.1016/j.oraloncology.2013.10.010. PMID: 24189058

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