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Gliofibroma

MedGen UID:
226850
•Concept ID:
C1266178
•
Neoplastic Process
Synonyms: gliofibroma; gliofibroma (morphologic abnormality)
SNOMED CT: Gliofibroma (128909006)
 
Monarch Initiative: MONDO:0003170

Definition

An astrocytic tumor affecting young people. Morphologically, it is characterized by the presence of collagenous tissue surrounding neoplastic astrocytes. In some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGliofibroma

Recent clinical studies

Etiology

The spectrum of morphological findings in pediatric central nervous system MN1-fusion-positive neuroepithelial tumors.
Lubieniecki F, Vazquez V, Lamas GS, Camarero S, Nuñez FJ, Baroni L, Schüller U, Alderete D
Childs Nerv Syst 2023 Feb;39(2):379-386. Epub 2022 Dec 19 doi: 10.1007/s00381-022-05741-y. PMID: 36534132
Cervical intramedullary gliofibroma in a child: a case report and review of the literature.
Matsumura A, Takano S, Nagata M, Anno I, Nose T
Pediatr Neurosurg 2002 Feb;36(2):105-10. doi: 10.1159/000048362. PMID: 11893894
Monitoring tumor activity in low grade glioma of childhood.
Mölenkamp G, Riemann B, Kuwert T, Sträter R, Kurlemann G, Schober O, Jürgens H, Wolff JE
Klin Padiatr 1998 Jul-Aug;210(4):239-42. doi: 10.1055/s-2008-1043885. PMID: 9743959
Gliofibromas (including malignant forms), and gliosarcomas: a comparative study and review of the literature.
Cerda-Nicolas M, Kepes JJ
Acta Neuropathol 1993;85(4):349-61. doi: 10.1007/BF00334444. PMID: 8480509
Problems in the nosology of desmoplastic tumors of childhood.
Rushing EJ, Rorke LB, Sutton L
Pediatr Neurosurg 1993 Mar-Apr;19(2):57-62. doi: 10.1159/000120701. PMID: 8443097

Diagnosis

The spectrum of morphological findings in pediatric central nervous system MN1-fusion-positive neuroepithelial tumors.
Lubieniecki F, Vazquez V, Lamas GS, Camarero S, Nuñez FJ, Baroni L, Schüller U, Alderete D
Childs Nerv Syst 2023 Feb;39(2):379-386. Epub 2022 Dec 19 doi: 10.1007/s00381-022-05741-y. PMID: 36534132
Recurrence of cervical intramedullary gliofibroma.
Tokunaga K, Nagoshi N, Ohara K, Shibuya M, Suzuki S, Tsuji O, Okada E, Fujita N, Yagi M, Watanabe K, Nakamura M, Matsumoto M
Spinal Cord Ser Cases 2021 Nov 5;7(1):97. doi: 10.1038/s41394-021-00461-y. PMID: 34741004Free PMC Article
Gliofibroma: Report of Four Cases and Review of the Literature.
Jones MC, Díaz V, D'Agustini M, Altamirano E, Baglieri N, Drut R
Fetal Pediatr Pathol 2016;35(1):50-61. Epub 2015 Dec 31 doi: 10.3109/15513815.2015.1122124. PMID: 26720861
Intracranial gliofibroma mimicking a meningioma: a case report and review of literature.
Deb P, Sarkar C, Garg A, Singh VP, Kale SS, Sharma MC
Clin Neurol Neurosurg 2006 Feb;108(2):178-86. doi: 10.1016/j.clineuro.2004.11.021. PMID: 16412839
Gliofibroma with extensive calcified deposits.
Kim NR, Suh YL, Shin HJ, Park IS
Clin Neuropathol 2003 Jan-Feb;22(1):14-22. PMID: 12617189

Therapy

Carboplatinum and vincristine chemotherapy for central nervous system gliofibroma: case report and review of the literature.
Suarez CR, Raj AB, Bertolone SJ, Coventry S
J Pediatr Hematol Oncol 2004 Nov;26(11):756-60. doi: 10.1097/00043426-200411000-00014. PMID: 15543013

Prognosis

Epigenome-wide data collection in a case of gliofibroma.
Behling F, Hennersdorf F, Schittenhelm J
Folia Neuropathol 2021;59(2):212-218. doi: 10.5114/fn.2021.106278. PMID: 34284549
Autonomic dysreflexia associated with cervical spinal cord gliofibroma: case report.
Mizuno H, Honda F, Ikota H, Yoshimoto Y
BMC Neurol 2021 Jun 29;21(1):252. doi: 10.1186/s12883-021-02271-z. PMID: 34187375Free PMC Article
Gliofibroma: Report of Four Cases and Review of the Literature.
Jones MC, Díaz V, D'Agustini M, Altamirano E, Baglieri N, Drut R
Fetal Pediatr Pathol 2016;35(1):50-61. Epub 2015 Dec 31 doi: 10.3109/15513815.2015.1122124. PMID: 26720861
Intracranial gliofibroma mimicking a meningioma: a case report and review of literature.
Deb P, Sarkar C, Garg A, Singh VP, Kale SS, Sharma MC
Clin Neurol Neurosurg 2006 Feb;108(2):178-86. doi: 10.1016/j.clineuro.2004.11.021. PMID: 16412839
Cervical intramedullary gliofibroma in a child: a case report and review of the literature.
Matsumura A, Takano S, Nagata M, Anno I, Nose T
Pediatr Neurosurg 2002 Feb;36(2):105-10. doi: 10.1159/000048362. PMID: 11893894

Clinical prediction guides

The spectrum of morphological findings in pediatric central nervous system MN1-fusion-positive neuroepithelial tumors.
Lubieniecki F, Vazquez V, Lamas GS, Camarero S, Nuñez FJ, Baroni L, Schüller U, Alderete D
Childs Nerv Syst 2023 Feb;39(2):379-386. Epub 2022 Dec 19 doi: 10.1007/s00381-022-05741-y. PMID: 36534132
Recurrence of cervical intramedullary gliofibroma.
Tokunaga K, Nagoshi N, Ohara K, Shibuya M, Suzuki S, Tsuji O, Okada E, Fujita N, Yagi M, Watanabe K, Nakamura M, Matsumoto M
Spinal Cord Ser Cases 2021 Nov 5;7(1):97. doi: 10.1038/s41394-021-00461-y. PMID: 34741004Free PMC Article
Autonomic dysreflexia associated with cervical spinal cord gliofibroma: case report.
Mizuno H, Honda F, Ikota H, Yoshimoto Y
BMC Neurol 2021 Jun 29;21(1):252. doi: 10.1186/s12883-021-02271-z. PMID: 34187375Free PMC Article
Gliofibroma: Report of Four Cases and Review of the Literature.
Jones MC, Díaz V, D'Agustini M, Altamirano E, Baglieri N, Drut R
Fetal Pediatr Pathol 2016;35(1):50-61. Epub 2015 Dec 31 doi: 10.3109/15513815.2015.1122124. PMID: 26720861
Disseminated spinal cord astrocytoma with features of gliofibroma: a review of the literature.
Prayson RA
Clin Neuropathol 2013 Jul-Aug;32(4):298-302. doi: 10.5414/NP300592. PMID: 23320999

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