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Minimal deviation adenocarcinoma of endocervical type

MedGen UID:
696308
•Concept ID:
C1272765
•
Neoplastic Process
Synonym: Adenoma malignum
SNOMED CT: Adenoma malignum (385478001); Minimal deviation adenocarcinoma of endocervical type (388986005); Adenoma malignum (388986005)

Professional guidelines

PubMed

Image quantification technology of the heterochromatin and euchromatin region for differential diagnosis in the lobular endocervical glandular hyperplasia.
Kimura F, Kobayashi T, Kanai R, Kobayashi Y, Yuhi O, Ota H, Yamaguchi M, Yokokawa Y, Uehara T, Ishii K
Diagn Cytopathol 2019 Jun;47(6):553-563. Epub 2019 Feb 13 doi: 10.1002/dc.24155. PMID: 30761780
Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.
Meserve EE, Nucci MR
Surg Pathol Clin 2016 Jun;9(2):243-68. doi: 10.1016/j.path.2016.01.006. PMID: 27241107
Endocervical adenocarcinoma and its variants: their morphology and differential diagnosis.
Young RH, Clement PB
Histopathology 2002 Sep;41(3):185-207. doi: 10.1046/j.1365-2559.2002.01462.x. PMID: 12207781

Recent clinical studies

Etiology

Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas.
Chen L, Niu Y, Wan X, Yu L, Zhang X, Strickland AL, Dong L, Zhou F, Lu W
BMC Cancer 2021 Oct 11;21(1):1095. doi: 10.1186/s12885-021-08792-7. PMID: 34635081Free PMC Article
Gastric-type mucinous carcinoma of the cervix and its precursors - historical overview.
Mikami Y
Histopathology 2020 Jan;76(1):102-111. doi: 10.1111/his.13993. PMID: 31846534
Primary endocervical gastric-type adenocarcinoma: a clinicopathologic and immunohistochemical analysis of 23 cases.
Lu S, Shen D, Zhao Y, Kang N, Wang X
Diagn Pathol 2019 Jul 6;14(1):72. doi: 10.1186/s13000-019-0852-y. PMID: 31279344Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171

Diagnosis

Biology and management of lobular endocervical glandular hyperplasia.
Miyamoto T, Kobara H, Shiozawa T
J Obstet Gynaecol Res 2022 Dec;48(12):3056-3067. Epub 2022 Sep 30 doi: 10.1111/jog.15441. PMID: 36177810Free PMC Article
Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas.
Chen L, Niu Y, Wan X, Yu L, Zhang X, Strickland AL, Dong L, Zhou F, Lu W
BMC Cancer 2021 Oct 11;21(1):1095. doi: 10.1186/s12885-021-08792-7. PMID: 34635081Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.
Meserve EE, Nucci MR
Surg Pathol Clin 2016 Jun;9(2):243-68. doi: 10.1016/j.path.2016.01.006. PMID: 27241107
Endocervical adenocarcinoma: selected diagnostic challenges.
Ronnett BM
Mod Pathol 2016 Jan;29 Suppl 1:S12-28. doi: 10.1038/modpathol.2015.131. PMID: 26715171

Therapy

Endocervicosis of the Uterine Cervix.
Mobarki M, Karpathiou G, Forest F, Corsini T, Peoc'h M
Int J Gynecol Pathol 2016 Sep;35(5):475-7. doi: 10.1097/PGP.0000000000000277. PMID: 26825004
Pseudoinfiltrative tubal metaplasia of the endocervix: a potential form of in utero diethylstilbestrol exposure-related adenosis simulating minimal deviation adenocarcinoma.
Vang R, Vinh TN, Burks RT, Barner R, Kurman RJ, Ronnett BM
Int J Gynecol Pathol 2005 Oct;24(4):391-8. doi: 10.1097/01.pgp.0000170064.95465.5c. PMID: 16175088
Cytologic and cytochemical features of adenoma malignum of the uterine cervix.
Ishii K, Katsuyama T, Ota H, Watanabe T, Matsuyama I, Tsuchiya S, Shiozawa T, Toki T
Cancer Cytopathol 1999 Oct 25;87(5):245-53. doi: 10.1002/(sici)1097-0142(19991025)87:5<245::aid-cncr2>3.0.co;2-0. PMID: 10536348

Prognosis

Comparison of Clinicopathological and Prognostic Characteristics Between Minimal Deviation Adenocarcinoma and Gastric-type Endocervical Adenocarcinoma.
Kum SJ, Jung YY, Kim HS
Anticancer Res 2024 May;44(5):2193-2204. doi: 10.21873/anticanres.17026. PMID: 38677732
Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas.
Chen L, Niu Y, Wan X, Yu L, Zhang X, Strickland AL, Dong L, Zhou F, Lu W
BMC Cancer 2021 Oct 11;21(1):1095. doi: 10.1186/s12885-021-08792-7. PMID: 34635081Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis.
Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, Soslow RA, Park KJ
Am J Surg Pathol 2015 Nov;39(11):1449-57. doi: 10.1097/PAS.0000000000000532. PMID: 26457350Free PMC Article
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085

Clinical prediction guides

Comparison of Clinicopathological and Prognostic Characteristics Between Minimal Deviation Adenocarcinoma and Gastric-type Endocervical Adenocarcinoma.
Kum SJ, Jung YY, Kim HS
Anticancer Res 2024 May;44(5):2193-2204. doi: 10.21873/anticanres.17026. PMID: 38677732
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis.
Karamurzin YS, Kiyokawa T, Parkash V, Jotwani AR, Patel P, Pike MC, Soslow RA, Park KJ
Am J Surg Pathol 2015 Nov;39(11):1449-57. doi: 10.1097/PAS.0000000000000532. PMID: 26457350Free PMC Article
Cytologic features of gastric-type adenocarcinoma of the uterine cervix.
Kawakami F, Mikami Y, Sudo T, Fujiwara K, Hirose T, Itoh T
Diagn Cytopathol 2015 Oct;43(10):791-6. Epub 2015 Jul 14 doi: 10.1002/dc.23304. PMID: 26173165
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085
p16 Immunoreactivity in unusual types of cervical adenocarcinoma does not reflect human papillomavirus infection.
Houghton O, Jamison J, Wilson R, Carson J, McCluggage WG
Histopathology 2010 Sep;57(3):342-50. Epub 2010 Aug 19 doi: 10.1111/j.1365-2559.2010.03632.x. PMID: 20727021

Recent systematic reviews

Tissue-based Immunohistochemical Biomarker Expression in Malignant Glandular Lesions of the Uterine Cervix: A Systematic Review.
Lee S, Sahasrabuddhe VV, Mendoza-Cervantes D, Zhao R, Duggan MA
Int J Gynecol Pathol 2018 Mar;37(2):128-140. doi: 10.1097/PGP.0000000000000406. PMID: 28582347

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