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Ligneous conjunctivitis

MedGen UID:
226895
•Concept ID:
C1274789
•
Disease or Syndrome
Synonym: Ligneous Conjunctivitis
SNOMED CT: Ligneous conjunctivitis (403435005)
 
Monarch Initiative: MONDO:0100560
OMIM®: 217090
Orphanet: ORPHA97231

Definition

A rare form of chronic conjunctivitis characterized by the development of firm fibrin-rich, woody-like pseudomembraneous lesions mainly on the tarsal conjunctivae. Ligneous conjunctivitis is usually the initial and most common manifestation of type I congenital plasminogen deficiency. [from MONDO]

Professional guidelines

PubMed

Treatment of Ligneous Conjunctivitis with Plasminogen Eyedrops.
Caputo R, Shapiro AD, Sartori MT, Leonardi A, Jeng BH, Nakar C, Di Pasquale I, Price FW Jr, Thukral N, Suffredini AL, Pino L, Crea R, Mathew P, Calcinai M
Ophthalmology 2022 Aug;129(8):955-957. Epub 2022 Mar 26 doi: 10.1016/j.ophtha.2022.03.019. PMID: 35346720
Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis.
Ozbek-Uzman S, Yalniz-Akkaya Z, Nurozler Tabakci B, Singar E, Burcu A
Cornea 2021 Mar 1;40(3):299-302. doi: 10.1097/ICO.0000000000002573. PMID: 33290319
Treatment of plasminogen deficiency patients with fresh frozen plasma.
Kızılocak H, Ozdemir N, Dikme G, Koç B, Atabek AA, Çokuğraş H, İskeleli G, Dönmez-Demir B, Christiansen NM, Ziegler M, Ozdağ H, Schuster V, Celkan T
Pediatr Blood Cancer 2018 Feb;65(2) Epub 2017 Sep 6 doi: 10.1002/pbc.26779. PMID: 28876531

Recent clinical studies

Etiology

Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis.
Ozbek-Uzman S, Yalniz-Akkaya Z, Nurozler Tabakci B, Singar E, Burcu A
Cornea 2021 Mar 1;40(3):299-302. doi: 10.1097/ICO.0000000000002573. PMID: 33290319
An international registry of patients with plasminogen deficiency (HISTORY).
Shapiro AD, Menegatti M, Palla R, Boscarino M, Roberson C, Lanzi P, Bowen J, Nakar C, Janson IA, Peyvandi F
Haematologica 2020 Mar;105(3):554-561. Epub 2020 Jan 30 doi: 10.3324/haematol.2019.241158. PMID: 32001536Free PMC Article
Plasminogen deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID: 19141167
Plasminogen deficiency.
Schuster V, Hügle B, Tefs K
J Thromb Haemost 2007 Dec;5(12):2315-22. Epub 2007 Sep 26 doi: 10.1111/j.1538-7836.2007.02776.x. PMID: 17900274
Plasminogen and tissue-type plasminogen activator deficiency as risk factors for thromboembolic disease.
Brandt JT
Arch Pathol Lab Med 2002 Nov;126(11):1376-81. doi: 10.5858/2002-126-1376-PATTPA. PMID: 12421144

Diagnosis

Diagnosis of Immunoglobulin G4-related disease in a child with ligneous conjunctivitis: a novel mutation in plasminogen gene and plasminogen activator inhibitor-1 polymorphism.
Emiroğlu M, Bozkurt B, Emiroğlu HH, Koplay M, Koçak N, Karabağli P
Blood Coagul Fibrinolysis 2023 Oct 1;34(7):456-461. Epub 2023 Jul 27 doi: 10.1097/MBC.0000000000001246. PMID: 37577870
Ligneous Conjunctivitis Secondary to Viral Conjunctivitis.
Quintero-Estades JA, Iacob CE, Donnenfeld ED, Perry HD
Cornea 2023 Jan 1;42(1):118-120. Epub 2022 Sep 29 doi: 10.1097/ICO.0000000000003154. PMID: 36459582
Destructive membranous periodontal disease (ligneous gingivitis): a literature review.
Sivolella S, De Biagi M, Sartori MT, Berengo M, Bressan E
J Periodontol 2012 Apr;83(4):465-76. Epub 2011 Aug 22 doi: 10.1902/jop.2011.110261. PMID: 21859319
Plasminogen and tissue-type plasminogen activator deficiency as risk factors for thromboembolic disease.
Brandt JT
Arch Pathol Lab Med 2002 Nov;126(11):1376-81. doi: 10.5858/2002-126-1376-PATTPA. PMID: 12421144
Ligneous conjunctivitis.
Cohen Tervaert D, Cruysberg JR, Deutman AF, Manschot WA
Doc Ophthalmol 1986 Dec 30;64(1):5-11. doi: 10.1007/BF00166679. PMID: 3582101

Therapy

Ligneous conjunctivitis: Fresh-frozen plasma and heparin use intra-and postoperatively, a report of two cases.
Almeida SCGB, Marback PMF
Arq Bras Oftalmol 2024;87(3):e20220288. Epub 2024 Mar 22 doi: 10.5935/0004-2749.2022-0288. PMID: 38537040
Plasminogen deficiency.
Celkan T
J Thromb Thrombolysis 2017 Jan;43(1):132-138. doi: 10.1007/s11239-016-1416-6. PMID: 27629020
Plasminogen deficiency.
Mehta R, Shapiro AD
Haemophilia 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID: 19141167
Ligneous conjunctivitis.
Lancet 1990 Jan 13;335(8681):84. PMID: 1967424
Ligneous conjunctivitis.
McGrand JC, Rees DM, Harry J
Br J Ophthalmol 1969 Jun;53(6):373-81. doi: 10.1136/bjo.53.6.373. PMID: 4183365Free PMC Article

Prognosis

Novel homozygous mutation of plasminogen in ligneous conjunctivitis: a case report and literature review.
Xu L, Sun Y, Yang K, Zhao D, Wang Y, Ren S
Ophthalmic Genet 2021 Apr;42(2):105-109. Epub 2021 Jan 11 doi: 10.1080/13816810.2020.1867753. PMID: 33427557
Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis.
Ozbek-Uzman S, Yalniz-Akkaya Z, Nurozler Tabakci B, Singar E, Burcu A
Cornea 2021 Mar 1;40(3):299-302. doi: 10.1097/ICO.0000000000002573. PMID: 33290319
An international registry of patients with plasminogen deficiency (HISTORY).
Shapiro AD, Menegatti M, Palla R, Boscarino M, Roberson C, Lanzi P, Bowen J, Nakar C, Janson IA, Peyvandi F
Haematologica 2020 Mar;105(3):554-561. Epub 2020 Jan 30 doi: 10.3324/haematol.2019.241158. PMID: 32001536Free PMC Article
Clinical, histopathological, and genetic aspects in one case of ligneous conjunctivitis.
Raimann R, Moya R, Anguita R, Kobus R, Pérez M, Gonzalez P
Ophthalmic Genet 2018 Oct;39(5):642-644. Epub 2018 Jul 30 doi: 10.1080/13816810.2018.1502791. PMID: 30058940
Co-existing ligneous conjunctivitis and IgG4-related disease.
Chiang WY, Liu TT, Huang WT, Kuo MT
Indian J Ophthalmol 2016 Jul;64(7):532-4. doi: 10.4103/0301-4738.190154. PMID: 27609168Free PMC Article

Clinical prediction guides

Novel homozygous mutation of plasminogen in ligneous conjunctivitis: a case report and literature review.
Xu L, Sun Y, Yang K, Zhao D, Wang Y, Ren S
Ophthalmic Genet 2021 Apr;42(2):105-109. Epub 2021 Jan 11 doi: 10.1080/13816810.2020.1867753. PMID: 33427557
Anterior Segment Surgeries Under Topical Fresh Frozen Plasma Treatment in Ligneous Conjunctivitis.
Ozbek-Uzman S, Yalniz-Akkaya Z, Nurozler Tabakci B, Singar E, Burcu A
Cornea 2021 Mar 1;40(3):299-302. doi: 10.1097/ICO.0000000000002573. PMID: 33290319
An international registry of patients with plasminogen deficiency (HISTORY).
Shapiro AD, Menegatti M, Palla R, Boscarino M, Roberson C, Lanzi P, Bowen J, Nakar C, Janson IA, Peyvandi F
Haematologica 2020 Mar;105(3):554-561. Epub 2020 Jan 30 doi: 10.3324/haematol.2019.241158. PMID: 32001536Free PMC Article
Ligneous conjunctivitis: a case report.
Shimabukuro M, Iwasaki N, Nagae Y, Nakagawa Y, Ohtori Y, Inoue Y, Tano Y
Jpn J Ophthalmol 2001 Jul-Aug;45(4):375-7. doi: 10.1016/s0021-5155(01)00342-2. PMID: 11485769
Ligneous conjunctivitis in plasminogen-deficient mice.
Drew AF, Kaufman AH, Kombrinck KW, Danton MJ, Daugherty CC, Degen JL, Bugge TH
Blood 1998 Mar 1;91(5):1616-24. PMID: 9473227

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